Which laxative cleans the colon best? new study aims to find out
NCT ID NCT04598880
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study compared two low-volume laxatives used to clean the colon before a colonoscopy: one liter of polyethylene glycol with ascorbate (PEG1A) and sodium picosulfate with magnesium citrate (PSCM). The goal was to see which one provides a higher quality colon cleansing, which helps doctors find and remove polyps and detect colorectal cancer. Over 1,100 outpatients participated, and the results could improve how patients prepare for colonoscopies.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Polyethylene glycol with ascorbate (PEG1A) and sodium picosulfate with magnesium citrate (PSCM)
What this could lead to
If one laxative proves superior, it could lead to better colon cancer detection and more comfortable preparation for patients.
What could go wrong
This is a completed Phase 4 trial comparing existing drugs, so no major breakthrough is expected. Results may show no significant difference between the two.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Clínica Universidad de Navarra
Madrid, Spain
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Hospital Costa del Sol
Marbella, Spain
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Hospital Germans Trias i Pujol
Badalona, Spain
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Hospital Gregorio Marañón
Madrid, Spain
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Hospital La Paz
Madrid, Spain
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Hospital Quirón
Málaga, Spain
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Hospital Ramón y Cajal
Madrid, Spain
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Hospital Santa Bárbara
Soria, Spain
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Hospital Virgen de las Nieves
Granada, Spain
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Hospital de Poniente
Almería, Spain
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Hospital de Viladecans
Viladecans, Barcelona, Spain
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Hospital de la Princesa
Madrid, Spain
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Hospital del Mar
Barcelona, 08003, Spain
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Organización Sanitaria Integrada Araba
Alava, Spain