Which antibiotic works best after a Child's ruptured appendix? a new trial aims to find out
NCT ID NCT05943223
First seen Jul 07, 2026 · Last updated Jul 08, 2026 · Updated 1 time
Summary
This trial compares two antibiotic regimens given after surgery for a ruptured appendix in children. One group receives piperacillin/tazobactam, the other receives ceftriaxone plus metronidazole. The goal is to see which treatment leads to a shorter hospital stay and fewer complications. This is a small pilot study to test whether a larger, more definitive trial is possible.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Piperacillin/tazobactam
- What this could lead to
- If piperacillin/tazobactam works better, it could become the preferred antibiotic for children with perforated appendicitis, reducing hospital stays and complications.
- What could go wrong
- This is a small pilot study testing feasibility, not effectiveness. Results may not be definitive, and the drug may not prove superior.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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McMaster Children's Hospital
Hamilton, Ontario, L8N 3Z5, Canada