Metformin pause: does a Two-Week break worsen blood sugar control?

NCT ID NCT07659444

Recruiting now Knowledge-focused Sponsor: University of Castilla-La Mancha Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at what happens when adults with metabolic syndrome stop taking their usual metformin medication for 14 days. Researchers want to see if a short break affects insulin sensitivity, blood sugar levels, and other health markers. Participants will be randomly assigned to either stop metformin for two weeks or continue as usual, and will undergo glucose tests and wear a continuous glucose monitor. The goal is to understand the real-world impact of temporary metformin interruptions.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: metformin withdrawal (behavioural intervention)
What this could lead to: If successful, this study could help doctors understand whether short breaks from metformin are safe and how quickly glucose control changes.
What could go wrong: This is a small, early-stage study with only 28 participants. It is not testing a new treatment, so results may not apply to everyone or lead to direct health changes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for GLUCOSE INTOLERANCE are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

abdominal obesity-metabolic syndrome glucose intolerance Insulin Resistance metabolic syndrome X

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GLUCOSE INTOLERANCE METABOLIC SYNDROME (METS)

Contacts and locations

Locations

University of Castilla-La Mancha
RECRUITING

Toledo, Toledo, 45071, Spain

More trials for these conditions

Other studies related to the condition(s) this trial covers.