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New drug cocktail aims to outsmart Hard-to-Treat colorectal cancer

NCT ID NCT07079631

Recruiting now Disease control Sponsor: BioNTech SE Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 02, 2026 · Updated 3 times

Summary

This study is testing whether adding two new drugs (BNT314 and BNT327) to standard chemotherapy can help people with metastatic colorectal cancer that hasn't responded well to initial treatment. The trial will enroll about 482 participants across multiple sites. The goal is to see if the combination can shrink tumors or slow cancer growth, while monitoring for side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
BNT314 (a biologic that helps the immune system fight cancer) combined with BNT327 (an immune checkpoint inhibitor) and chemotherapy
What this could lead to
If successful, this combination could offer a new treatment option for people with metastatic colorectal cancer that hasn't responded well to initial therapy.
What could go wrong
This is an early-phase trial (phase I/II) with a small number of participants, so the benefits are uncertain. Side effects from the combination of drugs could be significant.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

colorectal cancer colorectal neoplasm neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

METASTATIC COLORECTAL CANCER

Contacts and locations

Locations

  • Asklepios Tumorzentrum Hamburg

    RECRUITING

    Hamburg, 22763, Germany

  • Centro Integral Oncologico Clara Campal

    RECRUITING

    Madrid, 28050, Spain

  • Christie NHS Foundation

    RECRUITING

    Manchester, M20 4BX, United Kingdom

  • Cleveland Clinic Taussig Cancer Institute Case Comprehensive Cancer Center

    RECRUITING

    Cleveland, Ohio, 44195, United States

  • Guy's & St Thomas' NHS Foundation Trust, Guy's Hospital

    RECRUITING

    London, SE19RT, United Kingdom

  • Hospital HM Nou Delfos

    RECRUITING

    Barcelona, 08023, Spain

  • Hämatologisch-Onkologische Praxis Eppendorf - HOPE

    RECRUITING

    Hamburg, 20249, Germany

  • National Cancer Center Hospital

    RECRUITING

    Chūōku, 104-0045, Japan

  • National Cancer Center Hospital East

    RECRUITING

    Kashiwa, 277-8577, Japan

  • START Midwest

    RECRUITING

    Grand Rapids, Michigan, 49546, United States

  • The Royal Marsden NHS

    RECRUITING

    Sutton, SM2 5PT, United Kingdom

  • The University of Texas MD Anderson Cancer Center

    RECRUITING

    Houston, Texas, 77030, United States

  • Vall D'Hebrón Hospital

    RECRUITING

    Barcelona, 08035, Spain

  • Yale University

    RECRUITING

    New Haven, Connecticut, 06511, United States

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