Laughing gas may soothe painful tube insertion in toddlers
NCT ID NCT04008628
First seen Jul 01, 2026 · Last updated Jul 01, 2026
Summary
This trial investigates whether inhaling a 50/50 mix of nitrous oxide (laughing gas) and oxygen can reduce pain when a nasogastric tube is placed in children aged 3 months to 3 years. The study includes children with mild to moderate dehydration from conditions like gastroenteritis or bronchiolitis. Pain is measured using a standard scale, and parents also report their own anxiety levels.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
50/50 nitrous oxide/oxygen mixture (Kalinox)
What this could lead to
If effective, this could offer a simple, fast-acting pain relief option for young children undergoing a common but uncomfortable emergency procedure.
What could go wrong
This is a small, early-phase study with only 23 participants, so results may not apply to all children. The gas may not reduce pain significantly, and side effects like nausea or dizziness are possible.
Disclaimer
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the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Ambroise Paré hospital, Pediatric emergency department
Boulogne-Billancourt, 92100, France
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Louis Mourier Hospital, Pediatric emergency department
Colombes, 92700, France
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Poissy Hospital, Pediatric emergency department
Poissy, Île-de-France Region, 78300, France
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Trousseau Hospital, Pediatric emergency department
Paris, Île-de-France Region, 75012, France