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Can Time-Restricted eating tame insulin resistance? a new study aims to find out

NCT ID NCT07710274

Disease control Sponsor: National University Health System, Singapore Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 17, 2026 · Last updated Jul 17, 2026

Summary

This pilot study tests a personalized lifestyle program called PRISM for adults with metabolic syndrome and insulin resistance. Participants follow a time-restricted eating schedule (eating all meals within an 8-hour window) and are later assigned extra lifestyle changes like physical activity, a low-sugar diet, or sleep tips. The goal is to see if this approach is practical and can improve insulin resistance, measured by a blood test called HOMA-IR.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
time-restricted eating combined with physical activity, low glycemic load diet, or sleep hygiene
What this could lead to
If successful, this approach could offer a practical, non-drug way to manage insulin resistance and reduce the health burden of metabolic syndrome.
What could go wrong
This is a small pilot study focused on feasibility, not proof of effectiveness. The results may not apply to everyone, and sticking to the eating and lifestyle changes can be challenging.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 200 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jul 2026

An estimate. Start dates often move.

Expected to finish

Jul 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

21 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Participants will be included for if they are: * (1) adults aged 21-70 years old; * (2) willing and able to comply with using a CGM, smart ring, food logging app * (3) able to provide written informed consent; * (4) English-speaking and literate; * (5) meet the inclusion criteria for metabolic syndrome and insulin resistance. * The criteria for insulin resistance is HOMA-IR ≥ 2.5. * The criteria for metabolic syndrome is to have high waist circumference (≥ 80cm for females and ≥ 90cm for males); and any two of the four below: * (1) raised triglycerides: 1.7 mmol/L or on treatment; * (2) reduced HDL cholesterol: \< 1.0 mmol/L (40 mg/dL) in men, \< 1.3 mmol/L (50 mg/dL) in women, or on treatment; * (3) high blood pressure: 130/85 mmHg or on treatment; or * (4) raised fasting glucose: 5.6 mmol/L (100 mg/dL) or previously diagnosed with T2DM Exclusion Criteria: Participants will be excluded from both phases if they are: * (1) on insulin therapy; * (2) are pregnant or lactating; * (3) have a medical condition or are on a treatment that may interfere with study participation or metabolic assessments, as determined by the study investigators; * (4) currently participating in other lifestyle modification programs.

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Conditions

The condition(s) this trial relates to.

abdominal obesity-metabolic syndrome metabolic syndrome X

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Metabolic syndrome (METS)

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • National University of Singapore

    Singapore, 117597, Singapore

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