Inflammatory bowel disease

This study tests whether a vaccine can prevent C. difficile infection in adults 65 and older. About 32,000 participants will receive either the vaccine or a placebo shot. The study will track infections and side effects over up to three and a half years.

This early-stage trial explores whether adding two experimental capsules, ND-12 and H-6, to standard mesalazine treatment can better control chronic inflammatory diarrhea in adults, including those with active ulcerative colitis. Participants will take the combination or a placeb…

This study follows 200 adults in Japan with moderate to severe ulcerative colitis who are already prescribed risankizumab by their doctor. Researchers will track how well the drug controls symptoms like diarrhea and rectal bleeding over up to 156 weeks. The goal is to see if the …

This study tests a new medicine called afimkibart in children aged 2 to 17 with moderate to severe ulcerative colitis, a disease that causes inflammation and sores in the colon. The goal is to see if the drug can safely help children feel better and achieve remission (no symptoms…

This study is testing the drug vedolizumab (Entyvio) in 400 adults with moderate to severe ulcerative colitis or Crohn's disease. Participants first receive the drug through an IV for 6 weeks, then switch to injections under the skin for the rest of the year. The main goal is to …

This phase 3 study tests the drug risankizumab in about 120 children aged 2 to 18 with moderate to severe ulcerative colitis. The trial has three parts: an initial 12-week IV treatment period, a 52-week maintenance phase where patients get one of two doses by injection, and a lon…

This study tests if the drug vorinostat is safe and can help people with moderate-to-severe Crohn's disease by reducing gut inflammation. Participants who respond well may then receive a maintenance treatment with ustekinumab for up to two years. The goal is to control symptoms a…

This study tests whether combining two drugs—vedolizumab and tofacitinib—can quickly bring moderate to severe ulcerative colitis under control. About 65 adults will receive both drugs for 8 weeks, and those who respond will continue on vedolizumab alone for nearly a year. The goa…

This phase 2 trial tests an oral drug called ibezapolstat in 20 people who have had three or more C. diff infections in the past year. The goal is to see if the drug can cure the current infection and reduce the chance of it coming back. Participants will take the drug twice a da…

This study is testing whether combining two different biologic drugs can better control moderate to severe Crohn's disease. One hundred adults will first receive either vedolizumab plus adalimumab or vedolizumab plus ustekinumab. Those who respond well will then switch to vedoliz…

This study tests a daily pill called filgotinib in 80 children aged 8 to 17 with moderate to severe ulcerative colitis, a chronic gut disease. The goal is to see if the drug can reduce inflammation and help children feel better. All participants receive the drug, and the study tr…

This study tests whether adding a structured coping skills program to standard biologic medication improves emotional well-being and disease remission in people with early Crohn's disease. 170 adults with active Crohn's for less than 5 years will receive either the coping program…

This trial is testing whether adding a Lactobacillus probiotic or a trace element supplement to standard ulcerative colitis treatment can help keep the disease in remission. About 132 adults with mild to moderate ulcerative colitis will be randomly assigned to one of three groups…

This trial is testing whether personalized, adaptive treatment strategies can help people hospitalized with acute severe ulcerative colitis. The approach adjusts medication based on how each patient responds, aiming to improve outcomes and reduce the need for colon removal. The s…

This phase 3 trial tests a drug called afimkibart in 100 children aged 2-17 with moderate-to-severe Crohn's disease. The goal is to see if it can help children feel better and heal their intestines. Participants will receive the drug as an IV infusion or injection, and researcher…

This phase 3 trial is testing a drug called tulisokibart in about 1,200 people with moderate-to-severe Crohn's disease who haven't had success with other treatments. The drug is given by IV or injection and aims to reduce symptoms and heal the gut lining. The study compares tulis…

This phase 3 trial tests mirikizumab, an injected drug, in 90 children with moderate-to-severe Crohn's disease. The study looks at whether the drug can improve symptoms and heal the gut lining over 52 weeks. Participants receive mirikizumab during a 12-week induction period, then…

This study tests the long-term safety and effectiveness of mirikizumab in 150 children and adolescents with moderate-to-severe ulcerative colitis or Crohn's disease. Participants who completed earlier mirikizumab studies can join. The trial lasts about 172 weeks and aims to see i…

This study looks at people with inflammatory bowel disease (Crohn's or ulcerative colitis) who feel fine but still have moderate to severe inflammation inside their gut. It compares two approaches: switching to a different targeted medication versus staying on the current one. Th…

This trial tests whether a 12-week dietary intervention can improve gut health, reduce inflammation, and enhance quality of life in adults with ulcerative colitis who are in remission. Participants are randomly assigned to a Mediterranean diet, a Mediterranean diet combined with …

This phase 2 study is testing two new drugs — mirikizumab (given by IV or injection) and LY4395089 (a pill) — in 60 adults with moderately to severely active ulcerative colitis or Crohn's disease. The goal is to see if these treatments are safe and can help control the disease. T…

This study tests whether adding a new oral drug, LY4268989, to the existing treatment mirikizumab works better than mirikizumab alone for adults with moderate-to-severe ulcerative colitis. About 252 participants will receive either the combination or mirikizumab plus a placebo fo…

This study tests whether adding the weight-loss drug tirzepatide to the Crohn's drug mirikizumab helps people with moderate-to-severe Crohn's disease who are also overweight or have obesity. About 290 adults will receive either mirikizumab alone or mirikizumab plus tirzepatide. T…

This study tests whether stem cells from a donor can help control Crohn's disease, a chronic gut condition causing pain and diarrhea. About 46 adults will receive either stem cells or a placebo through IV infusions over 16 weeks. Researchers will track symptom changes and side ef…

This phase 3 trial tests whether adding tirzepatide (a weight-loss drug) to mirikizumab (an anti-inflammatory drug) helps people with moderate-to-severe ulcerative colitis who are also overweight or obese. The goal is to see if the combination can reduce both gut symptoms and bod…

This study tests whether adding a new drug (LY4395089) to an existing treatment (mirikizumab) works better than mirikizumab alone for adults with moderate-to-severe Crohn's disease. About 60 participants will be followed for 62 weeks to check safety and how well the combination r…

This study tests a new drug called BI 3032950 in 80 adults with moderate to severe ulcerative colitis who haven't improved on other treatments. In the first part, the drug is given by IV every 4 weeks for 12 weeks. Those who respond then receive injections under the skin every 4 …

This study tests an oral drug called LY4268989 (MORF-057) in adults with moderate-to-severe ulcerative colitis. About 1,431 participants will receive either the drug or a placebo for up to 108 weeks. The goal is to see if the drug can safely help control the disease and improve s…

This study tests a new drug called RO7790121 for people with moderate to severe ulcerative colitis, a condition that causes inflammation in the colon. About 350 adults who haven't responded well to other treatments will receive either the drug or a placebo. The main goal is to se…

This study follows 200 adults with Crohn's disease or ulcerative colitis who are prescribed Zymfentra as part of their regular care. Participants answer online surveys about their bowel habits for one year to see if symptoms improve. The goal is to understand how effective this m…

This study looks at whether a special liquid diet called exclusive enteral nutrition (EEN) can help adults with active Crohn's disease feel better and reduce inflammation. About 300 participants will use EEN as their main treatment for 12 weeks. Researchers will check remission r…

This study tests a new drug called RO7790121 (Afimkibart) in people with moderate-to-severe Crohn's disease. The goal is to see if the drug can reduce symptoms and heal the gut lining better than a placebo. About 425 adults who have not responded well to other treatments will tak…

This study looks at how children and teenagers with moderate to severe ulcerative colitis or Crohn's disease process a drug called vedolizumab when given as a shot under the skin. About 70 participants who already responded to vedolizumab given through a vein will receive the sho…

This phase 2 trial tests a drug called DISC-0974 in 21 adults with inflammatory bowel disease (IBD) who also have anemia caused by inflammation. The study aims to see if the drug safely raises hemoglobin levels compared to a placebo. Participants receive injections of either DISC…

This study looks at whether using two drugs together (upadacitinib and vedolizumab) works better than just one drug (upadacitinib alone) for people with moderate-to-severe ulcerative colitis, a chronic bowel disease. Researchers will review medical records from 150 adults across …

This study is checking the long-term safety of guselkumab, a biologic drug given as a shot, in children with moderate to severe Crohn's disease, ulcerative colitis, or juvenile psoriatic arthritis. About 196 kids who already completed a prior guselkumab study and benefited from i…

This study is for people who have both an autoimmune disease (like rheumatoid arthritis, lupus, or multiple sclerosis) and an advanced cancer that has spread or cannot be removed by surgery. It tests the safety and effectiveness of the immunotherapy drug nivolumab, given alone or…

This study observes 35 adults with moderate-to-severe Crohn's disease or ulcerative colitis to see how long they continue taking guselkumab in everyday medical practice. Researchers will track treatment persistence and early symptom relief, like reduced bowel urgency. No experime…

This study tests whether guselkumab works better than risankizumab for people with moderate to severe Crohn's disease. About 530 adults will receive one of the two drugs and be followed for a year. The goal is to see which drug leads to deeper remission, meaning fewer symptoms an…

This study tests whether MK-8690, a drug given as a shot, can help people with moderate-to-severe ulcerative colitis achieve remission. About 100 adults who haven't responded well to other treatments will receive either MK-8690 or a placebo. The main goal is to see if more people…

This study tests a new medicine, JNJ-78934804, against an existing drug (guselkumab) in 460 people with moderate-to-severe Crohn's disease. The goal is to see if the new drug can reduce symptoms and heal the gut lining better at 48 weeks. Participants must have had Crohn's for at…

This study follows 200 Chinese patients with moderate-to-severe ulcerative colitis who have never taken biologic drugs. They will receive guselkumab as part of their normal care. Researchers will measure changes in symptoms and quality of life over 48 weeks to see how well the dr…

This study tests whether the experimental drug icotrokinra can reduce symptoms and gut inflammation in people with moderate-to-severe Crohn's disease. About 1,092 adults will receive either the drug or a placebo for up to 40 weeks. The goal is to see if the drug can bring about r…

This phase 3 trial tests whether the experimental drug JNJ-78934804 can help people with moderate to severe ulcerative colitis achieve remission better than the existing drug guselkumab. About 644 participants will receive either the new drug or guselkumab, and researchers will c…

This study tests an oral medication called icotrokinra for people with moderate to severe ulcerative colitis, a chronic condition that causes inflammation and ulcers in the colon. About 882 adults and adolescents will receive either the drug or a placebo to see if it can bring ab…

This study tests two drugs, eltrekibart and mirikizumab, alone or together, in 140 adults with moderate-to-severe ulcerative colitis. The goal is to see if they can safely reduce inflammation and help patients achieve remission. Participants must have tried other treatments witho…

This trial tests whether adding regular MRI scans to standard monitoring (stool tests and symptom checks) can improve outcomes for people with Crohn's disease who are starting biotherapy. Crohn's is a chronic inflammatory bowel disease that can damage the full thickness of the in…

This trial tests whether a short course of azithromycin, taken before starting anti-TNF therapy, can reduce the body's tendency to develop antibodies against the biologic drug. Antibodies can make the treatment less effective over time. The study enrolls adults with Crohn's disea…

This study tests a new drug called SSGJ-627 in 288 adults with moderate to severe ulcerative colitis, a chronic bowel disease. The goal is to see if it safely controls symptoms like bleeding and diarrhea. Participants must have tried other treatments without success.

This Phase 2 trial is testing three long-acting antibodies, alone or in combination, for people with moderate-to-severe ulcerative colitis. The study will enroll 645 adults to see if these treatments can reduce inflammation and lead to remission. Participants receive the antibodi…

This study tests a new drug called RO7837195 for people with moderate to severe ulcerative colitis who haven't gotten better with other treatments. About 224 participants will receive either the drug or a placebo for 12 weeks to see if it can bring about remission. The goal is to…

This large Phase 3 trial tests whether VE303, a capsule containing 8 harmless bacteria, can prevent repeat Clostridioides difficile (C. diff) infections. About 852 people who have had at least one prior C. diff infection will take VE303 or a placebo for 14 days. The main goal is …

This pilot study tests whether a specific probiotic, given as a rectal enema, can improve gut health in people with mild-to-moderate ulcerative colitis. Researchers will measure changes in the gut microbiome and signs of rectal healing. The trial enrolls 20 adults aged 18 to 80 w…

This study tests a new antibody drug called XmAb942 for moderate-to-severe ulcerative colitis, a chronic inflammatory bowel disease. First, healthy volunteers will receive the drug to check safety. Then, about 270 people with ulcerative colitis will get either XmAb942 or a placeb…

This study is for people with active Crohn's disease that hasn't improved with standard treatments. Participants will receive a stem cell transplant followed by a drug called vedolizumab to help keep the disease in remission. The goal is to see if this combination can reduce symp…

This study tests an oral medication called ozanimod in children aged 12-17 with moderate-to-severe ulcerative colitis who haven't responded to standard treatments. The goal is to see if the drug can safely bring the disease into remission. About 120 participants will receive eith…

This phase 3 study tests a drug called afimkibart in 600 people with moderate-to-severe Crohn's disease. Participants receive either the drug or a placebo to see if it can reduce symptoms and gut inflammation. The trial is double-blind, meaning neither patients nor doctors know w…

This trial tests an experimental oral drug called BRS201 in people with active mild ulcerative colitis. Participants take the drug or a placebo for four weeks each in a crossover design, and researchers measure changes in gut inflammation markers and symptoms. The study involves …

This study is testing a new oral drug called etrasimod in 30 elderly patients with active ulcerative colitis. Researchers will track how many patients achieve remission after 4 weeks and look for improvements in the gut lining after a year. The goal is to see if the drug is safe …

This study tests whether a daily cranberry supplement can help restore healthy gut bacteria in adults with Crohn's disease. Fifty participants will take either the cranberry supplement or a placebo for 10 weeks. Researchers will track changes in gut bacteria, inflammation, and sy…

This study tests an experimental pill called MORF-057 (zotemtegrast) in 385 adults with moderate-to-severe Crohn's disease. The drug works by blocking a protein that drives gut inflammation. Participants will receive one of three doses of the drug or a placebo for 14 weeks to see…

This study tests whether mirikizumab, an injected drug that blocks IL-23, can reduce inflammatory strictures (narrowed areas) in the small bowel caused by Crohn's disease. About 60 adults with at least one stricture will receive the drug and be monitored with MRI and symptom scor…

This early-stage trial tests whether a stool transplant (FMT) can help cancer patients who develop severe diarrhea or colon inflammation from immune-checkpoint inhibitor drugs. About 40 patients with various cancers will receive the transplant via colonoscopy. The main goal is to…

This study tests an investigational drug called duvakitug in people with moderate-to-severe ulcerative colitis who have already responded to treatment. The goal is to see if duvakitug can help maintain remission better than a placebo over 40 weeks, with an optional long-term exte…

This study tests whether repeated fecal microbiota transplants (FMT) combined with a special liquid diet can safely control active Crohn's disease in children aged 2–16 who are newly diagnosed. The goal is to see if this approach can achieve remission and heal the gut lining with…

This study looks at whether certain biologic drugs (like infliximab, adalimumab, vedolizumab, and ustekinumab) can prevent Crohn's disease from flaring up again after bowel surgery. Researchers will review medical records of about 198 adults who started one of these drugs within …

This study tests whether repeated fecal microbiota transplants (FMT) from healthy donors, combined with a special liquid diet, can safely help children aged 2–16 with active Crohn's disease that hasn't improved with standard treatments. The goal is to see if this approach can red…

This study tests whether fecal microbiota transplantation (FMT) capsules, made from healthy donor stool, can prevent C. diff infection from coming back better than standard antibiotics. About 100 adults with a first or first-recurrent C. diff infection will get either antibiotics…

This study tests whether giving children with active ulcerative colitis a series of fecal microbiota transplants (FMT) along with a special liquid diet (partial enteral nutrition) can help control the disease. The trial includes children aged 2 to 16 who either have not responded…

This study watches 300 adults with moderate to severe ulcerative colitis who are prescribed etrasimod by their doctor. Researchers track symptoms like stool frequency and rectal bleeding over 52 weeks using health questionnaires. The goal is to see how well the drug works outside…

This study tests a new medicine called MH002, which contains live bacteria meant to restore gut health in people with mild-to-moderate ulcerative colitis. About 204 adults whose current treatment isn't working well enough will receive either a low dose, high dose, or placebo caps…

This Canadian study is testing whether switching to the drug guselkumab (Tremfya) can help people with inflammatory bowel disease (IBD) who didn't respond well enough to ustekinumab. Researchers will track symptoms, test results, and overall health in 200 participants over one ye…

This study watches how well IL-23 inhibitors work for adults with active Crohn's disease in everyday clinics. About 665 people will get treatment chosen by their doctor and be checked at 12 and 52 weeks. The main goal is to see how many reach remission (symptom-free) by week 12, …

This study tests an experimental oral drug called INT-210 in adults with active ulcerative colitis, a chronic inflammatory bowel disease. Participants take either 200 mg or 400 mg of INT-210 twice daily for 12 weeks. The main goals are to check the drug's safety and how the body …

This study looks at whether early surgery or waiting and trying biologic drugs first is better for people with Crohn's disease who have bowel blockages. About 138 participants will be randomly assigned to either have surgery soon or receive biologic therapy. The goal is to see wh…

This study explores whether people with inactive inflammatory bowel disease (IBD) can safely stop taking proton pump inhibitors (PPIs), a common acid-reducing medication. Evidence suggests PPIs may make IBD treatments less effective and increase hospital visits. The trial will re…

This study tests a daily medication called etrasimod in 36 adolescents aged 12 to 17 with moderate-to-severe ulcerative colitis. The goal is to see if the drug can safely help control the disease and reduce inflammation over a year, with an option to continue treatment for up to …

This study is monitoring the safety and effectiveness of the drug Jyseleca (filgotinib) in Korean patients with rheumatoid arthritis or ulcerative colitis. Researchers will track side effects and disease activity over 24 weeks. About 2,040 participants are being observed during r…

This study tests an oral drug called TAK-279 (Zasocitinib) in 268 adults with moderate-to-severe Crohn's disease who haven't responded well to other treatments. Participants take one of three doses or a placebo daily for 12 weeks to see if it reduces gut inflammation and ulcers, …

This study tests whether guselkumab can help people with Crohn's disease whose current treatment (ustekinumab) has stopped working. Crohn's disease causes severe gut inflammation. About 78 Chinese adults with active Crohn's will receive guselkumab and be followed for 48 weeks to …

This study will follow 500 people with Crohn's disease or ulcerative colitis who are starting guselkumab, a biologic drug. Researchers will measure how many achieve remission and how the treatment affects daily life, including fatigue and work productivity. The goal is to underst…

This study tests a drug called guselkumab in 120 children with moderate to severe Crohn's disease. The goal is to see if it can reduce symptoms and heal the gut lining over 52 weeks. Participants must have active Crohn's confirmed by endoscopy. This is a phase 3 trial, meaning it…

This study tracks 220 adults with moderate-to-severe ulcerative colitis or Crohn's disease who are starting guselkumab, a biologic drug. Researchers will measure how many achieve remission (symptom control) and whether they can stop steroids. The goal is to see how well the drug …

This early study is testing whether giving a transplant of healthy gut bacteria (called IMT) through a feeding tube is safe and doable in 40 adults who have had part of their colon removed due to diverticulitis or sigmoid colon cancer. Participants get the transplant a couple of …

This study will follow 100 people in Saudi Arabia with moderate to severe Crohn's disease or ulcerative colitis who are starting guselkumab. Researchers will measure how long patients continue the treatment in real-world clinics, along with early symptom improvements. No new drug…

This trial tests whether using ultrasound during surgery to choose where to cut the bowel leads to better outcomes for people with Crohn's disease. About 44 adults with Crohn's disease affecting the last part of the small intestine will be randomly assigned to have their surgery …

This early-stage trial is testing whether a pill made from freeze-dried healthy donor stool (MTP-101P) is safe and can restore good bacteria in people having part of their colon removed. Forty adults aged 18-75 with colon polyps, early-stage cancer, or diverticulitis will take th…

This phase 3 trial tests duvakitug, an injected drug, in about 980 adults with moderate to severe Crohn's disease who haven't improved with other treatments. The study is double-blind and placebo-controlled, meaning some participants get the drug and some get a dummy shot. The go…

This study tests an experimental pill called ISM5411 (Garutadustat) in 80 adults with active ulcerative colitis. Half receive the drug, half a placebo, and neither patients nor doctors know who gets what. The goal is to check if the drug is safe and helps control the disease.

This study looks at whether taking a mix of probiotics (good bacteria) can change the gut microbiome of children and teens aged 5-18 with inflammatory bowel disease (IBD). About 40 participants will be randomly assigned to take probiotics or a placebo, then switch after a period.…

This study tests whether increasing the dose of guselkumab can help people with Crohn's disease who don't get better with standard doses. About 210 adults with active Crohn's will receive guselkumab, and after 12 weeks, those who haven't responded will get a higher dose more ofte…

This study tests a daily pill called etrasimod in 24 children aged 2 to 12 with moderate to severe ulcerative colitis, a chronic inflammatory bowel disease. The goal is to see if the drug can safely help children reach remission (few or no symptoms) over 52 weeks. Participants wh…

This phase 2 trial is testing four different drugs—risankizumab, trosunilimab, lutikizumab, and ABBV-8736—in about 540 adults with moderate to severe Crohn's disease. The goal is to see if these targeted therapies can reduce inflammation and improve symptoms. Participants will re…

This study follows 40 children with Crohn's disease or ulcerative colitis who developed severe psoriasis from anti-TNF drugs and switched to ustekinumab. Researchers will check if their digestive symptoms stay controlled and if their skin improves after 3-6 months. The goal is to…

This study tests whether taking oral vancomycin while on other antibiotics can prevent a repeat Clostridioides difficile infection (CDI) in people who had one in the last 120 days. Researchers will compare vancomycin to a placebo in 300 adults. Participants take the study drug tw…

This study tests upadacitinib (RINVOQ), a daily oral medication, in 110 children aged 2 to 18 with moderate to severe Crohn's disease who haven't improved with other treatments. The trial has three parts: an initial 12-week open-label phase, a 52-week double-blind maintenance pha…

This pilot study tests two stem cell treatments for anal fistulas in people with Crohn's disease. One uses donor stem cells (Alofisel), the other uses stem cells from the patient's own fat. The goal is to see which works better at closing the fistula. The study plans to enroll 20…

This study tracks 250 people with moderate-to-severe Crohn's disease who are switching to either upadacitinib or risankizumab after a first treatment didn't work well enough. Researchers will see if these drugs help patients achieve remission without needing steroids over 18 mont…

This study tests an experimental drug called SAR441566 in about 204 adults with moderate-to-severe ulcerative colitis, a chronic bowel disease causing inflammation and symptoms like diarrhea and bleeding. Participants will receive either the drug or a placebo for up to 52 weeks t…

This study tests whether a special medical food called LH VIOLA, taken as a partial replacement for regular meals, can help people with Crohn's disease or ulcerative colitis who are at risk of malnutrition maintain or regain weight and muscle strength. About 146 participants will…

This study tests whether capsules containing freeze-dried healthy donor gut bacteria can take root in the intestines of people with Crohn's disease. Researchers will check if the bacteria engraft in the ileum and colon, and explore changes in symptoms and inflammation. The trial …

This study looks at how well etrasimod works for people with moderate to severe ulcerative colitis when used in normal doctor visits. About 360 adults aged 18 to 65 will take etrasimod as prescribed by their doctor and fill out health questionnaires online. Researchers will track…

This phase 3 study tests whether duvakitug can help people with moderate-to-severe Crohn's disease maintain remission. About 751 participants who responded to prior treatment will receive either duvakitug or a placebo injection for up to 40 weeks, with an option to continue in an…

This study looks at the long-term safety of a drug called vedolizumab given as a shot under the skin to children and teenagers with ulcerative colitis or Crohn's disease. About 70 participants who did well on the drug in an earlier study will keep getting it, while those who didn…

This pilot study tests a new procedure for people with Crohn's disease who have anal fistulas that haven't healed with standard treatments. Doctors take a small amount of fat from the patient's belly, process it mechanically in the same surgery, and inject it into the fistula tra…

This study looks at how well risankizumab works for people with moderate to severe ulcerative colitis in real-world settings. About 200 adults in Germany and Austria will take the drug as prescribed by their doctor and be followed for up to 52 weeks. The goal is to see if symptom…

This study tests if upadacitinib, a newer pill, works as well as standard steroid injections for treating sudden, severe flare-ups of ulcerative colitis. About 46 adults with acute severe colitis will receive either upadacitinib or steroids for 3 months, with frequent checkups. T…

This study tests an experimental drug called SAR441566 in 260 adults with moderate to severe Crohn's disease. Participants will receive different doses of the drug or a placebo for up to 52 weeks to see if it reduces gut inflammation and improves symptoms. The goal is to find a s…

This study follows 50 people with moderate to severe Crohn's disease or ulcerative colitis to see how long they stay on guselkumab in real-world settings. Researchers will measure treatment persistence and early symptom improvements using patient diaries. The goal is to understan…

This study tests a special form of vitamin B3 (nicotinamide) that releases in the lower gut to treat mild to moderate ulcerative colitis. About 459 adults will receive either a low or high dose of the vitamin or a placebo. The goal is to see if it can reduce symptoms and improve …

This early-stage study is testing whether an oral probiotic called R-3750 is safe and tolerable for people with mild to moderate ulcerative colitis. About 36 adults will take the probiotic and be monitored for side effects, inflammation, and symptom changes. The goal is to see if…

This study tests whether a capsule containing healthy gut bacteria (restorative microbiota therapy) is safe and feasible for people with severe colitis caused by cancer immunotherapy. About 20 participants with steroid-resistant colitis will receive either the bacteria or a place…

This study tests a once-daily food supplement designed to improve gut bacteria in people with mild-to-moderate ulcerative colitis. About 162 adults will take either the supplement or a placebo for 24 weeks, alongside their usual treatment. The goal is to see if the supplement hel…

This study tests whether adding a low dose of upadacitinib (a JAK inhibitor) to a standard TNF inhibitor (like infliximab or adalimumab) works better than simply increasing the dose of the TNF inhibitor alone for people with moderate-to-severe Crohn's disease. About 312 adults wh…

This early-stage trial tests BDHK-2009, an experimental tablet for inflammatory bowel diseases like ulcerative colitis and Crohn's disease. The study involves 68 healthy adults aged 18 to 55 to see if the drug is safe and how the body handles it. Participants receive either a sin…

This study tests the safety of giving a second injection of a patient's own frozen fat-derived cells (stromal vascular fraction) to treat anal fistulas that didn't heal in a previous trial. About 25 adults with Crohn's disease who still have active fistulas will receive the injec…

This study tests whether transplanting healthy donor stool into the gut can help people with ulcerative colitis reach remission without steroids. About 85 adults with active UC will receive either fecal transplants or a placebo. The goal is to see if a larger, definitive trial is…

This study tests whether butyrate enemas can help Hispanic children aged 7-21 with mild-to-moderate ulcerative colitis. Butyrate is a natural substance made by gut bacteria that may reduce inflammation. The goal is to see if it can lower disease activity scores and improve marker…

This study tests whether two types of fibre supplements—acacia gum and microcrystalline cellulose—can reduce gut inflammation in people with ulcerative colitis. Sixty-nine participants will add one of the fibres or a placebo to their usual diet for six weeks. Researchers will mea…

This study tests tirzepatide, a drug used for diabetes, in 60 adults with Crohn's disease who have active inflammation in the small bowel despite other treatments. The goal is to see if tirzepatide can heal the gut lining better than switching to another standard biologic therapy…

This study tests a new strategy to prevent Crohn's disease from returning after bowel surgery. Instead of waiting 6 months for a colonoscopy, doctors will use a simple stool test at 3 months to decide if treatment needs to be stepped up earlier. The goal is to reduce the number o…

This phase 2 trial tests an experimental pill called HRS-7085 in 48 adults with moderate to severe ulcerative colitis. Participants receive either a low dose, high dose, or placebo for several weeks. The study checks for safety, symptom improvement, and how the drug moves through…

This study tests risankizumab, a drug already used in adults, in children aged 2 to 18 with moderate to severe Crohn's disease. About 110 kids will receive the drug intravenously then by injection over several years. The goal is to see if it safely reduces symptoms and gut inflam…

This study tests if the drug mirikizumab can heal damage deep in the gut wall in people with Crohn's disease. About 75 adults with active symptoms and inflammation seen on MRI will receive the drug. The main goal is to see if the gut shows at least 25% improvement after 24 weeks.

This study tests whether giving two drugs together (vedolizumab and upadacitinib) for 12 weeks works better than vedolizumab alone to reduce bowel inflammation and ulcers in adults with moderate to severe Crohn's disease. About 396 participants will receive the combo or a placebo…

This study follows 900 children ages 6-17 who are newly diagnosed with Crohn's disease and starting anti-TNF therapy. Researchers will track healing of the intestine using blood tests, stool samples, colonoscopy, and MRI over one year. The goal is to understand why some children …

This study tests the long-term safety of an oral drug called zasocitinib (TAK-279) in adults with moderate to severe Crohn's disease or ulcerative colitis. Participants who responded to the drug in earlier studies can continue treatment for up to 3 years. The main goal is to see …

This study tests whether adding selenium supplements to standard advanced therapies (like biologics) helps people with moderate to severe ulcerative colitis achieve remission. About 180 participants will receive either selenium or a placebo for a set period. The goal is to see if…

This study looks at the long-term safety of a medicine called tulisokibart for people with moderate to severe Crohn's disease or ulcerative colitis. It is an extension study, meaning participants must have already taken tulisokibart in a previous study. The main goal is to see ho…

This study looks at the safety and effectiveness of Velsipity tablets taken daily for up to 52 weeks by people with moderate to severe ulcerative colitis. About 553 participants will be followed in real-world medical settings. The goal is to see if the drug can help control sympt…

This study looks at how well ozanimod works compared to azathioprine for people with steroid-dependent ulcerative colitis in Japan. Researchers will review medical records of 150 adults to see which drug helps patients stop steroids and stay symptom-free. The goal is to find a be…

This study tests whether a newer surgical method called Kono-S anastomosis can better prevent Crohn's disease from returning after bowel surgery compared to the standard side-to-side technique. About 600 adults with Crohn's disease needing bowel resection will be randomly assigne…

This study tests an experimental treatment called DB-3Q, made from stem cell particles, for people with Crohn's disease who have painful tunnels (fistulas) near the anus. About 36 adults will receive either the treatment or a placebo to see if it safely closes the fistulas and im…

This study tests a dietary supplement called ButyMixx in 40 adults with ulcerative colitis who are in remission. ButyMixx contains sodium butyrate and a beneficial yeast to support gut health. Participants take two sachets daily for 8 weeks, and researchers check for symptom chan…

This study tests an experimental drug called TQH3906 in adults with moderate-to-severe ulcerative colitis or Crohn's disease. About 135 participants will receive either the drug or a placebo for 12 weeks to see if it safely reduces inflammation and improves symptoms. The goal is …

This study is for children with ulcerative colitis or Crohn's disease who already completed a previous vedolizumab trial. It aims to see how safe the drug is over a longer period. About 240 kids will receive vedolizumab infusions or be observed without treatment. Researchers will…

This phase 2 trial tests whether adding a freeze-dried fecal microbiota transplant (FMT) to standard biologic drugs (vedolizumab or ustekinumab) helps people with ulcerative colitis reach remission more safely and effectively. About 40 adults with active UC will receive either FM…

This study looks at 220 adults with Crohn's disease whose symptoms returned while on adalimumab. Half will get a higher dose of adalimumab, and the other half will switch to vedolizumab. The goal is to see which approach leads to better control of the disease after 24 weeks, usin…

This study tests a medicine called vedolizumab in children and teens with moderate to severe Crohn's disease. The goal is to see if the drug can reduce inflammation and keep symptoms under control over the long term. Participants first receive three infusions over six weeks, then…

This study tests whether a computer program that calculates a personalized dose of infliximab based on blood tests can help children with Crohn's disease achieve deep remission better than standard dosing. About 180 children and young adults (ages 6–22) newly diagnosed with Crohn…

This study tests whether adding a special diet (Crohn's Disease Exclusion Diet) to the standard drug infliximab helps children with Crohn's disease feel better and stay in remission longer. About 140 children starting infliximab will be randomly assigned to receive the diet plus …

This study tests an experimental oral drug called obefazimod in 212 adults with moderate-to-severe Crohn's disease who haven't responded well to other treatments. Participants receive either obefazimod or a placebo daily for 12 weeks (induction), then up to 40 more weeks (mainten…

This study tests whether taking capsules made from healthy donor stool (fecal microbiota transplantation, or FMT) can prevent another bout of C. diff infection in people who have had it come back at least twice. 76 adults will receive either active FMT capsules or placebo, and re…

This study tests a sequential treatment for moderate to severe ulcerative colitis. First, patients take upadacitinib (a fast-acting pill) along with vedolizumab (a slow but safe infusion) for 8 weeks to quickly reduce inflammation. Then, they continue with vedolizumab alone for l…

This study is testing whether a Mediterranean-like diet called Nordiet can improve gut health and reduce inflammation in 160 teens and adults with Crohn's disease or ulcerative colitis. Participants will follow the diet for four weeks while researchers check changes in gut bacter…

This study tests whether transplanting healthy stool bacteria (FMT) can improve liver health in people with primary sclerosing cholangitis (PSC) and inflammatory bowel disease. 58 adults will receive either FMT or a placebo via colonoscopy and enemas. The main goal is to see if F…

This study tests a new drug called duvakitug in about 980 people with moderate-to-severe ulcerative colitis. Participants receive either duvakitug or a placebo as an injection under the skin for up to 12 weeks. The goal is to see if the drug can help achieve remission, meaning le…

This study is testing an interleukin-23 monoclonal antibody, a drug that blocks a key inflammatory protein, in 200 adults with moderate to severe Crohn's disease or ulcerative colitis. Participants receive the drug and are followed for 54 weeks to see if they can achieve remissio…

This study compares two drugs—upadacitinib (a pill) and infliximab (an infusion)—as second-line treatments for acute severe ulcerative colitis. About 226 adults will be randomly assigned to one of the two drugs for 3 months. The main goal is to see if upadacitinib can reduce symp…

This study tests a new drug called SAR442970 for people with moderate to severe ulcerative colitis, a condition that causes inflammation and sores in the colon. About 99 adults will receive either the drug or a placebo to see if it can help control the disease and reduce symptoms…

This study looks at how well newer inflammatory bowel disease (IBD) medications work in children whose previous anti-TNF treatment stopped working or didn't help. About 1,100 kids with Crohn's disease or ulcerative colitis will answer questions about their symptoms and health ove…

This study tests an oral biologic called MB-001 in 100 adults with moderate-to-severe ulcerative colitis. Participants take either MB-001 or a placebo daily for 12 weeks, then may continue in an open-label phase. Researchers will check for side effects and measure improvements in…

This study tests whether acupuncture can reduce the number of flare-ups in people with Crohn's disease who are currently in remission. About 106 participants will receive either real or sham acupuncture over several months. The goal is to see if this ancient practice can help kee…

This study looks at whether replacing a normal diet with specialized milkshakes for 6 weeks can improve how well biologic drugs work in children aged 6-18 with active Crohn's disease. About 90 participants will either follow their normal diet or drink the milkshakes alongside the…

This study tests whether a diet made from common American foods like sandwiches, grilled meats, and oatmeal can reduce inflammation and improve symptoms in people with ulcerative colitis. Over 8 weeks, 122 participants will receive catered meals and guidance from a dietitian. The…

This pilot study tests whether the weight-loss drug tirzepatide (Zepbound) combined with a Mediterranean diet can help control mild Crohn's disease. Twenty-four adults with Crohn's who are already on biologic therapy and have a BMI of 27 or higher will receive either tirzepatide …

This study tests whether adding a special diet (Crohn's Disease Exclusion Diet) to standard medication helps children with unstable Crohn's disease have fewer flare-ups over a year. About 120 kids aged 6-17 will be randomly assigned to either diet plus medication or medication al…

This phase 2 trial is testing an experimental drug called SAR442970 in about 99 adults with moderate to severe Crohn's disease. Participants will receive either the drug or a placebo as a shot under the skin. The main goal is to see if the drug can improve the appearance of the g…

This study tests whether combining guselkumab with JAK inhibitors (upadacitinib or tofacitinib) can help people with inflammatory bowel disease that hasn't improved with other treatments. About 80 participants will receive the drug combination and be monitored for 12 and 52 weeks…

This study looks at whether a drug called guselkumab can help people with moderate to severe Crohn's disease who did not improve or could not tolerate another drug called ustekinumab. About 60 adults will receive guselkumab and be followed for 52 weeks. The main goal is to see ho…

This study compares two treatments for children aged 6-18 with Crohn's disease: one group gets infliximab alone, another gets immunosuppressives alone, and a third gets both. The goal is to see which approach leads to more kids achieving remission (feeling better and showing heal…

This study tests whether giving several fecal transplants (instead of just one) works better to clear repeat C. diff infections in people with ulcerative colitis. About 64 adults with active colitis and repeat C. diff will receive either one or multiple infusions of healthy donor…

This study tests whether fecal transplants from carefully selected 'superdonors' can help people with mild-to-moderate ulcerative colitis achieve remission. 42 adults with a recent diagnosis will receive either superdonor FMT or a placebo via colonoscopy and capsules. The main go…

This study tests whether removing extra tissue (the mesentery) during standard Crohn's surgery is safe and helps prevent the disease from returning. About 30 adults with Crohn's disease who are already on biotherapy will undergo this procedure. The main goal is to see if the surg…

This study tests whether dapagliflozin, a drug currently used for diabetes, can help control inflammation in people with mild-to-moderate ulcerative colitis. Researchers will give 50 adults either dapagliflozin plus standard mesalamine or mesalamine alone, and track changes in sy…

This Phase 2 study is testing two new drugs, MT-501 and MT-201, in 140 adults with moderate-to-severe Crohn's disease or ulcerative colitis. The goal is to see if these treatments are safe and can improve symptoms and gut healing. Researchers will monitor side effects and measure…

This study tests whether a program of weekly surveys can help veterans with inflammatory bowel disease (IBD) feel better and avoid flare-ups. About 250 veterans at four VA hospitals will either get the usual care or also complete short weekly check-ins for 12 months. The goal is …

This study tests whether taking freeze-dried fecal transplant capsules (PRIM-DJ2727) can help adults with ulcerative colitis stay in remission and avoid flare-ups. About 58 participants will take the capsules or a placebo for 12 weeks alongside their usual treatment. The goal is …

This study tests whether improving nutrition before surgery reduces complications in people with inflammatory bowel disease (IBD). About 150 adults scheduled for intestinal surgery will receive a nutrition specialist and special shakes. Researchers will track hospital stay length…

This study tests an experimental drug called HSK47388 in 150 adults with moderately to severely active ulcerative colitis, a chronic bowel disease causing inflammation and sores. Participants will receive either the drug or a placebo to see if it improves symptoms and helps heal …

This study looks at two drugs, guselkumab and ustekinumab, in 100 adults with moderate-to-severe Crohn's disease that has caused narrowing (strictures) in the bowel. The goal is to see which drug better controls symptoms and improves imaging results over 52 weeks. Participants co…

This study is testing whether the drug ustekinumab (Stelara) can help people with moderate-to-severe Crohn's disease who also have bowel strictures (narrowing of the intestine). About 239 participants will receive ustekinumab and be followed for a year. The goal is to see if the …

This early-phase trial tests whether a patient's own immune cells, engineered to target BCMA and/or CD19, can calm severe ulcerative colitis that hasn't responded to other treatments. Twelve adults with moderate-to-severe active disease will receive a single infusion of these CAR…

This early-stage trial tests whether statins, a common cholesterol medicine, can prevent strictures (narrowing) in the gut for adults with Crohn's disease. About 20 participants will take either statins or a placebo daily for 6-12 months after surgery. Researchers will check for …

This study tests whether taking a daily prebiotic supplement for 8 weeks can improve gut health and reduce inflammation in people with ulcerative colitis. Researchers will collect stool samples and track symptoms in 70 adults. The goal is to see if prebiotics can help manage the …

This study tests whether combining two drugs—upadacitinib and ustekinumab—works better than just increasing the dose of ustekinumab alone for people with Crohn's disease who didn't get enough help from standard treatment. About 214 adults with active Crohn's will be randomly assi…

This study follows about 240 people in Japan with moderate to severe Crohn's disease who are taking upadacitinib, an approved drug. Researchers will track side effects and how well the drug controls the disease over up to 64 weeks. The goal is to see how the drug works in everyda…

This study tests an experimental drug called SAR444336 in 54 adults with microscopic colitis who are currently in remission using budesonide. The goal is to see if the drug can help them stay symptom-free without needing budesonide. Participants will receive either the study drug…

This study is testing whether transplanting stool from a healthy donor into the colon can prevent recurrent C. diff infections. The procedure, done via colonoscopy, aims to restore good bacteria that keep C. diff in check. Researchers are tracking 500 people to see if this stops …

This study tests a stem cell transplant for people aged 13-28 with severe Crohn's disease that hasn't responded to other treatments. Doctors take the patient's own blood stem cells, then use high-dose therapy to wipe out overactive immune cells before returning the stem cells. Th…

This study is testing an upgraded amino acid-based nutritional supplement for 30 children and adults who have severe gut problems like inflammatory bowel disease, short bowel syndrome, or severe allergies. Participants will use the supplement as part of their diet for 28 days. Re…

This study tests a new drug called OD-07656 in people with moderate to severe ulcerative colitis, a chronic bowel disease. The goal is to see if it safely reduces symptoms like bleeding and diarrhea, and if it can make a follow-up treatment (vedolizumab) work better. About 57 adu…

This study tests an experimental oral drug called GS-5290 (tilpisertib fosmecarbil) in 176 adults with moderate to severe ulcerative colitis. Participants are randomly assigned to receive either the drug or a placebo for 12 weeks. The main goal is to see if the drug can improve s…

This study compares quality of life in adults with Crohn's disease during a flare when treated either with standard care or an adapted Crohn's disease exclusion diet plus partial enteral nutrition. The diet limits certain foods and uses a nutritional drink (Modulen) to help contr…

This study tests whether adding mebendazole, a common deworming medication, to standard mesalamine therapy can improve symptoms in people with mild-to-moderate ulcerative colitis. 46 adults will take mebendazole or a placebo twice daily for 6 months. Researchers will measure chan…

This study tests whether adding upadacitinib (Rinvoq) to standard steroid treatment helps people with a severe ulcerative colitis flare-up recover faster and avoid emergency care or surgery. About 110 adults with acute severe ulcerative colitis will be randomly assigned to get ei…

This study tests whether a diet that removes refined and intolerant foods can help people with Crohn's disease stay in remission after bowel surgery. Researchers will track quality of life and nutrition in 35 participants. The goal is to create a practical dietary plan for Chines…

This study is testing whether adding the allergy medicine desloratadine to standard ulcerative colitis treatment can better control inflammation and symptoms. About 44 adults with mild to moderate ulcerative colitis will take either desloratadine plus mesalamine or mesalamine alo…

This study follows 500 people with ulcerative colitis who have already tried at least two advanced medications without success. Participants choose either to continue trying different medications or to have their colon removed (colectomy). Researchers will compare quality of life…

This study tests whether adding a special diet called the Crohn's Disease Exclusion Diet (CDED) to standard anti-TNF therapy can improve outcomes for people with active Crohn's disease or ulcerative colitis. Eighty adults starting anti-TNF drugs will be randomly assigned to eithe…

This study tests whether removing a larger portion of the mesentery (the tissue that connects the intestine to the abdominal wall) during surgery for Crohn's disease can reduce the chance of the disease coming back. 204 adults with Crohn's disease limited to the ileocecal area wi…

This study tests whether treating Crohn's disease with a goal of healing the entire gut wall (seen on ultrasound) leads to better results than treating based on symptoms and blood tests alone. About 304 adults with moderate to severe Crohn's will be split into two groups and foll…

This study tracks 50 children and adults with non-malignant disorders like immune deficiencies and anemias who receive a stem cell transplant after a reduced-intensity chemotherapy regimen. The goal is to see if this approach improves survival and reduces severe graft-versus-host…

This study looks at whether removing certain food additives (like carrageenan and polysorbates) from the diet can improve symptoms and gut health in people with moderately active ulcerative colitis. About 70 participants will be randomly assigned to either a normal healthy diet o…

This study tests whether breathing pure oxygen in a pressurized chamber (hyperbaric oxygen therapy) can help people hospitalized with moderate to severe ulcerative colitis flares. The goal is to see if this treatment can stop symptoms like rectal bleeding and frequent stools, and…

This study is testing whether people with Crohn's disease or ulcerative colitis who are in deep remission can safely reduce their dose of the biologic drug ustekinumab. Participants will either switch from injections every 4 weeks to every 8 weeks, or from every 8 weeks to every …

This early study tests whether injecting stem cells from donated fat tissue can help heal complex anal fistulas in people with Crohn's disease who haven't gotten better with standard treatments. Nine adults will receive the stem cell injection and be followed for six months to ch…

This study tests whether taking vitamin D3 supplements can lower inflammation in people with moderate ulcerative colitis. Sixty adults aged 20-40 will either get standard care plus a placebo or standard care plus a high dose of vitamin D3 every two weeks for 12 weeks. Researchers…

This study tests whether high-dose chemotherapy followed by a stem cell transplant can help people with severe Crohn's disease that hasn't responded to other treatments. It includes up to 20 children and adults aged 10 to 60. The goal is to see if the approach is safe and can red…

This study is testing a less intense chemotherapy and radiation regimen before a stem cell transplant for children and young adults up to age 55 with non-cancerous blood disorders like immune deficiencies, anemias, and metabolic diseases. The goal is to see if this gentler prepar…

This study compares two treatment approaches for people newly diagnosed with moderate-to-severe ulcerative colitis (UC). One group gets early treatment with mirikizumab, a biologic drug, while the other starts with standard azathioprine pills and can switch to mirikizumab later i…

This pilot study is testing whether drinking 8 ounces of pomegranate juice daily for 8 weeks can reduce gut inflammation and improve quality of life in people with mild-to-moderate ulcerative colitis. Researchers will also look at how the juice affects gut bacteria. The study inv…

This study tests an experimental cell therapy called TRX103 for people with moderate to severe Crohn's disease that hasn't improved with standard treatments. About 39 adults will receive TRX103 along with a low dose of a chemotherapy drug to prepare the body. The main goal is to …

This study tests whether fecal microbiota transplants (FMT) given as capsules can safely improve symptoms in people newly diagnosed with rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, Crohn's disease, or ulcerative colitis. Two hundred participants will receiv…

This early trial tests whether a device that sends mild electrical pulses to the sacral nerve can safely help control symptoms of ulcerative colitis. The study will enroll 15 adults whose disease has not responded well to standard medications. Researchers will track changes in di…

This study will follow about 4,000 people who have received a fecal microbiota transplant (FMT) — a procedure that transfers gut bacteria from a healthy donor to restore balance in the gut. It aims to see how well FMT works over 3 months, 1 year, and 5 years for conditions like r…

This study follows 80 Chinese adults with moderate to severe ulcerative colitis who are already prescribed upadacitinib by their doctor. Researchers will collect routine medical data over one year to see if the drug improves symptoms like bloody diarrhea. No extra tests or visits…

This study is testing whether a smartphone app called SMART-IBD can help teenagers with inflammatory bowel disease (IBD) remember to take their medications and manage their symptoms. About 70 teens aged 13-17 will either use the full app with reminders and challenges or just a si…

This study follows 275 Crohn's disease patients in Japan who receive darvadstrocel, a stem cell injection, for complex anal fistulas. Researchers will monitor side effects and whether fistulas close over 36 months. The goal is to see if this treatment is safe and works in real-wo…

This study tests a new surgery for people with Crohn's disease in the last part of the small intestine. The surgery removes the diseased section and nearby fatty tissue, then reconnects the bowel in a special way (Kono-S anastomosis). The goal is to see if this lowers the chance …

This phase 2 trial tests whether rupatadine, an allergy medicine, can help control inflammation in people with mild-to-moderate ulcerative colitis. About 60 adults will take rupatadine or a standard treatment (mesalamine) for several weeks. The goal is to see if rupatadine reduce…

This study tests two treatments for people with repeat C. diff infections: a lab-made bacteria mix called MTC01 and a fecal transplant (FMT) from a healthy donor. Both are given during a colonoscopy. The goal is to see which is safer and better at stopping the infection from comi…

This phase 3 trial tests the drug vedolizumab in 408 adults in China with moderate-to-severe Crohn's disease. Participants receive IV infusions of vedolizumab or a placebo over several weeks. The goal is to see if vedolizumab can reduce symptoms like abdominal pain and diarrhea, …

This study tests whether adding diet advice and stress management sessions to standard advanced therapy helps people with Crohn's disease or ulcerative colitis reach remission. About 160 adults with active IBD will be split into four groups, each receiving different combinations …

This study tests whether adding vedolizumab (Entyvio) to a short course of steroids works better than standard steroids alone for colitis caused by immune checkpoint inhibitors. About 80 adults with grade 2-3 diarrhea will receive either vedolizumab plus a short steroid taper or …

This study tests a new drug, LB-P8, in 87 adults with primary sclerosing cholangitis (PSC), a rare liver disease. The goal is to see if LB-P8 is safe and can lower levels of alkaline phosphatase (ALP), a marker of liver damage. Participants will receive either LB-P8 or a placebo,…

This study tests a new oral drug called BRS201 in 20 adults with severe ulcerative colitis who have not improved with standard treatments. Participants take the drug twice daily for 4 weeks and attend 8 clinic visits for blood, stool, and urine tests. The goal is to see if BRS201…

This study is testing whether adding the antifungal drug fluconazole to standard IL-23 therapy helps people with mild to moderate Crohn's disease. About 120 adults will be randomly assigned to receive either fluconazole or a placebo alongside their usual treatment. The main goal …

This study tests whether a carefully designed diet can change the gut bacteria in people with active ulcerative colitis and reduce disease activity. Twenty adults with mild to moderate colitis will follow the diet and have their gut bacteria and inflammation levels measured. The …

This study is testing whether a remote monitoring app can help people with active inflammatory bowel disease (Crohn's or ulcerative colitis) spend more time in remission. About 290 adults whose disease is flaring will use the app to track symptoms and health data. The goal is to …

This study tests a new drug, BCD-261, in 198 adults with moderate to severe ulcerative colitis who haven't improved with standard treatments. Participants receive one of three doses of BCD-261 or a placebo as an injection. The goal is to see if the drug can reduce inflammation an…

This study tests whether budesonide extended-release tablets can safely help children aged 5 to 17 with mild to moderate ulcerative colitis achieve remission. About 70 participants will receive either a low dose, high dose, or placebo for 56 days. The goal is to reduce symptoms l…

This study tests a new drug called BCD-261 in 204 adults with moderate to severe active Crohn's disease who haven't improved with standard treatments. Participants receive either a low, medium, or high dose of BCD-261 or a placebo by injection. The goal is to see if the drug can …

This trial is developing an AI-powered device that listens to children's heart, breath, and bowel sounds to identify signs of common diseases like congenital heart disease, bronchopneumonia, and abdominal issues. It will involve 30,000 children aged 0-18, some with these conditio…

This study is testing whether two simple stool tests—fecal calprotectin and a fecal immunochemical test (FIT)—can predict early on if biologic therapy will help people with moderate-to-severe ulcerative colitis. Researchers will measure these markers at weeks 2 and 4 after starti…

This study explores whether measuring heart rate variability—the natural ups and downs in heartbeat timing—can help detect complications like leaks or abscesses after planned colorectal surgery. Researchers will monitor patients for a week after surgery and compare heart rate pat…

This study looks at 200 adults with inflammatory bowel disease (IBD) who are hospitalized due to worsening symptoms. Researchers want to see if testing blood or stool for CMV (a common virus) is as accurate as the standard method of testing a tissue sample from the colon. The goa…

This study is testing a new stool test that measures calprotectin, a protein that signals inflammation in the gut. The goal is to see if the test can help doctors diagnose Crohn's disease or ulcerative colitis and tell them apart from irritable bowel syndrome. About 220 adults wi…

This study compares a new imaging technique called Texture and Colour Enhancement Imaging (TXI) with standard white light during colonoscopy in 219 people with inflammatory bowel disease (IBD). The goal is to see if TXI finds more dysplastic (precancerous) lesions. Each patient w…

This study is developing an artificial intelligence system that analyzes CT and MRI scans to diagnose and predict outcomes for digestive diseases like Crohn's disease, ulcerative colitis, and intestinal tuberculosis. Researchers are using data from 21 hospitals in China to train …

This study is testing a device called the AlgometRx Nociometer to see if it can measure inflammation in children with inflammatory bowel disease (IBD). The device checks how different nerve fibers respond, which may give doctors a clearer picture of disease activity. Researchers …

This study is testing a special PET/MR scan that uses a radioactive tracer to detect scar tissue in the bowel of people with Crohn's disease. The goal is to see if the scan can tell the difference between scarred (fibrotic) strictures and inflamed ones, which would help doctors d…

This study will collect capsule endoscopy images from 10,000 patients to train an artificial intelligence system to detect bowel diseases, Crohn's disease, celiac disease, chronic diarrhea, and tumors. The goal is to improve diagnostic accuracy and reduce the time doctors spend r…

This early-phase study tests whether a special PET scan tracer, Ga68-FAPI-46, can detect early fibrosis (scarring) in the small bowel of people with Crohn's disease. About 45 participants will be divided into those with known strictures and those without, to compare scan results.…

This pilot study tests a new device called the Retro-TCE capsule, which is a small camera attached to a string that is inserted into the lower gut to take pictures without needing sedation. The study will enroll 30 people, including healthy volunteers and those with Lynch syndrom…

This study is testing whether a shorter, abbreviated MRI scan (called MRE) works just as well as the standard, longer scan for detecting inflammation and damage in the bowel of people with Crohn's disease. Researchers will enroll 300 children and adults who already need an MRE as…

This study tests a new drug called AZD5148 to see if it can prevent repeat C. diff infections in adults. About 230 people will get either the drug or a placebo as a single injection. The goal is to stop the infection from coming back after standard treatment.

This study tests EXL01, a single strain of a beneficial gut bacterium (Faecalibacterium prausnitzii), to see if it can prevent repeat Clostridioides difficile infections in people at high risk. About 56 adults who have had at least two C. diff episodes will take EXL01 or a placeb…

This study tests whether a specific diet can change gut bacteria and help prevent another C. difficile infection in adults who have had one. Twenty participants will receive prepared meals and health counseling, then follow a similar diet for 6 more weeks. Researchers will track …

This study tests whether Aquamin, a natural mineral supplement from seaweed, can prevent pouchitis—a painful inflammation of the J-pouch—in people with ulcerative colitis who have had their colon removed. About 52 participants will take Aquamin or a placebo for up to 8 months. Th…

This phase 3 trial tests whether a gradual taper of vancomycin is as good as a 10-day course of fidaxomicin at preventing another C. difficile infection. About 500 adults with a first or second C. diff episode will be randomly assigned to one of the two treatments. The main goal …

This study tests whether the drug etrasimod can prevent pouchitis, a common inflammation of the internal pouch created after colon removal surgery. Researchers will give either etrasimod or a placebo to 40 high-risk patients for 48 weeks and track how many develop pouchitis. The …

This study tests whether starting biologic drugs only after seeing signs of Crohn's disease on a colonoscopy is as good as starting them right after surgery to prevent the disease from coming back. About 292 adults with Crohn's who had bowel surgery will be randomly assigned to o…

This trial tests a prevention bundle for hospital patients who carry C. difficile bacteria but have no symptoms. The bundle includes enhanced room cleaning and special precautions. Researchers hope to prevent these carriers from developing active infections and spreading the bact…

This study is testing a web-based tool that estimates a person's risk of developing Crohn's disease based on their lifestyle and family history. Researchers will enroll 80 healthy people who have a parent or sibling with inflammatory bowel disease. Participants will receive perso…

This study tests whether giving a daily dose of oral vancomycin can prevent Clostridioides difficile (C. diff) infection in critically ill adults who are already on other antibiotics in the hospital. About 176 high-risk patients will receive either vancomycin or a placebo while t…

This study tests an oral drug called EXL01 to see if it can prevent Crohn's disease from coming back after bowel surgery. About 80 adults who recently had surgery for Crohn's will receive either EXL01 or a placebo for up to 24 weeks. Doctors will use a camera to check the bowel f…

This study tests whether a special chair that delivers high-intensity electromagnetic stimulation can improve bowel leakage (fecal incontinence) and quality of life in people who have a J-pouch after surgery for ulcerative colitis. Participants will sit on the Emsella chair for 2…

This phase 2 trial tests whether a dietary supplement called tributyrin can reduce rectal bleeding in people who developed chronic radiation proctitis after pelvic radiotherapy. Participants take the supplement orally for 12 weeks, and researchers will measure changes in bleeding…

This study tests a small device placed under the skin near the tailbone that sends mild signals to a nerve, aiming to reduce sudden bowel urgency in people with ulcerative colitis. About 137 adults with the condition will take part. The device is implanted in a same-day procedure…

This phase 4 trial tests whether taking a 2 mg prolonged-release melatonin tablet before bed can improve sleep quality in adults with inflammatory bowel disease (Crohn's disease or ulcerative colitis) whose disease is in remission. Participants must have poor sleep (PSQI score >5…

This study tests whether a low dose of Interleukin-2 (IL-2) can safely reduce symptoms in people with moderate-to-severe Crohn's disease. About 30 participants aged 12 to 80 will receive the drug to find the best dose that works with the fewest side effects. The goal is to improv…

This study tests whether virtual reality (VR)-guided brain-gut behavioral therapy can help manage pain in hospitalized adults with inflammatory bowel disease (IBD). Researchers want to see if the approach is practical and acceptable to patients. About 40 participants will try the…

This pilot study will test a 24-week digital self-management program designed to help people with inflammatory bowel disease (IBD) manage their symptoms and build long-term healthy habits. The program is accessed via web or mobile device and is used alongside standard care. The s…

This study tests whether duloxetine, a medication that affects brain signals, can reduce disability and psychological distress in adults with inflammatory bowel disease (IBD). About 32 participants will take duloxetine for a period, and researchers will measure changes in anxiety…

This study tests whether combining repetitive transcranial magnetic stimulation (rTMS) with an anti-inflammatory diet can reduce constipation and improve quality of life in people with Crohn's disease. Fifty patients aged 40-60 will be split into two groups: one gets both rTMS an…

This study tests whether morning bright light therapy can help people with Crohn's disease or ulcerative colitis by reducing gut leaks and inflammation. About 30 adults with stable medication will use a light box each morning for 8 weeks. Researchers will check changes in gut bar…

Many people with Crohn's disease still have belly pain, bloating, or irregular bowel habits even when their disease is not active. This study tests whether a low dose of amitriptyline, a medication already used for irritable bowel syndrome, can safely reduce those symptoms. One h…

This study tests whether a pre-packaged low-residue diet (Maifu Changqing®) helps people with inflammatory bowel disease (IBD) prepare for colonoscopy more comfortably and effectively. About 500 adults with IBD will be enrolled across multiple hospitals in China. The goal is to s…

This study tests whether a pre-packaged low-residue nutrition formula (Maifu Changqing®) can improve bowel cleanliness and comfort during colonoscopy preparation for 1,000 adults with inflammatory bowel disease (IBD). Participants will be randomly assigned to receive either the s…

This pilot study tests whether the MyIBDDiet app helps people with inflammatory bowel disease (IBD) learn about and follow an anti-inflammatory diet. Forty adults with IBD who are not in a flare will use the app for 30 to 60 days and complete surveys about its ease of use and the…

This study tests whether a special online therapy for insomnia, adapted for people with ulcerative colitis (UC), is helpful and practical. About 20 adults with active UC and insomnia will take part. They will complete online questionnaires, keep a daily sleep diary, and attend 5 …

This study tests a smartphone app called COBMINDEX that teaches stress-reduction techniques to people with Crohn's disease. Researchers want to see if using the app improves wellbeing, fatigue, and pain as much as working with a human therapist. The trial will enroll 200 adults w…

This study tests whether a ketogenic (low-carb, high-fat) or carnivore (all meat) diet can improve quality of life and reduce symptoms in adults with inflammatory bowel disease (Crohn's or ulcerative colitis) or rheumatoid arthritis. Participants are randomly assigned to one of t…

This study tests if pentoxifylline, a drug already used for other conditions, can safely reduce symptoms of mild to moderate ulcerative colitis. About 60 adults will take the drug and be monitored for changes in bowel symptoms and quality of life. The goal is to see if this offer…

This study looks at whether people with certain cancers prefer getting their immune therapy as a shot under the skin (subcutaneous) or through a needle in a vein (intravenous). About 880 adults who are already eligible for standard treatments like nivolumab or pembrolizumab will …

This early-stage study tests a new drug called KAN-004 in 21 adults who have diarrhea or colon inflammation from cancer immunotherapy. The main goal is to see if the drug is safe and tolerable. Participants must have a solid tumor and be at least 18 years old.

This study tests a virtual group program that teaches teens with inflammatory bowel disease (IBD) coping skills and heart rate biofeedback to reduce stress, anxiety, and depression. About 128 participants aged 13–18 will be randomly assigned to the program or a waitlist. The goal…

This study tests whether one hour of morning light therapy each day for four weeks can improve sleep quality and reduce inflammation in adults with ulcerative colitis who have active inflammation and poor sleep. Thirty participants will wear a sleep tracker, complete surveys, and…

This study tests whether a special 5-day diet that mimics fasting can lower inflammation and improve quality of life in people with mild to moderate ulcerative colitis. Participants will follow the diet for three cycles while researchers track symptom changes. The goal is to see …

This study tests whether adding fermented foods like kimchi, sauerkraut, yogurt, and kefir to the diet can reduce inflammation and improve quality of life in people with mild to moderate ulcerative colitis. Researchers will measure changes in a stool marker of inflammation and tr…

This study tests whether far-infrared (fIR) light therapy is safe and can ease symptoms in people with Crohn's disease. Forty participants will receive 10 weekly sessions of fIR at different intensities or a sham treatment. Researchers will monitor side effects, symptom scores, a…

This study tests whether using virtual reality (VR) can safely reduce abdominal pain in people with Crohn's disease who are not currently experiencing active inflammation. Researchers at Mayo Clinic will enroll 15 participants to see if VR improves pain and quality of life over 1…

This study looks at whether a single educational session about the benefits of exercise can help people with Crohn's disease or ulcerative colitis (IBD) become more physically active. The goal is to reduce fatigue, improve digestion, and enhance quality of life. About 71 adults w…

This study looks at whether people with moderate-to-severe inflammatory bowel disease (IBD) need to take a steroid (dexamethasone) before each infliximab infusion to prevent allergic reactions. Researchers will compare those who get the steroid routinely with those who only get i…

This study looks at whether a low sulfur diet can reduce ongoing symptoms like belly pain and diarrhea in people whose Crohn's disease is otherwise quiet. Twenty adults with Crohn's in remission will either follow a low sulfur diet or their usual diet for 8 weeks. Participants wo…

This study tests a proprietary amino acid drink given twice daily for up to 4 days to older adults (60+) hospitalized with infections who have delirium. 20 participants get the drink, 20 get standard care, and 20 non-delirious controls are observed. The goal is to see if the drin…

This study tests whether a 12-week personalized aerobic exercise program, done at home with telemedicine guidance, can improve fitness, disease control, and quality of life in adults with inactive or mildly active inflammatory bowel disease (IBD). Twenty-eight participants will e…

This study tests whether fecal microbiota transplantation (FMT) capsules can help people with diarrhea and colitis caused by immune checkpoint inhibitor cancer treatment. About 20 adults with melanoma or kidney cancer will receive either FMT or placebo capsules alongside their st…

This study looks at whether a 12-week remote exercise program can improve quality of life for people with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. About 72 adults with IBD will use a smartphone app to follow guided physical activities at…

This study aims to understand what causes primary sclerosing cholangitis (PSC), a rare chronic liver disease. About 143 adults with PSC will provide blood, saliva, urine, stool, and tissue samples, plus undergo imaging and procedures like colonoscopy and liver biopsy. No treatmen…

This study is testing whether a blood test measuring a protein called LRG can tell if the gut lining has healed in people with ulcerative colitis. Researchers will compare blood LRG levels with colonoscopy and tissue samples in 100 patients. If the blood test works, it could offe…

This study is building a registry of medical information from people with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. The goal is to use this data to better understand how IBD develops and progresses, which could help improve future treatme…

This study aims to create a large library of recorded endoscopy procedures from adults undergoing upper or lower gastrointestinal exams. The goal is to use these videos to develop and validate artificial intelligence tools that can automatically detect and report quality metrics,…

This study follows pregnant women with inflammatory bowel disease (IBD) and their children for up to four years after birth. Researchers want to see whether the mother's disease activity or use of immunosuppressant or biologic medications affects pregnancy outcomes or the child's…

This study is a pregnancy registry that gathers information from women with chronic neurological conditions like multiple sclerosis, NMOSD, and myasthenia gravis who are planning pregnancy, currently pregnant, or within one year postpartum. Participants can contribute blood, brea…

This study follows 1,500 children newly diagnosed with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, to understand why some respond well to treatments while others develop complications. Researchers will collect medical data and biological sa…

This study aims to learn how the immune system controls inflammation in the gut for people with Crohn's disease or ulcerative colitis. Up to 1,000 participants aged 0 to 75 will receive standard medical care and may provide blood, tissue, or white blood cell samples. No experimen…

This study aims to learn more about Hermansky-Pudlak Syndrome (HPS), a rare inherited disease that causes light skin/eye color, bleeding problems, and often deadly lung scarring. Researchers will follow 600 people with HPS and their family members to track how the disease progres…

This study looks at whether an Enhanced Recovery After Surgery (ERAS) protocol helps people recover better after colorectal surgery. The protocol includes non-narcotic pain control, careful fluid management, early eating and walking, and early removal of drains. Researchers will …

This study surveys 400 adults with inflammatory bowel disease (IBD) from two medical centers to understand how social factors like insurance, income, and support affect medication adherence and quality of life. Researchers focus on Hispanic and Black patients, who often have wors…

This study tests the safety and tolerability of a new drug called XmAb412, a monoclonal bispecific antibody, in healthy adults aged 18 to 55. Participants receive either the drug or a placebo, and researchers monitor for side effects and how the drug moves through the body. The g…

This study looks at the long-term safety of the drug ustekinumab compared to other biologic treatments in adults with Crohn's disease or ulcerative colitis. Researchers will use health records from the Department of Defense to track rates of cancer, serious infections, and other …

This study looks at how eating salt affects gut health in people with Crohn's disease. Researchers will track salt intake and measure gut inflammation in 300 participants. The goal is to understand if a high-salt diet worsens symptoms and to improve dietary advice for managing th…

This study looks at whether an MRI without a bowel-distending drink (like PEG or mannitol) can still accurately measure inflammation in the small bowel of people with Crohn's disease. Many patients find these drinks hard to tolerate, causing vomiting or diarrhea. If skipping the …

This study aims to develop a risk score for Crohn's disease by following 10,000 first-degree relatives (parents, siblings, or children) of people with Crohn's. Participants aged 16 to 35 will give blood and stool samples and answer lifestyle questionnaires every six months. The g…

This study is testing whether changes in two stool markers — a fecal immunochemical test (qFIT) and calprotectin (FC) — measured two weeks after starting standard therapy can predict whether people with ulcerative colitis will relapse or need stronger medication within a year. Re…

This early-phase study is testing whether afimkibart, an experimental drug for ulcerative colitis, changes how the body processes common medications like caffeine, warfarin, and omeprazole. About 25 people with moderate to severe active ulcerative colitis will receive afimkibart …

This study screens children and adolescents aged 5 to 18 who have chronic conditions like congenital heart disease, inflammatory bowel disease, celiac disease, or rheumatic diseases for lipid metabolism disorders. Participants provide a blood sample and complete a questionnaire a…

This study tests whether a new laboratory method—staining for a protein called claudin 2—can more accurately measure healing in the gut of people with ulcerative colitis or Crohn's disease. Researchers will compare this method with standard scoring systems and track whether it pr…

This study looks at whether teaching children and teens with inflammatory bowel disease (IBD) about ultra-processed foods (like packaged snacks and sugary drinks) can help them eat less of them. About 120 participants will complete online food diaries and receive either nutrition…

This study looks at how the bacteria in your gut might cause stomach issues like diarrhea and colitis when you take certain cancer drugs called immune checkpoint inhibitors. Researchers will collect stool, blood, and tissue samples from 800 people with melanoma, lung cancer, or g…

This pilot study is testing how well two common pain relievers—acetaminophen (Tylenol) and ibuprofen (Advil)—work for period cramps in women with Crohn's disease. Twenty-four women will take each drug for two menstrual cycles and report their symptoms. The main goal is to see if …

This observational study compares inflammatory markers in the blood and tissue of people with active Crohn's disease or ulcerative colitis versus healthy volunteers. Researchers aim to identify differences in the IL-23/Th17 inflammatory pathway and other immune signals. The study…

This observational study is collecting blood, stool, and tissue samples from 6,000 people with inflammatory bowel disease (Crohn's disease or ulcerative colitis), along with their relatives and healthy volunteers. Researchers aim to identify biomarkers that can assess intestinal …

This study uses health insurance claims data from Korea to count how many children under 18 have Crohn's disease or ulcerative colitis, and how their treatment changes as they grow. Researchers will look at patterns of medication use, hospital visits, and costs over several years…

This study looks at how children with Crohn's disease or ulcerative colitis burn energy at rest. Researchers will measure resting energy expenditure using a special breathing test and compare it to standard formulas. The goal is to see if energy use is linked to disease activity …

This study is checking how common chronic kidney disease is in children with inflammatory bowel disease (IBD), like Crohn's disease or ulcerative colitis. Researchers will look at medical records from 600 children with IBD and compare them to children without IBD. The goal is to …

This study uses a homemade device with electrodes placed on the belly to record electrical signals from the stomach and intestines. Researchers will compare these signals in healthy volunteers, people with Crohn's disease (with or without fibrosis), and people with functional gas…

This study looks at bile acid profiles in children with ulcerative colitis (UC) who also have a C. difficile infection. Researchers want to see if changes in bile acids and gut bacteria make these children more vulnerable. They will compare three groups: children with UC flare-up…

This study collects small tissue samples (biopsies) from people undergoing routine endoscopy and grows them into mini-organs called organoids in the lab. These organoids mimic the real intestine and help researchers understand diseases like Crohn's and ulcerative colitis. The goa…

This study compares the gut microbiome—bacteria, fungi, and viruses—in people with Crohn's disease, with or without arthritis, and healthy controls. Researchers aim to find microbial biomarkers linked to arthritis in Crohn's patients. No treatment is given; it is purely observati…

This study follows about 1,182 pregnant women with ulcerative colitis who are taking or have taken ozanimod. Researchers will watch for any health problems in the mothers and their babies, such as birth defects or pregnancy complications. The goal is to learn whether the drug is …

This study investigates whether advanced treatments for Crohn's disease also improve sleep quality. Adults with active Crohn's who are about to start a new advanced therapy will wear a Fitbit Inspire 3 for five days at three different times: before treatment, at week 4, and at we…

This study looks at proteins and bacteria in the gut of people with Crohn's disease compared to healthy individuals. Researchers will analyze samples from colonoscopies to understand what goes wrong in Crohn's. The goal is to find new ways to diagnose and treat the disease. 40 ad…

This study is looking for genetic clues that might predict how well people with inflammatory bowel disease (IBD) will respond to a common treatment called anti-TNF therapy. Researchers will collect blood samples from 40 patients who have not used anti-TNF before and track their r…

This study follows 1,000 adults who have long-term bladder or bowel problems from past cancer radiation and are receiving hyperbaric oxygen therapy (HBOT). Researchers want to learn which patients improve most and when treatment works best. The goal is to better understand how to…

This study tests whether a simple blood test that reads epigenetic markers can help doctors pick the best biologic drug (ustekinumab or vedolizumab) for adults with active Crohn's disease. 378 participants will be randomly assigned to either have their treatment guided by this te…

This study looks at whether a protein in the blood called LRG can accurately show how active Crohn's disease or ulcerative colitis is in the gut. Researchers will compare LRG levels with standard endoscopic and symptom scores in 100 European adults. If successful, LRG could becom…

This study is tracking over 25,000 people with inflammatory bowel disease (IBD) to understand why many continue to have abdominal pain even when their disease is in remission. Researchers will use questionnaires, blood and stool samples, heart rate recordings, and genetic data to…

This study is testing an educational tool designed for people with melanoma who also have an autoimmune disease and are considering treatment with immune checkpoint inhibitors. Researchers want to see if the tool is easy to use and helpful for both patients and healthcare provide…

This study will compare kidney function in 3,000 adults with Crohn's disease or ulcerative colitis to 3,000 adults without these conditions. Participants will provide blood and urine samples and have a kidney ultrasound. The goal is to learn how common kidney problems are in IBD …

This study involves 1,000 adults with inflammatory bowel disease (IBD) who need a colonoscopy. Researchers want to see how well current bowel preparation methods work and what factors lead to poor preparation. The goal is to create a tool that predicts which patients might have t…

This study looks at how much energy, water, and waste are used during different types of bowel imaging tests for people with ulcerative colitis or Crohn's disease. The goal is to see if a simple, non-invasive ultrasound can be a greener alternative to colonoscopy and CT scans. Ab…

This study follows 153 people aged 60 and older with inflammatory bowel disease (IBD) to see how disease activity affects frailty. Researchers will also check whether frailty raises the risk of hospitalization or death. Participants will have their frailty, IBD symptoms, and over…

This study looks at how the gut and kidneys work together in people with enteric hyperoxaluria, a condition that raises the risk of kidney stones. Researchers will give participants a high-oxalate diet (like spinach) and measure oxalate levels in urine and stool. The goal is to u…

This study tests whether drinking 1.5 liters of water before an MRI scan can give doctors clear images of the small bowel in people with Crohn's disease, compared to the standard polyethylene glycol (PEG) prep. About 194 participants will be randomly assigned to water or PEG, and…

This early-phase study tests the safety of a new drug called SPH7854 in 111 healthy adults. Participants receive either the drug or a placebo, and researchers monitor side effects and how the drug moves through the body. The goal is to see if it is safe enough to test in people w…

This study aims to identify biological markers that can predict how patients with inflammatory bowel disease (IBD) will respond to a type of medication called TNF-alpha inhibitors. Researchers will collect blood and tissue samples from 100 adults, including healthy controls and I…

This study follows 575 Crohn's disease patients who have had ileocecal resection surgery. Researchers collect blood, tissue, and microbiome samples to classify the disease and identify factors that predict recurrence. The goal is to improve prevention and treatment strategies for…

This study collects tissue, blood, and stool samples from 200 children with inflammatory bowel disease (IBD) or other gut disorders. Researchers will use a cutting-edge technique called spatial transcriptomics to map gene activity directly inside gut tissue. The goal is to better…

This study follows 420 adults with Crohn's disease who are in deep remission to see if a non-invasive intestinal ultrasound can predict when symptoms will return. Participants get regular ultrasounds over 18 months, and researchers compare those who relapse to those who don't. Th…

This study follows 450 adults who have early signs of inflammatory bowel disease (Crohn's or ulcerative colitis) found during routine colon cancer screening, but who have no symptoms yet. Researchers will collect blood, stool, and tissue samples over time to see how the disease p…

This early-stage study tests a new drug called PVT401 in 36 healthy volunteers to see if it is safe and how the body handles it. Participants receive either the drug or a placebo by IV, either as a single dose or multiple doses over five weeks. The goal is to gather safety data b…

This study looks at how chronic perianal conditions like fistulas and abscesses impact a person's sexual health and body image—something often overlooked by doctors. Researchers will survey 60 adults using questionnaires to measure these effects and identify gaps in communication…

This study looks at whether repeated sessions of hyperbaric oxygen therapy (HBOT) can damage DNA in people who have had radiation for cancer. HBOT is used to help heal tissues damaged by radiation, but it also creates reactive oxygen molecules that might harm DNA. Researchers wil…

This study looks at whether people with ulcerative colitis (UC) who are in deep remission (no signs of inflammation) can safely reduce or stop their medication. Researchers will compare two groups: those who continue their current therapy and those who decrease or stop it. The go…

This study looks at how the bacteria and diet of pregnant women with inflammatory bowel disease (IBD) may influence gut inflammation in their babies. Researchers will collect samples from 80 mothers and infants over a year to track gut microbes and diet. The goal is to find patte…

This study observes how doctors use a treat-to-target strategy for people with Crohn's disease or ulcerative colitis in routine care. Researchers will review medical records of 2000 adults over 24 months to see if adjusting treatment based on disease activity improves outcomes. N…

This study tracks how fecal microbiota transplantation (FMT) alters the gut microbiome in 20 adults with recurrent Clostridioides difficile infection. Researchers will analyze stool samples before and up to 90 days after FMT to see which bacteria take hold. The goal is to underst…

This study aims to collect blood samples and medical data from 3000 people with autoimmune diseases like lupus, scleroderma, and myositis. Researchers will use these samples to find new biomarkers and better understand these conditions. The goal is to help develop new treatments …

This study is creating a registry of 500 patients with eosinophilic gastrointestinal disorders (EGIDs), including eosinophilic esophagitis, gastroenteritis, and colitis. Researchers will collect questionnaires, endoscopy images, biopsy samples, and physical exam findings to learn…

This study looks at how gut bacteria change the energy use of immune cells in people with inflammatory bowel disease (IBD) and healthy adults. Researchers will give healthy volunteers a short course of antibiotics to alter their gut bacteria, then measure immune cell metabolism u…

This study looks at whether measuring infliximab levels in saliva is as good as measuring it in blood for children with inflammatory bowel disease (IBD). Fifteen children starting infliximab will provide saliva and blood samples during routine visits. The goal is purely to gather…

This study is testing whether giving the COVID-19 booster and flu vaccine at the same time is as good as giving them a month apart for people with weakened immune systems. It also compares getting a COVID-19 booster every 3 months versus every 6 months. The trial involves 660 adu…

This study collects DNA from 1200 patients receiving routine care at the University of Chicago. Researchers look for genetic differences that might affect how well a drug works or how likely it is to cause side effects. The goal is to see if giving this genetic information to doc…

This study follows 100 hospitalized patients with Clostridioides difficile infection to track how quickly the bacteria clears from the gut during and after standard antibiotic treatment. Researchers will also analyze gut bacteria and immune responses in stool samples to identify …

This study is testing whether a simple ultrasound can accurately measure muscle loss in people with inflammatory bowel disease (Crohn's or colitis). Currently, doctors use CT scans to check for muscle wasting, but CT involves radiation and is not always available. Researchers wil…

This early-phase study at Stanford University is testing whether the statin drug rosuvastatin changes bile acid levels and gut bacteria in people with primary sclerosing cholangitis (PSC), a liver disease with no cure. Researchers will enroll 15 adults with PSC and inflammatory b…

This study looks at how nutrition and body composition (like muscle and fat) impact the health of people with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. Researchers will follow 300 participants starting new medical treatments or having sur…

This study looks at whether removing a urinary catheter one day after colorectal surgery is as safe as the standard three days. About 176 adults having certain pelvic surgeries will be randomly assigned to early or standard removal. The goal is to see if shorter use lowers infect…

This study follows 945 women with Crohn's disease or ulcerative colitis to see how pregnancy affects their condition. Researchers will track disease flares during pregnancy, after childbirth, and during breastfeeding. The goal is to better understand the link between IBD and preg…

This study is testing whether two dietary supplements, Goodphyte IB Defense and Goodphyte Immunity, are acceptable and easy for adults with chronic diseases like IBD, hypertension, anemia, or multiple sclerosis to take. Researchers will also check if the supplements improve how w…

This study interviews 60 children aged 10-17 with inflammatory bowel disease (Crohn's or colitis) to learn what makes it easier or harder for them to be physically active. Participants fill out two questionnaires and talk one-on-one with a researcher. No treatment or exercise pro…

This study will follow 150 people with radiation rectal injury to see if different subtypes of the condition lead to different outcomes. Researchers will collect medical records, endoscopy images, and test results but will not change any treatments. The goal is to fill gaps in kn…

This study watches 200 adults with C. diff infection to see how standard antibiotics and fecal microbiota transplantation (FMT) help people recover. Researchers will collect stool, blood, and urine samples over up to 5 years to understand why some treatments succeed and others fa…

This early-stage study is testing an experimental drug called HW201877 in 104 healthy adults to see if it is safe and how the body processes it. The drug is being developed for inflammatory bowel disease (IBD), but this trial does not involve people with IBD. Participants will re…

This study aims to find new markers in the blood that can detect an imbalance of gut bacteria linked to inflammatory bowel disease (IBD). Researchers will compare 60 people with IBD and 60 people without IBD by collecting stool, blood, and tissue samples. The goal is to develop a…

This study aims to create a standardized quality system for confocal enteroscopy, a technique that lets doctors see cells in real time during a small bowel exam. Researchers will enroll 600 people aged 18-70 who need small bowel endoscopy, along with certified gastroenterologists…

This study looks at 40 newborns with isolated rectal bleeding to see how many have a cow's milk protein allergy versus a temporary condition called transient neonatal colitis. By removing and then reintroducing cow's milk from the diet, doctors can confirm an allergy if bleeding …

This study looks at gut bacteria and related chemicals in 120 adults to understand why inflammatory bowel disease (IBD) and depression often occur together. Researchers will compare people with both conditions, those with IBD only, and healthy volunteers. The goal is to find uniq…

This study tracks 1,400 adults with Crohn's disease across multiple hospitals in China to understand how common hard-to-treat cases are and how well current treatments work. Researchers will compare patients who respond poorly to therapy with those who do better, and look for fac…

This study looks at whether the unique mix of bacteria and fungi in the gut can predict how well Crohn's disease patients will respond to treatment. Researchers will collect stool, blood, and tissue samples from 100 adults during routine colonoscopies and track their health for a…

This study tests a new 3D visualization tool called vEUA that helps surgeons see fistulas more clearly before operating on people with perianal Crohn's disease. About 30 adults who need surgery for fistulas or abscesses will be randomly assigned to standard care or care with the …

This study is a national registry that will follow up to 4,000 people who receive a fecal microbiota transplant (FMT) for C. diff infection or other gut conditions. Researchers will track side effects, infections, and whether the disease comes back. The goal is to better understa…

This research study collects health information from 10,000 people with brain inflammation conditions like Long COVID, ME/CFS, and autoimmune diseases. Participants use a smartphone app to share symptoms, health history, and wearable data. The goal is to find disease subtypes and…

This study from Aarhus University is looking at how common magnesium deficiency is in people with Crohn's disease, ulcerative colitis, ileostomy, or bile acid diarrhea. Magnesium is important for muscles, nerves, and heart health, but standard blood tests may miss a deficiency. T…

This study is creating a large database to collect information on people with rare diseases like amyloidosis, sarcoidosis, and Gaucher disease. Researchers will track patients' health over time, including their symptoms, treatments, and outcomes. The goal is to improve diagnosis …

This study explores whether ultrasound and elastography can detect fibrosis (scarring) in the gut of people with ulcerative colitis. Researchers will compare ultrasound images with tissue samples from biopsies to find new biomarkers. The goal is to develop a non-invasive method t…

This study is a large registry that will follow 10,000 people with inflammatory bowel disease (IBD) in Germany over many years. Its goal is to collect real-world information on how well treatments work, how the disease changes over time, and how it affects patients' daily lives. …

The PLANET study is looking at whether tiny plastic particles in our environment can trigger gut inflammation and raise the risk of inflammatory bowel disease (IBD). Researchers will measure microplastics in stool samples from pregnant women, their healthy relatives, and people w…

This study looks at how common exocrine pancreatic insufficiency (EPI) is in people with active Crohn's disease who are starting a biologic therapy. EPI means the pancreas doesn't make enough enzymes to digest food properly. Researchers will check for EPI at the start of treatmen…

This study explores how traditional Chinese medicine tools, such as tongue and pulse diagnosis, can help identify unique features of inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. Researchers will compare 30 people with IBD to 30 healthy volun…

This study looks at how sleep problems affect people with ulcerative colitis, a type of inflammatory bowel disease. Researchers will study 152 participants to see how sleep quality relates to gut bacteria, nerve function, and disease activity. The goal is to understand the connec…

This study looks at a common problem after bowel surgery called postoperative ileus, where the bowel temporarily stops working. The researchers want to test a scoring system called IFEED to see if it can better define this condition and predict how long patients stay in the hospi…

This study looks at how natural cannabis compounds (phytocannabinoids) affect immune cells from 100 people with chronic inflammatory diseases like rheumatoid arthritis, lupus, and Crohn's disease. Researchers will take a blood sample and expose the cells to different cannabis ext…

This study looks at whether a toxin called deoxynivalenol (DON), found in grains, might be a risk factor for inflammatory bowel disease (IBD). Researchers will measure DON levels in 100 people—some with Crohn's disease and others without IBD—to see how the body processes it. The …

This study is testing whether robotic surgery is a practical option for people with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. Researchers will compare robotic surgery to standard laparoscopic surgery in 100 adults to see which approach wo…

This study looks at 120 people with various immune deficiencies to see if a chronic gut virus infection is tied to liver or digestive problems. Researchers will collect blood, stool, urine, and biopsy samples to screen for enteric viruses. The goal is to identify which patients a…

This study looks at how well the drug guselkumab works in adults with Crohn's disease. Researchers will use intestinal ultrasound and blood tests to measure response over one year. The goal is to find better ways to track treatment success without invasive procedures. About 90 pa…

This study collects tissue and blood samples from 300 people with autoimmune diseases like Crohn's, multiple sclerosis, and celiac disease. Researchers aim to identify the specific targets of immune cells (T cells) that cause inflammation. The goal is to discover new targets for …

This study follows 216 adults with inflammatory bowel disease (IBD) who are in remission. They wear a wrist monitor and fill out sleep questionnaires for one year to see if changes in sleep quality can predict when a flare-up will happen. The goal is to find early warning signs o…

This study looks at how immune cells and inflammatory molecules differ in people with migraine, especially those who also have autoimmune diseases like multiple sclerosis, rheumatoid arthritis, or endometriosis. Researchers will compare blood samples from 396 women to measure reg…

This study compares two types of minimally invasive surgery—robotic and laparoscopic—for people with inflammatory bowel disease (IBD) who need colorectal surgery. Researchers want to see which approach leads to fewer complications, less pain, and faster recovery. About 110 adults…

This study involves about 50 adults with Crohn's disease who have a permanent ileostomy (a surgically created opening in the belly to pass waste). The goal is to create new tools—a patient questionnaire and an endoscopic scoring system—to accurately measure disease activity in th…

This study uses MRI scans to look at bone marrow fat in teenagers newly diagnosed with Crohn's disease, comparing them to healthy teens. The goal is to understand if Crohn's affects bone health early on. Researchers will also measure bone density using other imaging methods. The …

This study is testing a new device called a wireless thermal capsule, which is swallowed and measures temperature as it travels through the digestive tract. The goal is to see if it can reliably detect small temperature changes that might indicate inflammation from diseases like …

This study is for adults in South Korea with ulcerative colitis or Crohn's disease who are already taking vedolizumab injections. Researchers will look at medical records to track side effects and how well the treatment works. No new medicine or treatment is given—this is just an…

This study aims to understand why Crohn's disease often returns after surgery by examining specific immune cells that respond to a protein called IL-23. Researchers will collect tissue samples from 40 patients with Crohn's disease during routine colonoscopies, before and after 12…

This study looks at whether microplastics are found more often in children with inflammatory bowel disease (IBD) compared to healthy children. Researchers will collect samples of tissue, blood, urine, and stool from 40 children during routine endoscopy. No treatment is given—the …

This observational study will follow 1,000 pregnant women with inflammatory bowel disease (IBD) who are taking newer medications (non-anti-TNF biologics or targeted small molecules). Researchers will track serious infections and other adverse events in mothers and their children …

This study is a large registry that will collect information from over 4,000 people with Crohn's disease or ulcerative colitis in Argentina. Doctors will record details about patients' diagnosis, treatments, and any safety issues like infections. The goal is to better understand …

This study tests a new imaging method using a special dye (FAPI) to detect bowel scarring in people with Crohn's disease. Scarring affects up to half of patients and often leads to surgery, but current tests can't spot it early. The study will involve 30 adults starting biologic …

This study is collecting health data, voice recordings, and biological samples from 100 IBD patients in Luxembourg (part of a larger 800-person study across Europe). Researchers hope to find patterns that can predict when a patient's treatment needs to change. The goal is to use …

Inflammatory bowel disease (IBD) is a lifelong condition with no cure. Biologic drugs are a first-line treatment, but they fail in 30-50% of patients. This study will collect data from 200 IBD patients to build a predictive model using clinical features and machine learning. The …

This study is looking at why the immune system attacks the gut in people with celiac disease and other immune-related gut disorders. Researchers will collect blood and tissue samples from 200 adults to study immune cells and genes. The goal is to better understand what goes wrong…

This study is looking at people with eosinophilic gastrointestinal disorders, which cause inflammation in the gut. Researchers want to see if simple questionnaires can tell how well a patient is doing, compared to looking at tissue samples from endoscopies. The goal is to find be…

This study aims to find out how often men with inflammatory bowel disease (IBD) have HPV infection in their mouth and anal area. Researchers will collect swab samples from 384 men with Crohn's disease or ulcerative colitis and test for HPV and abnormal cell changes. The goal is t…

This study follows 48 adults with active Crohn's disease or ulcerative colitis who are starting biologic or JAK inhibitor therapy. Researchers use a quick, painless bioelectrical impedance scan to measure muscle mass and other body composition changes at the start, 24 weeks, and …

This study is collecting blood, urine, and stool samples from 500 children with autoimmune diseases and healthy controls. Researchers will analyze these samples to find molecular patterns that could help diagnose these conditions and guide treatment decisions. The goal is to crea…