DNA vaccine shows promise against anal precancer in HIV patients
NCT ID NCT03603808
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested a DNA-based vaccine called VGX-3100 in 44 HIV-positive adults with high-grade anal precancer caused by HPV types 16 or 18. The vaccine was given with a mild electric pulse (electroporation) to help cells absorb it and boost the immune system's attack on the abnormal cells. The main goal was to see if the lesions shrank or disappeared within 48 weeks. The approach aims to control the disease and prevent progression to cancer, but does not eliminate the need for ongoing HIV management.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Anal Dysplasia Clinic MidWest
Chicago, Illinois, 60614, United States
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Boston Medical Center
Boston, Massachusetts, 02118, United States
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Grady Health System
Atlanta, Georgia, 30303, United States
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Laser Surgery Care
New York, New York, 10011, United States
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Montefiore Medical Center
The Bronx, New York, 10461, United States
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University of California, San Francisco
San Francisco, California, 94143, United States
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University of Puerto Rico
San Juan, 00936-3027, Puerto Rico
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Wake Forest Baptist health Sciences
Winston-Salem, North Carolina, 27157, United States