New pill vs. infusion: which works better for severe colitis?
NCT ID NCT07550673
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study compares two drugs—upadacitinib (a pill) and infliximab (an infusion)—as second-line treatments for acute severe ulcerative colitis. About 226 adults will be randomly assigned to one of the two drugs for 3 months. The main goal is to see if upadacitinib can reduce symptoms like bloody diarrhea and frequent bowel movements as effectively as infliximab by day 7.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- upadacitinib and infliximab
- What this could lead to
- If upadacitinib works as well as infliximab, it could offer a new second-line option for people with severe ulcerative colitis who don't respond to first treatment.
- What could go wrong
- This is an early-phase 4 trial with 226 participants, so results may not apply to everyone. Both drugs have known risks like infection and allergic reactions.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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3201 Hospital
RECRUITINGHanzhong, Shaanxi, 710005, China
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Ankang Central Hospital
RECRUITINGAnkang, Shaanxi, 725000, China
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Shaanxi Provincial Nuclear Industry 215 Hospital
RECRUITINGXianyang, Shaanxi, 712000, China
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Xijing Hosipital of Digestive Disease
RECRUITINGXi'an, Shaanxi, 710005, China
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