Can genes predict colorectal cancer drug success?

NCT ID NCT01822444

Completed Knowledge-focused Sponsor: Cancer Trials Ireland Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at 76 adults with advanced colorectal cancer to find genetic markers that might predict how well a combination of chemotherapy (FOLFOX) and the drug bevacizumab works. The goal was to understand which patients benefit most, not to test a new cure. Participants had a specific gene mutation (mutant K-ras) and received standard treatment while researchers analyzed their DNA and tumor responses.

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Conditions

The condition(s) this trial relates to.

colonic neoplasm colorectal cancer colorectal neoplasm rectal neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED COLORECTAL CANCER

Contacts and locations

Locations

Beaumont Hospital

Dublin, Ireland
Bon Secours Hospital

Cork, Ireland
Cork University Hospital

Cork, Ireland
Galway University Hospital

Galway, Ireland
Gemeinschaftspraxis Haematologie/Onkologie

Lebach, Germany
Kilnikum Ludwigsburg

Ludwigsburg, Germany
Medizinische Klinik III, Universitaetsklinikum

Aachen, Germany
Medizinische Klinik and Poliklinik Mainz

Mainz, Germany
Onkologisches Zentrum

Deggendorf, Germany
Private Practice Oncology

Speyer, Rhineland-Palatinate, Germany
Sligo General Hospital

Sligo, Ireland
St James Hospital

Dublin, Ireland
St Vincent's University Hospital

Dublin, D4, Ireland
The Adelaide and Meath Hospital, Dublin Incorporating the National Children's Hospital

Dublin, Ireland
Univeritaetsmedizin Mannheim

Mannheim, Germany
University Hospital Saarland

Homburg, Germany
Waterford Regional Hospital

Waterford, Ireland

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