New hope for GIST: experimental combo targets hard-to-treat tumors

NCT ID NCT07406633

Recruiting now Disease control Sponsor: Kumquat Biosciences Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 11, 2026 · Updated 5 times

Summary

This study tests whether adding an experimental drug (KQB198) to the standard cancer pill imatinib can shrink or control advanced gastrointestinal stromal tumors (GIST). About 46 adults with a specific gene mutation (KIT or PDGFRA) will receive the combination. The goal is to see if the combo is safe and works better than imatinib alone.

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Conditions

The condition(s) this trial relates to.

digestive system cancer digestive system neoplasm Digestive System Neoplasms gastrointestinal stromal tumor

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GASTRO INTESTINAL STROMAL TUMOUR GASTROINTESTINAL TUMORS GIST GIST - GASTROINTESTINAL STROMAL TUMOR GIST METASTATIC CANCER

Contacts and locations

Locations

Cleveland Clinic
RECRUITING

Cleveland, Ohio, 44195, United States
Dana-Farber Cancer Institute
RECRUITING

Boston, Massachusetts, 02215, United States
Fox Chase Cancer Center
RECRUITING

Philadelphia, Pennsylvania, 19111, United States
Fred Hutchinson Cancer Center
RECRUITING

Seattle, Washington, 98109, United States
Huntsman Cancer Institute
RECRUITING

Salt Lake City, Utah, 84112, United States
Mayo Clinic - Jacksonville
RECRUITING

Jacksonville, Florida, 32224, United States
Mayo Clinic - Rochester
RECRUITING

Rochester, Minnesota, 55905, United States
Moffitt Cancer Center
RECRUITING

Tampa, Florida, 33612, United States
Northwell Health/R.J. Zuckerberg Cancer Center
RECRUITING

Lake Success, New York, 11042, United States
Oregon Health & Science University
RECRUITING

Portland, Oregon, 97239, United States
Sylvester Comprehensive Cancer Center
RECRUITING

Miami, Florida, 33136, United States
USC Norris Comprehensive Cancer Center
RECRUITING

Los Angeles, California, 90033, United States
UT MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
University of Chicago Medical Center
RECRUITING

Chicago, Illinois, 60637, United States
University of Iowa Health Care
RECRUITING

Iowa City, Iowa, 52242, United States
University of Michigan Hospitals
RECRUITING

Ann Arbor, Michigan, 48109, United States
University of North Carolina at Chapel Hill
RECRUITING

Chapel Hill, North Carolina, 27599, United States

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