New drug combo aims to prevent deadly bowel blockages in ovarian cancer
NCT ID NCT07648745
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This completed phase 2 trial tested whether the drug cediranib, given with chemotherapy, is safe for women with advanced ovarian cancer who are at risk of bowel obstruction. 30 participants received the combination. The study focused on whether the treatment caused serious bowel tears or holes. If the cancer worsened, patients could switch to a different drug combination.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Cediranib (a drug that blocks blood vessel growth) combined with paclitaxel chemotherapy
- What this could lead to
- If successful, this could show that cediranib can be used safely in women with advanced ovarian cancer who are at risk of bowel obstruction, potentially offering a treatment option where few exist.
- What could go wrong
- This is a small, early-phase trial with only 30 participants and no comparison group. The main goal is safety, not effectiveness, so it may not lead to a proven treatment. There is also a risk of serious side effects like bowel perforation.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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The Christie NHS Foundation Trust
Manchester, M20 4BX, United Kingdom
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