New biopsy method may predict cancer spread without surgery

NCT ID NCT03336658

Completed Knowledge-focused Sponsor: Insel Gruppe AG, University Hospital Bern Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at 150 colorectal cancer patients to see if counting tumor buds in biopsy samples could predict whether cancer has spread to lymph nodes or other organs. Researchers used a special stain to find tumor buds and counted them in the densest area. They then used a computer model to estimate the risk of spread and survival. The goal was to standardize this method so doctors can better plan treatment without relying on surgery alone.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could lead to a standardized way to predict cancer spread and survival from biopsy samples, helping doctors plan treatment more accurately.
What could go wrong: This is an observational study, not a treatment trial. The prediction model was developed from past data and may not work perfectly in new patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

colorectal cancer colorectal carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CRC

Contacts and locations

Locations

Department of visceral surgery and transplant surgery, Berne University Hospital

Bern, 3010, Switzerland

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