New drug targets Hard-to-Treat cancer mutation in early trial

NCT ID NCT06619587

Recruiting now Disease control Sponsor: Genentech, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jul 29, 2026 · Updated 5 times

Summary

This study tests a new drug called GDC-7035, designed to target cancers with a specific genetic change called KRAS G12D. The trial includes about 410 adults with advanced solid tumors that have not responded to other treatments. Researchers will give the drug alone or with other cancer therapies to check its safety and how well it works.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: GDC-7035 (a drug targeting the KRAS G12D mutation)
What this could lead to: If successful, this could lead to a new targeted treatment option for people with advanced solid tumors that have a specific KRAS G12D mutation.
What could go wrong: This is a very early (first-in-human) study, so safety and effectiveness are not yet known. Many early-stage cancer drugs do not end up working in larger trials.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SOLID TUMOR

Contacts and locations

Locations

Abramson Cancer Center;Univ of Pennsylvania
RECRUITING

Philadelphia, Pennsylvania, 19104-5127, United States
Asan Medical Center.
RECRUITING

Seoul, 005505, South Korea
British Columbia Cancer Agency
RECRUITING

Vancouver, British Columbia, V5Z 4E6, Canada
Centre Georges Francois Leclerc
RECRUITING

Dijon, 21000, France
Dana Farber Cancer Institute
RECRUITING

Boston, Massachusetts, 02215, United States
Florida Cancer Specialist-Lake Mary
COMPLETED

Lake Mary, Florida, 32746, United States
Gustave Roussy
RECRUITING

Villejuif, Val-de-Marne, 94805, France
Hadassah University Hospital - Ein Kerem
RECRUITING

Jerusalem, 9112001, Israel
Hospital Clinico Universitario de Valencia
RECRUITING

Valencia, 46010, Spain
Hospital Universitario 12 de Octubre
RECRUITING

Madrid, 28041, Spain
Hospital Universitario Virgen de la Victoria
RECRUITING

Málaga, 29010, Spain
Hospital Universitario Virgen del Rocio - PPDS
RECRUITING

Seville, 41013, Spain
Institut Bergonie
RECRUITING

Bordeaux, 33076, France
Instituto de Investigacion Oncologica Vall dHebron (VHIO) - EPON
RECRUITING

Barcelona, 08035, Spain
Mary Crowley Medical Research Center
RECRUITING

Dallas, Pennsylvania, 75230-2571, United States
Montefiore Einstein Cancer Center
RECRUITING

The Bronx, New York, 10461, United States
NIHR UCLH Clinical Research Facility
RECRUITING

London, W1T 7HA, United Kingdom
National Cancer Centre
RECRUITING

Singapore, 168583, Singapore
National University Hospital
RECRUITING

Singapore, 119074, Singapore
O'Quinn Medical Tower at McNair Campus
RECRUITING

Houston, Texas, 77054, United States
Peter Maccallum Cancer Centre
RECRUITING

Parkville, Victoria, 3052, Australia
Princess Margaret Cancer Centre
RECRUITING

Toronto, Ontario, M5G 1X6, Canada
Rambam Health Care Campus
RECRUITING

Haifa, 3109601, Israel
Royal Marsden Hospital - Surrey
RECRUITING

Sutton, SM2 5PT, United Kingdom
SCRI Oncology Partners
RECRUITING

Nashville, Tennessee, 37203, United States
START - Midwest - EDOS
RECRUITING

Grand Rapids, Michigan, 49546-7062, United States
START Madrid_Hospital Universitario HM Sanchinarro_CIOCC
RECRUITING

Madrid, 28050, Spain
Sarah Cannon Research Institute at HealthONE
RECRUITING

Denver, Colorado, 80218, United States
Seoul National University Bundang Hospital
RECRUITING

Seongnam, 13620, South Korea
Seoul National University Hospital
RECRUITING

Seoul, 03080, South Korea
Severance Hospital, Yonsei University Health System
RECRUITING

Seoul, 3722, South Korea
Sir Mortimer B Davis Jewish General Hospital
RECRUITING

Montreal, Quebec, H3T 1E2, Canada
Slade Health Inward goods
RECRUITING

Mount Kuring-Gai, New South Wales, 2080, Australia
St Vincent's Hospital Sydney
RECRUITING

Darlinghurst, New South Wales, 2010, Australia
Tel Aviv Sourasky Medical Center PPDS
RECRUITING

Tel Aviv, 6423906, Israel
The Chaim Sheba Medical Center
RECRUITING

Ramat Gan, 5262100, Israel
The Christie
RECRUITING

Manchester, M20 4BX, United Kingdom
UC San Diego Moores Cancer Center
RECRUITING

La Jolla, California, 92093-1503, United States
University of Illinois
RECRUITING

Chicago, Illinois, 60612, United States
Western General Hospital;Edinburgh Cancer Center
RECRUITING

Edinburgh, Midlothian, EH4 2LF, United Kingdom
Yale Cancer Center
RECRUITING

New Haven, Connecticut, 06510, United States

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