Genentech, Inc.

This early-stage trial is testing an experimental oral drug called RO7656594 in people with advanced or metastatic prostate cancer that has progressed after standard treatments. The study aims to find safe doses and check for any signs that the drug can shrink tumors or lower PSA…

This study tests a treatment called OpRegen for people with geographic atrophy, an advanced form of dry age-related macular degeneration that causes blind spots. The therapy involves surgically placing cells under the retina to try to preserve vision. About 60 participants will b…

This study tests a new drug called RO7837195 in 224 people with moderate-to-severe ulcerative colitis who haven't gotten better with other treatments. Half will get the drug, half a placebo, to see if it can bring about remission by week 12. The goal is to find a new option for t…

This study tests a new drug called GDC-4198, alone or combined with another drug (giredestrant), against a standard treatment (abemaciclib plus giredestrant) in people with advanced ER+/HER2- breast cancer that has worsened after prior CDK4/6 inhibitor therapy. The trial has two …

This study tests a new drug, GDC-7035, for people with advanced solid tumors that have a specific genetic change called KRAS G12D. The drug is given alone or with other cancer treatments. The goal is to see if it is safe and how well it works. About 410 adults with these tumors w…

This early-phase study tests a new drug, RO7566802, alone or with another drug (atezolizumab) in people with advanced solid tumors that have not responded to standard treatments. The main goals are to check safety, find the right dose, and see if the drug shrinks tumors. About 25…

This early-stage trial tests a new drug, GDC-0587, alone or with another drug (giredestrant), in people with advanced ER-positive, HER2-negative breast cancer whose cancer worsened after prior CDK4/6 inhibitor therapy. The study aims to find safe doses and check for side effects.…

This Phase 2 trial tests whether adding a personalized cancer vaccine (autogene cevumeran) and an immunotherapy drug (atezolizumab) to standard chemotherapy (mFOLFIRINOX) can keep pancreatic cancer from coming back after surgery. About 260 people whose tumors were completely remo…

This early-stage study tests a new medicine called RO7823653, given as an eye injection, for people with diabetic macular edema (DME) — a condition that causes blurry vision due to diabetes. The study will check if the drug is safe and tolerable when used alone or together with a…

This early-stage trial is testing whether combining two drugs, cevostamab and elranatamab, is safe and effective for people with multiple myeloma that has come back or stopped responding to treatment. About 120 participants will receive the drug combination, and researchers will …

This study tests different drug combinations in people with early-stage non-small cell lung cancer that can be removed with surgery. The drugs are chosen based on specific genetic markers in each person's tumor. The goal is to see if these treatments shrink the tumor before surge…

This program offers early access to giredestrant for people with ER-positive, HER2-negative breast cancer that is either early stage or has spread. Participants must have confirmed ER+ and HER2- tumors. The goal is to provide treatment before the drug is widely available in the U…

This study looks at how a refillable eye implant (PDS) that delivers ranibizumab affects the cells on the inside of the cornea in people with wet age-related macular degeneration (nAMD). About 188 participants will get the implant, refilled every 24 weeks, and doctors will measur…

This early-stage study tests an experimental drug called vixarelimab in 24 adults with moderate to severe ulcerative colitis. The goal is to see how the drug affects the gut and to check its safety. Participants must have tried other treatments without success.

This study tests an experimental drug called selnoflast in 162 people with atherosclerosis (hardened arteries) who are at high risk for heart attacks or strokes. Participants will receive either selnoflast or a placebo, on top of their usual heart medications. The goal is to see …

This study is for adults with advanced solid tumors that have spread or cannot be removed by surgery. It tests a new drug, enzelkitug, given alone or with standard immunotherapy drugs. The main goals are to check safety, find the right dose, and see if the drug can shrink tumors.…

This study is for people with advanced liver cancer (hepatocellular carcinoma) who also have moderate cirrhosis (Child-Pugh B7 or B8). It tests the safety of two drugs, atezolizumab and bevacizumab, given together or alone as a first treatment. The goal is to see if these drugs a…

This early-stage study tests an inhaled drug called GDC-6988 in people with lung conditions that cause thick mucus, like non-CF bronchiectasis and COPD. The main goal is to check if the drug is safe and tolerable. About 128 adults with stable disease and good lung function will t…

This registry follows pregnant women who have taken mycophenolate, a drug used to prevent organ rejection and treat autoimmune diseases. Researchers will collect data on pregnancy complications and birth defects up to one year after birth. The goal is to better understand the dru…

This study looks at how a single dose of the drug inavolisib is handled by the body in people with moderate or severe liver impairment compared to healthy volunteers. About 32 adults will take one dose and have their blood levels measured. The goal is to understand safety and dos…

This early-stage study tests a new drug called RO7875913 in 40 healthy volunteers to see if it is safe and how the body processes it. Participants will receive the drug and be monitored for side effects and drug levels in the blood. The study does not aim to treat any disease, bu…