Cancer drug vismodegib tested for Long-Term use in small study

NCT ID NCT00959647

Completed Disease control Sponsor: Genentech, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at the long-term safety of the cancer drug vismodegib in 19 patients with ovarian cancer, basal cell carcinoma, or metastatic colorectal cancer. All participants had previously taken vismodegib in an earlier Genentech trial and were expected to benefit from continued treatment. The main goal was to track side effects and see how many patients stopped treatment due to them.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Vismodegib (also known as Erivedge)
What this could lead to: If successful, this study could show that long-term vismodegib treatment is safe and helps control certain cancers.
What could go wrong: This is a small, early-phase extension study with only 19 participants, so results may not apply broadly. Side effects are possible and the drug may not work for everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

basal cell carcinoma colorectal cancer colorectal neoplasm ovarian cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BASAL CELL CARCINOMA METASTATIC COLORECTAL CANCER OVARIAN CANCER

Contacts and locations

Locations

Children's Hospital

Oakland, California, 94609, United States
Comprehensive Cancer Care

Palm Springs, California, 92262, United States
DermSurgery Associates, PA

Houston, Texas, 77030, United States
Irfan Firdaus, D.O.

Cincinnati, Ohio, 45242, United States
Johns Hopkins Univ Med Center

Baltimore, Maryland, 21231, United States
Karmanos Cancer Institute..

Detroit, Michigan, 48201, United States
Nevada Cancer Research Foundation

Las Vegas, Nevada, 89169, United States
Stanford Univ Medical Center

Stanford, California, 94305, United States
TGen Clinical Research Srvs

Scottsdale, Arizona, 85258, United States
University Of Michigan

Ann Arbor, Michigan, 48109-0934, United States

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