New hope for advanced GIST: experimental drug NB003 takes on resistant tumors
NCT ID NCT07379047
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests an experimental drug called NB003 in people with advanced GIST that has worsened after standard treatments. The trial has two parts: one compares NB003 to the approved drug regorafenib as a third-line therapy, and the other tests NB003 alone as a second-line therapy. The goal is to see if NB003 can shrink tumors or delay cancer growth.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
NB003 (a drug taken by mouth)
What this could lead to
If successful, NB003 could offer a new treatment option for people with advanced GIST whose cancer has stopped responding to other drugs.
What could go wrong
This is an early-to-mid-stage trial, so NB003 may not work better than existing treatments or could have unexpected side effects. Results may not apply to all patients.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Asan Medical Center
NOT_YET_RECRUITINGSeoul, South Korea
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Beijing Cancer Hospital
RECRUITINGBeijing, Beijing Municipality, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Cancer Hospital Affiliated to Harbin Medical University
NOT_YET_RECRUITINGHarbin, Heilongjiang, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Fudan University Shanghai Cancer Center
NOT_YET_RECRUITINGShanghai, Shanghai Municipality, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Guangxi Medical University Affiliated Cancer Hospital
NOT_YET_RECRUITINGNanning, Guangxi, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Henan Cancer Hospital
NOT_YET_RECRUITINGZhengzhou, Henan, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hubei Cancer Hospital
NOT_YET_RECRUITINGWuhan, Hubei, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Jiangsu Cancer Hospital
NOT_YET_RECRUITINGNanjing, Jiangsu, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Jiangsu Province Hospital
NOT_YET_RECRUITINGNanjing, Jiangsu, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Jilin Cancer Hospital
NOT_YET_RECRUITINGChangchun, Jilin, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
NOT_YET_RECRUITINGShanghai, Shanghai Municipality, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Samsung Medical Center
NOT_YET_RECRUITINGSeoul, South Korea
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Shandong Cancer Hospital
NOT_YET_RECRUITINGJinan, Shandong, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Shandong Provincial Hospital
NOT_YET_RECRUITINGJinan, Shandong, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Shanxi Cancer Hospital
NOT_YET_RECRUITINGTaiyuan, Shanxi, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Sichuan Cancer Hospital
NOT_YET_RECRUITINGChengdu, Sichuan, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Sir Run Run Shaw Hospital , affiliated with the Zhejiang University School of Medicine
NOT_YET_RECRUITINGHangzhou, Zhejiang, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Sun Yat-sen University Cancer Center
NOT_YET_RECRUITINGGuangzhou, Guangdong, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The Affiliated Hospital of Guizhou Medical University
NOT_YET_RECRUITINGGuiyang, Guizhou, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The Affiliated Hospital of Qingdao University
RECRUITINGQingdao, Shandong, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The First Affiliated Hospital of Anhui Medical University
NOT_YET_RECRUITINGHefei, Anhui, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The First Affiliated Hospital of Chongqing Medical University
NOT_YET_RECRUITINGChongqing, Chongqing Municipality, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The First Affiliated Hospital of Fujian Medical University
NOT_YET_RECRUITINGFuzhou, Fujian, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The First Affiliated Hospital of Nanchang University
NOT_YET_RECRUITINGNanchang, Jiangxi, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The First Affiliated Hospital of Sun Yat-sen University
NOT_YET_RECRUITINGGuangzhou, Guandong, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The First Affiliated Hospital of Zhejiang University School of Medicine
NOT_YET_RECRUITINGHangzhou, Zhejiang, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The First Affiliated Hospital of Zhengzhou University
NOT_YET_RECRUITINGZhengzhou, Henan, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The Fourth Hospital of Hebei Medical University
NOT_YET_RECRUITINGShijiazhuang, Hebei, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The Second Hospital of Anhui Medical University
RECRUITINGHefei, Anhui, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Union Hospital Tongji Medical College Huazhong University of Science and Technology
RECRUITINGWuhan, Hubei, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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West China Hospital of Sichuan University
NOT_YET_RECRUITINGChengdu, Sichuan, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Xiangya Hospital, Central South University
NOT_YET_RECRUITINGChangsha, Hunan, China
Contact Phone: •••-•••-•••• Email: •••••@•••••