Inflammatory bowel disease

This study looked at whether the HPV vaccine works in girls aged 9 to 17 who are taking medicines that weaken their immune system, such as after an organ transplant or for diseases like lupus. The goal was to see if their bodies produce enough antibodies to protect against HPV. T…

This study tested a Novavax COVID-19 booster vaccine in 21 people with weakened immune systems due to inflammatory bowel disease or organ transplants. The goal was to see if the booster improved antibody levels and immune protection against COVID-19. Participants had already rece…

This study looked at 108 adults with Crohn's disease whose symptoms returned while on standard ustekinumab treatment. Researchers gave them a re-induction infusion and then split them into two groups: one continued the usual shot every 8 weeks, the other got a shot every 4 weeks.…

This study tested fecal microbiota transplantation (FMT) from different donors to treat ulcerative colitis, a type of inflammatory bowel disease. Researchers gave 102 patients a one-time colonoscopic infusion of fresh fecal bacteria from healthy donors. The goal was to see if don…

This study investigates whether giving vitamin D supplements to adults with inflammatory bowel disease (Crohn's disease or ulcerative colitis) who also have low vitamin D levels can improve their iron status. Participants take high-dose vitamin D3 weekly for 8 weeks, then a lower…

This study tests whether giving patients their own stool bacteria through a temporary stoma can reduce inflammation in the unused part of the colon, a condition called diversion colitis. Sixty-six people with rectal cancer who have a temporary ileostomy will receive either a dail…

This study is testing a new device called SEGER IDEA™ that helps surgeons close openings in the bowel during keyhole surgery. It is the first time this device is being used in humans. Ten adults having certain types of bowel surgery will take part. The main goal is to see if the …

This phase 2 trial tests whether OSE-127, an antibody that blocks a key immune signal, can reduce disease activity in people with moderate to severe ulcerative colitis who have not responded to or cannot tolerate previous treatments. Participants are randomly assigned to receive …

This study tested whether using two advanced drugs together (either two biologics or one biologic plus a small molecule) is safe and effective for people with inflammatory bowel disease (IBD) who haven't gotten better on standard treatments. Researchers followed 117 patients in C…

This trial tests whether a nurse-led education program, based on the Health Belief Model, can improve treatment adherence in people with inflammatory bowel disease (Crohn's disease or ulcerative colitis) who are receiving anti-TNF therapy. The program aims to address patients' co…

This study tested whether taking tempeh powder (a source of isoflavones) and vitamin D3 daily for 8 weeks could improve vitamin D levels, reduce inflammation, and boost quality of life in people with inflammatory bowel disease (IBD). Fifty adults with ulcerative colitis or Crohn'…

This early-stage study tested a new treatment called MB310 in 29 adults with mild-to-moderate ulcerative colitis. The main goal was to see if it is safe and how well it takes hold in the body. Participants received either MB310 or a placebo, and researchers monitored side effects…

This study tested the drug mirikizumab in 172 adults with moderate-to-severe ulcerative colitis who still had bowel urgency despite other treatments. The main goal was to see if the drug reduces the sudden, urgent need to use the bathroom. Participants were followed for 36 weeks …

This study tested whether a seaweed-derived supplement called Aquamin® can reduce gut permeability (often called 'leaky gut') in people with ulcerative colitis, irritable bowel syndrome with diarrhea, and healthy volunteers. Thirty-five adults took Aquamin capsules for 90 days. R…

This completed observational study looked at how well the drug tofacitinib works for people with ulcerative colitis in everyday Swedish clinics. Researchers used a national registry to track disease remission and whether patients stayed on the medication. The study included 102 p…

This study tested the drug mirikizumab in 63 children aged 2 to 17 with moderate-to-severe ulcerative colitis, a chronic bowel disease. The goal was to see if the drug could help control the disease and improve symptoms. All children received the drug, and researchers measured re…

This study compared two common antibiotics—azithromycin (single dose) and doxycycline (7-day course)—for treating anal chlamydia in women who also had a vaginal chlamydia infection. The goal was to see which treatment clears the anal infection better, since anal chlamydia often g…

This study tested the drug upadacitinib in people with Crohn's disease that only affects the small bowel, a type that is often harder to treat. Researchers compared 3 patients with small-bowel Crohn's to others with Crohn's in different areas, using ultrasound to measure bowel in…

This study looked at whether the drug ustekinumab can help people with moderate to severe Crohn's disease reach 'deep remission' — meaning no symptoms, healed gut lining, and healed gut wall. Researchers followed 156 patients for 44 weeks and checked what factors helped predict t…

This study looked at the long-term safety of vedolizumab, a biologic drug given by IV, in 59 children with ulcerative colitis or Crohn's disease. Participants had already completed a previous study and continued treatment to monitor for side effects. The goal was to see if the dr…

This study tested whether mirikizumab can help people with moderate to severe ulcerative colitis stay in remission (symptom-free) after they had already responded to an initial treatment. About 1,300 adults who completed a prior induction study were randomly assigned to receive m…

This study tested a drug called ustekinumab in 112 children with moderate-to-severe ulcerative colitis, a condition causing inflammation in the colon. The goal was to see if the drug could reduce symptoms like diarrhea and bleeding and help the colon heal. Children first received…

This study tested the drug tofacitinib (Xeljanz) in 10 adults with chronic granulomatous disease (CGD) who had ongoing inflammation in the gut, skin, or lungs. Participants took the pill daily for 3 months to see if it was safe and could help control symptoms. The goal was to fin…

This study tested whether adding fenofibrate, a drug typically used for high cholesterol, to the standard treatment mesalamine can improve symptoms and quality of life in people with mild-to-moderate ulcerative colitis. The trial enrolled 60 adults and measured changes in disease…

This study tested a daily pill called ABX464 (obefazimod) as a long-term maintenance therapy for people with moderate to severe ulcerative colitis. 217 patients who completed a prior 16-week induction study took the drug for up to 96 weeks. The main goal was to see how many patie…

This study tested whether cleaning therapy dogs with a special disinfectant (chlorhexidine) before hospital visits could reduce the spread of harmful germs to children. The trial involved 45 children aged 3 to 17 who interacted with therapy dogs. Researchers checked if the cleani…

This study tested whether people with ulcerative colitis can use a home stool test to catch inflammation early and prevent symptom flares. Over 700 adults in remission used a smartphone-based test kit to measure calprotectin levels. The goal was to see if this proactive monitorin…

This study tested a medicine called vedolizumab in 121 children with moderate to severe ulcerative colitis, a condition causing inflammation and pain in the gut. The goal was to see if the drug could help children achieve remission, meaning their symptoms improve and tests show l…

This study looked at 150 adults with Crohn's disease to see if advanced imaging could predict how well the drug Ustekinumab controls inflammation. Researchers measured changes in the gut wall and compared them to standard tests. The goal was to improve treatment monitoring for th…

This study looked at whether adding mesalazine (a standard anti-inflammatory drug) to biologic treatments like infliximab or vedolizumab helps people with moderate to severe ulcerative colitis achieve endoscopic remission (healing of the gut lining). The trial enrolled 438 adults…

This study tested a treatment called RBX2660 (REBYOTA) for people with recurrent Clostridioides difficile infection. The treatment is made from healthy human stool bacteria and was given during a colonoscopy. The goal was to see if this delivery method is safe and works well. For…

This study tested whether the antifungal drug fluconazole could lower levels of certain antibodies (ASCA) and prevent Crohn's disease from returning after bowel surgery. Thirty-five adults with Crohn's disease who had recent ileal or ileocecal resection were randomly assigned to …

This study tested a new drug called tulisokibart (PRA023) in 55 people with moderate-to-severe Crohn's disease who had not responded well to other treatments. The main goals were to check safety and see if the drug could improve gut healing and reduce symptoms. After 12 weeks, so…

This study looked at whether giving the antibiotic vancomycin helps cancer patients who have diarrhea and a positive screening test for C. difficile but a negative toxin test. Only 9 patients were enrolled, far fewer than planned. Researchers measured changes in C. difficile leve…

This completed Phase 2b trial tested an oral tablet called JNJ-77242113 against placebo in 252 adults with moderate-to-severe ulcerative colitis. The goal was to see if the drug could reduce symptoms and inflammation better than a dummy pill. Researchers measured clinical respons…

This study tested whether eating less fat and more fiber can reduce the chance of a repeat Clostridioides difficile infection in cancer patients. Eight participants with leukemia, lymphoma, or other cancers followed a specific diet. Researchers tracked diarrhea and measured C. di…

This study tested whether a device that uses light to monitor blood flow (photoplethysmography) could help doctors manage fluids better during colorectal surgery. The goal was to reduce complications after surgery. 160 adults having colorectal surgery took part. The approach is n…

This study tested two ways of using liquid nutrition to prevent Crohn's disease from flaring up again in children aged 6 to 18. One group got all their calories from a special liquid diet for one week out of every four (cyclic), while the other group got 25% of their calories fro…

This phase 2b trial tested a new drug called TEV-48574 (duvakitug) in 290 adults with moderate to severe ulcerative colitis or Crohn's disease. The study aimed to see if the drug could help patients achieve clinical remission (for UC) or an endoscopic response (for CD) after 14 w…

This study tested whether taking capsules containing healthy gut bacteria could help clear drug-resistant germs (including C. difficile) from the intestines of 42 hospitalized adults who needed at least 7 days of antibiotics. Participants received either the bacteria capsules or …

This phase 2 study tested an experimental antibiotic called CRS3123 against the standard treatment vancomycin for Clostridioides difficile infection (C. diff). 43 adults with a first episode or first recurrence of C. diff took either CRS3123 or vancomycin for 10 days. The main go…

This study tested fecal microbiota transplant (FMT) in 24 adults with recurrent Clostridium difficile infection (C. diff) that didn't get better with standard antibiotics. FMT involves placing healthy donor stool into the patient's colon to restore good bacteria. The goal was to …

This study tested whether fecal transplants from healthy donors could help people with ulcerative colitis, a chronic condition causing inflammation in the colon. 85 participants received either donor or their own stool via tubes and enemas. The goal was to see if donor transplant…

This study looked back at medical records of 81 people with severe ulcerative colitis to see if starting upadacitinib early works better than using it after other treatments fail. Researchers checked how many avoided surgery and achieved remission within 12 weeks. The goal is to …

This study looked at the safety of giving repeated doses of remestemcel-L, a stem cell therapy, to 73 people with moderate-to-severe Crohn's disease that didn't respond to standard treatments. Participants had already received the drug in an earlier study and were given three mor…

This study tested a probiotic called INF108F in 20 breastfed infants with a food allergy that causes blood in their stool. The goal was to see if the probiotic could improve the balance of gut bacteria and reduce symptoms like reflux and fussiness. While the treatment aims to con…

This study tested whether sulfasalazine, a drug used for arthritis, can improve liver health and symptoms in people with primary sclerosing cholangitis (PSC) who also have inflammatory bowel disease. 32 adults across the US took either the drug or a placebo for a set time. Resear…

This phase 3 trial tested a stem cell treatment called PROCHYMAL in 98 people with moderate-to-severe Crohn's disease who had already responded to an earlier stem cell dose. The goal was to see how long the benefit lasts and whether a repeat dose can bring back symptom relief. Pa…

This study tested an experimental pill called MORF-057 in 39 adults with moderate to severe ulcerative colitis. The drug aims to reduce gut inflammation by blocking a specific protein. Researchers measured changes in colon tissue health and symptom scores after 12 weeks of treatm…

This phase 3 trial tests whether infusions of PROCHYMAL, a type of adult stem cell, can help people with moderate-to-severe Crohn's disease who haven't responded to standard treatments. Over 300 participants will receive either stem cells or a placebo through an IV four times ove…

This study tested a 15-day diet called UC-TREAT, rich in high-fiber foods, fermented foods, and berries, in 36 adults—some healthy and some with quiescent (inactive) ulcerative colitis. Researchers measured changes in gut bacteria, digestive symptoms, and diet acceptability. The …

This study tested whether adding the drug bezlotoxumab to standard treatment could prevent serious outcomes in people with a severe C. diff infection. Researchers used a special score to identify 44 high-risk patients. The goal was to see if the drug reduced organ failure, infect…

This study tested whether a daily dose of grape powder (46 grams) could improve gut bacteria and reduce inflammation in adults with Crohn's disease who were in remission. Twenty-one participants took the grape powder and provided stool and blood samples. The goal was to see if gr…

This study tested whether physiotherapist-led pelvic floor and bowel training could improve bowel function in people who had ileo-anal pouch surgery for ulcerative colitis or familial adenomatous polyposis. Fifty-three participants were randomly assigned to either the behavioural…

This phase 3 study tested the safety of guselkumab in 38 people with moderate-to-severe Crohn's disease. Participants received the drug first through an IV, then as injections. The main goal was to track side effects, but researchers also looked at whether symptoms improved. Resu…

This phase 2 trial tested the safety of P28GST, a protein from a parasite, in 10 adults with moderate Crohn's disease. Participants received three injections over three months. The goal was to see if the protein could safely control inflammation, especially after intestinal surge…

This study tested whether hyperbaric oxygen therapy (HBOT) can help heal severe tissue damage caused by past radiation treatment. 39 adults who had radiotherapy and developed serious radiation injuries received HBOT sessions in a pressurized chamber while breathing pure oxygen. T…

This study tested whether a prebiotic called 2'-fucosyllactose can help people with mild-to-moderate ulcerative colitis. 38 adults took the prebiotic or a placebo for four weeks, then switched. Researchers measured symptoms, gut bacteria, and inflammation markers. The goal was to…

This study tested a web-based telemonitoring system called TECCU for people with moderate-to-severe inflammatory bowel disease (Crohn's disease or ulcerative colitis). 290 participants in Spain were randomly assigned to use the app or receive usual care. The goal was to see if th…

This study tested whether rutin, a natural compound found in plants, can help people with ulcerative colitis. 60 adults took rutin tablets or a placebo for 30 days. The goal was to see if rutin reduces gut inflammation and improves symptoms like diarrhea and abdominal pain.

This study followed 152 adults with moderate to severe ulcerative colitis who were prescribed tofacitinib by their doctors in France. Researchers tracked how many patients felt better after one and two years of treatment, using symptom scores and noting if they needed other medic…

This study tested what happens when patients with rheumatoid arthritis, Crohn's disease, or eye inflammation switch from the original drug Remicade to its lower-cost biosimilar Inflectra. Over 260 adults who had been on Remicade for at least 4 months were switched. The main goal …

This completed study looked at how safe and effective upadacitinib (RINVOQ) is for Korean adults with moderate to severe ulcerative colitis or Crohn's disease. About 600 participants were followed for up to 52 weeks while taking the drug as prescribed by their doctor. The main go…

This study looked at whether a higher dose (10 mg/kg) of the drug infliximab (TA-650) could help people with Crohn's disease who were not getting enough benefit from the standard dose (5 mg/kg). The 39 participants received the higher dose every 8 weeks. The main goal was to see …

This study tested switching 38 adults with inflammatory bowel disease (Crohn's or ulcerative colitis) from intravenous infliximab to a subcutaneous (under-the-skin) injection. Researchers measured drug levels, quality of life, and patient satisfaction over 24 weeks. The goal was …

This study tested a drug called TA-650 in 21 children with moderate to severe ulcerative colitis, a condition causing inflammation and sores in the colon. The goal was to see if the drug could reduce disease activity and improve symptoms. Children received the drug by infusion at…

This study tested a drug called TA-650 (also known as infliximab) in 14 children with moderate to severe Crohn's disease. The drug was given as an IV infusion to reduce inflammation and control symptoms. The goal was to see if it could lower disease activity scores and improve th…

This study looked at the long-term safety and effectiveness of an oral medication called RPC1063 for people with moderate to severe ulcerative colitis. It included 877 adults who had already taken part in earlier RPC1063 trials. The goal was to see how well the drug controls the …

This study looked at how safe and effective the drug Rinvoq is for adults with moderate to severe ulcerative colitis. About 300 people in Japan took Rinvoq as part of their normal care and were followed for up to 60 weeks. The main goal was to track serious infections and other s…

This study tested whether tranexamic acid, a drug that helps blood clot, can lower the chance of infection after gastrointestinal surgery. Over 3,300 adults at higher risk for complications took part. The goal was to see if the drug reduces surgical site infections compared to a …

This study monitored 688 people in South Korea with ulcerative colitis, Crohn's disease, or pouchitis who were treated with Kynteles (vedolizumab) as part of their normal care. The main goal was to track side effects, and researchers also looked at how many patients saw symptom i…

This study tested an experimental drug called ABBV-668 in 30 adults with moderate to severe ulcerative colitis, a condition that causes inflammation and bleeding in the colon. Participants took the drug twice daily for 16 weeks, and researchers checked for side effects and signs …

This study tested a new drug called PF-06480605 in 246 adults with moderate to severe ulcerative colitis. Participants received different doses of the drug or a placebo for 12 weeks, then everyone received the active drug for 40 more weeks. The goal was to see if the drug could h…

This study tested whether adding a transanal (through the anus) approach to standard laparoscopic pelvic pouch surgery could improve outcomes for patients with ulcerative colitis or familial adenomatous polyposis. The transanal method may give surgeons better control and visibili…

This study followed 150 people with inflammatory bowel disease (ulcerative colitis or Crohn's disease) who were given VedAryo (vedolizumab) to see if it helps control their condition and is safe. Participants received the drug by IV at the start, after 2 weeks, after 6 weeks, and…

This completed study tested a dietary plan combining a special diet for inflammatory bowel disease (IBD-AID) with a pea protein drink (Kate Farms Peptide 1.5) in 20 adults experiencing a Crohn's disease flare and starting new immunologic therapy. The goal was to see if this appro…

This study tested whether a blood test measuring proteins can help doctors choose the best treatment for people newly diagnosed with inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease. 300 patients were split into two groups: one where doctors had …

This early-stage study tested a new biologic drug called AZD7798 in 112 people, including healthy volunteers and patients with Crohn's disease. The main goal was to check if the drug is safe and how the body processes it. Researchers gave single or repeated doses and monitored fo…

This study tested an experimental drug called ABX464 in 355 adults with moderate to severe ulcerative colitis who had not responded well to other treatments. The goal was to see if the drug could reduce symptoms like diarrhea, bleeding, and colon inflammation. Participants receiv…

This study tested whether ustekinumab, a drug that blocks inflammation, can help children aged 2 to 17 with moderate-to-severe Crohn's disease. 101 participants first received the drug through an IV, then some continued with injections while others got a placebo. The goal was to …

This study tests a new delayed-release metronidazole capsule designed to release the drug directly in the colon, where C. diff bacteria live. 18 healthy adults will receive a single dose of either the new capsule or the standard tablet to compare how much drug reaches the colon v…

This study tested whether adding the antibiotic minocycline to standard mesalamine treatment helps control mild-to-moderate ulcerative colitis. 46 adults took part. Researchers measured disease activity using a symptom score. The trial is complete, but results are not yet publish…

This study tested whether adding atorvastatin (a cholesterol-lowering drug) to standard mesalamine treatment improves quality of life and reduces inflammation in adults with ulcerative colitis. 54 participants completed the trial. The goal was to see if the drug's anti-inflammato…

This study tested a new drug called IBI112 in 150 people with moderate to severe ulcerative colitis, a condition that causes inflammation and sores in the colon. The goal was to see if IBI112 could help patients achieve remission (no symptoms) after 12 weeks of treatment. Partici…

This registry study followed 156 Chinese patients with moderate to severe Crohn's disease who were prescribed Humira (adalimumab) by their doctors. The goal was to see how safe and effective the drug is in real-world use over one year. Researchers tracked serious side effects and…

This study tested a once-daily pill called ABX464 (obefazimod) in 639 people with moderate-to-severe ulcerative colitis who had not responded well to other treatments. The goal was to see if the drug could help bring about remission and improve bowel inflammation within 8 weeks. …

This study tested a new daily pill, ABX464, for people with moderate to severe ulcerative colitis who did not get better with other treatments. About 636 adults and teens took either 25 mg, 50 mg, or a placebo for 8 weeks. The main goal was to see if the drug could help achieve r…

This study looked at the long-term safety of a drug called spesolimab in adults with moderate to severe ulcerative colitis who had already finished earlier trials. Researchers tracked side effects and checked if patients achieved remission over about 6.5 years. The goal was to se…

This study tested whether mirikizumab, a biologic drug, can improve symptoms and gut healing in 100 people with moderate-to-severe ulcerative colitis who had a specific type of inflammation seen on biopsy. Participants received either mirikizumab or vedolizumab, and doctors track…

This study tested two doses of a daily pill called ozanimod in 198 Japanese adults with moderate to severe ulcerative colitis. The goal was to see if it could reduce symptoms and inflammation better than a placebo. The trial also checked long-term safety. Ozanimod works by calmin…

This study tested a new drug called spesolimab in 98 adults with moderate-to-severe ulcerative colitis who did not get better with other biologic treatments. The goal was to see if the drug could safely reduce symptoms and help the colon heal. The trial was completed and looked a…

This study tested a drug called spesolimab in 27 adults with Crohn's disease who also have fistulas near the anus. The drug is given by IV every 4 weeks for 24 weeks. The study had two parts: first, researchers took tissue samples to learn what causes the fistulas; second, they c…

This phase 2 study tested whether adding spesolimab to standard TNF inhibitor therapy could help heal the gut lining in people with mild-to-moderate ulcerative colitis. Twenty-two adults who still had active disease despite TNF inhibitor treatment received spesolimab or a placebo…

This phase 2 trial tested a drug called spesolimab in 8 adults with moderate to severe ulcerative colitis. The main goal was to understand how the drug works in the body, while also checking for safety and any signs of improvement. Participants received the drug for 12 weeks, and…

This study looked at the long-term safety and effectiveness of adalimumab (Humira) in 59 children with ulcerative colitis who had already completed a previous trial. The children received injections every other week or weekly. Researchers tracked side effects and how well the dru…

This study looked at how well a special diet (called CDED plus NEP) works for children aged 8 to 18 with active Crohn's disease. The diet aims to reduce inflammation and help the gut heal without needing steroids or other strong drugs. Researchers tracked 58 kids in real-world cl…

This study looked at 73 adults with Crohn's disease who needed surgery to remove a diseased part of the bowel. Researchers compared two different ways to reconnect the healthy ends: one that removes the fatty tissue around the bowel (mesentery) and one that keeps it (Kono-S). The…

This study looked at whether regularly measuring levels of anti-TNF drugs and antibodies in the blood can help doctors better manage inflammatory bowel disease (Crohn's and ulcerative colitis). 260 patients were split into two groups: one where doctors used these test results to …

This study looked at whether adding probiotics (Bacillus Clausii) to standard mesalamine treatment helps people with ulcerative colitis stay in remission. 70 adults in remission were split into groups: mesalamine alone, probiotics alone, or both. Researchers tracked disease activ…

This study tested the drug ustekinumab (STELARA) in 182 Chinese adults with moderate-to-severe Crohn's disease. The goal was to see if the drug could reduce symptoms and heal the gut lining over 52 weeks. Participants received the drug by IV and later by injection, and researcher…

This completed study looked at the long-term safety and effectiveness of vedolizumab (Entyvio) in over 1,100 people with moderate to severe ulcerative colitis who had not responded well to other treatments. Researchers tracked side effects and how well the drug controlled disease…

This study tested an oral drug called amiselimod (MT-1303) in 322 adults with mild to moderate ulcerative colitis. Participants received either a low dose, high dose, or placebo for 12 weeks, with an optional 36-week open-label period. The goal was to see if the drug could reduce…

This study tested two team-based care models for 657 adults with inflammatory bowel disease (Crohn's or ulcerative colitis) who also had mild to severe behavioral health symptoms. One model used in-person visits with a team including a gastroenterologist, nurse, nutritionist, and…

This study compares contrast-enhanced ultrasound to standard CT and MRI scans for detecting bowel inflammation in children aged 10–18 with Crohn's disease. Participants receive an ultrasound with a microbubble contrast agent alongside their regularly scheduled CT or MRI. The goal…

This study tested whether a thermal camera could detect intestinal inflammation in 43 children with Crohn disease. The camera measures heat patterns on the belly, which may reflect underlying inflammation. Researchers compared these readings to standard stool tests and symptom sc…

This study tested whether a quick MRI without contrast injection can spot signs of Crohn's disease as well as the standard MRI with contrast. 250 patients were scanned using both methods, and radiologists compared the results. If the injection-free approach works, it could make f…

This study tested whether simple blood test ratios, like CRP-to-albumin, can help monitor disease activity in people with ulcerative colitis. Researchers compared these blood markers to standard colonoscopy and symptom scores in 80 patients. The goal was to find a less invasive, …

This study looked at four substances in the blood (Osteoprotegerin, sRANKL, NFkB, and TFF3) to see if they could help diagnose inflammatory bowel disease (IBD), which includes Crohn's disease and ulcerative colitis. Researchers measured these markers in 70 newly diagnosed patient…

This study tested whether curcumin, the active ingredient in turmeric, can prevent Crohn's disease from coming back after surgery. 61 adults who had recent surgery for Crohn's were given either curcumin or a placebo, along with standard thiopurine drugs, for 6 months. The goal wa…

This study tested whether a diet that avoids certain inflammatory foods could lower the risk of developing Crohn's disease in healthy people who have a close relative with the condition. Twenty-nine participants followed the 'Tasty & Healthy' diet for 8 weeks. The main goal was t…

This observational study followed 145 adults who received REBYOTA™ to prevent another Clostridioides difficile infection (CDI) after completing antibiotics. Researchers collected information from medical records over 6 months to see how many people stayed infection-free. The goal…

This early study tested whether giving people with Crohn's disease a fecal transplant (FMT) after surgery could help prevent the disease from coming back. 23 adults who had surgery for Crohn's received FMT either by capsules or colonoscopy. The goal was to see if the capsules cou…

This study tested whether extending standard vancomycin treatment for C. diff infection with a 2-week taper (lowering the dose gradually) reduces the chance of the infection returning. 263 adults who had a first episode or first recurrence of C. diff were randomly assigned to rec…

This study tested whether combining a fecal microbiota transplant (FMT) with the drug bezlotoxumab could prevent repeat Clostridium difficile infections in people with inflammatory bowel disease (IBD). Sixty-one adults with at least two prior C. diff infections were randomly assi…

This study tests whether a 9-week relaxation response mind-body program can improve quality of life and reduce symptoms in people with irritable bowel syndrome (IBS) or inflammatory bowel disease (IBD). Participants attend weekly group sessions that include breathing exercises, m…

This study tested a 21-step enhanced recovery protocol for children aged 10-18 undergoing elective gastrointestinal surgery. The protocol included things like shorter fasting times, early eating and moving, and less use of opioids. The goal was to see if it could shorten hospital…

This study looked at whether placing a bridge device during loop ileostomy creation reduces complications like infections or stoma problems. 166 adults having elective colorectal surgery took part. The goal was to see if the device improves outcomes or just adds difficulty to car…

This study tests whether cognitive behavioral therapy (CBT) can reduce anxiety and depression in people with inflammatory bowel disease (Crohn's disease or ulcerative colitis). Participants receive either psychologist-led or self-administered CBT over 8 weeks. The goal is to see …

This study tested a 12-week online mind-body program for adults with chronic conditions like heart failure, cancer, and liver disease. The program included mindful movement, meditation, breathwork, and coping skills. Researchers measured changes in anxiety, depression, fatigue, a…

This study tested whether nurse coaching could help people with inflammatory bowel disease (IBD) better manage their symptoms, improve self-care, and enhance quality of life. Forty adults with IBD in remission participated. Researchers measured changes in symptom burden, self-car…

This study involved 324 adults with conditions like Crohn's disease, arthritis, or psoriasis who switched from a standard to a higher-concentration form of adalimumab (AVT-02). Researchers measured injection site pain and how well patients stuck with their treatment over 180 days…

This early-phase study tested whether TUDCA, a bile acid supplement, is safe and can reduce stress in gut cells of people with active ulcerative colitis. Fourteen adults took TUDCA for 6 weeks while researchers measured changes in cell stress markers from colon biopsies. The goal…

This study tested whether eating steamed broccoli sprouts daily for 28 days could increase anti-inflammatory compounds in the blood and stool of people with mild ulcerative colitis. 23 participants took either 1 or 3 servings of sprouts per day. The goal was to see if this diet i…

This study tested whether eating gluten-free for one week reduces gut symptoms and fatigue in people with ulcerative colitis. Fifteen participants followed both a high-gluten and a gluten-free diet in random order, with symptom questionnaires and samples collected. The goal is to…

This study tested a comprehensive self-management program for people with inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease. The program included eight sessions covering topics like symptom tracking, relaxation, diet, and pain management. Research…

This completed trial tested whether four free self-help resources—a symptom-tracking app, a cognitive behavioral therapy workbook, a helpline, and a peer mentor—can reduce disability in people with moderate-to-severe Crohn's disease or ulcerative colitis. Over 800 adults particip…

This study tested a 12-week nursing program based on the Roy Adaptation Model for adults who recently had a colostomy. It aimed to reduce anxiety and depression and improve quality of life compared to standard care. 115 participants were randomly assigned to either the special pr…

This study looked at whether a tailored physical activity program could improve bone density in 15 children and teens with inflammatory bowel disease (IBD). Kids with IBD often have weaker bones due to inflammation, medication, and lower activity levels. The program focused on mo…

This study tested whether a liquid diet called Neocate Splash could change gut bacteria and ease stomach symptoms in people with chronic granulomatous disease (CGD) and inflammatory bowel disease (IBD). Three participants followed the diet for up to 4 weeks, with hospital stays a…

This small study tested whether an AI-powered virtual reality app could safely provide mental health support to 22 adults with inflammatory bowel disease (IBD) who also had mild anxiety or depression. The goal was to see if the digital session was practical and acceptable, not to…

This pilot study tested whether giving ondansetron (Zofran) before drinking bowel-cleansing liquid helps children have a cleaner colon and feel less sick. 41 kids aged 2 to 20 took either ondansetron or a placebo before their colonoscopy. The study measured bowel cleanliness and …

This early-stage trial tested whether an oral biologic drug called MB-001 is safe in 48 healthy adults. Participants received either a single dose or five daily doses of the drug or a placebo. The main goal was to check for side effects and see how the body processes the drug. Th…

This study tested whether a low-calorie, plant-based diet that mimics fasting could reduce depressive symptoms in people with inflammatory bowel disease (IBD). 42 adults with mild-to-moderate depression and IBD followed either the fasting-mimicking diet or a calorie-sufficient pl…

This study compares two simple educational tools—a written PDF and an audio podcast—to see which helps people with inflammatory bowel disease (IBD) learn more about their condition. Participants fill out questionnaires at the start and after three months to measure knowledge, sat…

This study looked at how a protein called IL-22 binding protein (IL-22BP) affects gut healing in people with Crohn's disease or ulcerative colitis. Researchers compared samples from 52 patients and healthy volunteers to understand how IL-22BP is regulated during disease flares. T…

This study looks at how being physically fit changes the bacteria in your gut. Researchers will compare the gut microbes of 30 healthy men, from inactive to elite athletes, by testing their exercise capacity and analyzing stool samples. The goal is to find connections between fit…

This study investigates whether gut microorganisms and their byproducts play a role in triggering severe flare-ups of ulcerative colitis. Researchers will compare patients hospitalized with severe colitis to those with milder symptoms, analyzing stool and blood samples over three…

This study investigates whether analyzing bowel sounds with a computer can help measure disease activity in children with Crohn's disease. Researchers will record bowel sounds and compare them to a standard disease activity score. The goal is to find a noninvasive, painless way t…

This study aimed to create a detailed map of the cells in the human appendix and understand their genetic activity. Researchers analyzed appendix tissue from 5 patients undergoing colon cancer surgery. The goal was to learn more about the appendix's role in the immune system and …

This study analyzed data from 500 Crohn's disease patients to create a tool that uses routine blood tests to predict the risk of needing intestinal surgery. The goal is to help doctors move from reacting to problems to preventing them. The model is still in early development and …

This completed study took small tissue samples from the colons of 40 people during routine colonoscopies. Using advanced genetic techniques, researchers created a detailed map of the different cell types and their gene activity. The goal is to better understand how colon diseases…

This Phase 1 trial tested the safety and tolerability of INT-210 capsules in 86 healthy adults aged 18-45. Participants received single or multiple doses of the drug or a placebo, and researchers monitored side effects and how the drug moves through the body. The study also looke…

This completed study looked at over 107,000 patients in Germany to understand the long-term side effects of systemic steroids (corticosteroids) used for conditions like asthma, COPD, and arthritis. Researchers compared patients who took steroids with those who did not, tracking r…

This study looked at how a soy-based diet or a similar diet without soy changes gut bacteria in people with Crohn's disease (in remission or active) and healthy volunteers. Researchers measured inflammation markers and tracked whether symptoms stayed stable over one week. The goa…

This study measured how often adults with inflammatory bowel disease (Crohn's disease or ulcerative colitis) show signs of eating disorders, including avoidant/restrictive food intake disorder (ARFID). Researchers used questionnaires to assess eating habits and nutritional status…

This study tested a new scoring system called CAT-DESIRE to evaluate ulcerative colitis severity using colonoscopy images. Researchers reviewed images from 235 patients to see if the new score is reliable and can predict long-term outcomes. The goal is to provide a simple, accura…

This study looked at 343 adults who were diagnosed with inflammatory bowel disease (Crohn's disease or ulcerative colitis) before age 17. Researchers compared their employment rates and education levels to the general population to understand how the disease may affect long-term …

This study looked at 84 children and teens with inflammatory bowel disease (IBD) to see if daily physical activity is linked to better bone density. Participants wore activity monitors and had bone scans. The goal is to understand if staying active could help prevent bone loss, a…

This completed study looked at 115 people with inflammatory bowel disease (IBD) to see if their condition raises the risk of atherosclerosis, a hardening of the arteries that can lead to heart attacks and strokes. Researchers measured artery stiffness and thickness, and tracked h…

This completed study looked at 63 Crohn's disease patients who had an anal fistula treated with anti-TNF drugs and a seton drain. Researchers tracked how long the fistula stayed closed and what factors might cause it to come back. The goal is to better understand long-term outcom…

This study looked at antibodies in the intestines of 160 people: 80 with Crohn's disease, 40 with ulcerative colitis, and 40 without inflammatory bowel disease. Researchers took blood samples and intestinal biopsies to compare antibody levels in the gut versus the blood. The goal…

This study looked at 366 adults referred for suspected inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. The goal was to find simple, non-invasive markers that can help doctors diagnose IBD more accurately and predict how the disease will progres…

This study examined how differences in the BAFF gene might affect a person's risk of developing ulcerative colitis and how well they respond to the drug vedolizumab. Researchers analyzed genetic samples from 841 people with ulcerative colitis. The goal was to better understand th…

This study observed 165 people with inflammatory bowel disease (Crohn's or ulcerative colitis) in Poland who were already taking or starting vedolizumab. Researchers tracked whether patients chose intravenous or subcutaneous (under-the-skin) injections, and how long they stayed o…

This study looked at how being isolated during the COVID-19 pandemic affected the mental health of 232 people with inflammatory bowel disease (IBD). Researchers used questionnaires to measure depression, anxiety, and other psychological symptoms. The goal was to understand what f…

This study looked at whether taking a bowel-cleaning liquid before a capsule endoscopy helps doctors see the small intestine better and find more problems. 230 adults scheduled for the procedure were randomly assigned to get either a split dose, a single morning dose, or no speci…

This study tracked 646 people with complex fistulas (abnormal tunnels) caused by Crohn's disease or other conditions. Researchers observed the standard surgical treatments patients received at their clinics and recorded outcomes like fistula closure and complications. The goal is…

This completed Italian study looked at how often children with inactive inflammatory bowel disease (IBD) also have disorders of gut-brain interaction (DGBIs), like irritable bowel syndrome. Researchers used the Rome IV questionnaire to compare 220 children with quiescent IBD to h…

This study measured calprotectin, a protein in stool that signals gut inflammation, in 121 healthy adults aged 22 and older. Participants collected a single stool sample at home and mailed it in. The goal is to establish what level is normal, helping doctors better tell apart inf…

This study reviewed medical records of 966 children diagnosed with Crohn's disease or ulcerative colitis between 1988 and 2011. Researchers looked at how often children needed surgery and how treatments like immunosuppressants and anti-TNF drugs were used over time. The goal was …

This completed study looked at 300 Crohn's disease patients to see if CT scan images could predict who would need surgery within a year of diagnosis. Researchers built a computer model using 'radiomics' to analyze the scans. The goal is to help doctors start stronger treatments e…

This completed study from China looked at 50 adults with Crohn's disease who were treated with two newer biologic drugs, Ustekinumab and Vedolizumab. The goal was to see how well these drugs control the disease and what factors might predict a good response. By analyzing past med…

This completed observational study looked at 669 Crohn's disease patients to see if finding hidden anal fistulas early with MRI leads to better long-term health. Researchers compared patients who had no symptoms but were found to have fistulas on MRI to those who had symptoms. Th…

This study looked at physical fitness in 100 children and teens (ages 10-17) with chronic inflammatory bowel disease (Crohn's disease, ulcerative colitis, or unclassified colitis) and compared them to healthy kids of the same age, weight, and sex. Researchers measured cardiorespi…

This study looked at how much of the drug risankizumab (Skyrizi) passes into the breast milk of women with inflammatory bowel disease (IBD). Ten breastfeeding mothers who were already taking the drug provided milk samples over several weeks. The goal is to understand potential ex…

This study looked at 120 adults with inflammatory bowel disease (IBD) to see if simple stool tests can tell if the disease is active or in remission, just like a colonoscopy does. Colonoscopy is the current gold standard but is expensive, invasive, and not ideal for frequent chec…

This study looked at whether adding walnuts to your diet can change the bacteria in your gut and reduce signs of colon cancer risk. About 140 people at higher risk for colorectal cancer ate walnuts for a month. Researchers measured changes in gut bacteria, blood markers, and colo…

This study looked at how hormonal birth control might help manage inflammatory bowel disease (IBD) symptoms that get worse during a woman's period. Researchers surveyed 50 women with IBD to understand their preferences for birth control and whether they would join a future trial.…

This early-stage trial tested a new oral drug called IPG11406 in 66 healthy adults to see if it is safe and how the body processes it. The drug is designed to treat inflammatory bowel diseases like Crohn's disease and ulcerative colitis. Participants received either the drug or a…

This small, early-stage study tested whether a new drug called AZD7798 changes how a special imaging tracer binds to the gut in people with Crohn's disease. Nine adults with active Crohn's disease involving the small intestine received multiple doses of AZD7798 and underwent PET …

This study aims to create a tool that helps nurses better assess and care for the sexual health needs of men with inflammatory bowel disease (IBD). The research involved 792 participants, including men with IBD and their partners, as well as healthcare professionals. The goal is …

This early-stage study tested a single dose of the experimental antibody SM17 in 30 healthy Chinese adults to see if it is safe and how the body processes it. The study did not aim to treat any disease. Results will help plan future trials for conditions like eczema, asthma, and …

This pilot study tested whether a transition coach can help 16-17 year olds with Juvenile Idiopathic Arthritis or Inflammatory Bowel Disease move from pediatric to adult care. The coach met with each teen for 8 one-hour sessions covering self-advocacy, medication management, and …

This study looked at how a short course of antibiotics changes the nerve and glia cells in the lower gut of 10 healthy adults. Researchers took colon tissue samples before and after antibiotic treatment to count these cells and measure gene activity. The goal was to understand if…

This study analyzed data from over 8,700 pregnant women with inflammatory bowel disease (Crohn's or ulcerative colitis) to see how well doctors follow guidelines when prescribing antiTNFα drugs and whether the benefits outweigh the risks for both mother and baby. Researchers look…

This study looked at 211 adults with long-standing inflammatory bowel disease (IBD) to see which colonoscopy method finds precancerous growths better: high-definition white light or dye spraying. Participants had IBD for at least eight years. The goal was to improve cancer screen…

This study tested a new way to deliver the drug ozanimod using a skin patch instead of oral capsules. 24 healthy adults either took one capsule or wore a patch for 7 days. Researchers measured drug levels in the blood and checked for skin reactions to see if the patch works well …

This study looked at 139 children having a colonoscopy to see how often the CMV virus is found in their gut tissue and blood. Some children had inflammatory bowel disease (Crohn's or colitis) and some did not. The goal was to learn which tests best detect CMV in the gut, helping …

This completed study examined whether differences in the IL-7 receptor gene are linked to the risk of developing ulcerative colitis and how well patients respond to the drug vedolizumab. Researchers enrolled 898 people, including those with UC and healthy controls, and analyzed t…

This completed study looked at whether certain gene variations (BAFF) are linked to the risk and features of Crohn's disease. Researchers compared 824 people with and without the disease. The goal was to better understand the genetic factors involved, which could guide future res…

This early-stage study tested a single dose of AZD5148, a potential treatment for C. difficile infection, in 16 healthy Japanese adults. The main goal was to see if the drug is safe and how the body processes it. Participants received either the drug or a placebo by injection and…

This study looked at whether giving extra nutrition through a vein in the arm (instead of a central line) helps people recover after colorectal surgery. 200 adults who had surgery for conditions like colorectal cancer or inflammatory bowel disease took part. The goal was to see i…

This study observed 92 adults with Crohn's disease or ulcerative colitis who were receiving vedolizumab either as an intravenous infusion or a subcutaneous injection. Researchers tracked treatment patterns, such as whether patients stayed on their current form or switched, over 1…

This study looked at how inflammatory bowel disease (IBD) affects oral health and daily life. Researchers compared 138 adults with IBD to people without IBD, using a questionnaire to measure oral health-related quality of life. The goal was to understand which factors, like medic…

This study looked at teeth from 14 adults living in areas with high or low rates of Crohn's disease. Researchers measured metals and other environmental chemicals in the teeth to see if differences might help explain why some areas have more Crohn's disease. The goal was to gathe…

This study looked at 40 children aged 6 to 17 with inflammatory bowel disease (Crohn's or ulcerative colitis) to understand how DNA that escapes from cells might make inflammation worse. Researchers analyzed blood, stool, and gut tissue samples to see if a specific pathway (cGAS-…

This study looked at how the immune system responds to Clostridium difficile infection in hospitalized patients. Researchers took blood samples every two days to measure immune markers. The goal was to find out why some patients have repeat infections. The study involved 56 parti…

This study looked at how well stool and blood samples could be collected from 7 adults with an active C. diff infection. Researchers wanted to see if the collection, shipping, and testing methods worked smoothly. Participants also filled out questionnaires about their symptoms. T…

This study looked at gut bacteria in 214 people: children and older adults recently diagnosed with Crohn's disease, plus healthy controls. Researchers compared the bacteria and genetic profiles to see if age-related differences could explain why Crohn's starts at different life s…

This study looked at 818 people with Crohn's disease to see if variations in the TNFSF4 gene are linked to the disease and how well patients respond to the drug ustekinumab. Researchers analyzed blood samples to find genetic patterns. The goal is to better understand why some pat…

This study looked at 234 adults with ulcerative colitis whose gut lining had healed (Mayo 0 or 1). Researchers tracked how increasing, decreasing, or switching treatments affected patients' quality of life over 6 and 12 months. They also measured inflammation markers like fecal c…

This completed study looked at whether differences in the IL-7 receptor gene are linked to the risk of developing Crohn's disease and how well patients respond to the drug infliximab. Researchers analyzed genetic samples from 303 Crohn's patients and 514 healthy people. The goal …

This study looked at 59 adults with Crohn's disease who had surgery to remove diseased parts of their intestine. The goal was to see if certain immune cells in the blood and gut could predict whether the disease would come back within a year. By understanding these patterns, doct…

This study looked at tiny, lab-grown versions of the intestine called organoids, made from tissue samples of people with inflammatory bowel disease (Crohn's or ulcerative colitis), a genetic polyp condition (FAP), and healthy volunteers. The goal was to understand how intestinal …

This completed study from Xijing Hospital looked at 180 adults with mild-to-moderate ulcerative colitis starting 5-ASA therapy. Researchers compared checking symptoms at 4, 8, or 12 weeks to see which timing best predicted treatment success at 48 weeks. The goal was to help docto…

This study looked at how many girls and young women aged 11 to 20 with chronic diseases (like diabetes or immune conditions) got the HPV vaccine, compared to those without chronic illness. Researchers reviewed records of 223 participants from a hospital in France. The goal was to…

This study tested how well the flu vaccine works and if it's safe for people with inflammatory bowel disease (IBD). Researchers compared 228 adults with IBD who were either taking immunosuppressive drugs or not. The goal was to see if the vaccine triggers a strong immune response…

This early-stage study tested the safety of AGMB-129, a potential drug for fibrostenotic Crohn's disease, in 30 healthy adults. Participants received multiple doses of the drug or a placebo to see how well it was tolerated and how the body processes it. The goal was to find safe …

This study collected blood, saliva, stool, urine, and skin samples from 19 people with unknown or poorly understood immune system problems. The goal was to learn how different parts of the immune system work together. No treatments or drugs were tested. Participants were followed…

This study looked at 11 adults with Crohn's disease who had surgery to remove damaged parts of their intestine. Researchers compared two surgical methods—Kono-S and standard side-to-side—to see how each affected the gut's bacteria and immune cells. The goal was to gather clues ab…

This study looked at whether two blood-based scores (CALLY and HAALP) can help doctors tell when ulcerative colitis is active. Researchers measured these scores in 100 patients and compared them to standard inflammation markers. The goal was to see if these scores could be a simp…

This completed observational study followed 72 adults with moderate to severe Crohn's disease who were starting vedolizumab treatment. The goal was to see if the drug could lead to complete remission—meaning no symptoms, normal inflammation markers, and healed bowel walls—after 1…

This study measured levels of the laxative PEG 3350 and its breakdown products in the blood and urine of 158 children who were already taking it, compared to children not taking it. The goal was simply to learn how the body processes this medicine, not to change any treatments. R…

This study looked at 159 people with ulcerative colitis who started a new advanced therapy. Researchers examined tissue samples from the colon to see if microscopic signs of inflammation could predict future problems like hospital stays or surgery. The goal is to help doctors dec…

This completed study examined gut bacteria in 15 people with inflammatory bowel disease (IBD) or Parkinson's disease, comparing them to healthy individuals. Researchers analyzed stool and blood samples to see if bacteria from the gut move into the bloodstream. The goal was to und…

This study looked at whether certain proteins in the blood can predict if the drug vedolizumab (Entyvio) will reduce inflammation in the small bowel of people with Crohn's disease. Researchers used MRI scans to measure changes in the bowel wall after treatment. The goal is to hel…

This study looked at how nutrition, meal patterns, and diet affect quality of life, gut symptoms, and mood in 50 people with inflammatory bowel disease (IBD). Researchers collected data using food recalls and questionnaires. The goal was to better understand the role of diet in m…

This study takes small tissue samples from people with inflammatory bowel disease (IBD) and healthy volunteers to grow 'mini guts' (organoids) in the lab. Researchers will then expose these organoids to radiation to mimic radiation enteritis and test potential treatments. The goa…

This completed study looked at 100 people who reported a suspected chemical submission (being secretly given drugs). Researchers performed detailed toxicology tests on blood and urine samples to find out which substances were present. The goal was to confirm how many cases involv…

This study looked at 150 adults with Crohn's disease who had narrowings in the small intestine (strictures) but no symptoms. Researchers reviewed medical records to see how often these silent strictures later caused problems like belly pain, nausea, or vomiting. The goal is to he…

This completed study interviewed 10 IBD patients and 6 healthcare professionals to understand how they make shared decisions about using telemonitoring versus standard care. The goal is to improve the decision-making process so patients feel more engaged and informed. The study d…

This completed study looked at how a special form of vitamin B3 (nicotinamide) is processed in 28 patients with low tryptophan levels due to respiratory infections or inflammatory bowel disease. Participants took either 500 mg or 1000 mg of the supplement daily for four weeks. Th…

This study looked back at 52 Crohn's disease patients with anal fistulas who were treated with biotherapy (infliximab, adalimumab, ustekinumab, or vedolizumab). Researchers compared their MRI scans at the start of treatment and during follow-up to see how the fistulas changed ove…