Genentech, Inc.

This study is for people with advanced liver cancer that cannot be removed by surgery and who also have severe cirrhosis (Child-Pugh B7 or B8). It tests the safety of two drugs, atezolizumab and bevacizumab, given together or alone as a first treatment. The goal is to see if this…

This early-stage study tests an experimental drug called vixarelimab in 24 people with moderate to severe ulcerative colitis. The goal is to see how the drug affects the gut and how safe it is. Participants must have tried other treatments without success.

This early-stage trial tests a combination of two experimental drugs, cevostamab and elranatamab, in people with multiple myeloma that has come back or stopped responding to treatment. The main goals are to check safety and find the best dose. About 120 adults with this blood can…

This study is testing an inhaled drug called GDC-6988 in people with lung diseases that cause mucus buildup, such as COPD and non-cystic fibrosis bronchiectasis. The main goals are to see if the drug is safe and how well it works. About 128 participants will take the drug using a…

This early-stage trial tests a new drug called RO7656594 in people with advanced or metastatic prostate cancer. The main goals are to check safety, find the best dose, and see if the drug can lower PSA levels. About 210 participants will take part, and they must have already trie…

This early-phase trial tests a new drug, enzelkitug, alone or with standard immunotherapies, in people with advanced solid tumors that have spread. The main goals are to check safety and find the right dose. About 450 adults with cancers like lung, melanoma, or breast cancer are …

This study tests a new drug (GDC-4198) alone or with another drug (giredestrant) for people with advanced ER+/HER2- breast cancer that has worsened after prior treatment. About 285 participants will be enrolled to see if the new combination is safer or works better than an existi…

This study looks at how a refillable eye implant (PDS) that delivers the drug ranibizumab affects the cells on the inside of the cornea in people with wet age-related macular degeneration (nAMD). About 188 participants will receive the implant and be followed for 48 weeks. The ma…

This early-stage study tests a new medicine (RO7823653) given as an eye injection, alone or with another drug (faricimab), in people with diabetic macular edema—a condition that causes vision loss due to diabetes. The main goal is to check safety and how the drug moves in the bod…

This study tests whether adding a personalized cancer vaccine (autogene cevumeran) and an immunotherapy drug (atezolizumab) to standard chemotherapy can help prevent pancreatic cancer from coming back after surgery. About 260 people whose tumors were completely removed and who ha…

This study tests an experimental drug called selnoflast in 162 people with atherosclerosis (hardened arteries) who are at high risk for heart attacks or strokes. The goal is to see if selnoflast can reduce inflammation in the arteries better than a placebo, when added to standard…

This study tests an experimental drug called RO7566802, given alone or with another drug (atezolizumab), in people with advanced solid tumors that have not responded to standard treatments. The main goal is to check the safety and find the best dose. About 250 adults with incurab…

This study is for people with early-stage non-small cell lung cancer that can be removed with surgery. It tests different drug combinations before and after surgery, chosen based on the tumor's specific biomarkers. The goal is to see if these targeted treatments can shrink or eli…

This study looks at how moderate or severe liver problems change the way the body handles a single dose of the drug inavolisib. About 32 adults with and without liver impairment will take one dose, and researchers will measure drug levels and safety. The goal is to understand dos…