Virus therapy takes on tough colorectal cancer in new trial

NCT ID NCT07446322

Recruiting now Disease control Sponsor: Oncolytics Biotech Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 16, 2026 · Updated 2 times

Summary

This study tests whether adding a virus-based drug (pelareorep) to standard chemotherapy can help people with a specific type of advanced colorectal cancer that has stopped responding to initial treatment. About 60 adults whose cancer has spread and has certain genetic features (RAS mutation, MSS) will be randomly assigned to receive either standard chemo plus the virus or standard chemo alone. The goal is to see if the combination shrinks tumors better and improves survival.

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Conditions

The condition(s) this trial relates to.

colorectal cancer colorectal carcinoma renal cell adenocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MCRC MSS METASTATIC COLORECTAL CANCER RAS-MUTATED METASTATIC COLORECTAL CANCER

Contacts and locations

Locations

Central Alabama Research
RECRUITING

Homewood, Alabama, 35209, United States
Clinical Research Advisors (Beverly Hills)
NOT_YET_RECRUITING

Beverly Hills, California, 90211, United States
Clinical Research Advisors (Downtown LA)
NOT_YET_RECRUITING

Los Angeles, California, 90033, United States
Clinical Research Advisors (Encino)
NOT_YET_RECRUITING

Encino, California, 91316, United States
Clinical Research Advisors (Korea Town)
NOT_YET_RECRUITING

Koreatown, California, 90020, United States
Clinical Research Advisors (West Covina)
NOT_YET_RECRUITING

West Covina, California, 91790, United States
Clinical Research Advisors (West Hollywood)
NOT_YET_RECRUITING

Los Angeles, California, 90048, United States
Community Health Network
NOT_YET_RECRUITING

Indianapolis, Indiana, 46250, United States
Emory Winship Cancer Institute
RECRUITING

Atlanta, Georgia, 30302, United States
Gabrail Cancer Center
RECRUITING

Canton, Ohio, 44718, United States
Rutgers Cancer Institute
RECRUITING

New Brunswick, New Jersey, 08901, United States
Summit Health Cancer Center
RECRUITING

Florham Park, New Jersey, 07932, United States
Washington University School of Medicine
NOT_YET_RECRUITING

St Louis, Missouri, 63110, United States

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