New ulcerative colitis drug put through drug interaction test
NCT ID NCT07665723
First seen Jun 27, 2026 · Last updated Jul 24, 2026 · Updated 2 times
Summary
This early-phase study is testing whether afimkibart, an experimental drug for ulcerative colitis, changes how the body processes common medications like caffeine, warfarin, and omeprazole. About 25 people with moderate to severe active ulcerative colitis will receive afimkibart along with a cocktail of these drugs to measure any interactions. The goal is to gather safety and drug-processing data, not to treat the disease directly.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Afimkibart (also known as RO7790121, PF-06480605, RVT-3101)
- What this could lead to
- If successful, this study will show whether afimkibart changes how the body processes other drugs, helping doctors prescribe safer combinations for ulcerative colitis.
- What could go wrong
- This is a very early, small study (25 people) focused on drug interactions, not on treating the disease itself. Results may not apply to all patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Allied Biomedical Research Institute, Inc
RECRUITINGMiami, Florida, 33155, United States
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Charite Research Organisation GmbH
RECRUITINGBerlin, 10117, Germany
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Erick H. Alayo Medical Corporation - Gastro SB Clinic
RECRUITINGChula Vista, California, 91910, United States
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Gastro Health Research
RECRUITINGMiami, Florida, 33176-2416, United States
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Royal Liverpool University Hospital
RECRUITINGLiverpool, L7 8XP, United Kingdom
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Royal Victoria Infirmary
RECRUITINGNewcastle upon Tyne, NE1 4LP, United Kingdom
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University College London Hospitals
RECRUITINGLondon, W1T 7HA, United Kingdom
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