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Which antibiotic works best after a Child's ruptured appendix? a new trial aims to find out

NCT ID NCT05943223

Disease control Sponsor: McMaster Children's Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 07, 2026 · Last updated Jul 08, 2026 · Updated 1 time

Summary

This trial compares two antibiotic regimens given after surgery for a ruptured appendix in children. One group receives piperacillin/tazobactam, the other receives ceftriaxone plus metronidazole. The goal is to see which treatment leads to a shorter hospital stay and fewer complications. This is a small pilot study to test whether a larger, more definitive trial is possible.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Piperacillin/tazobactam
What this could lead to
If piperacillin/tazobactam works better, it could become the preferred antibiotic for children with perforated appendicitis, reducing hospital stays and complications.
What could go wrong
This is a small pilot study testing feasibility, not effectiveness. Results may not be definitive, and the drug may not prove superior.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

16 people

The number who actually took part.

Started

Sep 2024

Finished

Oct 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

Up to 18 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Laparoscopic appendectomy * Perforated appendicitis confirmed intra-operatively (i.e., visible hole in appendix, fecalith found in peritoneal cavity, intra-abdominal abscess, and/or purulent fluid in peritoneal cavity) Exclusion Criteria: * Non-operative treatment (e.g., due to abscess) * Interval laparoscopic appendectomy * Conversion to open procedure * Non-perforated appendicitis * Confirmed or suspected allergy to penicillins or cephalosporins * Renal impairment

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Conditions

The condition(s) this trial relates to.

appendicitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Appendicitis perforated

Contacts and locations

Locations

  • McMaster Children's Hospital

    Hamilton, Ontario, L8N 3Z5, Canada