New hope for Tough-to-Treat colon cancer: experimental drug combo enters final testing

NCT ID NCT07549412

Recruiting now Disease control Sponsor: EMD Serono Research & Development Institute, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Aug 14, 2026 · Updated 3 times

Summary

This Phase 3 trial tests a new drug called precemtabart tocentecan, alone or with bevacizumab, against a standard treatment for metastatic colorectal cancer that has progressed after prior therapies. About 1,020 participants will be randomly assigned to one of three treatment groups. The main goal is to see if the new drug helps people live longer.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: precemtabart tocentecan (a drug), bevacizumab, and trifluridine/tipiracil
What this could lead to: If successful, this could offer a new treatment option for people with metastatic colorectal cancer who have already tried standard therapies, potentially extending survival.
What could go wrong: This is a large Phase 3 trial, but the experimental drug is still unproven. It may not improve survival or could cause side effects. Results may take years.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

colorectal cancer colorectal neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

METASTATIC COLORECTAL CANCER

Contacts and locations

Locations

Blue Ridge Cancer Care - 300202915
RECRUITING

Roanoke, Virginia, 24014-2419, United States
Cancer Institute Hospital of JFCR
RECRUITING

Kōtoku, Tokyo-To, 135-8550, Japan
China Medical University Hospital
RECRUITING

Taichung, 40447, Taiwan
Flinders Medical Centre
RECRUITING

Bedford Park, South Australia, 5042, Australia
Florida Cancer Specialists - St. Petersburg Bayfront
RECRUITING

St. Petersburg, Florida, 33701-4553, United States
Florida Cancer Specialists East - FCS EAST - West Palm Beach
RECRUITING

West Palm Beach, Florida, 33401, United States
Florida Cancer Specialists-Broadway
RECRUITING

Fort Myers, Florida, 33901, United States
GenesisCare North Shore (Oncology)
RECRUITING

St Leonards, New South Wales, 2065, Australia
Icon Cancer Centre Chermside
RECRUITING

Chermside, Queensland, 4032, Australia
Illinois Cancer Specialists
RECRUITING

Arlington Heights, Illinois, 60005, United States
Illinois CancerCare PC
RECRUITING

Peoria, Illinois, 61615-7822, United States
Kanagawa Cancer Center - Dept of Gastroenterology
RECRUITING

Yokohama, Kanagawa, 241-8515, Japan
Kindai University Hospital
RECRUITING

Sakai-shi, Osaka, 590-0197, Japan
Kyungpook National University Chilgok Hospital
RECRUITING

Daegu, Gyeongsangnam-do, 700-721, South Korea
Mater Misericordiae Ltd - PARENT
RECRUITING

South Brisbane, Queensland, 4101, Australia
Minnesota Oncology Hematology, P.A.
RECRUITING

Saint Louis Park, Minnesota, 55416, United States
Missouri Cancer Associates - 150518964
RECRUITING

Columbia, Missouri, 65201, United States
National Cancer Center Hospital
RECRUITING

Chūōku, Tokyo-To, 104-0045, Japan
Profound Research LLC at Cancer and Leukemia Center
RECRUITING

Sterling Heights, Michigan, 48098, United States
Rocky Mountain Cancer Centers, LLP- Aurora
RECRUITING

Lone Tree, Colorado, 80124, United States
SCRI Oncology Partners
RECRUITING

Nashville, Tennessee, 37203, United States
Samsung Medical Center
RECRUITING

Seoul, 06351, South Korea
Severance Hospital, Yonsei University Health System - Division of Infectious Diseases
RECRUITING

Seoul, 03722, South Korea
Sichuan Cancer Hospital
RECRUITING

Chengdu, Sichuan, 610041, China
Springfield Clinic
RECRUITING

Springfield, Illinois, 62702, United States
Sun Yat-sen University Cancer Center
RECRUITING

Guangzhou, Guangdong, 510060, China
Texas Oncology DFW
RECRUITING

Bedford, Texas, 75246, United States
Texas Oncology, P.A. - Abilene - 300210366
RECRUITING

Abilene, Texas, 79606, United States
Texas Oncology, P.A. - Tyler
RECRUITING

Tyler, Texas, 75702, United States
Texas Oncology- San Antonio
RECRUITING

San Antonio, Texas, 78240, United States
Texas Oncology-South Austin
RECRUITING

Austin, Texas, 78745, United States
The Catholic University of Korea, Seoul St. Maryâ
RECRUITING

Seoul, 06591, South Korea
University Health Network - Princess Margaret Cancer Centre
RECRUITING

Toronto, Ontario, M5G 2M9, Canada
Virginia Oncology Associates
RECRUITING

Newport News, Virginia, 23606, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.