Cold vs. hot snare: which is better for removing colon polyps?

NCT ID NCT05545787

Completed Disease control Sponsor: Qingwei Jiang Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study compared two methods for removing non-cancerous colon polyps that are 10-19 mm in size: cold snare (no heat) and hot snare (uses heat). 216 adults undergoing colonoscopy were randomly assigned to one method. The goal was to see if cold snare is as effective and safe as hot snare for complete removal.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: cold snare endoscopic mucosal resection and hot snare endoscopic mucosal resection
What this could lead to: If successful, this could show that cold snare removal is just as effective as hot snare but with fewer risks, improving colon polyp treatment.
What could go wrong: This is a completed trial with 216 participants, but results may not apply to larger polyps or other populations. Both procedures carry risks like bleeding or perforation.

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Conditions

The condition(s) this trial relates to.

polyp of large intestine

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COLORECTAL POLYP

Contacts and locations

Locations

Beijing Daxing District People's Hospital

Beijing, Beijing Municipality, 102600, China
Beijing Dongcheng District First People's Hospital

Beijing, Beijing Municipality, 100010, China
Beijing Fangshan District Liangxiang Hospital

Beijing, Beijing Municipality, 102401, China
Beijing Sixth Hospital

Beijing, Beijing Municipality, 100191, China
Beijing Tsinghua Changgung Hospital

Beijing, Beijing Municipality, 102218, China
Emergency General Hospital

Beijing, Beijing Municipality, 100028, China
Henan Provincial People's Hospital

Zhengzhou, Henan, 450003, China
PLA Western Theater General Hospital

Chengdu, Sichuan, 610083, China
Peking Union Medical College Hospital

Beijing, Beijing Municipality, 100730, China
Seventh Medical Center, General Hospital of the Chinese People's Liberation Army

Beijing, Beijing Municipality, 100700, China
The Affiliated Hospital of Qingdao University

Qingdao, Shandong, 266005, China
The First Affiliated Hospital of Chongqing Medical University

Chongqing, Chongqing Municipality, 400016, China
The First Affiliated Hospital of Nanchang University

Nanchang, Jiangxi, 330006, China
The First Hospital of Shanxi Medical University

Taiyuan, Shanxi, 030001, China
West China Longquan Hospital, Sichuan University

Chengdu, Sichuan, 610041, China

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