Intestinal disorder

This study tests a new vaccine called Shigella4V, designed to protect against shigellosis, a severe diarrheal disease. Researchers are giving the vaccine to healthy adults, children, and 9-month-old infants to check its safety and whether it triggers a strong immune response. Dif…

This study tested a new vaccine designed to protect against severe diarrhea caused by Shigella bacteria. The vaccine was first given to adults in Europe, then to adults, children, and infants in Africa. Researchers checked for side effects and measured immune responses to find th…

This early-stage trial tested a new vaccine (CJCV2) designed to protect against Campylobacter infection, a leading cause of foodborne illness. Fifty-nine healthy adults received three different doses of the vaccine, with or without an immune-boosting adjuvant (ALFQ). The main goa…

This phase 3 study tested the 9-valent HPV vaccine (Gardasil 9) in over 1,000 Japanese males aged 16 to 26. The goal was to see if the vaccine could prevent persistent HPV infections that can lead to genital warts and anal cancers. Participants received either the vaccine or a pl…

This study looks at the long-term safety of imatinib, a daily pill for certain cancers like GIST and CML. It includes 250 patients who were already benefiting from imatinib in a previous Novartis trial and continue taking it. The main goal is to track side effects over time, with…

This trial tests a temporary device called CG-100 that is placed inside the intestine during colorectal cancer surgery. The device is designed to protect the surgical connection while it heals, potentially reducing leaks and other complications. The study includes adults aged 22 …

This study tests whether a secure website with educational sessions, goal-setting, and tracking tools can help survivors of several cancers (including breast, prostate, colorectal, and others) improve their diet, increase physical activity, and manage weight. Participants are age…

This study tests a new drug called MBX 1416 in 10 people who have low blood sugar episodes after weight loss surgery. Participants receive two injections of the drug, a low dose and a high dose, about two weeks apart. The goal is to see if the drug can raise the lowest blood suga…

This trial compares three modern radiotherapy techniques—helical tomotherapy and two types of dynamic arc therapy (RapidArc and VMAT)—for treating prostate, cervical, and anal canal cancers that require pelvic lymph node irradiation. The goal is to determine which method is most …

This study looked at 108 adults with Crohn's disease whose symptoms returned while on standard ustekinumab treatment. Researchers gave them a re-induction infusion and then split them into two groups: one continued the usual shot every 8 weeks, the other got a shot every 4 weeks.…

This phase 2 trial is testing whether a combination of chemotherapy (mFOLFOX6), a targeted therapy (bevacizumab), and an immunotherapy (PD-1 inhibitor) can help people with a specific type of locally advanced colorectal cancer called microsatellite stable (MSS). Unlike other colo…

This study tested the drug larotrectinib in 215 adults with various solid cancers that have a specific change in the NTRK gene. The drug is taken orally and works by blocking the action of the altered gene. The main goal was to see how many patients had their tumors shrink or dis…

This early-phase study tested the safety of combining two drugs—pembrolizumab (an immunotherapy) and AMG386 (which targets blood vessel growth)—in 62 people with advanced solid tumors like melanoma, ovarian, renal, or colorectal cancer. The main goals were to find the safest dose…

This pilot study tests whether a purified green tea extract called EGCG can help prevent colon cancer from coming back after surgery. 51 patients who had their colon cancer removed took either the extract or a placebo. Researchers are checking for changes in DNA methylation, a ma…

This study tests whether psyllium fiber bars can help postmenopausal women with irritable bowel syndrome and diarrhea who experience accidental bowel leakage. Researchers will examine changes in gut bacteria and stool chemicals to see if fiber improves symptoms. The study involve…

This study tests a combination of three immunotherapy drugs—PDS0101, M7824, and NHS-IL12—in people with advanced HPV-related cancers such as cervical, anal, and throat cancers. The goal is to see if the mix can shrink tumors or stop them from growing. Participants receive the dru…

This study tested fecal microbiota transplantation (FMT) from different donors to treat ulcerative colitis, a type of inflammatory bowel disease. Researchers gave 102 patients a one-time colonoscopic infusion of fresh fecal bacteria from healthy donors. The goal was to see if don…

This trial investigates whether adding a dietary supplement called sodium nucleinate to standard FOLFOX chemotherapy helps people with metastatic colorectal cancer (cancer that has spread). Participants are randomly assigned to receive either the supplement or a placebo alongside…

This study investigates whether giving vitamin D supplements to adults with inflammatory bowel disease (Crohn's disease or ulcerative colitis) who also have low vitamin D levels can improve their iron status. Participants take high-dose vitamin D3 weekly for 8 weeks, then a lower…

This study tests whether giving patients their own stool bacteria through a temporary stoma can reduce inflammation in the unused part of the colon, a condition called diversion colitis. Sixty-six people with rectal cancer who have a temporary ileostomy will receive either a dail…

This study is testing a new device called SEGER IDEA™ that helps surgeons close openings in the bowel during keyhole surgery. It is the first time this device is being used in humans. Ten adults having certain types of bowel surgery will take part. The main goal is to see if the …

This phase 2 trial tested a combination of two drugs—paclitaxel (given intravenously and directly into the abdomen) and oral nilotinib—in 21 adults with cancers that had spread to the lining of the abdomen and could not be surgically removed. The goal was to see if the treatment …

This phase 2 trial tests whether OSE-127, an antibody that blocks a key immune signal, can reduce disease activity in people with moderate to severe ulcerative colitis who have not responded to or cannot tolerate previous treatments. Participants are randomly assigned to receive …

This large phase III trial studied whether adding the targeted drug cetuximab to standard chemotherapy after surgery helps prevent cancer from coming back in patients with stage III colon cancer. Over 3,300 patients took part, and the study focused on those with a specific geneti…

This study tested whether using two advanced drugs together (either two biologics or one biologic plus a small molecule) is safe and effective for people with inflammatory bowel disease (IBD) who haven't gotten better on standard treatments. Researchers followed 117 patients in C…

This study tested whether giving a mix of immunotherapy drugs (tislelizumab and IL-2) plus chemotherapy before surgery could shrink tumors more effectively in people with locally advanced rectal cancer. The trial involved 130 adults whose cancers had not spread but were hard to t…

This trial compares two types of oral nutritional supplements given to colorectal cancer patients before surgery. One group receives standard high-protein drinks, while the other gets immunonutrition drinks enriched with arginine, nucleotides, vitamin D, and omega-3 fatty acids. …

This trial tests whether a nurse-led education program, based on the Health Belief Model, can improve treatment adherence in people with inflammatory bowel disease (Crohn's disease or ulcerative colitis) who are receiving anti-TNF therapy. The program aims to address patients' co…

This early-phase trial tested an experimental drug called KVA12123, given alone or with the immunotherapy Keytruda, in 40 adults with advanced solid tumors (like lung, breast, or colon cancer) that had stopped responding to standard treatments. The main goals were to check safety…

This completed study looked at whether adding an immune-boosting drug called thymalfasin to standard chemoradiotherapy and a PD-1 inhibitor could help shrink advanced rectal tumors before surgery. Researchers studied 47 patients with stage II/III mid-low rectal cancer. The main g…

This study tests whether a combination of three drugs—cisplatin, nivolumab, and temozolomide—can shrink tumors in people with advanced colorectal cancer that has not responded to other treatments. The cancer must be a specific type called MMR-proficient. The trial involves 18 par…

This study tested whether taking tempeh powder (a source of isoflavones) and vitamin D3 daily for 8 weeks could improve vitamin D levels, reduce inflammation, and boost quality of life in people with inflammatory bowel disease (IBD). Fifty adults with ulcerative colitis or Crohn'…

This trial tests whether a program of exercise, nutrition advice, and psychological support—started four weeks before surgery and continued afterward—can reduce complications in people having colon cancer surgery. Participants are adults over 40 with non-metastatic colon cancer w…

This early-stage study tested a new treatment called MB310 in 29 adults with mild-to-moderate ulcerative colitis. The main goal was to see if it is safe and how well it takes hold in the body. Participants received either MB310 or a placebo, and researchers monitored side effects…

This pilot study tested whether a combination of phentermine and topiramate, two drugs used for weight loss, could help shrink uric acid kidney stones in obese people with type 2 diabetes or pre-diabetes. Nineteen participants were randomly assigned to receive the drug combo or c…

This completed phase 2 trial tested whether the drug cediranib, given with chemotherapy, is safe for women with advanced ovarian cancer who are at risk of bowel obstruction. 30 participants received the combination. The study focused on whether the treatment caused serious bowel …

This early-phase trial tested a new drug called vilastobart, alone or with another drug (atezolizumab), in 125 people with advanced solid tumors that had stopped responding to standard treatments. The main goals were to check safety and find the right dose. Researchers also looke…

This study tested whether a daily dose of Travelan (IMM-124E) tablets could prevent moderate-to-severe diarrhea in healthy adults deliberately infected with ETEC bacteria, a common cause of travelers' diarrhea. Sixty-three volunteers took either Travelan or a placebo for 7 days. …

This study tested the drug mirikizumab in 172 adults with moderate-to-severe ulcerative colitis who still had bowel urgency despite other treatments. The main goal was to see if the drug reduces the sudden, urgent need to use the bathroom. Participants were followed for 36 weeks …

This study tested whether a seaweed-derived supplement called Aquamin® can reduce gut permeability (often called 'leaky gut') in people with ulcerative colitis, irritable bowel syndrome with diarrhea, and healthy volunteers. Thirty-five adults took Aquamin capsules for 90 days. R…

This early-phase study tested a personalized cancer vaccine (RO7198457) in 273 patients with advanced solid tumors like melanoma, lung, and breast cancer. The vaccine was given alone or with an immunotherapy drug (atezolizumab) to see if it was safe and how the body responded. Th…

This early-phase study tested whether adding indomethacin, a common anti-inflammatory drug, to standard platinum-based chemotherapy is safe for people with colorectal, esophageal, or ovarian cancers. The 13 participants received escalating doses of indomethacin alongside their ch…

This study tested a new drug called VR-AD-1005 for treating severe diarrhea caused by cholera. The drug aims to reduce fluid loss and the need for antibiotics, which could help fight antibiotic resistance. 150 adults with cholera took part, and researchers measured stool output a…

This completed observational study looked at how well the drug tofacitinib works for people with ulcerative colitis in everyday Swedish clinics. Researchers used a national registry to track disease remission and whether patients stayed on the medication. The study included 102 p…

This study tested the drug mirikizumab in 63 children aged 2 to 17 with moderate-to-severe ulcerative colitis, a chronic bowel disease. The goal was to see if the drug could help control the disease and improve symptoms. All children received the drug, and researchers measured re…

This study compared two common surgeries for perianal fistula—a painful tunnel near the anus. One hundred adults were split into two groups: one received the LIFT procedure (which aims to preserve muscle control) and the other received fistulotomy with a seton (a thread placed in…

This phase III trial tested whether adding a monoclonal antibody called edrecolomab to surgery helps people with stage II colon cancer live longer or stay cancer-free longer. About 2,100 participants were randomly assigned to receive either the antibody or no additional treatment…

This study compared two common antibiotics—azithromycin (single dose) and doxycycline (7-day course)—for treating anal chlamydia in women who also had a vaginal chlamydia infection. The goal was to see which treatment clears the anal infection better, since anal chlamydia often g…

This phase 2 trial tested a combination of three drugs—encorafenib, binimetinib, and cetuximab—in 95 patients with a specific type of advanced colorectal cancer (BRAF V600E mutation) who had not received prior treatment for their metastatic disease. The goal was to see how many p…

This study tested whether a 20-minute arm cycling exercise, done twice daily for five days, could improve lung function and recovery in 60 elderly patients after colon cancer surgery. Participants also received standard physical therapy. The goal was to see if the arm exercise co…

This small study tested whether filling central catheters with sodium bicarbonate (baking soda) when not in use could prevent infections in children with intestinal failure. Six children participated, and the study looked at how many catheter-related bloodstream infections occurr…

This study tested whether adding the arthritis drug Celebrex to an experimental chemo drug called EPO906 could reduce severe diarrhea in people with advanced colorectal cancer. The trial enrolled 75 patients who had already tried other treatments. The first phase found the safest…

This early-stage trial tested a new drug called AZD6244 combined with standard chemotherapies in 140 people with advanced solid tumors (breast, colon, lung, melanoma, kidney). The main goal was to see if the combination is safe and tolerable, and to find the best dose. Researcher…

This Phase 3 trial tested a new drug combination called MK-4280A (favezelimab plus pembrolizumab) against standard treatments (regorafenib or TAS-102) in 441 people with advanced colorectal cancer that had stopped responding to prior therapy. The goal was to see if the new combin…

This study tested two different ways of stitching the belly wall closed after colorectal cancer surgery to see which one better prevents the wound from bursting open. Forty adults having open surgery were randomly assigned to either an interrupted 'figure-of-X' stitch or a contin…

This study tested two surgical methods for treating a type of anal fistula called transsphincteric anal fistula. Forty adults were randomly assigned to receive either the standard LIFT procedure or a modified version that approaches the fistula from the side. Researchers measured…

This phase 2 trial tested a biologic drug called barzolvolimab in 86 adults with active eosinophilic esophagitis, a condition that causes trouble swallowing due to inflammation in the esophagus. Participants received either the drug or a placebo as a shot under the skin. The stud…

This early-phase trial tested two drugs together—pembrolizumab (Keytruda) and XL888—in 47 people with advanced gastrointestinal cancers like colorectal and pancreatic cancer that had spread or could not be removed. The main goal was to find the safest dose and check for side effe…

This study tested whether adding bevacizumab to a powerful four-drug chemotherapy regimen (FOLFOXIRI) could shrink liver tumors in people with colorectal cancer that had spread only to the liver and could not be removed surgically. The goal was to see if more patients could then …

This study tested whether giving pantoprazole (a stomach acid reducer) to critically ill ICU patients prevents stress ulcers and reduces death. Over 3,300 adults at high risk were randomly assigned to receive pantoprazole or a placebo daily while in the ICU. Researchers tracked d…

This study tested whether adding the anti-inflammatory drug celecoxib to standard FOLFOX chemotherapy helps prevent cancer from returning in people with stage III colon cancer after surgery. Over 2,500 participants were randomly assigned to receive either celecoxib or a placebo a…

This study tested the drug upadacitinib in people with Crohn's disease that only affects the small bowel, a type that is often harder to treat. Researchers compared 3 patients with small-bowel Crohn's to others with Crohn's in different areas, using ultrasound to measure bowel in…

This study tested whether injecting a special dye (ICG) during laparoscopic colorectal cancer surgery helps surgeons see blood flow and choose a safer spot to cut. Over 560 adults took part, with half getting the dye and half relying on the surgeon's usual judgment. The main goal…

This study tested a temporary device called Colovac 2 in 24 people undergoing colon cancer surgery. The device is placed inside the bowel to protect the surgical connection while it heals, potentially avoiding the need for a temporary stoma. Researchers checked if the device stay…

This study looked at whether the drug ustekinumab can help people with moderate to severe Crohn's disease reach 'deep remission' — meaning no symptoms, healed gut lining, and healed gut wall. Researchers followed 156 patients for 44 weeks and checked what factors helped predict t…

This registry followed 152 patients with colorectal cancer that had spread mainly to the liver. Doctors used tiny beads called LifePearl Microspheres loaded with the chemotherapy drug irinotecan, delivered directly to the liver's blood supply. The goal was to see how and when thi…

This study tested whether placing a temporary drain in the pelvis after rectal cancer surgery reduces the risk of serious infections like leaks or abscesses. About 500 patients were randomly assigned to receive a drain or not. The main goal was to see if drainage lowered pelvic s…

This study looked at the long-term safety of vedolizumab, a biologic drug given by IV, in 59 children with ulcerative colitis or Crohn's disease. Participants had already completed a previous study and continued treatment to monitor for side effects. The goal was to see if the dr…

This registry followed 500 adults with colorectal cancer that spread to the liver. All were treated with a microwave ablation device that uses heat to destroy tumors. The goal was to see how well the device controls tumors locally over 12 months and to track any side effects. The…

This study tested whether mirikizumab can help people with moderate to severe ulcerative colitis stay in remission (symptom-free) after they had already responded to an initial treatment. About 1,300 adults who completed a prior induction study were randomly assigned to receive m…

This study tested a drug called ustekinumab in 112 children with moderate-to-severe ulcerative colitis, a condition causing inflammation in the colon. The goal was to see if the drug could reduce symptoms like diarrhea and bleeding and help the colon heal. Children first received…

This phase 3 trial tested whether adding two months of Folfirinox chemotherapy before standard radiation and chemo could help more patients with early-stage rectal cancer avoid major surgery. 218 adults with small, low-lying tumors were enrolled. The goal was to see if more patie…

This study compared two low-volume laxatives used to clean the colon before a colonoscopy: one liter of polyethylene glycol with ascorbate (PEG1A) and sodium picosulfate with magnesium citrate (PSCM). The goal was to see which one provides a higher quality colon cleansing, which …

This early-phase trial tested a combination of two drugs (MEK162 and mFOLFIRI) in 25 adults with advanced RAS-positive colorectal cancer that had stopped responding to standard treatment. The main goal was to find the safest dose and check for side effects. Researchers also looke…

This study looked at whether a probiotic called LP-LDL can lower cholesterol and improve heart health in adults with celiac disease. 50 participants took the probiotic to see if it reduced their cholesterol levels and body mass index. The goal was to find a safe way to manage hea…

This early-phase study tested an experimental drug called COM902, alone or with other drugs, in 94 people with advanced cancers like ovarian, lung, and colon cancer. The main goal was to check safety and find the right dose. Researchers also looked for early signs that the drug m…

This early-stage study tested a new antibody drug (similar to cetuximab) in 18 people with advanced colorectal cancer that had stopped responding to standard treatments. The main goal was to check safety and how the drug moves through the body. Participants received one of two do…

This study tested an experimental drug called CBX-12 in 69 adults with advanced solid tumors (like ovarian, lung, breast, or colon cancer) that had stopped responding to standard therapies. The main goals were to check the drug's safety, find the best dose, and see if it could sh…

This early-stage study tested a custom-made yeast vaccine designed to train the immune system to recognize and attack leftover cancer cells. Five adults with various cancers (like colorectal, breast, or lung) who had completed initial treatment received the vaccine. The goal was …

This study looked at whether a seaweed supplement or a Mediterranean-style diet could help people with pre-diabetes control their blood sugar and strengthen their immune system against infections. Researchers studied 45 adults with pre-diabetes, measuring changes in blood glucose…

This study tested a treatment plan for locally advanced rectal cancer that uses a short course of radiation followed by chemotherapy, aiming to avoid surgery. 39 patients were enrolled. The goal was to see if the cancer could be completely controlled without an operation, using a…

This early-stage study tested a new drug called BI 765049, alone or combined with another drug (ezabenlimab), in 21 Asian adults with advanced solid tumors (stomach, colorectal, pancreatic, liver, head and neck, or lung cancer) that have a specific marker called B7-H6. The main g…

This completed study compared moderate exercise (like brisk walking) with the drug metformin in 226 adults with prediabetes. Participants were randomly assigned to either exercise for 30-45 minutes, 5 days a week, or take metformin twice daily for 12 weeks. Researchers measured c…

This study tested whether a new drug called A140 works as well as the standard drug Erbitux for people with a certain type of advanced colorectal cancer (RAS wild-type). Both drugs were given together with chemotherapy. The trial involved 688 adults and measured how many patients…

This study looked at the long-term safety of the cancer drug vismodegib in 19 patients with ovarian cancer, basal cell carcinoma, or metastatic colorectal cancer. All participants had previously taken vismodegib in an earlier Genentech trial and were expected to benefit from cont…

This study tested the drug tofacitinib (Xeljanz) in 10 adults with chronic granulomatous disease (CGD) who had ongoing inflammation in the gut, skin, or lungs. Participants took the pill daily for 3 months to see if it was safe and could help control symptoms. The goal was to fin…

This study tested a DNA-based vaccine called VGX-3100 in 44 HIV-positive adults with high-grade anal precancer caused by HPV types 16 or 18. The vaccine was given with a mild electric pulse (electroporation) to help cells absorb it and boost the immune system's attack on the abno…

This study tested whether a personalized diet, based on a blood test that identifies food allergies, can help people with eosinophilic esophagitis (EoE). 56 participants were randomly assigned to either a personalized elimination diet or a sham diet. The goal was to see if the pe…

This study tested whether adding an immunotherapy drug called APX005M to standard treatment helps people with advanced rectal cancer achieve a complete response (no cancer left after treatment). 58 adults with stage II or III rectal cancer at high risk took part. The goal was to …

This study tested a new way to reconnect the colon after removing a cancerous section using a robot. The technique uses a special double purse-string stitch and a single stapler. Thirty-nine patients with sigmoid colon cancer were included, and the study looked at how well the te…

This study tested whether adding fenofibrate, a drug typically used for high cholesterol, to the standard treatment mesalamine can improve symptoms and quality of life in people with mild-to-moderate ulcerative colitis. The trial enrolled 60 adults and measured changes in disease…

This study tested a combination of two drugs, lenvatinib and pembrolizumab, in 611 people with advanced cancers like breast, ovarian, stomach, colorectal, brain, bile duct, or pancreatic cancer that had stopped responding to standard treatments. The goal was to see if the combo c…

This study tested a daily pill called ABX464 (obefazimod) as a long-term maintenance therapy for people with moderate to severe ulcerative colitis. 217 patients who completed a prior 16-week induction study took the drug for up to 96 weeks. The main goal was to see how many patie…

This study tested whether giving growth hormone to children with short bowel syndrome could help them reduce or stop needing IV nutrition. Fourteen children aged 3-18 who had been on IV nutrition for at least 3 years took part. The results will show if the hormone improves intest…

This study tested an experimental drug called CTX-009 in 49 adults with metastatic colorectal cancer that had worsened after two or three prior treatments. The goal was to see if the drug could shrink tumors or stop them from growing. Results will help determine if further testin…

This early-phase study tested a new drug, HBM1020, in 17 people with advanced solid tumors that had stopped responding to standard treatments. The main goal was to check safety and find the right dose. The drug was given by IV every three weeks. Because this is a Phase 1 trial, i…

This study tested whether a short course of radiation followed by chemotherapy could eliminate the need for surgery in people with early-stage rectal cancer. 63 patients were enrolled, and the treatment aimed for a complete clinical response, meaning no tumor could be found on ex…

This study tested a device called Colovac+ in 27 adults having surgery for colorectal cancer. The device is placed inside the bowel to protect the surgical connection and keep stool away while it heals. The goal was to see if it is safe and effective, and whether it could help pa…

This early-phase study tested the safety of combining the immunotherapy drug pembrolizumab with precise, high-dose radiation (SBRT) to the liver in 15 adults with colorectal cancer that had spread only to the liver. The goal was to see if this combination could prevent the cancer…

This study tested whether people with ulcerative colitis can use a home stool test to catch inflammation early and prevent symptom flares. Over 700 adults in remission used a smartphone-based test kit to measure calprotectin levels. The goal was to see if this proactive monitorin…

This study tested whether cleaning therapy dogs with a special disinfectant (chlorhexidine) before hospital visits could reduce the spread of harmful germs to children. The trial involved 45 children aged 3 to 17 who interacted with therapy dogs. Researchers checked if the cleani…

This study tested whether a daily bath with a traditional Chinese herbal mixture called Tongyangxiao can help surgical wounds heal faster after anal fistula surgery. 115 patients used either the herbal bath or a standard antiseptic bath for 14 days after surgery. Researchers meas…

This study compared two methods for removing non-cancerous colon polyps that are 10-19 mm in size: cold snare (no heat) and hot snare (uses heat). 216 adults undergoing colonoscopy were randomly assigned to one method. The goal was to see if cold snare is as effective and safe as…

This study tested a new two-drug combination (encorafenib and cetuximab) against standard treatments in 107 Chinese patients with a specific genetic mutation (BRAF V600E) that makes colorectal cancer harder to treat. The goal was to see if the new combo could slow cancer growth b…

This study tested a medicine called vedolizumab in 121 children with moderate to severe ulcerative colitis, a condition causing inflammation and pain in the gut. The goal was to see if the drug could help children achieve remission, meaning their symptoms improve and tests show l…

This study looked at 170 extremely preterm infants (born at or before 27 weeks) to see if adding a human milk fortifier to all feedings early on helps them grow better and reduces a dangerous gut condition called necrotizing enterocolitis. One group received the fortifier as soon…

This study tested a treatment for people with colorectal cancer that spread to the liver and had not responded to at least two prior therapies. The treatment combined a strong chemotherapy cocktail delivered directly to the liver (FOLFOXIRI via hepatic arterial infusion) with an …

This study looked at 150 adults with Crohn's disease to see if advanced imaging could predict how well the drug Ustekinumab controls inflammation. Researchers measured changes in the gut wall and compared them to standard tests. The goal was to improve treatment monitoring for th…

This phase 3 trial tested whether combining sotorasib (a pill) and panitumumab (an infusion) can slow tumor growth better than standard chemotherapy in 160 adults with metastatic colorectal cancer that has a specific KRAS G12C mutation. Participants were randomly assigned to rece…

This study compared two surgical techniques for treating Hirschsprung's disease in children: the traditional Soave method and a newer heart-shaped anastomosis. The trial involved 177 children under 14 years old across multiple hospitals. The goal was to see which approach leads t…

This phase 2 study tested the immunotherapy drug prolgolimab in 30 people with a specific type of colorectal cancer (MSI/dMMR) that had not spread. Participants received the drug for 6 months before planned surgery. The main goal was to see if the cancer completely disappeared in…

This study looked at whether adding mesalazine (a standard anti-inflammatory drug) to biologic treatments like infliximab or vedolizumab helps people with moderate to severe ulcerative colitis achieve endoscopic remission (healing of the gut lining). The trial enrolled 438 adults…

This study tested a treatment called RBX2660 (REBYOTA) for people with recurrent Clostridioides difficile infection. The treatment is made from healthy human stool bacteria and was given during a colonoscopy. The goal was to see if this delivery method is safe and works well. For…

This early-phase study tested a combination of two drugs, cabozantinib and TAS-102, in 15 people with advanced colorectal cancer that had spread and stopped responding to standard treatments. The main goal was to find the safest dose and identify side effects. The study is comple…

This study tested whether a 3-year physical activity program could help prevent colon cancer from coming back in 889 patients who had surgery and chemotherapy for high-risk stage II or stage III colon cancer. Participants were randomly assigned to either the exercise program plus…

This study tested a newer, less invasive surgery called ETAP (done through the anus) against standard laparoscopic surgery (done through the belly) for low rectal cancer. 226 adults took part. The goal was to see if ETAP is as good at removing all cancer while possibly leading to…

This phase II trial tested the immunotherapy drug nivolumab (Opdivo) in 35 adults with advanced colorectal cancer that has a specific marker (class II expression) and is microsatellite stable, a type that usually does not respond to immunotherapy. The goal was to see if the drug …

This trial tested a new method called underwater ESD for removing large, flat colon polyps. Instead of using gas to inflate the colon, doctors fill it with saline water. The goal was to see if this reduces complications like bleeding or perforation and improves complete removal. …

This study tested whether the antifungal drug fluconazole could lower levels of certain antibodies (ASCA) and prevent Crohn's disease from returning after bowel surgery. Thirty-five adults with Crohn's disease who had recent ileal or ileocecal resection were randomly assigned to …

This early-phase trial tested a combination of three drugs—vemurafenib, cetuximab, and irinotecan—in 47 people with advanced solid tumors that have a specific BRAF V600 mutation and could not be removed by surgery or had spread. The main goal was to find the safest dose and under…

This study tested a new drug called tulisokibart (PRA023) in 55 people with moderate-to-severe Crohn's disease who had not responded well to other treatments. The main goals were to check safety and see if the drug could improve gut healing and reduce symptoms. After 12 weeks, so…

This study looked at whether removing small, early-stage anal cancers with local surgery alone is safe and effective for people with HIV. The goal was to see if this less invasive approach could avoid the need for stronger treatments like radiation or chemotherapy. Sixteen partic…

This study tested two versions of a low-calorie Mediterranean diet, each with different carb and fat levels, combined with moderate aerobic exercise in 36 adults with obesity and fatty liver disease (NAFLD). The goal was to see if one diet plan worked better than the other at red…

This study tested whether the drug ritlecitinib could prevent intestinal damage and symptoms when people with celiac disease ate gluten. 62 adults with well-controlled celiac disease (on a gluten-free diet) took either the drug or a placebo along with a daily gluten challenge. Th…

This study looked at whether giving the antibiotic vancomycin helps cancer patients who have diarrhea and a positive screening test for C. difficile but a negative toxin test. Only 9 patients were enrolled, far fewer than planned. Researchers measured changes in C. difficile leve…

This study tested a drug called axitinib against a placebo in 52 people with advanced colorectal cancer that had spread to the liver and stopped responding to chemotherapy. The goal was to see if axitinib could help control the cancer and to test a special ultrasound technique th…

This study looked at whether a diet rich in tomatoes could improve liver health, gut function, and blood sugar in people with non-alcoholic fatty liver disease (NAFLD). Eighty participants either ate a tomato-free diet or one with added tomatoes and sauce for six weeks. Researche…

This study compared two surgical methods for treating a burst section of the colon caused by diverticulitis, a condition that leads to severe abdominal infection. 102 adults with this infection were randomly assigned to either a traditional two-step surgery (Hartmann procedure) o…

This study tested a device called the VAC-Stent, which combines a covered metal stent with negative pressure (suction) to seal leaks in the esophagus or colon. Researchers collected data from 110 patients to see if the device safely and effectively closed the leaks. The goal was …

This study tested a new experimental treatment called HPVST cells in 32 people with HPV-related cancers that had returned or not responded to standard care. The cells are grown from the patient's own blood and trained to attack HPV-infected cancer cells. The goal was to find a sa…

This study tested whether an oral rehydration solution (ORS) with added calcium works better than standard ORS for adults with severe watery diarrhea, including cholera. Researchers measured stool output, diarrhea duration, and other symptoms in 396 adults. The goal is to find a …

This completed Phase 2b trial tested an oral tablet called JNJ-77242113 against placebo in 252 adults with moderate-to-severe ulcerative colitis. The goal was to see if the drug could reduce symptoms and inflammation better than a dummy pill. Researchers measured clinical respons…

This study tested whether a program of diet, aerobic exercise, and balance training could improve nerve function and balance in people with prediabetes or early type 2 diabetes. About 61 participants were assigned to either the program or standard care. The goal was to see if the…

This study tested whether doing aerobic exercise at home with remote supervision (tele-exercise) works as well as exercising in a hospital for people with prediabetes. Forty-two adults with prediabetes walked for 30 minutes, five days a week, for three weeks. One group exercised …

This study compared two ways to close skin after colorectal cancer surgery: a tissue adhesive (skin bond) and traditional skin stapling. Researchers looked at wound infection rates within 30 days, pain, and cost in 304 patients. The goal was to see if skin bond leads to fewer inf…

This study tested a new drug called TAK-676, alone and with pembrolizumab, in 248 adults with advanced solid tumors that had no standard treatment options. The main goal was to check safety and find the highest dose that causes few side effects. The study also looked at how well …

This study tested giving chemotherapy before a less invasive surgery for early rectal cancer. The goal was to see if this approach could allow patients to keep their rectum instead of needing major surgery. 58 people took part, and the treatment was considered successful if at le…

This completed trial tested whether a mix of 43 plant polyphenols can counteract health damage from environmental pollutants. 98 adults took either the polyphenol supplement or a placebo for a period. Researchers measured changes in gut health, inflammation, and blood markers to …

This study tested whether eating less fat and more fiber can reduce the chance of a repeat Clostridioides difficile infection in cancer patients. Eight participants with leukemia, lymphoma, or other cancers followed a specific diet. Researchers tracked diarrhea and measured C. di…

This study looked at 180 people with rectal cancer that had spread to lymph nodes in the pelvis. One group received a three-drug chemotherapy regimen (FOLFOXIRI) followed by surgery to remove the affected lymph nodes. The other group got standard chemoradiotherapy before surgery.…

This phase 3 trial tested whether a surgical procedure called laparotomy plus heated chemotherapy (HIPEC) could improve outcomes for colorectal cancer patients at high risk of cancer spreading in the abdomen. 150 patients who had already undergone surgery and chemotherapy were ra…

This study looks at the long-term safety of a drug called CC-93538 (cendakimab) for people with eosinophilic esophagitis, a condition that causes inflammation in the esophagus. It enrolled 367 adults and teens who had already taken part in earlier studies of the same drug. The ma…

This study tested an experimental drug called BMS-986016 (anti-LAG-3) alone or combined with nivolumab in people with advanced solid tumors that had spread or couldn't be removed by surgery. It included several cancer types like lung, stomach, liver, kidney, bladder, head and nec…

This study tested whether a device that uses light to monitor blood flow (photoplethysmography) could help doctors manage fluids better during colorectal surgery. The goal was to reduce complications after surgery. 160 adults having colorectal surgery took part. The approach is n…

This study tested a fish oil emulsion called Omegaven to treat liver disease in 36 children who depend on long-term intravenous (IV) nutrition. The goal was to lower bilirubin levels, a sign of liver damage. The treatment aims to control the disease and improve liver function.

This phase 2 trial compares two oral targeted drugs—ripretinib and sunitinib—in 108 people with advanced gastrointestinal stromal tumors (GIST) whose cancer has worsened on or who cannot tolerate imatinib. The main goal is to see which drug better delays cancer growth. Participan…

This phase II trial tested the chemotherapy drug paclitaxel in 40 patients with advanced or metastatic gastrointestinal stromal tumor (GIST) whose cancer had stopped responding to three standard treatments: imatinib, sunitinib, and regorafenib. The study focused on patients with …

This early-phase study tested a new drug called gevokizumab alongside standard cancer treatments in 167 adults with advanced colorectal, stomach, or kidney cancer that had spread. The goal was to find a safe and active dose and see if the combination could help control the diseas…

This study tested a new way to reconnect the pancreas to the intestine during Whipple surgery for certain cancers. The new method uses a stent and wraps the connection with omentum (fatty tissue) to try to prevent leaks. 48 patients were split into two groups to compare the new t…

This study tested a special collagen mesh (Surgicoll-Mesh) placed in the abdomen during surgery for cancers that have spread to the lining of the belly. The goal was to see if it could prevent serious problems like bowel blockages, infections, or the need for more surgery. 60 adu…

This early-phase trial tested an experimental drug called BAT8010 in 23 people with advanced or metastatic solid tumors who had no other standard treatment options. The main goals were to check safety, find the best dose, and see if the drug shows any sign of shrinking tumors. Pa…

This study tested a new method called underwater endoscopic submucosal dissection (UESD) for removing large colon growths. Instead of using gas to inflate the colon, the doctor fills it with saline (salt water) to improve visibility and make the procedure easier. The trial involv…

This study looked at whether a high-protein drink with added arginine can reduce problems like infections and slow bowel movement after colorectal surgery. It included 44 adults who were malnourished or at risk of malnutrition before their operation. Participants received either …

This completed Phase 2 trial tested whether a special DNA-based test could predict how well patients with stomach or rectal cancer respond to immunotherapy (tislelizumab) combined with chemotherapy and/or radiation. 189 adults with advanced cancer participated. The goal was to se…

This study tested two ways of using liquid nutrition to prevent Crohn's disease from flaring up again in children aged 6 to 18. One group got all their calories from a special liquid diet for one week out of every four (cyclic), while the other group got 25% of their calories fro…

This early-phase study tested a personalized immunotherapy (iNeo-Vac-P01) in 6 patients with stage III colorectal or non-small cell lung cancer who had already completed surgery and standard adjuvant therapy. The vaccine was designed to target unique neoantigens from each patient…

This study tested whether a special ultrasound technique (D-CEUS) can predict how well rectal cancer responds to chemotherapy and radiation. The goal is to identify good responders who might avoid major surgery and instead have a less invasive procedure. Only 2 people took part, …

This study tested whether a bedside ultrasound (POCUS) can accurately detect or rule out bowel obstruction in 150 adults with abdominal pain. Doctors performed the ultrasound after a physical exam, then compared results to a CT scan. The goal is to see if this quick, radiation-fr…

This study tests whether a software called ColoMaia II can help doctors find abnormal growths (polyps) in the colon during a routine colonoscopy. About 600 adults aged 40 to 80 having a screening or diagnostic colonoscopy will be randomly assigned to have the procedure with or wi…

This study tests a special SPECT imaging agent that seeks out a protein called LRRC15, found on many aggressive cancers like pancreatic, breast, lung, and brain tumors. The goal is to see if this scan can help doctors diagnose and stage these cancers more accurately. Healthy volu…

This study compares contrast-enhanced ultrasound to standard CT and MRI scans for detecting bowel inflammation in children aged 10–18 with Crohn's disease. Participants receive an ultrasound with a microbubble contrast agent alongside their regularly scheduled CT or MRI. The goal…

This study looked at whether measuring a protein called calprotectin in the blood can help diagnose acute appendicitis. Researchers compared 74 patients with abdominal pain, some with confirmed appendicitis and others with non-specific pain. They measured calprotectin levels and …

This study tested whether a thermal camera could detect intestinal inflammation in 43 children with Crohn disease. The camera measures heat patterns on the belly, which may reflect underlying inflammation. Researchers compared these readings to standard stool tests and symptom sc…

This study tested whether a low-dose CT scan, enhanced with deep learning image reconstruction, can diagnose acute abdominal conditions as accurately as a standard CT scan. 246 adults with abdominal pain received both scans, and the low-dose version used less than 30% of the usua…

This study looked at how well a special biopsy method called EUS-FNB can diagnose hard-to-reach tumors in the abdomen, such as those near the bile duct or small intestine. Researchers reviewed data from 131 patients who had this procedure over 10 years. The goal was to see if thi…

This study tested whether a special light technology (enhanced white light endoscopy) helps doctors find more precancerous growths in the colon compared to standard colonoscopy. Over 800 adults aged 45 to 85 undergoing colonoscopy took part. The goal was to see if the enhanced li…

This early-phase trial tested a radioactive tracer called 68Ga-NODAGA-SNA009 in 12 people with colorectal cancer. The tracer targets a protein (GPA33) found on cancer cells and is used with PET scans to see where the cancer is in the body. The main goals were to check safety and …

This study tested whether an artificial intelligence system called CAD EYE can accurately predict if colon polyps are cancerous during a screening colonoscopy. Researchers compared the AI's predictions to the doctor's judgment and the final lab results. The goal is to see if AI c…

This study tested whether specially trained dogs can identify breast, lung, prostate, or colorectal cancer by sniffing breath samples collected on masks. Over 1,300 people provided breath samples before their regular cancer screening or biopsy. The dogs' results were compared to …

This study tested two radioactive imaging agents, NDX-3315 and NDX-3324, to see if they can safely and accurately detect eosinophilic esophagitis (EoE), a condition where immune cells build up in the esophagus. It involved 34 people—some healthy and some with EoE. The goal was to…

This pilot study compared two stool-based tests—Cologuard and the fecal immunochemical test (FIT)—for colorectal cancer screening in adults aged 45-49. Researchers mailed the tests to eligible participants and tracked how many completed screening, had abnormal results, and follow…

This study tested a new digital scope called LUMENEYE to see if it can better measure how much a rectal tumor has shrunk after chemotherapy and radiation. 82 patients who were good candidates for organ preservation were included. The goal was to see if the scope could help doctor…

This study looked at 416 people who had left-sided colon surgery. A few days after surgery, each person got both a CT scan and an endoscopy to check for leaks where the colon was reconnected. The goal was to see which test is more accurate at finding these leaks. Results help doc…

This study tested a smart underwear device to see if it can detect lactose intolerance by measuring gas events after drinking lactose. 37 adults (some lactose tolerant, some intolerant) wore the device and consumed both lactose and a placebo (sucrose) on separate days. The goal w…

This study tested a simple blood test to screen for anal dysplasia, a precancerous condition linked to HPV. Researchers enrolled 104 people with past or current anal HPV, plus some healthy controls. The goal was to see if the blood test could detect and classify anal dysplasia wi…

This study tested whether using artificial intelligence (AI) during colonoscopy helps find more polyps in people with Lynch syndrome, a genetic condition that raises colon cancer risk. One hundred participants each had two colonoscopies back-to-back, with the second using either …

This early-stage study tested whether a single oral dose of HB-2121 is safe in adults. Researchers monitored 18 participants for side effects and tracked how the drug moves through the body over 30 days. The goal is to develop a new way to diagnose celiac disease.

This study tested an artificial intelligence (AI) tool that helps doctors diagnose colorectal polyps during a colonoscopy. The AI analyzes images from a special high-magnification endoscope to predict whether a polyp is cancerous or not. The goal is to improve accuracy and reduce…

This study tested an artificial intelligence model that combines CT scans, digital pathology images, and patient history to improve diagnosis and risk prediction for gastrointestinal stromal tumors (GISTs). Researchers enrolled 300 patients with suspected stomach tumors. The AI a…

This study tests whether giving general practitioners a list of patients who have not completed colorectal cancer screening encourages those patients to get screened. Over 48,000 patients aged 50-74 are involved, and their doctors either receive the list or do not. The goal is to…

This study tested whether a Mediterranean-style diet could help prevent episodes of diverticulitis, a painful digestive condition. 71 adults who had recently recovered from a diverticulitis attack were randomly assigned to follow either a Mediterranean diet or standard high-fiber…

This study tested whether personalized reminders (like texts or emails) could encourage more people to return their at-home stool test kits for colon cancer screening. Over 2,100 adults aged 45 to 75 who had not yet returned their kit took part. The goal was to see if these gentl…

This study looked at whether a Mediterranean diet, weight loss, or both could lower colorectal cancer risk in 180 obese African Americans aged 45-75. Participants followed one of four plans for six months, and researchers measured changes in bile acids, gut bacteria, and cell act…

This study tested whether curcumin, the active ingredient in turmeric, can prevent Crohn's disease from coming back after surgery. 61 adults who had recent surgery for Crohn's were given either curcumin or a placebo, along with standard thiopurine drugs, for 6 months. The goal wa…

This study looked at whether mailing free stool tests (FIT kits) to people's homes could increase colorectal cancer screening rates. Over 4,300 adults aged 45-75 who were at average risk took part. The goal was to make screening easier for those who might otherwise skip it, espec…

This study looked at whether giving extra help and information to spouses of colorectal cancer patients could get them to complete a simple at-home screening test (FIT). About 60 people took part. The goal was to find out what stops them from screening and if a tailored approach …

This study tested whether giving a daily mix of two types of friendly bacteria (Lactobacilli) to children at genetic risk could prevent or slow down autoimmune diseases like celiac disease, type 1 diabetes, and thyroid problems. The researchers enrolled 202 children who already h…

This study tested a special version of the Diabetes Prevention Program designed specifically for men. 301 men with pre-diabetes or high risk took part to see if the program helped them lose weight and prevent type 2 diabetes. The program focused on lifestyle changes and was deliv…

This trial compares two approaches to a nerve block (TAP block) for pain after colorectal cancer surgery. One group receives the standard numbing drug bupivacaine, while the other gets bupivacaine plus dexmedetomidine, a drug that may extend pain relief. The study measures pain s…

This trial investigates whether inhaling a 50/50 mix of nitrous oxide (laughing gas) and oxygen can reduce pain when a nasogastric tube is placed in children aged 3 months to 3 years. The study includes children with mild to moderate dehydration from conditions like gastroenterit…

This study tests whether a 9-week relaxation response mind-body program can improve quality of life and reduce symptoms in people with irritable bowel syndrome (IBS) or inflammatory bowel disease (IBD). Participants attend weekly group sessions that include breathing exercises, m…

This study looked at whether giving fewer antibiotics after appendicitis surgery could lower the risk of antibiotic side effects without compromising patient safety. Over 650 adults who had surgery for simple or complicated appendicitis took part. The goal was to find the right b…

This study tested a 21-step enhanced recovery protocol for children aged 10-18 undergoing elective gastrointestinal surgery. The protocol included things like shorter fasting times, early eating and moving, and less use of opioids. The goal was to see if it could shorten hospital…

This study tested whether putting special elastic tape on the belly can help relieve severe pain, bloating, and nausea in people with advanced cancer who have bowel blockage and fluid buildup. 38 adults whose symptoms didn't improve after standard treatments were randomly assigne…

This study looked at whether adding the drug nefopam to standard pain relief (morphine and paracetamol) can reduce the amount of morphine needed after major colon surgery. 80 adults having planned surgery for colon cancer or diverticulosis took part. The main goal was to measure …

This study explores whether practicing tai chi, a gentle mind-body exercise, can reduce symptoms of irritable bowel syndrome with constipation (IBS-C). Adults aged 18 to 70 with IBS-C will take part in tai chi sessions and report their symptom severity and satisfaction. The goal …

This study tested whether using warm, humidified carbon dioxide gas during low-pressure laparoscopic colorectal surgery reduces pain 24 hours after the procedure. 148 adults having surgery for colon or rectal tumors (benign or malignant) took part. One group received warm, moist …

This study tested a drug called M701, given directly into the belly, combined with standard cancer therapy, for people with malignant ascites (fluid buildup) from stomach, colon, or ovarian cancer. The goal was to see if M701 could delay the need for fluid drainage and improve su…

This study tested whether a daily probiotic capsule containing two bacterial strains could reduce gastrointestinal symptoms like bloating, gas, and cramps in adults with lactose intolerance and methanogenic intestinal overgrowth. Twenty-two adults took either the probiotic or a p…

This study tested whether a structured recovery plan (ERAS) could reduce infections and speed up recovery compared to standard care in 102 adults who had emergency abdominal surgery for a blocked or perforated bowel. Participants were randomly assigned to receive either the ERAS …

This study tested whether a daily probiotic called Weizmannia coagulans BC99 can improve symptoms of chronic constipation in adults. One hundred participants took either the probiotic or a placebo for a period, and researchers measured changes in stool consistency and gut bacteri…

This study looked at whether placing a bridge device during loop ileostomy creation reduces complications like infections or stoma problems. 166 adults having elective colorectal surgery took part. The goal was to see if the device improves outcomes or just adds difficulty to car…

This study tests whether cognitive behavioral therapy (CBT) can reduce anxiety and depression in people with inflammatory bowel disease (Crohn's disease or ulcerative colitis). Participants receive either psychologist-led or self-administered CBT over 8 weeks. The goal is to see …

This study tested whether professional socio-aesthetics (specialized beauty and well-being care) can improve quality of life, reduce pain, and ease anxiety in adults undergoing chemotherapy for lung, breast, colon, or prostate cancer. 400 participants were randomly assigned to re…

This trial investigates whether drinking coffee after pancreatic surgery can help the bowel start working again sooner. About 200 adults who had open pancreatic surgery will receive either regular coffee, decaf coffee, or water twice a day. The main goal is to see how quickly the…

Many colorectal cancer survivors lose muscle mass and strength after chemotherapy. This study tested whether adding creatine supplements to a 10-week resistance training program could help. Twenty-seven survivors participated, comparing those who took creatine with those who only…

This study tested whether a dietary supplement containing digestive enzymes (Galactol®) could reduce bloating after meals in people with irritable bowel syndrome (IBS). 300 adults were randomly assigned to take the enzyme supplement plus a low-FODMAP diet, or just the diet alone,…

This study tested whether a numbing injection into the abdominal wall muscles (called a TAP block) can reduce pain for people with acute appendicitis waiting for emergency surgery. 105 adults in the emergency department received the block, and researchers measured how much pain m…

This study tested a web app called PrehabPal designed to help frail adults aged 65 and older prepare for colon cancer surgery. The app creates a personalized prehabilitation program and offers coaching. Researchers compared it to standard written instructions in 132 participants …

This study tested whether naldemedine, a drug already used for opioid-induced constipation, can also prevent nausea and vomiting when cancer patients start strong painkillers. 120 adults with cancer who were beginning opioid therapy took either naldemedine or a placebo for up to …

This study tested a small, disposable device that gently stimulates nerves in the ear to see if it could reduce the amount of strong painkillers (opioids) needed after open abdominal or pelvic surgery. 286 adults who had surgery for cancer or a liver transplant took part. The goa…

This study tested whether a self-regulation hypnotic intervention could help reduce pain and anxiety during brachytherapy for rectal cancer. Fifty-two adults were randomly assigned to receive either hypnosis training or standard care with pain and anxiety medication. Researchers …

This study tested whether personalized guidance from a dietitian on a low-FODMAP diet works better than just giving patients a standard brochure for managing irritable bowel syndrome (IBS). Fifty adults with IBS followed the diet for 8 weeks. Researchers measured symptom severity…

This study tested an investigational drug called ponsegromab in 187 adults with lung, pancreatic, or colorectal cancer who also had cachexia—a condition causing severe weight loss, loss of appetite, and fatigue. The goal was to see if ponsegromab could help patients gain weight a…

This study tested a new device called MOWOOT for people with chronic constipation. 86 adults who already used standard treatment (trans-anal irrigation) tried the MOWOOT device to see if it improved their symptoms and quality of life. The goal was to compare the new device's effe…

This study tested a hands-on therapy called visceral osteopathy for people with functional constipation. 27 adults received either osteopathic manual therapy or standard dietary advice. The goal was to see if the manual therapy could improve bowel symptoms and quality of life bet…

This study tested health and wellness products to see if they could improve common stomach issues like gas, bloating, diarrhea, and constipation. About 500 adults from across the U.S. took part. Participants took either the product or a placebo (a dummy pill) and reported their s…

This pilot study tested whether a digital platform offering two carbohydrate-reduced diets (low FODMAP or low-carb) could help adults with irritable bowel syndrome (IBS). 32 participants used the app for four weeks, reporting their symptoms and quality of life. The goal was to se…

This completed pilot study tested whether electro-acupuncture can improve symptoms of irritable bowel syndrome with constipation (IBS-C). Sixty IBS-C patients were randomly assigned to receive either real electro-acupuncture or a sham (fake) version. The study also collected bloo…

This study tested whether silkworm pupa tablets can improve nutrition and reduce frailty in people who had surgery for stomach, colorectal, esophageal, or pancreatic cancer. 120 participants took the tablets for 3 months. Researchers measured weight, frailty, muscle mass, and qua…

This pilot study tested a drug called TD-1211 in 95 people who had constipation from taking opioid pain medications. The main goal was to see if the drug was safe and tolerable. Researchers also looked at whether it increased the number of complete and spontaneous bowel movements…

This study tested a drug called TD-1211 in healthy volunteers and people with constipation caused by opioid painkillers. The goal was to see if it is safe and helps with bowel movements. Participants took different doses of TD-1211 or a placebo, and researchers monitored their sa…

This study tested a drug called TD-1211 in 217 adults who have constipation because of opioid painkillers. The goal was to see if it safely increases the number of complete spontaneous bowel movements each week. Participants took either the study drug or a placebo for several wee…

This study tested a new drug called TD-1211 in 69 adults who had constipation because of opioid painkillers. The goal was to see if the drug is safe and helps people have more bowel movements. Participants stopped using other laxatives during the study to see how well TD-1211 wor…

This pilot study tested whether rimegepant (Nurtec), a drug used for migraines, can reduce chronic abdominal pain in people with irritable bowel syndrome (IBS). Thirty-nine adults with non-constipation IBS took either the drug or a placebo for 28 days. Researchers measured change…

This study tested whether naloxegol, a drug used for constipation caused by painkillers, can help people who had heart surgery recover normal bowel function faster. About 305 adults participated. The goal was to see if taking naloxegol around the time of surgery reduces the time …

This study tested the drug linaclotide in children aged 2 to 5 years with functional constipation, a common condition with no approved treatments. In the first part, children received either linaclotide or a placebo for 12 weeks to see if it increased bowel movements. In the seco…

This small study tested whether training with a robotic exoskeleton (a wearable robot suit) can help improve bowel function in people with spinal cord injury. Ten adults with long-term spinal cord injury used the exoskeleton in a supervised program. Researchers measured changes i…

This study tested whether a daily mix of a special fiber (guar gum) and a probiotic (Lacticaseibacillus rhamnosus GG) could help children with long-term constipation. Fifty-two children aged 4 to 16 took either the supplement plus diet advice or just diet advice for 12 weeks. Res…

This pilot study tested an 8-week course of a multi-ingredient nutritional supplement (AV1PD1A) in 9 adults with hydrogen-dominant small intestinal bacterial overgrowth (SIBO). The main goal was to see if the supplement was safe and tolerable. Participants took three capsules dai…

This study tested whether the Paula Method of muscle exercises can help people who have bowel control problems after rectal cancer surgery. 62 adults who had surgery and still had symptoms took part. The exercises aim to strengthen muscles naturally without drugs or surgery.

This study tested whether psyllium husk, a type of fiber supplement, can reduce bowel symptoms and improve quality of life in people who had rectal cancer surgery. 24 participants who had ongoing bowel issues after surgery took psyllium husk. The goal was to see if it helps with …

This study tested whether a standardized Boswellia extract (a herbal supplement) combined with patient education could reduce symptoms of irritable bowel syndrome (IBS) like belly pain, bloating, and irregular bowel habits. Sixty adults with moderate IBS took the extract twice da…

This study tested a 12-week online mind-body program for adults with chronic conditions like heart failure, cancer, and liver disease. The program included mindful movement, meditation, breathwork, and coping skills. Researchers measured changes in anxiety, depression, fatigue, a…

This study tested whether applying a magnetic field to the belly can reduce constipation severity. 75 adults with chronic constipation were split into three groups: one received active magnetic therapy twice a week for 8 weeks, one received a sham treatment (device on but no magn…

This study tested a low-volume irrigation device (Qufora IrriSedo MiniGo) in 92 adults with fecal incontinence, chronic constipation, or both. Participants used the device at home to see if it improved bowel function and daily life. The goal was to find a simple, non-drug option …

This study looked at whether giving people a gentle abdominal massage before surgery could help prevent constipation after the operation. Sixty adults who were already constipated and scheduled for general surgery took part. Half received a 15-minute massage twice a day before su…

This study tested whether a temporary stent placed inside the bowel could replace a traditional ileostomy (a bag outside the body) after rectal cancer surgery. 570 patients at high risk for leaks were randomly assigned to either the stent or ileostomy. The goal was to see if the …

This study tested a probiotic (BB-12 with LGG) in 123 children with autism and stomach problems. The goal was to see if different doses are safe and can improve behavior and gut health. Researchers tracked side effects, behavior changes, and gut bacteria over 56 days of treatment…

This study compared two types of nerve blocks—erector spinae plane (ESP) and quadratus lumborum (QL)—to see which provides better pain relief after appendix surgery in children aged 3-13. Sixty children received one of the blocks along with general anesthesia. Researchers measure…

This study tested whether a single dose of TRPTI (oleoylethanolamide), a dietary supplement, could improve how the body handles sugar in 19 healthy adults. Participants received either 150 mg, 300 mg, or a placebo in random order, then had their blood sugar and insulin levels mea…

This study looked at whether exercising in the morning or evening helps control blood sugar better in pregnant women with gestational diabetes or glucose intolerance. 39 women walked or stepped for 30 minutes either after breakfast or after dinner. The researchers measured blood …

This study tested whether nurse coaching could help people with inflammatory bowel disease (IBD) better manage their symptoms, improve self-care, and enhance quality of life. Forty adults with IBD in remission participated. Researchers measured changes in symptom burden, self-car…

This study looked at whether doing special exercises before colorectal cancer surgery (called prehabilitation) helps patients recover better compared to standard care. Over 700 adults scheduled for surgery took part. The main goal was to see if the exercise group had better physi…

This study tested whether using a cold therapy device on the belly after appendix removal helps control pain in children ages 7 and older. Half the kids got the cold pack plus usual care, the other half got usual care alone. Researchers measured pain scores, morphine use, and hos…

This pilot study tested whether a daily prebiotic fiber bar is safe and tolerable for people with Parkinson's disease. Twenty adults (ages 60-75) ate one bar each day for four weeks. Researchers checked gut symptoms, quality of life, and markers of intestinal inflammation from bl…

This study tested whether two nurse phone calls during the first three cycles of chemotherapy could improve the emotional state and quality of life of patients with breast, colon, or rectal cancer. 274 patients were randomly assigned to receive either standard care or standard ca…

This study tested whether ethosuximide, a drug used for epilepsy, can reduce belly pain in people with irritable bowel syndrome (IBS). 162 adults with IBS took either the drug or a placebo. The goal was to see if the drug could lower pain and improve quality of life.

This study looked at whether cutting out certain carbs (FODMAPs) can help people with celiac disease who still have stomach issues even after following a gluten-free diet. Researchers surveyed and then ran a controlled trial with 80 adults who had celiac disease and irritable bow…

This study tested whether giving simethicone (a defoaming agent) and dicyclomine (which reduces gut spasms) before or during an ERCP procedure improves how well doctors can see and work. 90 adults were split into three groups: one got no extra medication, one got simethicone befo…

This completed trial tested whether a probiotic called Bacillus coagulans can help adults with mild to moderate IBS-D (diarrhea-predominant irritable bowel syndrome). Fifty participants took either the probiotic or a placebo capsule twice daily for 8 weeks. Researchers tracked ch…

This study tested a web-based support program for people with colorectal cancer undergoing treatment. The program provided information and tips on physical, emotional, and daily-life challenges. Researchers measured whether it helped reduce symptoms and improve quality of life co…

This study tested whether a probiotic called Bifidobacterium longum can ease constipation in infants and toddlers. 84 children received either the probiotic, a common laxative (lactulose), or both for 28 days. Researchers tracked bowel movements, stool consistency, and gut bacter…

This study tested a constipation training program for mothers of children aged 4-6 with functional constipation. The program used motivational interviewing to help mothers manage their child's condition. Researchers measured changes in children's bowel movements and stool consist…

This study tested whether a low-immunogenic oat variety called Saul is well-tolerated by adults with celiac disease who are in remission. Forty participants ate 50 grams of gluten-free Saul oat flakes daily for 14 days. Researchers tracked symptoms and blood markers to see if the…

This small study tested whether wearing bright light glasses each morning could improve symptoms of irritable bowel syndrome (IBS) and reduce leaky gut. Five adults with IBS used the light device for two weeks. The goal was to see if the light therapy eases belly pain, bloating, …

This study investigates whether women who have completed breast cancer treatment have a higher chance of developing colorectal polyps or colon cancer. Researchers will perform screening colonoscopies in 216 asymptomatic breast cancer survivors and check for abnormal growths. The …

This study compares two simple educational tools—a written PDF and an audio podcast—to see which helps people with inflammatory bowel disease (IBD) learn more about their condition. Participants fill out questionnaires at the start and after three months to measure knowledge, sat…

This study examined how Mexican-American families discuss their risk for diabetes, heart disease, breast cancer, and colon cancer. Researchers interviewed 498 adults from Mexican-American households in Houston to understand how culture and family history influence health communic…

This study looked at whether having a special consultation with a radiotherapy technician (called a manipulator) helps cancer patients feel more informed about their treatment. Researchers enrolled 308 adults with various cancers who were getting radiation therapy. They compared …

This study looked at whether using a physical activity screener, along with exercise coaching and self-monitoring, could help breast and colon cancer survivors become more active and spend less time sitting. Twenty survivors who had finished their main cancer treatment at least t…

This study enrolled 800 adults undergoing upper endoscopy to find risk factors and blood markers that could help diagnose and monitor eosinophilic esophagitis (EoE), a chronic allergic condition of the esophagus. Researchers compared people with and without EoE, collecting blood,…

This study tested whether a weekly electronic survey could help identify cancer treatment delays and racial differences. About 100 adults with newly diagnosed breast or colorectal cancer who hadn't started treatment yet filled out a short survey each week for 8 weeks. The goal wa…

This study investigates whether having an empty bladder reduces movement of the mesorectum (tissue around the rectum) during radiotherapy for rectal cancer. About 50 adults with rectal cancer receive planning CT scans and weekly CBCT scans under both empty and full bladder condit…

This study looked at how a protein called IL-22 binding protein (IL-22BP) affects gut healing in people with Crohn's disease or ulcerative colitis. Researchers compared samples from 52 patients and healthy volunteers to understand how IL-22BP is regulated during disease flares. T…

This study looked at 30 adults with Alpha-Gal syndrome, a condition where eating red meat causes allergic reactions. Participants ate cooked ground pork with or without a sugar called alpha-gal, then researchers checked for allergic reactions, gut symptoms, and changes in immune …

This completed study surveyed over 2,500 appendicitis patients to understand their satisfaction and regret after choosing either surgery or antibiotics. Researchers aim to use this information to design decision-support tools that help future patients make choices aligned with th…

This study looks at how being physically fit changes the bacteria in your gut. Researchers will compare the gut microbes of 30 healthy men, from inactive to elite athletes, by testing their exercise capacity and analyzing stool samples. The goal is to find connections between fit…

This study looked at 294 women with deep endometriosis affecting the rectum. Researchers compared how patients felt after conservative surgery versus more radical bowel removal. The goal was to see which approach leads to fewer bowel and bladder problems and to find factors that …

This study investigates whether gut microorganisms and their byproducts play a role in triggering severe flare-ups of ulcerative colitis. Researchers will compare patients hospitalized with severe colitis to those with milder symptoms, analyzing stool and blood samples over three…

This study looks at whether a narrowed inferior mesenteric artery (IMA) — seen on routine CT scans — is linked to a higher chance of anastomotic leakage after rectal cancer surgery. Anastomotic leakage is a serious complication where the surgical connection leaks. The study will …

This study developed a risk assessment scale to identify hospitalized patients likely to develop constipation. Researchers enrolled 516 adults staying at least 4 days in the hospital. The goal is to catch high-risk individuals early and start prevention measures.

This study looked at colon tissue samples from 200 people with irritable bowel syndrome (IBS) to understand why their gut barrier may be leaky. Researchers tested whether substances released by mast cells (a type of immune cell) can damage the gut lining and nerves. The goal is t…

This study investigates how differences in cell membrane voltage, caused by varying physical pressures inside a tumor, help colorectal cancer resist chemotherapy and evade the immune system. Using advanced lab models and tissue samples from 11 patients, researchers found that cel…

This study looked at how well people with self-reported fiber sensitivity tolerate different doses of soluble fiber. 141 adults took fiber or a placebo for 7 days, and researchers measured digestive symptoms and dropout rates. The goal was to find a dose that causes minimal disco…

This study followed 110 people with anal cancer to see if PET/CT scans can help doctors monitor the disease after initial treatment. Researchers tracked how long patients stayed cancer-free and measured metabolic activity in tumors. The goal is to find better ways to detect relap…

This study looks at whether placing a tube through the nose into the stomach (nasogastric tube) before surgery helps prevent breathing complications in infants with hypertrophic pyloric stenosis. The condition causes a blockage in the stomach outlet, leading to forceful vomiting.…

This study investigates whether analyzing bowel sounds with a computer can help measure disease activity in children with Crohn's disease. Researchers will record bowel sounds and compare them to a standard disease activity score. The goal is to find a noninvasive, painless way t…

This study aimed to create a detailed map of the cells in the human appendix and understand their genetic activity. Researchers analyzed appendix tissue from 5 patients undergoing colon cancer surgery. The goal was to learn more about the appendix's role in the immune system and …

This study analyzed data from 500 Crohn's disease patients to create a tool that uses routine blood tests to predict the risk of needing intestinal surgery. The goal is to help doctors move from reacting to problems to preventing them. The model is still in early development and …

This completed study took small tissue samples from the colons of 40 people during routine colonoscopies. Using advanced genetic techniques, researchers created a detailed map of the different cell types and their gene activity. The goal is to better understand how colon diseases…

This study looked at whether a new blood test called EPISPOT can predict how well chemotherapy works in people with metastatic colorectal cancer. Researchers measured circulating tumor cells in 168 patients before and during treatment. The goal was to see if early changes in thes…

This completed study looked at how common celiac disease is in Spain and what factors might influence it. Researchers tested nearly 5,000 people of all ages across five regions using blood tests and biopsies. They aimed to understand why earlier studies found different rates in c…

This study surveyed 231 adults with Lynch syndrome, an inherited condition that raises bowel cancer risk. Researchers wanted to find out how many people follow the UK recommendation of a colonoscopy every two years, and what makes it harder or easier to keep up with these check-u…

This study looked at whether magnetic stimulation of nerves in the lower back can change how the colon moves. It included 30 people: healthy volunteers, and patients with constipation or fecal incontinence. The goal was to understand the effect, not to treat the condition.

This study looked at the safety of Bevacizumab-Pfizer Biosimilar, a drug used to treat colorectal cancer, by analyzing medical records from 1,000 patients in Japan. Researchers focused on side effects like bleeding, high blood pressure, and kidney problems. The goal was to unders…

This study tested whether a theory-based chatbot could increase colorectal cancer screening rates. 500 adults aged 50-75 in Hong Kong were randomly assigned to receive either standard text reminders or a chatbot that provided personalized risk information and screening guidance. …

This Phase 1 trial tested the safety and tolerability of INT-210 capsules in 86 healthy adults aged 18-45. Participants received single or multiple doses of the drug or a placebo, and researchers monitored side effects and how the drug moves through the body. The study also looke…

This completed study looked at 324 extremely low birth weight preterm infants (≤1250 grams) to see how anemia and red blood cell transfusions affect oxygen levels in their digestive tract. Researchers used a non-invasive device to measure tissue oxygen and collected blood, urine,…

This study tested whether time-restricted feeding (eating only during an 8-hour window each day) could change certain blood markers linked to breast cancer risk. Twenty-nine postmenopausal women with prediabetes were randomly assigned to either the 8-hour eating schedule or a nor…

This completed study looked at over 107,000 patients in Germany to understand the long-term side effects of systemic steroids (corticosteroids) used for conditions like asthma, COPD, and arthritis. Researchers compared patients who took steroids with those who did not, tracking r…

This early-stage study tested two different forms of the experimental drug AQ280 in 9 healthy adults. The goal was to see how well the body absorbs the drug when given as a capsule versus a tablet that dissolves in water. The results will help researchers decide which form to use…

This completed study looked at how nerve damage from the chemotherapy drug oxaliplatin affects hand function, grip strength, and quality of life in 103 colorectal cancer patients. Researchers measured hand and finger strength, dexterity, and daily living abilities using standard …

This study looked at how a soy-based diet or a similar diet without soy changes gut bacteria in people with Crohn's disease (in remission or active) and healthy volunteers. Researchers measured inflammation markers and tracked whether symptoms stayed stable over one week. The goa…

This study looked at how fermented dairy (like yogurt) and non-fermented dairy (like milk) affect bowel habits and thinking skills in healthy women who have bowel movements every other day or less. 96 women took part, eating 300g of dairy daily for 4 weeks. The goal was to see if…

This completed study looked at 328 patients with intermediate or high-risk gastrointestinal stromal tumors (GISTs) who took imatinib after surgery. The goal was to find the best dose that balances effectiveness in preventing tumor return with the risk of side effects. Researchers…

This study looked at whether combining detailed MRI scans with whole genome sequencing can help doctors choose the best treatment for people with liver cancer. Researchers studied 200 adults who were scheduled for liver surgery. The goal was to see if these advanced tests provide…

This study tested whether a two-hour, peer-led workshop with religious messages could encourage Muslim women in North East England and Scotland to get screened for breast, bowel, and cervical cancer. 169 women aged 25-74 who were not up-to-date with all eligible screenings took p…

This study measured how often adults with inflammatory bowel disease (Crohn's disease or ulcerative colitis) show signs of eating disorders, including avoidant/restrictive food intake disorder (ARFID). Researchers used questionnaires to assess eating habits and nutritional status…

This study looked at whether a nerve block called the erector spinae plane block can protect kidney function during laparoscopic colorectal cancer surgery. Sixty adults having this surgery were divided into two groups: one received the nerve block plus standard anesthesia, the ot…

This study looked at 30 colorectal cancer patients to see if tumor deposits (small clusters of cancer cells found near the main tumor) can help predict survival and whether the cancer spreads to other organs. Researchers tracked overall survival and the appearance of new metastas…

This study tested a new scoring system called CAT-DESIRE to evaluate ulcerative colitis severity using colonoscopy images. Researchers reviewed images from 235 patients to see if the new score is reliable and can predict long-term outcomes. The goal is to provide a simple, accura…

This study looked at the best ways to encourage childhood cancer survivors who are at high risk for colorectal cancer to get screened at the recommended age. Researchers tested different methods to see which helped more people complete a colonoscopy or stool-based test. The goal …

This study looked at how 208 patients with severe diverticulitis were treated at a Brussels hospital network between 2015 and 2024. Researchers wanted to see which treatments doctors chose, such as medication alone, drainage, or different types of surgery. The goal was to underst…

This study looked for leftover cancer DNA in the blood of over 2,000 people who had surgery for stage II or III colorectal cancer. Participants did not receive any new treatment—they just gave blood samples over about 21 months. The goal was to find patients who might be eligible…

This study looked at 115 adults with prediabetes to understand why different people develop the condition. Researchers tested how each person's body responds to different foods, aiming to create personalized diet plans that prevent diabetes. The goal was to find biological marker…

This study looked at how the body processes TD-1211, a drug for opioid-induced constipation. Ten healthy men received a single dose of the drug with a radioactive tracer to track its absorption, distribution, and elimination. The goal was to understand the drug's behavior, not to…

This study looked at 343 adults who were diagnosed with inflammatory bowel disease (Crohn's disease or ulcerative colitis) before age 17. Researchers compared their employment rates and education levels to the general population to understand how the disease may affect long-term …

This early-stage study tested a single dose of TD-1211, an experimental drug for constipation, in 47 healthy adults split into younger (18-45) and older (65-85) groups. Researchers measured how the body absorbs and eliminates the drug and checked for side effects. The goal was to…

This study tested a physical activity program called PACE for African American colorectal cancer survivors. Researchers wanted to see if the program was practical and could increase steps and exercise. Twenty-one participants used Fitbits and watched videos to track their activit…

This study looked at 590 colorectal cancer patients to develop a risk tool that predicts postoperative delirium—a common complication causing confusion and slower recovery. Researchers combined blood test results (including the TyG index) with patient subtypes to create a scoring…

This study tested a special gluten-free food guide designed to help children and teens (ages 5-18) with newly diagnosed celiac disease eat a healthier diet. Forty participants received either standard care or the new guide. Researchers measured diet quality and how well they foll…

This study looked at whether difficulty digesting fructose (a sugar found in many foods) is linked to anxiety and changes in gut bacteria. Researchers compared 56 healthy young men who either absorb fructose normally or have trouble absorbing it. The goal was to see if fructose m…

This study looked at whether being more physically active, measured by daily steps, helps rectal cancer patients respond better to chemotherapy and radiation before surgery. About 120 participants wore smartwatches to track their steps, heart rate, and sleep. The goal was to see …

This study looked at whether an AI computer program could suggest cancer treatments that match what experts recommend. Researchers reviewed medical records of 30 people with stomach, colon, or pancreatic cancer. They entered key details into the AI and compared its suggestions to…

This completed study looked at how common fish allergy is among people who work with fish, like fishermen and fish-processing factory workers, compared to other workers. Researchers surveyed 486 people in Boulogne-sur-Mer, France, asking about allergic symptoms and exposure to fi…

This study tested whether adding calisthenics (bodyweight exercises like push-ups and squats) to gym class helps teens get stronger and feel better about themselves. 100 students aged 13-16 were split into two groups: one did calisthenics for 12 weeks, the other followed standard…

This study looked at 84 children and teens with inflammatory bowel disease (IBD) to see if daily physical activity is linked to better bone density. Participants wore activity monitors and had bone scans. The goal is to understand if staying active could help prevent bone loss, a…

This study followed 159 people with metastatic colorectal, pancreatic, biliary, or esophageal cancers who were starting a new line of therapy. Researchers collected blood samples (tumor markers and liquid biopsies) and patient-reported quality-of-life data to see if these could p…

This study looked at 42 infants who had surgery for a rare birth defect called esophageal atresia type III. Researchers gave the babies a sugary drink to see how often they developed dumping syndrome, a condition causing rapid blood sugar changes. The goal was to find out how com…

This study looked at 140 patients who had colon cancer surgery and chemotherapy at Rouen University Hospital. The goal was to see if living farther from the hospital caused a longer wait to start chemotherapy after surgery. The findings could help improve care for patients who li…

This completed study interviewed 12 patients waiting for either a colonoscopy or a colon capsule endoscopy. The goal was to understand what factors are most important to them when deciding between these two colon tests. Researchers used telephone interviews and analyzed the conve…

This study looked at how drinking beverages with different sweeteners—low-calorie sucralose, refined sugar, or natural fruit juice—affects blood sugar control and gut health in healthy adults. Over three weeks, 42 participants drank one type of sweetened drink daily. Researchers …

This completed study looked at how well young and middle-aged colorectal cancer survivors can identify and describe their specific emotions—a skill called emotional granularity—and whether that helps them build resilience. Researchers surveyed 242 survivors online and interviewed…

This completed study looked at 115 people with inflammatory bowel disease (IBD) to see if their condition raises the risk of atherosclerosis, a hardening of the arteries that can lead to heart attacks and strokes. Researchers measured artery stiffness and thickness, and tracked h…

This completed study looked at 63 Crohn's disease patients who had an anal fistula treated with anti-TNF drugs and a seton drain. Researchers tracked how long the fistula stayed closed and what factors might cause it to come back. The goal is to better understand long-term outcom…

This study tested whether an educational video on safe catheter care could reduce bloodstream infections in adults starting home parenteral nutrition for the first time. Twenty-five participants received the video training alongside standard care. Researchers tracked infection ra…

This study looked at antibodies in the intestines of 160 people: 80 with Crohn's disease, 40 with ulcerative colitis, and 40 without inflammatory bowel disease. Researchers took blood samples and intestinal biopsies to compare antibody levels in the gut versus the blood. The goal…

This study looked at how Hirschsprung disease, a rare birth defect affecting the bowel, impacts brain development and quality of life in children aged 8 to 13. Researchers tested thinking skills and surveyed families to understand long-term effects after surgery. The goal was to …

This study looked at 366 adults referred for suspected inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. The goal was to find simple, non-invasive markers that can help doctors diagnose IBD more accurately and predict how the disease will progres…

This study examined how differences in the BAFF gene might affect a person's risk of developing ulcerative colitis and how well they respond to the drug vedolizumab. Researchers analyzed genetic samples from 841 people with ulcerative colitis. The goal was to better understand th…

This study observed 165 people with inflammatory bowel disease (Crohn's or ulcerative colitis) in Poland who were already taking or starting vedolizumab. Researchers tracked whether patients chose intravenous or subcutaneous (under-the-skin) injections, and how long they stayed o…

This study tested whether a family history app can help doctors collect and use information about patients' family health risks. Over 600 adults aged 30-69 took part. The goal was to see if the app leads to better screening and genetic referrals for conditions like cancer, heart …

This study looked at 150 colorectal cancer patients to see if counting tumor buds in biopsy samples could predict whether cancer has spread to lymph nodes or other organs. Researchers used a special stain to find tumor buds and counted them in the densest area. They then used a c…

This study tested a new, faster care plan for people with chronic constipation at a University of Michigan gastroenterology clinic. Researchers wanted to see how often doctors ordered special tests and pelvic floor therapy, and how satisfied patients were with their care. The stu…

This study involved 132 adults with colorectal cancer who had standard surgery (low anterior resection) and a temporary ileostomy (a stoma to divert waste). The goal was to measure major complications after surgery and create a single safety endpoint. This will help doctors compa…

This study tested a new classification system for people whose colorectal cancer has spread only to the liver. Researchers looked at survival rates and compared different patient groups to see if the system helps predict outcomes. The goal is to better identify which patients mig…

This completed study looked at how often joint pain occurs in 71 people with ovarian, colorectal, or lung cancer who were taking the drug bevacizumab. Participants filled out a questionnaire about their joint pain over 6 months. The goal was to better understand this side effect.

This study looked at how being isolated during the COVID-19 pandemic affected the mental health of 232 people with inflammatory bowel disease (IBD). Researchers used questionnaires to measure depression, anxiety, and other psychological symptoms. The goal was to understand what f…

This study looked at whether taking a bowel-cleaning liquid before a capsule endoscopy helps doctors see the small intestine better and find more problems. 230 adults scheduled for the procedure were randomly assigned to get either a split dose, a single morning dose, or no speci…

This completed study looked back at medical records of 500 patients aged 50 or younger diagnosed with colorectal cancer or precancerous growths at a hospital in Shenzhen, China. Researchers compared those with early-stage disease to those with later-stage disease to identify fact…

This study looked at 26 adults having colorectal (bowel) cancer surgery while placed in a steep head-down position with legs raised in stirrups. Researchers measured blood flow and oxygen in the calf muscles during the operation to understand how a rare but serious leg injury cal…

This study tested whether a digital symptom checker could work as well as a traditional phone call for guiding patients to the right level of care. Researchers planned to include 120 adults from a primary care center, but only 22 took part. The main goal was to see if a larger tr…

This study tracked 646 people with complex fistulas (abnormal tunnels) caused by Crohn's disease or other conditions. Researchers observed the standard surgical treatments patients received at their clinics and recorded outcomes like fistula closure and complications. The goal is…

This study looked at how spinal cord epidural stimulation affects bladder, bowel, and blood pressure control in 61 adults with spinal cord injury. Researchers monitored participants in a lab and at home to understand autonomic dysreflexia and test stimulation as a therapy. The go…

This study looked at 57 patients with rectal cancer to compare surgical outcomes from three different treatment approaches: the RAPIDO protocol (short-course radiation plus chemotherapy), standard long-course radiation with chemotherapy, and surgery alone. Researchers measured th…

This study looked at 200 older adults (65+) having planned surgery for colorectal cancer. Researchers used a frailty test before surgery to see if it could predict complications like infections or longer hospital stays. The goal is to help doctors better plan care and reduce risk…

This study tested whether a flexible, personalized exercise program is practical for cancer patients receiving chemotherapy. Twenty-one adults with breast, ovarian, or colorectal cancer took part. The main goal was to see if patients would join, attend, and stick with the exercis…

This study looked at how different types of milk—A2 milk and protein-hydrolysed lactose-free A1 milk—affect gut symptoms and inflammation in 37 adults who usually feel discomfort from regular milk. Participants drank each milk type for three days while taking either a lactase cap…

This completed Italian study looked at how often children with inactive inflammatory bowel disease (IBD) also have disorders of gut-brain interaction (DGBIs), like irritable bowel syndrome. Researchers used the Rome IV questionnaire to compare 220 children with quiescent IBD to h…

This study measured calprotectin, a protein in stool that signals gut inflammation, in 121 healthy adults aged 22 and older. Participants collected a single stool sample at home and mailed it in. The goal is to establish what level is normal, helping doctors better tell apart inf…

This completed study looked at 60 people with obstructed defecation, a severe form of constipation. Researchers compared how well a noninvasive nerve stimulation treatment worked in obese versus non-obese participants. The goal was to see if body weight changes the treatment's ab…

This study reviewed medical records of 966 children diagnosed with Crohn's disease or ulcerative colitis between 1988 and 2011. Researchers looked at how often children needed surgery and how treatments like immunosuppressants and anti-TNF drugs were used over time. The goal was …

This completed study looked at 300 Crohn's disease patients to see if CT scan images could predict who would need surgery within a year of diagnosis. Researchers built a computer model using 'radiomics' to analyze the scans. The goal is to help doctors start stronger treatments e…

This completed study from China looked at 50 adults with Crohn's disease who were treated with two newer biologic drugs, Ustekinumab and Vedolizumab. The goal was to see how well these drugs control the disease and what factors might predict a good response. By analyzing past med…

This completed observational study looked at 669 Crohn's disease patients to see if finding hidden anal fistulas early with MRI leads to better long-term health. Researchers compared patients who had no symptoms but were found to have fistulas on MRI to those who had symptoms. Th…

This study looked at how prostate and colorectal cancer affect mitochondria—the energy factories in cells—and whether a 4-week home exercise program could improve them. Fifteen men awaiting surgery did either resistance or high-intensity interval training at home. Researchers mea…

This study looked at whether giving antibiotics early to extremely low birthweight babies (born before 31 weeks) might cause more harm than good. Researchers compared babies who got standard antibiotics to those who got a placebo. The goal was to see if early antibiotics increase…

This study looked at how blood sugar levels change in hospitalized babies with intestinal failure when their intravenous nutrition is given in cycles instead of continuously. Nine infants wore a small sensor on their thigh that measured glucose every 5 minutes for up to 30 days. …

This completed study from Oslo University Hospital involved 33 adults with celiac disease who followed a strict gluten-free diet. Over five separate one-day challenges, participants consumed wheat gluten, barley gluten, hydrolyzed barley gluten, or a placebo. Researchers measured…

This study followed 516 HIV-positive men who have sex with men over two years to track anal HPV infection and related lesions. Researchers used exams and anoscopy to see how often high-grade lesions appear or go away on their own. The goal is to gather evidence to better prevent …

This study tested whether tagatose, a low-calorie sweetener, can act as a prebiotic—meaning it selectively feeds beneficial gut bacteria and improves blood sugar control. Fifty-nine healthy adults with slightly high blood sugar or insulin resistance took either tagatose or a plac…

This study tested whether using an artificial intelligence system (ENDOAID) together with a small attachment on the colonoscope (Endocuff) helps doctors find more precancerous polyps (adenomas) than using AI alone. Over 1,700 adults aged 45-85 undergoing colonoscopy for screening…

This pilot study tested whether taking metformin 30 or 60 minutes before a meal affects carbohydrate absorption in people with obesity and prediabetes or type 2 diabetes. One participant completed three oral glucose tolerance tests—one without metformin, one with metformin taken …

This study looked at physical fitness in 100 children and teens (ages 10-17) with chronic inflammatory bowel disease (Crohn's disease, ulcerative colitis, or unclassified colitis) and compared them to healthy kids of the same age, weight, and sex. Researchers measured cardiorespi…

This study looked at how much of the drug risankizumab (Skyrizi) passes into the breast milk of women with inflammatory bowel disease (IBD). Ten breastfeeding mothers who were already taking the drug provided milk samples over several weeks. The goal is to understand potential ex…

This study looked at 120 adults with inflammatory bowel disease (IBD) to see if simple stool tests can tell if the disease is active or in remission, just like a colonoscopy does. Colonoscopy is the current gold standard but is expensive, invasive, and not ideal for frequent chec…

This study looked at whether adding walnuts to your diet can change the bacteria in your gut and reduce signs of colon cancer risk. About 140 people at higher risk for colorectal cancer ate walnuts for a month. Researchers measured changes in gut bacteria, blood markers, and colo…

This study looked at whether using a standardized set of measurements, including patient-reported outcomes, can improve care for people with colorectal cancer. Researchers followed 133 patients over time, collecting data on their health and quality of life. The goal was to see if…

This study looked at how hormonal birth control might help manage inflammatory bowel disease (IBD) symptoms that get worse during a woman's period. Researchers surveyed 50 women with IBD to understand their preferences for birth control and whether they would join a future trial.…

This early-stage trial tested a new oral drug called IPG11406 in 66 healthy adults to see if it is safe and how the body processes it. The drug is designed to treat inflammatory bowel diseases like Crohn's disease and ulcerative colitis. Participants received either the drug or a…

This study looked at whether exercising in the afternoon versus the morning makes a difference in blood sugar levels for people with pre-diabetes. Fifteen overweight adults aged 40-75 completed a 12-week high-intensity interval training program. The main goal was to see if aftern…

This study tested a tool built into electronic health records that prompts doctors to discuss heart health with cancer survivors during routine visits. Researchers enrolled 645 survivors of breast, prostate, colorectal, endometrial, and lymphoma cancers across 12 clinics. The goa…

This study looked at whether a surgery called STARR, used to treat severe constipation caused by a rectocele or intussusception, affects the anal sphincter's ability to stretch and hold. Nine patients were tested before and 3 months after surgery using a special balloon device (E…

This study looked at 500 women with non-celiac wheat sensitivity (NCWS) to see if they have more gynaecological issues than healthy women or those with celiac disease or irritable bowel syndrome. Researchers also tested whether a gluten-free diet could improve these problems. A s…

This small, early-stage study tested whether a new drug called AZD7798 changes how a special imaging tracer binds to the gut in people with Crohn's disease. Nine adults with active Crohn's disease involving the small intestine received multiple doses of AZD7798 and underwent PET …

This study looked at 74 people with metastatic colorectal cancer starting their first chemotherapy. Researchers took blood samples early in treatment to measure three markers: CEA, circulating tumor DNA, and total cell-free DNA. The goal was to see if early changes in these marke…

This study followed 56 patients who had surgery for non-metastatic colon cancer to see if the number and type of immune cells in their tumors could predict whether the cancer would come back. Researchers analyzed both blood samples and tumor tissue for various immune markers. The…

This study looked at whether a genetic test called QMPSF can help predict if stage II or III colon cancer will come back after surgery. Researchers analyzed tumor tissue from 401 patients for specific DNA changes. The goal was to see if these genetic markers are linked to cancer …

This study looks at whether certain combinations of genetic variations, rather than a single gene, can increase the risk of colorectal cancer. Researchers will compare the DNA of 700 patients with strong family histories of the disease against 350 healthy controls. The goal is to…

This study looked at 846 people who had a positive stool test for colorectal cancer and needed a follow-up colonoscopy. Researchers wanted to understand how involved patients felt in making decisions about their care and how satisfied they were with the entire screening and treat…

This completed study tested whether a new biomarker called 'mass response' can predict how well a cancer therapy will work. Researchers collected tumor cells from 72 patients with various cancers through fluid drainage or biopsies. The goal was to see if this biomarker could guid…

This study looked back at the medical records of 500 people with colorectal cancer from two regions in China. Researchers collected information on patients' backgrounds, lifestyle, and treatments to find patterns that affect survival. The goal was to understand regional differenc…

This study looked at why certain foods cause symptoms in people with Irritable Bowel Syndrome (IBS). Researchers focused on how gut bacteria produce histamine when digesting specific carbohydrates (FODMAPs). Thirty adults with IBS followed a low-FODMAP diet and took special drink…

This completed study looked at 29 patients with a hard-to-treat form of advanced colorectal cancer. The goal was to find new ways to group these patients based on the biology of their tumors. This could help doctors choose more effective treatments in the future. The study did no…

This study looked at 76 adults with advanced colorectal cancer to find genetic markers that might predict how well a combination of chemotherapy (FOLFOX) and the drug bevacizumab works. The goal was to understand which patients benefit most, not to test a new cure. Participants h…

This study explored how teenagers and their parents react emotionally and mentally when they learn about genetic risks for conditions like hereditary breast cancer, Lynch syndrome, or high cholesterol. Researchers surveyed 162 participants using questionnaires and interviews to m…

This study tested whether starting a colonoscopy with the patient lying on their back (supine) or on their left side (left-lateral) makes a difference. Researchers measured how long it took to complete the procedure, how much pain patients felt, and how difficult the procedure wa…

This study aims to create a tool that helps nurses better assess and care for the sexual health needs of men with inflammatory bowel disease (IBD). The research involved 792 participants, including men with IBD and their partners, as well as healthcare professionals. The goal is …

This study looks at whether the drug T-DXd works better than standard treatments for people with several types of HER2-positive solid tumors. Researchers will compare data from previous T-DXd trials with real-world medical records of patients who received standard care. The goal …

This study looked at whether cancer survivors living in rural areas can create their own survivorship care plans and learn from telehealth education. 261 survivors of breast, colorectal, lung, lymphoma, or prostate cancer took part. The goal was to see if this approach improves t…

This study looked at how two different diets affect gut bacteria and markers linked to colon cancer risk in 15 African American adults at higher risk. Participants ate a high-fat, animal-based diet and a low-fat, plant-based diet for three weeks each. Researchers measured changes…

This early-stage study tested a single dose of the experimental antibody SM17 in 30 healthy Chinese adults to see if it is safe and how the body processes it. The study did not aim to treat any disease. Results will help plan future trials for conditions like eczema, asthma, and …

This completed study tested whether giving families of children with long-term illnesses (like cancer, heart disease, or premature birth) a tablet computer with a special app helps them manage care at home. Researchers measured satisfaction, cost-effectiveness, and how well famil…

This completed study from West China Hospital examined tumor tissue from 100 colorectal cancer patients who had already received immunotherapy. Researchers measured levels of a protein called PHGDH to see if it was linked to how well the patients responded to treatment and how lo…

This study looked for the most effective and practical way to screen for anal high-grade lesions (a precancerous condition) in Thai men who have sex with men and transgender women. Researchers tested different screening methods in 950 participants to see which approach finds the …

This study looked at 36 adults with spina bifida to understand why they often have bowel issues. Researchers took small tissue samples from the colon during a routine scope and measured how the rectum works. The goal was to see if nerve damage affects the gut's lining and nerves,…

This study gave educational materials about colorectal cancer and screening to 188 adults aged 45-75 in the Tampa Bay area. Researchers used surveys to measure changes in knowledge and screening intentions. The goal was to see if education encourages people to talk to their docto…

This study looked at whether purified gluten or whole wheat (which contains gluten plus other proteins) causes stomach and gut symptoms in people with irritable bowel syndrome (IBS). Twenty-nine adults with IBS who had previously felt better on a gluten-free diet took part. They …

This study looked at whether using a special balloon-assisted scope (G-Eye) together with artificial intelligence (CAD-Eye) finds more polyps than a standard colonoscopy with AI alone. About 300 people aged 50-74 who had a positive stool test took part. The goal was to see if the…