New hope for lung cancer: personalized drug cocktails before surgery

NCT ID NCT04302025

Recruiting now Disease control Sponsor: Genentech, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 12, 2026 · Updated 4 times

Summary

This study tests different drug combinations in people with early-stage non-small cell lung cancer that can be removed with surgery. The drugs are chosen based on specific genetic markers in each person's tumor. The goal is to see if these treatments shrink the tumor before surgery and help prevent the cancer from coming back afterward. About 99 participants will receive therapy before and after their operation.

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Conditions

The condition(s) this trial relates to.

non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NON-SMALL CELL LUNG CANCER

Contacts and locations

Locations

AHN Cancer Institute ? Allegheny General Hospital
COMPLETED

Pittsburgh, Pennsylvania, 15212, United States
Baptist Clinical Research Institute
RECRUITING

Memphis, Tennessee, 38120, United States
Baylor College of Medicine
WITHDRAWN

Houston, Texas, 77030, United States
Boston Medical Center
WITHDRAWN

Boston, Massachusetts, 02118, United States
Cedars-Sinai Medical Center
WITHDRAWN

Los Angeles, California, 90048, United States
City of Hope - Orange County Lennar Foundation Cancer Center
WITHDRAWN

Irvine, California, 92618, United States
City of Hope Comprehensive Cancer Center
WITHDRAWN

Duarte, California, 91010, United States
Columbia University Medical Center
RECRUITING

New York, New York, 10032, United States
Dana-Farber Cancer Institute
RECRUITING

Boston, Massachusetts, 02215, United States
Dartmouth Hitchcock Medical Center
RECRUITING

Lebanon, New Hampshire, 03756, United States
Ellis Fischel Cancer Center
RECRUITING

Columbia, Missouri, 65201, United States
Karmanos Cancer Institute - Farmington Hills/Weisberg Cancer Treatment Center
WITHDRAWN

Farmington Hills, Michigan, 48334, United States
Kelsey Seybold Clnic
WITHDRAWN

Houston, Texas, 77025, United States
Laura and ISAAC Perlmutter Cancer Center at NYU Langone.
RECRUITING

New York, New York, 10016, United States
Lumi Research
WITHDRAWN

Kingwood, Texas, 77339, United States
Mayo Clinic
RECRUITING

Rochester, Minnesota, 55905, United States
MedStar Georgetown University Hospital (Lombardi Comprehensive Cancer Center)
RECRUITING

Washington D.C., District of Columbia, 20007, United States
Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States
Moffitt Cancer Center
RECRUITING

Tampa, Florida, 33612, United States
Northwestern Medicine Cancer Center Delnor
RECRUITING

Geneva, Illinois, 60134, United States
Northwestern Medicine Cancer Center Kishwaukee
RECRUITING

DeKalb, Illinois, 60115, United States
Northwestern Medicine Cancer Center Warrenville
RECRUITING

Warrenville, Illinois, 60555, United States
Northwestern University
RECRUITING

Chicago, Illinois, 60611, United States
Ohio State University
RECRUITING

Columbus, Ohio, 43210, United States
Seattle Cancer Care Alliance
WITHDRAWN

Seattle, Washington, 98109, United States
Siteman Cancer Center - Washington University Medical Campus
RECRUITING

St Louis, Missouri, 63108, United States
Tennessee Oncology - Nashville
WITHDRAWN

Nashville, Tennessee, 37203, United States
The Center for Cancer Prevention and Treatment at St.Joseph Hospital of Orange
RECRUITING

Orange, California, 92868, United States
UC Davis Comprehensive Cancer Center
RECRUITING

Sacramento, California, 95817, United States
UCSF Helen Diller Family CCC
WITHDRAWN

San Francisco, California, 94158, United States
USC Norris Cancer Center
WITHDRAWN

Los Angeles, California, 90033, United States
University Hospitals Cleveland Medical Center
WITHDRAWN

Cleveland, Ohio, 44016, United States
University of California Los Angeles - Jonsson Comprehensive Cancer Center
RECRUITING

Los Angeles, California, 90095, United States
University of Colorado - Anschutz Medical Campus (University of Colorado Health Sciences Center)
WITHDRAWN

Aurora, Colorado, 80045, United States
University of Michigan
RECRUITING

Ann Arbor, Michigan, 48109, United States
University of Texas MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030-4008, United States
Virginia Cancer Specialists (Fairfax) - USOR
RECRUITING

Fairfax, Virginia, 22031, United States
Yale Cancer Center
RECRUITING

New Haven, Connecticut, 06511, United States

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