New hope for GIST: experimental combo targets hard-to-treat tumors
NCT ID NCT07406633
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether adding an experimental drug (KQB198) to the standard cancer pill imatinib can shrink or control advanced gastrointestinal stromal tumors (GIST). About 46 adults with a specific gene mutation (KIT or PDGFRA) will receive the combination. The goal is to see if the combo is safe and works better than imatinib alone.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Cleveland Clinic
RECRUITINGCleveland, Ohio, 44195, United States
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Fred Hutchinson Cancer Center
RECRUITINGSeattle, Washington, 98195, United States
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Mayo Clinic - Jacksonville
RECRUITINGJacksonville, Florida, 32224, United States
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Mayo Clinic - Rochester
RECRUITINGRochester, Minnesota, 55905, United States
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Moffitt Cancer Center
RECRUITINGTampa, Florida, 33612, United States
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USC Norris Comprehensive Cancer Center
RECRUITINGLos Angeles, California, 90033, United States
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UT MD Anderson Cancer Center
RECRUITINGHouston, Texas, 77030, United States
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University of Michigan Hospitals
RECRUITINGAnn Arbor, Michigan, 48109, United States