New hope for advanced GIST: experimental drug NB003 takes on resistant tumors

NCT ID NCT07379047

Recruiting now Disease control Sponsor: Ningbo Newbay Technology Development Co., Ltd Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests an experimental drug called NB003 in people with advanced GIST that has worsened after standard treatments. The trial has two parts: one compares NB003 to the approved drug regorafenib as a third-line therapy, and the other tests NB003 alone as a second-line therapy. The goal is to see if NB003 can shrink tumors or delay cancer growth.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: NB003 (a drug taken by mouth)
What this could lead to: If successful, NB003 could offer a new treatment option for people with advanced GIST whose cancer has stopped responding to other drugs.
What could go wrong: This is an early-to-mid-stage trial, so NB003 may not work better than existing treatments or could have unexpected side effects. Results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

gastrointestinal stromal tumor

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED GIST - GASTROINTESTINAL STROMAL TUMOR

Contacts and locations

Locations

Asan Medical Center
NOT_YET_RECRUITING

Seoul, South Korea
Beijing Cancer Hospital
RECRUITING

Beijing, Beijing Municipality, China
Cancer Hospital Affiliated to Harbin Medical University
NOT_YET_RECRUITING

Harbin, Heilongjiang, China
Fudan University Shanghai Cancer Center
NOT_YET_RECRUITING

Shanghai, Shanghai Municipality, China
Guangxi Medical University Affiliated Cancer Hospital
NOT_YET_RECRUITING

Nanning, Guangxi, China
Henan Cancer Hospital
NOT_YET_RECRUITING

Zhengzhou, Henan, China
Hubei Cancer Hospital
NOT_YET_RECRUITING

Wuhan, Hubei, China
Jiangsu Cancer Hospital
NOT_YET_RECRUITING

Nanjing, Jiangsu, China
Jiangsu Province Hospital
NOT_YET_RECRUITING

Nanjing, Jiangsu, China
Jilin Cancer Hospital
NOT_YET_RECRUITING

Changchun, Jilin, China
Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
NOT_YET_RECRUITING

Shanghai, Shanghai Municipality, China
Samsung Medical Center
NOT_YET_RECRUITING

Seoul, South Korea
Shandong Cancer Hospital
NOT_YET_RECRUITING

Jinan, Shandong, China
Shandong Provincial Hospital
NOT_YET_RECRUITING

Jinan, Shandong, China
Shanxi Cancer Hospital
NOT_YET_RECRUITING

Taiyuan, Shanxi, China
Sichuan Cancer Hospital
NOT_YET_RECRUITING

Chengdu, Sichuan, China
Sir Run Run Shaw Hospital , affiliated with the Zhejiang University School of Medicine
NOT_YET_RECRUITING

Hangzhou, Zhejiang, China
Sun Yat-sen University Cancer Center
NOT_YET_RECRUITING

Guangzhou, Guangdong, China
The Affiliated Hospital of Guizhou Medical University
NOT_YET_RECRUITING

Guiyang, Guizhou, China
The Affiliated Hospital of Qingdao University
RECRUITING

Qingdao, Shandong, China
The First Affiliated Hospital of Anhui Medical University
NOT_YET_RECRUITING

Hefei, Anhui, China
The First Affiliated Hospital of Chongqing Medical University
NOT_YET_RECRUITING

Chongqing, Chongqing Municipality, China
The First Affiliated Hospital of Fujian Medical University
NOT_YET_RECRUITING

Fuzhou, Fujian, China
The First Affiliated Hospital of Nanchang University
NOT_YET_RECRUITING

Nanchang, Jiangxi, China
The First Affiliated Hospital of Sun Yat-sen University
NOT_YET_RECRUITING

Guangzhou, Guandong, China
The First Affiliated Hospital of Zhejiang University School of Medicine
NOT_YET_RECRUITING

Hangzhou, Zhejiang, China
The First Affiliated Hospital of Zhengzhou University
NOT_YET_RECRUITING

Zhengzhou, Henan, China
The Fourth Hospital of Hebei Medical University
NOT_YET_RECRUITING

Shijiazhuang, Hebei, China
The Second Hospital of Anhui Medical University
RECRUITING

Hefei, Anhui, China
Union Hospital Tongji Medical College Huazhong University of Science and Technology
RECRUITING

Wuhan, Hubei, China
West China Hospital of Sichuan University
NOT_YET_RECRUITING

Chengdu, Sichuan, China
Xiangya Hospital, Central South University
NOT_YET_RECRUITING

Changsha, Hunan, China

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