Can a common laxative beat the standard prep for colon cancer screening?

NCT ID NCT06666556

Completed Symptom relief Sponsor: Hospital Civil de Guadalajara Source: ClinicalTrials.gov ↗

First seen Jul 28, 2026 · Last updated Jul 29, 2026 · Updated 1 time

Summary

This trial compares two bowel-cleansing agents—lactulose and polyethylene glycol (PEG)—to see which provides a cleaner colon for colonoscopy. About 450 adults aged 18–79 scheduled for a screening colonoscopy will be randomly assigned to one of the two preparations. The study measures cleansing quality using the Boston Bowel Preparation Scale and tracks side effects like nausea and bloating to determine which option is more effective and better tolerated.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: lactulose or polyethylene glycol (PEG) as a bowel preparation agent before colonoscopy
What this could lead to: If lactulose works better, it could offer a more tolerable and effective option for cleaning the bowel before a colonoscopy, potentially improving screening quality.
What could go wrong: This is a Phase 4 trial comparing two existing agents, so the difference may be small. Side effects like nausea or bloating are possible with either preparation.

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Conditions

The condition(s) this trial relates to.

colorectal neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COLORECTAL CANCER SCREENING

Contacts and locations

Locations

Antigüo Hospital Civil de Guadalajara "Fray Antonio Alcalde"

Guadalajara, Jalisco, 44200, Mexico
IMSS Hospital General Regional 220 "José Vicente Villada"

México, Toluca de Lerdo, 50150, Mexico
Nuevo Hospital Civil de Guadalajara "Juan I. Menchaca"

Guadalajara, Jalisco, 44340, Mexico

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