New drug IDE574 enters human trials for Hard-to-Treat cancers

NCT ID NCT07540572

Recruiting now Disease control Sponsor: IDEAYA Biosciences Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a new drug called IDE574 in people with advanced solid tumors or a specific type of breast cancer (ER+, HER2-). The drug targets two enzymes that help cancer cells grow. The study has two parts: first, testing IDE574 alone in various cancers; second, combining it with another drug (fulvestrant) for breast cancer. About 160 participants will join to check safety, side effects, and whether the drug shrinks tumors.

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Conditions

The condition(s) this trial relates to.

castration-resistant prostate carcinoma colorectal adenocarcinoma colorectal carcinoma colorectal neoplasm estrogen-receptor positive breast cancer non-small cell lung carcinoma Spinocerebellar Degenerations

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CASTRATION-RESISTANT PROSTATE CANCER (CRPC) ER+, HER 2- BREAST CANCER MICROSATELLITE STABLE (MSS) COLORECTAL CARCINOMA NON-SMALL CELL LUNG CANCER (NSCLC)

Contacts and locations

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Locations

Florida Clinical Trials Group
RECRUITING

Plantation, Florida, 33322, United States
NEXT Texas LLC - Austin
RECRUITING

Austin, Texas, 78758, United States
NEXT Texas LLC - Dallas
RECRUITING

Dallas, Texas, 75039, United States
NEXT Texas LLC - Houston
RECRUITING

Houston, Texas, 77054, United States
NEXT Texas LLC - San Antonio
RECRUITING

San Antonio, Texas, 78229, United States
NEXT Virginia
RECRUITING

Fairfax, Virginia, 22031, United States
START Astera, LLC
RECRUITING

East Brunswick, New Jersey, 08816, United States

Contact Email: •••••@•••••
START Dallas Fort Worth, LLC
RECRUITING

Fort Worth, Texas, 76104, United States

Contact Email: •••••@•••••
START Mountain Region, LLC
RECRUITING

West Valley City, Utah, 84119, United States

Contact Email: •••••@•••••
START New York Long Island, LLC
RECRUITING

Lake Success, New York, 11042, United States

Contact Email: •••••@•••••
Start San Antonio, LLC
RECRUITING

San Antonio, Texas, 78229, United States

Contact Email: •••••@•••••

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