Underwater colonoscopy technique could make polyp removal safer and faster
NCT ID NCT07490574
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested a new method called underwater endoscopic submucosal dissection (UESD) for removing large colon growths. Instead of using gas to inflate the colon, the doctor fills it with saline (salt water) to improve visibility and make the procedure easier. The trial involved 295 adults across multiple hospitals in Italy. The goal was to see if UESD is as good as the standard gas-assisted method for removing the entire growth in one piece, and whether it reduces complications and procedure time.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Underwater endoscopic submucosal dissection (UESD) procedure
What this could lead to
If successful, this could offer a safer, faster, and more effective way to remove precancerous colorectal growths without surgery.
What could go wrong
This is a completed trial comparing two procedures, so results are known. However, the underwater method may not work for all lesion types or locations, and it requires specialized training.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Campus Bio Medico Hospital
Rome, RM, 00100, Italy