Could a lower oxygen threshold get kids home sooner?
NCT ID NCT06016244
First seen Jul 14, 2026 · Last updated Jul 15, 2026 · Updated 1 time
Summary
This trial tests whether using a lower oxygen saturation threshold (88%) versus the standard (92%) to decide when to give supplemental oxygen helps children aged 6 weeks to 12 years recover faster from respiratory distress. Participants are randomly assigned to one of two groups, and researchers measure how long it takes to meet discharge criteria. The goal is to find a safe, cost-effective approach that shortens hospital stays.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- oxygen saturation threshold (88% or 92%) for deciding when to give supplemental oxygen
- What this could lead to
- If successful, this could establish a safe, cost-effective oxygen target that shortens hospital stays and speeds recovery for children with breathing problems.
- What could go wrong
- This is a single-center trial, and results may not apply to all hospitals or children. The lower threshold (88%) might not be safe for every child, and the study may not detect rare complications.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
-
566 people
The number who actually took part.
- Started
-
Sep 2023
- Finished
-
Apr 2025
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
6 weeks to 12 years
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * 6 weeks to 12 years of age (corrected age for children with gestational age \< 37 weeks) * hospitalized with respiratory distress due to bronchiolitis, viral wheeze or lower respiratory tract infection, as diagnosed by the treating physician. Viral wheeze can only be diagnosed below the age of 6 years. * requiring supplemental oxygen as per usual care (SpO2 \<92% or for treating symptoms of respiratory distress as determined by the treating physician As respiratory distress in children with an asthma attack is mainly driven by hypoxia, they are at risk of undertreatment in the acute phase of the attack. Therefore, children aged 6-12 years of age with an asthma attack are excluded from this study. Exclusion Criteria: * children with, except for the studied diseases, pre-existing cardiopulmonary, neurological or hematological conditions (e.g. congenital thoracic malformation, airway malacia, post infectious bronchiolitis obliterans, childhood interstitial lung disease. primary immune deficiency) * children born \<32 weeks gestational age * children already included in other studies, which potentially interfere with this study * children (of parents) without a stable internet connection needed for answering questionnaires * children previously included in the current study * considering questionnaires are only available in Dutch and English, children (of parents) with different languages will be excluded.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Bronchial hyperreactivity are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Amphia Ziekenhuis
Breda, Netherlands
-
Canisius Wilhelmina Ziekenhuis
Arnhem, Netherlands
-
Franciscus Gasthuis en Vlietland
Rotterdam, Netherlands
-
Isala Klinieken
Zwolle, Netherlands
-
Martini Ziekenhuis
Groningen, Netherlands
-
Rijnstate Ziekenhuis
Arnhem, Netherlands
-
Spaarne Gasthuis
Haarlem, North Holland, 2035 RC, Netherlands
-
St Antonius Ziekenhuis
Nieuwegein, Netherlands
-
Tergooi Ziekenhuis
Hilversum, Netherlands
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- AI-Powered patient education: a new way to prepare parents for home care?
- Can a simple decision tool cut time on breathing support for sick infants?
- Which inhaler works best for preterm children with lung disease? a study seeks answers
- Laughing gas may soothe painful tube insertion in toddlers
- Which flow rate helps babies breathe better? new study tests two options
- AI stethoscope aims to cut unnecessary antibiotics in kids with cough