Ischemic stroke

This study tests a new device called the RapidPulse Aspiration System, which uses precisely timed suction to remove blood clots from brain arteries in people having a severe stroke. The trial will enroll 170 adults aged 18 to 80 who can be treated within 8 hours of stroke symptom…

This study tests a new drug called ASP2246 for adults who have trouble moving after a stroke. In the first part, small groups get increasing doses via brain surgery to check safety. In the second part, some get the drug and others get a sham surgery, with neither patient nor doct…

This study tests whether starting a special exercise program soon after a stroke can protect the brain from memory loss and dementia. Researchers will enroll 120 people who had a stroke in the past 6 months. Participants will do a mix of exercises, and the study will measure chan…

This study tests whether the antibiotic minocycline can improve recovery in people having an ischemic stroke. About 934 adults will receive either minocycline or a placebo, in addition to standard clot-busting medication. The goal is to see if minocycline leads to better function…

This study tests whether giving a second dose of the clot-busting drug prourokinase can help stroke patients who have a blocked medium or large artery and don't show improvement one hour after the first dose. About 122 adults will be enrolled within 4.5 hours of stroke onset. The…

This study tests a new device and technique (ADAPT 2.0) for removing blood clots in people having an acute ischemic stroke. The goal is to see if it can restore blood flow more completely and safely than current methods. About 750 adults who are already scheduled for clot removal…

This study tests whether starting virtual reality-based rehabilitation within 24 hours of an acute ischemic stroke can improve arm muscle strength, thinking skills, and motivation to exercise. One hundred adults recently diagnosed with stroke will be randomly assigned to either v…

This study is testing whether stem cells taken from a person's own bone marrow and then given back through the veins and nose can improve brain and nerve function. It includes 500 people with various conditions like stroke, Parkinson's, Alzheimer's, and nerve damage. The goal is …

This study compares two stomach-acid-lowering drugs—tegoprazan and rabeprazole—in about 3,300 heart disease patients who take blood thinners and are at high risk for stomach bleeding. The goal is to see if tegoprazan works as well as rabeprazole at preventing serious gut problems…

This study is testing whether a lower dose of the clot-busting drug tenecteplase is safer and just as effective as the standard dose for treating acute ischemic stroke in people aged 70 and older. About 798 participants will receive either a low dose (0.175 mg/kg) or the standard…

This study tests whether adding GM1, a natural brain substance, to standard clot-removal treatment helps people recover better after a severe stroke. About 868 adults in China who have a blocked artery in the front part of the brain will receive either GM1 or a placebo daily for …

This study tests whether the drug sivelestat sodium, given alongside standard clot-removal surgery, can help people recover better after a major stroke. The trial will include 868 adults aged 18-80 with large-vessel blockage in the front part of the brain. The goal is to see if t…

This Phase 3 trial tests whether the drug tirofiban can help people who have had a stroke but missed the usual treatment window (more than 24 hours after symptoms start). The study uses a special MRI scan to select patients whose stroke is caused by a specific type of artery bloc…

This study tests whether taking a daily fiber and magnesium supplement (WellBiome) for 6-8 weeks before heart surgery can improve recovery. Researchers will compare ICU time, complications, and hospital stay between 80 patients who get the supplement or a placebo. The goal is to …

This Phase 3 trial tests whether sovateltide, a drug that stimulates ETB receptors, can improve recovery after an acute ischemic stroke. About 514 adults aged 18-80 will receive either sovateltide or a placebo alongside standard care. The main goal is to see if more patients achi…

This study tests two experimental drugs, REGN7508 and REGN9933, to prevent strokes in people with atrial fibrillation (an irregular heartbeat) who cannot or choose not to take standard blood thinners. About 2,628 participants will receive one of the drugs or a placebo to see if t…

This large phase 3 trial is testing whether adding vicadrostat to the existing drug empagliflozin can reduce the risk of heart problems in adults with type 2 diabetes, high blood pressure, and heart disease. About 11,800 participants will take either the combination or a placebo …

This early-stage trial tests a brain-computer interface called BrainGate for people with paralysis from conditions like ALS or spinal cord injury. A small sensor is placed in the brain to interpret movement-related signals, allowing users to control a tablet computer just by thin…

This study compares a new 'virtual stroke unit' approach to standard stroke unit care for people with a stroke who are not eligible for a clot removal procedure. The virtual unit uses video calls and monitoring equipment to let a specialist team at a main hospital help guide care…

This study tests whether closing a small pouch in the heart (left atrial appendage) with a device, along with blood thinners, can prevent another stroke better than blood thinners alone. It includes 482 adults with atrial fibrillation who had a recent stroke despite taking antico…

This study tests whether pemafibrate, a drug that lowers triglycerides, can prevent the worsening of narrowed brain arteries in people who have already had a stroke or mini-stroke. About 270 participants will be randomly assigned to receive either pemafibrate plus standard care o…

This study tests a drug called tenecteplase (TNK) for people who have had a stroke caused by a blood clot in the brain. The drug is given up to 24 hours after symptoms start, using only a simple CT scan to decide who can get it. The goal is to see if TNK helps people recover bett…

This study tests whether removing a blood clot from the brain up to 72 hours after a stroke can help patients recover better than standard care. About 336 adults with severe strokes due to a large vessel blockage will be randomly assigned to get the clot removal procedure or usua…

This study looks at the long-term safety of the drug pelacarsen in people with high lipoprotein(a) and heart disease. About 5,700 participants who finished a previous pelacarsen trial will receive the drug and be monitored for side effects and heart events. The goal is to see if …

This Phase 3 trial tests a drug called Fortelyzin® (non-immunogenic staphylokinase) in 990 adults with acute ischemic stroke who can be treated between 4.5 and 24 hours after symptoms begin. Participants receive a single injection of the drug or a placebo. The goal is to see if t…

This study tests if a catheter-based device that closes a small pouch in the heart (left atrial appendage) can prevent strokes or blood clots in people with atrial fibrillation who are already taking blood thinners. About 4000 participants at high risk of stroke will be enrolled.…

This study tests whether implanting small filters in the carotid arteries (the main neck arteries) can prevent repeat strokes in people with atrial fibrillation who have already had a stroke. Participants will receive the filters plus standard blood thinners, or blood thinners al…

This study tests whether the clot-busting drug tenecteplase can help people who have a stroke more than 4.5 hours ago, including those who wake up with stroke symptoms. About 1,325 adults with brain imaging showing salvageable tissue will be randomly assigned to receive tenectepl…

This study is testing a medical device called the Penumbra System in 200 adults aged 18-75 who have had a severe stroke caused by a blocked artery. The device is used to remove the clot and restore blood flow to the brain. The main goal is to see how well and how safely the devic…

This early-stage trial tests whether stem cells from the placenta, given through an IV, are safe and might help people recover from a recent stroke. About 24 participants will receive either the stem cells or a placebo. Researchers will track their recovery over two years, focusi…

This study tests whether a clot-busting drug called tenecteplase can help people who have a stroke affecting the back part of the brain. Participants must start treatment between 4.5 and 24 hours after their first symptoms. The goal is to see if the drug improves recovery and dai…

This study tests a nurse-led program called BEST CARE ICTUS_HC for adults hospitalized with acute stroke in hospitals without specialized stroke units. The program includes staff training, swallowing tests, and environmental adaptations to help with attention and safety. Research…

This study tests a new device called the Adaptive Tip Catheter for removing blood clots in people having a severe stroke. About 74 adults will receive the catheter procedure within 24 hours of stroke symptoms. The goal is to see if the device can restore blood flow in the brain w…

This study looks at people over 65 who recently had a stroke with no clear cause. Doctors suspect they may have hidden atrial fibrillation (an irregular heartbeat) not caught in the hospital. The trial compares two treatments: a blood thinner (apixaban) or aspirin, to see which b…

This study tests whether giving hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) soon after emergency clot removal can improve recovery in people with severe stroke. Researchers plan to enroll 420 adults aged 18–80 who had a large-vessel blockage stroke …

This study compares two treatments for small ischemic strokes (lacunar strokes): a combination of antiplatelet drugs (pills) versus the standard clot-busting drug tPA given through an IV. The goal is to see if the pill combo works just as well but causes fewer bleeding problems. …

This study tests a new device that uses brain signals to time magnetic pulses for stroke rehabilitation. The device reads blood flow changes in the brain and fires a magnetic pulse at the right moment to boost brain activity. Researchers will first test the system in healthy adul…

This study tests the safety and feasibility of the BrainGate2 system, a brain-computer interface. Tiny sensors are placed in the brain area that controls movement, allowing people with tetraplegia (paralysis of all four limbs) to control a computer cursor or other assistive devic…

This study tests a new drug called TS23, an antibody that may help people recover from ischemic strokes by lowering the chance of bleeding in the brain. The trial involves 300 adults who have had a stroke and will receive either the drug or a placebo. Researchers will check for b…

This trial tests a special cannula that captures debris during high-risk heart valve surgery. The goal is to see if it reduces the chance of stroke, kidney injury, and delirium. About 842 patients aged 60 and older will be randomly assigned to receive either the new device or a s…

This study tests whether the antibiotic minocycline can improve recovery in people who have had a major stroke and undergone a procedure to remove a blood clot from a large brain artery. Even when the clot is successfully removed, many patients still have significant disability. …

This study tests whether adding the antibiotic minocycline to standard stroke treatment can improve recovery in people who had a severe stroke in the back of the brain. After a clot is removed, brain inflammation can limit healing. Minocycline may reduce that inflammation. The tr…

This study is testing a digital app called VIRTUES that provides educational resources and treatment recommendations for heart conditions like atrial fibrillation and heart failure. Researchers will enroll 2000 patients across 11 modules to see if the app is easy to use and helps…

This study tests whether placing a stent in the brain artery after removing a clot can improve recovery for people having a severe stroke. About 342 adults aged 18-80 with a blocked large artery and significant residual narrowing will be randomly assigned to get either standard c…

This study tests a tool called Savvy, which includes phone exercises, a weekly pill organizer, and text reminders, to help stroke survivors take their blood pressure medication as prescribed. Researchers will compare medication adherence and blood pressure control between those u…

This study tests a brain implant that records activity from the motor cortex and stimulates the sensory cortex. It aims to help people with severe arm or hand impairment—due to spinal cord injury, stroke, or amputation—control external devices like computers. The trial focuses on…

This study looks at whether the blood thinner warfarin can safely reduce stroke risk in people with end-stage kidney disease on dialysis who also have atrial fibrillation (an irregular heartbeat). About 718 adults will be randomly assigned to take warfarin or not, and researchers…

This early-stage study tests whether a drug called anisodine hydrobromide is safe for people having a stroke caused by a blocked large artery in the brain. About 92 adults aged 18 to 80 who are already scheduled for a clot-removal procedure will receive the drug. The main goal is…

This study tests whether starting heart rhythm control therapy soon after a stroke can prevent future strokes, heart-related deaths, or hospital stays in people with atrial fibrillation. About 1,746 participants will receive either early comprehensive treatment or usual care. The…

This study tests whether giving a clot-busting drug called tenecteplase directly into the brain artery after mechanical clot removal helps people recover better from a severe stroke. About 462 adults with a large vessel blockage in the front part of the brain will be randomly ass…

This phase 3 trial is testing whether adding baxdrostat to the standard drug dapagliflozin can better prevent heart failure and cardiovascular death in people with type 2 diabetes who already have heart disease and high blood pressure. About 11,300 participants will receive eithe…

This study tests whether a procedure called hemoadsorption, which filters the blood, can help people with severe ischemic stroke. Researchers will compare standard care plus hemoadsorption to standard care alone in 116 adults. The goal is to see if the procedure reduces the chanc…

This study tests a new drug called BB-031 in people who have had a stroke within the last 24 hours. About 228 participants will receive either the drug or a placebo, and researchers will check for safety, side effects, and how the drug works in the body over 90 days. The main goa…

This study is testing whether a device that uses mild electrical pulses to stimulate arm muscles and the tongue can help stroke survivors regain arm movement. Researchers will enroll 288 participants, including stroke patients with arm weakness and healthy controls. The main goal…

This study tests a new decision-making tool called IMPROVE that uses MRI scans to detect unstable plaques in the carotid artery. The goal is to see if this method is at least as good as the current standard (which mainly looks at how narrow the artery is) for selecting which pati…

This study is testing a drug called Mexidol in people who have had an ischemic stroke (a stroke caused by a blocked blood vessel in the brain). The goal is to see if Mexidol can reduce the size of the brain injury and improve recovery. The trial will involve 120 adults aged 18 to…

This study tests an experimental drug called QD202 in people who have had an acute ischemic stroke and received clot-busting medication. The drug is designed to cross into the brain and protect nerve cells. About 120 participants will receive either QD202 or a placebo daily for 5…

This study is testing whether using a blood test to guide antiplatelet therapy can better prevent recurrent strokes in people who have had a mild stroke or transient ischemic attack (TIA). About 5,100 participants will be assigned to either standard clopidogrel or ticagrelor base…

This study tests whether a custom 3D-printed external skull cap can prevent Sunken Flap Syndrome, a condition where the brain sinks after part of the skull is removed. 72 patients who had decompressive craniectomy will either wear the cap or not, and researchers will compare brai…

This study looks at whether people with atrial fibrillation can safely stop taking long-term blood thinners after a procedure that closes off a part of the heart called the left atrial appendage. Participants will get a reduced dose of the blood thinner apixaban for just 3 months…

This study is testing a device that sends mild electrical pulses to the vagus nerve in the neck, paired with physical therapy, to help people who had a stroke months or years ago. The goal is to see if this approach can safely improve arm and leg movement. About 40 adults with ch…

This study looks at how well and how safely the Tigertriever device works to remove blood clots from large brain vessels in people having an ischemic stroke. About 150 adults will be treated within 8 hours of their first symptoms. The goal is to restore blood flow and improve rec…

This study compares two common procedures—radiofrequency and cryoablation—for treating persistent atrial fibrillation, a heart rhythm disorder that raises stroke risk. Researchers will track 158 adults over 24 months to see which method better prevents strokes, transient ischemic…

This study tests whether tilting a stroke patient's head down 15 degrees for 30-90 minutes before a clot removal procedure can improve blood flow to the brain. About 118 adults with a specific type of stroke will be randomly assigned to either the head-down tilt or standard posit…

This Phase 2 trial tests whether a low dose of albumin, a natural blood protein, can protect brain tissue after an ischemic stroke. One hundred participants will receive either albumin or a placebo during a standard procedure to restore blood flow. The goal is to see if albumin r…

This study tests whether a special activity score, calculated from heart rate data, can help people who have completed cardiac rehab stick to exercise guidelines. About 318 participants will wear a smartwatch for 4 months and do an exercise test at the end. Researchers will compa…

This study tests whether a procedure to reopen a major blocked artery in the brain can help people who had a severe stroke 24 to 72 hours earlier. About 224 participants will either get the procedure plus standard care or standard care alone. The goal is to see if the procedure i…

This phase 3 trial tests whether adding tocilizumab, an anti-inflammatory drug, to standard emergency stroke treatment improves outcomes for people with a severe stroke in the back of the brain. About 348 adults will receive either tocilizumab or a placebo by IV right before a pr…

This study tests a device called GORE® CARDIOFORM Septal Occluder to close a small hole in the heart (PFO) in people who have had a stroke with no clear cause. About 636 participants will get the device plus blood-thinning medicine. The goal is to see if this reduces the chance o…

This study tests a new treatment for people who have had a stroke caused by a blood clot in the brain. A weak electrical current is applied through electrodes on the scalp to increase blood flow and protect brain tissue. The goal is to find the safest and most effective dose. The…

This study compares a procedure to remove blood clots (endovascular therapy) with standard medical care for people who have had a mild stroke caused by a blockage in a large brain artery. About 264 adults with mild symptoms (NIHSS score 2-5) will be enrolled within 24 hours of st…

This study tests a clot-busting drug called tenecteplase, given directly into the brain artery, for people having a medium-sized stroke. About 488 adults will be randomly assigned to get the drug or standard care. The goal is to see if the drug helps more people recover with litt…

This study compares two ways to reach a blood clot in the basilar artery, a key vessel at the back of the brain, during a stroke. One method uses the femoral artery in the groin, the other uses the radial artery in the wrist. Researchers want to see which approach leads to better…

This study looks at whether a procedure to remove a blood clot from the brain (endovascular therapy) can help people who had a mild stroke but then got worse because of a large blockage. The treatment is given more than 24 hours after the stroke started. About 272 adults with mil…

This Phase II trial tests a drug called LT3001 in 300 people who have had an acute ischemic stroke. Participants receive either a high or low dose of LT3001 or a placebo by IV infusion within 24 hours of their stroke. The study aims to see if the drug is safe and helps improve re…

This study tests whether text messages can help people who have finished cardiac rehab keep up healthy habits like weight management, physical activity, and taking medications. Researchers will enroll 400 people from groups often left out of heart research. The study compares dif…

This study tests whether a balloon angioplasty procedure can prevent early neurological decline in people who have had a minor stroke due to a narrowed brain artery. The trial will enroll 100 adults who have already received standard medication but still show fluctuating or worse…

This study looks at whether high-dose statins can reduce or stabilize fatty plaques in the brain's arteries that cause strokes. About 100 recent stroke patients will get intensive statin therapy and have their arteries scanned with a special MRI. The goal is to see if the plaques…

This study tests a drug called DM199 in about 728 people who have had a moderate stroke and cannot get clot-removing treatments. The drug is given through a vein and then as shots under the skin for three weeks. Researchers want to see if it helps patients recover better than a p…

This study tests whether a simple, non-invasive treatment called remote ischemic preconditioning (RIC) can improve blood flow around blocked arteries in people who have had a stroke. RIC involves inflating a blood pressure cuff on the arms for short periods to trigger the body's …

This study tests whether lying in a slight head-down position (20 degrees) can help people recover from a moderate stroke caused by narrowed arteries. Researchers will compare this position plus standard care to standard care alone in 600 participants. The goal is to see if more …

This study tests if briefly stopping and restarting blood flow in the neck after a stroke procedure can help the brain heal better. About 120 adults who had a major stroke and received emergency treatment to reopen a blocked artery will be randomly assigned to get this extra ther…

This study tests whether a simple, non-invasive treatment called remote ischemic conditioning (RIC) can help people recover better after a moderate stroke in the back part of the brain. RIC involves briefly inflating a blood pressure cuff on the arm to restrict blood flow, then r…

This study looks at whether adding evolocumab (a powerful cholesterol-lowering drug) to standard statin therapy helps people recover better after a stroke caused by hardening of the large arteries. Researchers will follow 1000 adults aged 18-80 for 90 days, comparing those who ge…

This study looks at whether adding a statin (atorvastatin or rosuvastatin) within 24 hours of a first small vessel stroke, alongside standard blood thinners (clopidogrel and aspirin), can reduce the risk of having another stroke within 90 days. About 600 adults aged 18-75 who had…

This phase 2 trial is testing whether TAK-755, a lab-made protein that helps break up blood clots, is safe and effective for people who have had an acute ischemic stroke. About 222 adults aged 18 to 80 will receive either TAK-755 or a placebo, along with standard stroke care, and…

This study is testing a device called EmboTrap II, which is used to remove blood clots from the brain in people having a stroke. The goal is to see if it is safe and works well at restoring blood flow. About 100 participants will be followed to track outcomes like bleeding and su…

This study tests whether adding a clot-dissolving medicine directly into the brain's arteries during standard clot-removal procedures helps people recover better after a stroke caused by a medium-sized blockage. About 530 adults with acute ischemic stroke will be randomly assigne…

This study is testing whether giving a clot-busting drug (tenecteplase) directly into the blocked brain artery can improve outcomes for people having a stroke caused by a medium-sized vessel blockage. About 282 participants will be randomly assigned to receive either the intra-ar…

This study looks at whether removing a large blood clot from the brain (endovascular thrombectomy) is better than standard medical care for stroke patients who already had a moderate-to-severe disability before their stroke. About 1,060 adults with a recent stroke and a pre-exist…

This study tests whether giving the protein albumin (given as an IV drip for four days) along with standard clot-removal treatment helps people recover better after a severe stroke caused by a large blockage. About 1,200 adults aged 18-80 with anterior circulation strokes will be…

This study tests whether using remote-controlled CT scans at local medical centers, guided by a hospital stroke team via video call, can speed up treatment for stroke patients. About 52 participants with suspected stroke will be randomly assigned to either this new approach or st…

This study tests whether genetic testing can help veterans at high risk for heart disease start and stick with statin medications. About 410 veterans aged 40-75 with diabetes or heart disease who are not currently taking statins will receive either a genetic report on their stati…

This study tests whether a single procedure that combines two heart treatments—pulmonary vein isolation (to correct irregular heartbeat) and left atrial appendage occlusion (to block a clot-prone area)—can prevent future strokes and major bleeding better than standard blood thinn…

This study tests a brain implant that records and stimulates brain areas to help adults with severe paralysis (from spinal cord injury, ALS, or stroke) control assistive devices like computers or wheelchairs. The main goal is to check safety, and researchers will also see if part…

This phase 3 trial tests whether a single injection of BXOS110, given within 3 hours of an acute ischemic stroke, can reduce overall disability compared to a placebo. About 1112 adults aged 18-85 with moderate to severe stroke are being enrolled. The main goal is to see if more p…

This study tests whether a newer clot-dissolving drug (tenecteplase) works better than the standard drug (alteplase) when given before a mechanical procedure to remove a large blood clot from the brain. About 850 adults who have had a severe stroke within the last 4.5 hours will …

This study tests whether a team of community health workers, social workers, and nurses can help stroke survivors who face social challenges like food or housing insecurity. The team visits participants at home starting within 72 hours of hospital discharge, offering referrals, c…

This study tests whether giving the steroid methylprednisolone right after a stroke clot removal procedure can help patients recover better. About 210 adults who had a major stroke from a blocked artery in the brain will be randomly assigned to receive either the steroid or a pla…

This study tests whether removing a blood clot from the brain (endovascular thrombectomy) plus standard medical care helps people who had a severe stroke 24 to 72 hours earlier. About 408 adults aged 18-85 with large-vessel blockage will be randomly assigned to get the procedure …

This study tests whether adding digital coaching to home-based cardiac rehabilitation helps veterans complete more rehab sessions and improve their heart health. 150 veterans with heart disease will be randomly assigned to standard home rehab or home rehab plus a private social m…

This study tests whether the clot-busting drug tenecteplase can help people who have had a stroke caused by a medium-sized blood vessel blockage in the brain. About 600 participants will receive either tenecteplase or standard care within 4.5 to 24 hours of symptoms starting. The…

This study tests whether amantadine, a drug already used for flu and Parkinson's, can help people recover after a stroke. Sixty adults who had an ischemic or hemorrhagic stroke will receive either amantadine or a placebo for one month. Researchers will track side effects and meas…

This study is testing a device called the NeVa stent retriever to see how well it can remove blood clots in people having a severe stroke. The goal is to restore blood flow to the brain in a single pass. The study will enroll 600 adults who are already scheduled to have this proc…

This study tests whether the clot-busting drug tenecteplase can help people who have had a stroke 24 to 72 hours earlier. Currently, such drugs are only given within a few hours. The trial will compare tenecteplase to standard care (blood thinners) in 330 adults with blocked brai…

This study looks at giving a second dose of the clot-busting drug tenecteplase to people having a stroke caused by a medium or large blocked artery. Participants must receive the first dose within 4.5 hours of symptoms and show little improvement after one hour. The goal is to se…

This study compares a new ambulatory (same-day) stroke care model to standard hospital care for patients aged 60 and older who have had a mild stroke or transient ischemic attack (TIA). Participants receive a full neurological assessment and treatment plan on the same day and the…

This study tests whether a home hospitalization program (NORA-HOME) is safe and effective for people who have had a minor stroke or transient ischemic attack (TIA). Researchers will compare home monitoring with standard hospital care in 250 participants. The goal is to see if hom…

This study tests whether giving a second dose of the clot-busting drug tenecteplase can help stroke patients who don't get better within an hour of the first dose. About 120 adults with acute ischemic stroke will receive either a second dose or standard care. The goal is to see i…

This study tests whether closing a small hole in the heart (called a PFO) plus medication is better than medication alone at preventing repeat strokes in people over 60 who have had a cryptogenic stroke (a stroke with no clear cause). About 714 participants will be randomly assig…

This study tests whether adding the drug cilostazol to the usual two blood thinners (aspirin and clopidogrel) can better prevent early stroke recurrence in people who had a stroke caused by narrowed arteries in the brain or neck. About 2,340 adults will be enrolled within 72 hour…

This study looks at 100 people who recently had a stroke and need surgery to clear a blocked neck artery. Half will get numbing medicine only in the neck (regional anesthesia), and the other half will be fully asleep (general anesthesia). The goal is to see which method leads to …

This study involves 792 people aged 60-80 who had a stroke linked to a patent foramen ovale (PFO), a small hole in the heart. It compares three approaches: closing the hole with a device plus antiplatelet drugs, taking newer blood thinners (apixaban, dabigatran, or rivaroxaban), …

This study looks at whether people aged 60 or younger who had a stroke caused by a hole in the heart (PFO) can safely stop taking blood thinners one year after the hole is closed. The goal is to see if stopping these drugs reduces the risk of bleeding without increasing the chanc…

This study tests a new device called Ceretrieve that is designed to remove blood clots from brain arteries in people having a severe stroke. About 132 participants will be treated within 24 hours of symptoms starting. The goal is to see if the device can safely restore blood flow…

This study tests a new device that uses stitches to close a small hole in the heart (called PFO) in people who have had a stroke. It compares the stitch method to a standard metal plug device. About 640 adults aged 18-60 with a PFO and a recent stroke will be enrolled. The goal i…

This study looks at two ways to prevent another stroke in older adults who have a hole in the heart (PFO) and had a stroke from an unknown cause. One option is a procedure to close the hole, plus lifelong blood thinners. The other is taking blood thinners alone. Researchers will …

This study looks at whether people at moderate risk for heart problems should continue or stop taking aspirin before a colonoscopy. About 2,500 participants will be randomly assigned to take either aspirin or a placebo for a few days around the procedure. The goal is to see which…

This study tests whether giving a clot-busting drug (tenecteplase) before transferring patients with a severe stroke in the back of the brain (basilar artery occlusion) to a specialized hospital can improve recovery. About 316 adults who had a stroke 4.5 to 24 hours earlier will …

This study tests whether adding the antibiotic minocycline to standard stroke care can improve survival and reduce disability in adults who have had a moderate stroke. About 1,164 participants will be randomly assigned to receive either minocycline pills for five days plus usual …

This study tests a new brain-computer interface called MindEx that uses four small chips implanted in the brain to help people with severe paralysis control a computer or tablet just by thinking. The goal is to improve independence and quality of life by allowing users to type, p…

This study looks at whether giving a clot-dissolving drug called Tenecteplase to stroke patients before they are moved to a hospital that can perform a clot-removal procedure improves their recovery. The trial involves 572 adults who had a stroke caused by a large blockage in the…

This study tests a drug called JX10 in people who have had a stroke and arrive at the hospital 4.5 to 24 hours later. The goal is to see if JX10 can improve recovery and reduce disability compared to a placebo. About 740 participants will be randomly assigned to receive JX10 or a…

This study tests whether performing carotid artery surgery within 72 hours of a mini-stroke or minor stroke is safer and more effective than waiting 4 to 15 days. About 456 participants with a blocked neck artery will be randomly assigned to one of two timing groups. The goal is …

This study compares a stent (CARESTO® heal) plus standard medication against medication alone in 536 people who recently had a stroke or retinal artery blockage due to a specific type of carotid artery disease that is not severely narrowed. The goal is to see if the stent can low…

This study tests whether taking atorvastatin (a cholesterol-lowering drug) before and after a brain stent procedure can prevent strokes and other serious events. About 354 adults with brain aneurysms will be randomly assigned to receive either atorvastatin or a placebo. The goal …

This study tests whether adding a fast-acting blood thinner (cangrelor) to standard clot removal improves recovery in people with a severe stroke. About 368 adults with a large artery blockage in the brain will receive either cangrelor plus the procedure or the procedure alone. T…

This study tests a surgery that moves a nerve from the neck to help people with arm weakness after a stroke. It is for those whose arm has not improved with rehab. The goal is to see if the surgery can improve arm movement and control.

This study is testing a new medical device system designed to quickly restore blood flow in people having a severe stroke caused by a blocked artery. About 500 adults who are treated within 8 hours of stroke symptoms will be enrolled. The goal is to see how well the device reopen…

This study tests whether removing a blood clot from a smaller brain vessel (distal medium vessel) using a catheter-based procedure helps people recover better from a stroke than standard medical therapy alone. About 584 adults who had a stroke within the last 12 hours and cannot …

This study looks at whether removing a blood clot from a medium-sized brain artery (M2 segment) helps people recover better after a stroke. About 200 adults who have had a stroke and are not helped by clot-busting medicine will be randomly assigned to get either standard care or …

This study looks at whether giving clot-busting drugs to stroke patients who are already on blood thinners is safe and effective. About 260 adults who had a stroke while taking common blood thinners will be enrolled. The goal is to see if this treatment can improve recovery witho…

This study tests whether stimulating the vagus nerve with a magnet, while doing walking exercises, can help people who had a stroke at least 6 months ago walk better. Twenty participants will do 6 weeks of in-clinic therapy followed by 6 weeks of home exercises. The main goals ar…

This study looks at stroke patients who had a clot successfully removed from a large brain artery. After the procedure, some patients have low blood pressure. The trial will test whether carefully raising their blood pressure by 20% (but not above 160 mmHg) leads to better recove…

This study tests two programs for people recovering from a stroke who are leaving inpatient rehab to go home. Half of the 520 participants will get a standard stroke education program, while the other half will get a program that helps modify their home environment. The goal is t…

This study tests whether a procedure to remove blood clots from medium-sized brain arteries, guided by advanced imaging, helps people recover better than standard medical care alone. It includes 568 adults who had a stroke within the past 24 hours. The goal is to see if more peop…

This study tests whether a drug called neflamapimod can improve recovery of movement and thinking after a moderate to severe ischemic stroke. About 90 adults aged 45 and older will receive either the drug or a placebo for 12 weeks. The goal is to see if the drug helps reduce disa…

This study tests a new drug called QHRD106 in people who have had a recent ischemic stroke (a stroke caused by a blocked blood vessel in the brain). The goal is to see if the drug can help patients recover better and have less disability. About 320 adults aged 18 to 80 who have n…

This study looks at the best time to start blood thinners in people with atrial fibrillation who had a stroke and emergency treatment to open a blocked artery. About 438 participants will be randomly assigned to start blood thinners within 4 days or between 5-14 days after the st…

This study looks at the best time to start blood thinners in people with atrial fibrillation who had a stroke and then emergency treatment to remove a clot. Some patients develop bleeding in the brain after the procedure, and doctors want to know if starting blood thinners early …

This study tests a program called CVD-FIT for African American adults who struggle to afford food and are at risk for heart disease. Participants get monthly income support, weekly incentives to buy healthy food, and phone-based education on heart health. The goal is to see if th…

This study tests a safe, non-drug treatment called remote ischemic preconditioning (RIC) to see if it can stop early neurological decline in people who have had a mild stroke caused by a blocked small artery. The treatment involves briefly inflating a blood pressure cuff on the a…

This study tests whether telemedicine support can improve stroke care in basic-level hospitals with limited resources. About 2,400 patients with acute ischemic stroke will be treated at hospitals that either receive round-the-clock remote guidance from expert stroke teams or do n…

This study tests a single injection of stem cells (B2065) given within 36 hours of a stroke. The goal is to see if it is safe and might help patients recover better. Fifty-four adults with moderate to severe stroke will receive either the stem cells or a placebo, and be followed …

This study tests whether a procedure to remove a blockage in the neck artery (endovascular treatment) plus standard medical care helps people recover better after a stroke. About 200 adults with acute ischemic stroke from a blocked internal carotid artery will be randomly assigne…

This study tests whether performing skull surgery early, before dangerous brain swelling occurs, can improve outcomes for people who have had a severe stroke and are at high risk of swelling. About 380 adults aged 18–75 will be randomly assigned to receive either early surgery pl…

This study tests a new device called the iNstroke 4F catheter, designed to remove blood clots from small blood vessels deep in the brain after a stroke. About 57 adults who have had a stroke within the past 24 hours will receive this treatment. The goal is to see if the catheter …

This study tests whether adding a protein from human urine (human urinary kallidinogenase) to the standard clot-busting drug tenecteplase helps people recover better after an acute ischemic stroke. The trial will enroll 200 adults who arrive at the hospital within 4.5 hours of st…

This study tests whether giving a clot-busting drug directly into the brain's arteries can help people having a stroke from a medium-sized blockage. About 382 adults who have had a stroke within the last 24 hours will be randomly assigned to receive either the drug or standard ca…

This study tests whether giving the clot-busting drug tenecteplase directly into the brain artery after mechanical clot removal can improve outcomes for people with acute ischemic stroke. About 132 adults aged 18-85 with large vessel blockages will be randomly assigned to receive…

This trial tests whether doing brain scans and clot-removal procedures in the same room speeds up treatment for severe strokes. About 390 patients with suspected large-vessel blockages will be randomly assigned to either the usual two-room process or a one-room approach. The goal…

This early-stage trial is testing a new treatment called NouvSoma001 for people who have had an ischemic stroke within the past week. The treatment uses tiny particles from stem cells, given through an IV, to see if it is safe and might help the brain recover. About 69 participan…

This study looks at how well a special intensive therapy called ACQUIRE Therapy works for children with motor problems caused by conditions like cerebral palsy, autism, or brain injury. The therapy involves many hours of play-based exercises each day, often with a cast or splint …

This study tests whether bringing blood pressure down very quickly (below 120 mmHg) after a stroke clot removal procedure improves recovery. About 910 stroke patients will be randomly assigned to either intensive or standard blood pressure management. The goal is to see if this a…

This study tests whether deep brain stimulation (DBS) combined with physical therapy can improve arm weakness in people who had a stroke 1 to 6 years ago. About 202 participants will receive either DBS plus rehab or rehab alone. The goal is to see if the treatment safely restores…

This study is testing whether giving air conditioners and a $100 electricity subsidy to older adults in Boston neighborhoods can reduce heat stress, heat strain, and related health problems. One hundred participants aged 55-95 who don't have AC will be randomly assigned to receiv…

This study tests a new way to manage blood pressure in people having a stroke who receive clot-busting medication. The goal is to see if adjusting blood pressure treatment can lower the risk of bleeding in the brain. About 340 participants will be randomly assigned to either the …

This study tests a smart management system that uses a WeChat app and home devices like blood pressure monitors to help people who have had a stroke or mini-stroke avoid another one. About 4,490 participants will either get usual care or use the system after leaving the hospital.…

This study tests whether a daily supplement made from salicornia (a salty plant) and B vitamins can help slow down memory and thinking problems in people who have had a small type of stroke called a lacunar infarct. About 300 adults aged 40-90 will take either the supplement or r…

This study looks at whether two different versions of Angong Niuhuang Pills can help people recover from an acute ischemic stroke. About 100 adults aged 18-80 will take one of the two pill types or receive no pills, and their recovery will be tracked for 84 days. The goal is to s…

This study tests whether giving the clot-busting drug tenecteplase directly into the brain artery after standard clot removal can improve blood flow in tiny vessels. About 20 adults who had a major stroke from a large clot will receive a single dose of the drug through a catheter…

This large trial is testing whether AI-guided robotic surgery can improve outcomes for people with a hemorrhagic stroke (bleeding in the brain). The study will compare this new, less invasive technique to standard surgery or medical management. Researchers hope the robotic approa…

This large Phase 3 trial is testing whether an investigational drug called SHPL-49 can help people recover better after an acute ischemic stroke. About 1,096 participants will receive either the drug or a placebo as an IV infusion twice daily for 7 days, alongside standard care. …

This study tests whether umbilical cord stem cells (Neuroncell-EX) can improve recovery in people who recently had a moderate to severe stroke. Eighty participants will receive either the stem cells or a placebo, plus standard care. The goal is to see if the treatment helps with …

This study tests whether a computer-based decision-support tool can help more people who have had a stroke or mini-stroke reach their LDL cholesterol goal of less than 1.8 mmol/L after one year of treatment with evolocumab. About 4,000 adults in China who recently had a non-cardi…

This study tests whether giving a clot-busting drug (rhTNK-tPA) before a clot-removal procedure helps stroke patients who arrive 4.5 to 24 hours after symptoms start. About 820 adults with a blocked large artery in the brain will receive either the drug or a placebo. The goal is …

This study tests whether combining a statin with ezetimibe (another cholesterol-lowering drug) works better than a statin alone in people who recently had a stroke. Researchers will enroll 300 adults aged 20 or older who had a stroke or TIA within the past 30 days and have high L…

This study tests whether giving the blood thinner tirofiban soon after standard clot-busting medication helps people recover better from a stroke. About 1,084 adults with moderate stroke symptoms will receive either tirofiban or a placebo within 6 hours of the initial treatment. …

This study tests whether a drug called tenecteplase can help people who have had a stroke and cannot get treatment within the usual 4.5-hour window. About 890 Chinese adults with a moderate to severe stroke will receive either the drug or standard care. Doctors will use a special…

This study tests a drug called sovateltide in 160 people who have had an ischemic stroke (a stroke caused by a blood clot). The goal is to see if the drug helps patients recover better and is safe. Participants receive either the drug or a placebo within 24 hours of their stroke,…

This study tests whether adding inclisiran (a twice-yearly injection) to standard care lowers LDL cholesterol more than standard care alone in 520 patients who recently had a heart attack, stroke, or urgent heart procedure. Participants are randomly assigned to receive inclisiran…

This study looks at whether giving the drug tirofiban soon after the standard clot-busting drug tenecteplase can help people recover better from a stroke. About 348 adults who had a stroke and received tenecteplase will be enrolled. The goal is to see if this combination reduces …

This study compares two treatments for people with a severe stroke caused by a large blood clot. One group gets standard care (medication), and the other gets standard care plus a procedure to remove the clot. The goal is to see if clot removal leads to better recovery and less d…

This study tests two different medicines given before a procedure to remove a blood clot from the brain in people having a major stroke. The goal is to see which medicine helps more people recover with little or no disability. About 800 adults who arrive at the hospital within 24…

This study tests whether dulaglutide, a once-weekly diabetes injection, can improve blood flow in the brains of people with severely narrowed arteries. About 130 participants who recently had a mini-stroke or mild stroke will receive either standard care or dulaglutide plus stand…

This study tests whether adding the blood thinner tirofiban after standard clot-busting treatment helps people with acute ischemic stroke recover better. About 976 adults whose stroke symptoms don't improve enough within an hour of initial treatment will receive either tirofiban …

This study tests whether giving aspirin within 3 hours of clot-busting treatment for stroke can improve recovery without causing dangerous bleeding. About 1,184 adults who had an ischemic stroke will receive either aspirin or a placebo. The goal is to see if early aspirin leads t…

This Phase 3 trial tests a drug called rhTNK-tPA (Mingfule) in people with acute ischemic stroke who can be treated 4.5 to 24 hours after symptoms start. The study plans to enroll 890 participants and will compare the drug to a placebo. The goal is to see if the drug helps patien…

This Phase 3 trial tests whether adding carotid artery stenting to standard mechanical clot removal improves recovery in people with acute ischemic stroke caused by a blockage in the internal carotid artery. About 404 participants aged 18-79 will be randomly assigned to receive e…

This study compares two treatments for stroke patients whose brain arteries remain blocked after initial clot removal, due to underlying hardening of the arteries (atherosclerosis). About 498 participants will be randomly assigned to receive either urgent stenting or continued st…

This study tests whether bempedoic acid, a cholesterol-lowering drug, can reduce artery inflammation and improve heart health in people with HIV. About 121 adults aged 40 and older with well-controlled HIV and at least one heart disease risk factor will receive either the drug or…

This study tests a drug called tenecteplase in people who have had a stroke and recently took a blood thinner (DOAC). The goal is to see if the drug helps them recover better after 90 days. About 912 participants will receive either tenecteplase or a placebo within 24 hours of th…

This study tests an experimental drug called KPCXM18 in people who have had an acute ischemic stroke within the past 12 hours. About 300 participants will receive either a low dose, a high dose, or a placebo by IV twice daily for about 12 days. The main goal is to see if the drug…

This study tests a special catheter designed to help remove large blood clots in the brain during a stroke. About 327 adults aged 22 to 85 who have a disabling stroke will be treated within 16 hours of symptoms. The goal is to see if the device safely restores blood flow in one p…

This study tests whether giving the blood-thinning drug tirofiban before a clot-removal procedure helps people recover better after a stroke caused by a blocked artery. About 870 adults with a large-vessel stroke will receive either tirofiban or a placebo before the procedure. Th…

This study tests whether giving patients 100% oxygen (normobaric hyperoxia) before a clot-removal procedure can improve their recovery three months after a severe stroke. About 1,500 adults with acute ischemic stroke will be randomly assigned to receive either the extra oxygen or…

This study tests whether a noninvasive arm cuff therapy, called remote ischemic conditioning, can improve recovery in people who have had a major stroke and undergone a clot-removal procedure. The therapy involves briefly inflating and deflating a cuff on the upper arm to protect…

This study tests whether common stroke-preventing medications—aspirin, clopidogrel, and statins—can reduce the risk of future stroke, heart attack, and dementia in people who have small, symptomless areas of brain damage called covert brain infarcts (CBIs). These are often found …

This study tests whether a non-invasive brain stimulation technique called TMS can improve recovery in people who have had a stroke and undergone a clot removal procedure. Sixty participants will receive either real or sham TMS sessions alongside standard care. Researchers will m…

This early-stage trial tests whether exosomes from stem cells can help people recover from a recent stroke. 29 participants will receive either the exosome treatment or a placebo, and researchers will check for safety and any signs of improved function. The study is small and exp…

This study is for people having a stroke caused by a blocked artery in the brain. It compares different methods of removing the clot (thrombectomy) to find which works best. About 1600 adults will take part, and the goal is to reduce long-term disability.

This study tests whether a traditional Chinese herbal formula called Qingre Huatan can prevent early neurological deterioration in people who have had an acute ischemic stroke within the last 48 hours. The trial will involve 72 participants, who will receive either the herbal gra…

This study tests a new drug called TBO-309, which helps prevent blood clots, in people having a stroke. It is given alongside standard treatments like clot-busting drugs or mechanical clot removal. The main goal is to see if it is safe, especially regarding bleeding in the brain,…

This study tests increasing doses of the clot-busting drug urokinase in 24 people with acute ischemic stroke, given within 6 hours of symptoms. The goal is to find the highest safe dose and develop a weight-based dosing plan. Researchers will watch closely for bleeding complicati…

This trial tests a wearable bracelet called Stroke Alarm that detects when a stroke causes arm weakness. People aged 50 and older with certain high-risk conditions (like recent mini-stroke, atrial fibrillation, or artery disease) wear the device for 3 months. The goal is to see i…

This study is looking for markers in blood and saliva that can quickly tell if a person is having a stroke, and what kind. Researchers will collect samples from 650 adults with suspected stroke within 24 hours of symptoms. The goal is to develop a fast, accurate test to help emer…

This pilot study tests whether a special PET scan using a tracer called Florbetaben can detect inflamed plaque in arteries of people who recently had a heart attack, stroke, or mini-stroke. The goal is to see if this imaging method can identify unstable plaques that are likely to…

This study looks at whether monitoring brain blood flow during stroke treatment can predict if a patient will recover well. Researchers will track 129 stroke patients for 90 days after treatment. The goal is to find a way to identify early on who might need extra care.

This study tests whether a new CT-angiography method can accurately diagnose brain death compared to the standard four-vessel angiography. About 50 adults with severe brain injury will receive both tests. If the CT method works as well, it could offer a faster, less invasive way …

This study is testing a special mattress that can measure heart rate, breathing, temperature, and body position without touching the patient. It is designed for people with heart disease who are in the hospital. The goal is to see if this wireless system works as well as standard…

This study tests whether a special PET/MR scan can tell which fatty deposits in the neck arteries are likely to cause a stroke. About 100 adults with known carotid plaque will get two types of PET tracers along with MRI to measure inflammation and scarring inside the plaque. Rese…

This study compares a new wireless heart sensor patch to standard hospital monitoring for detecting atrial fibrillation (an irregular heartbeat) in people who recently had a stroke. About 450 adults will be randomly assigned to wear the patch for up to 14 days or receive usual ca…

This study tests a wearable ECG patch (MEMO Patch) to see if it can detect atrial fibrillation—a heart rhythm issue that raises stroke risk—in 100 people who had a stroke with no known cause. Participants wear the patch for up to 14 days at home, and results are compared with sta…

This study tests whether a smartwatch algorithm can detect atrial fibrillation (AF), an irregular heartbeat that often goes unnoticed and raises stroke risk. Researchers will enroll 500 stroke survivors who will wear a standard heart monitor and a study-provided smartwatch for 30…

This study looks at whether a special type of CT scan (multimodal CT) can more accurately identify the blocked artery in people with medium vessel occlusion stroke. Researchers will compare this method to standard CT scans in 622 adults who had a stroke within the last 24 hours. …

This study is testing whether machine learning and special brain injury markers in blood and spinal fluid can warn doctors early when a patient with a brain bleed is developing delayed cerebral ischemia (lack of oxygen to the brain). Researchers will monitor 1,500 adults in inten…

This study is testing whether a new ultrasound device called SYLVER can measure blood flow in the brain as accurately as the standard CT scan. It involves 50 ICU patients with brain injuries or bleeding. If it works, doctors could monitor brain health at the bedside without movin…

This study tests whether giving a single dose of a common antibiotic soon after a breathing tube is placed can prevent lung infections and improve survival in ICU patients with severe brain injuries. Researchers will enroll 3,300 adults on ventilators due to stroke, trauma, or la…

This study compares two types of speech therapy for people with aphasia, a language disorder often caused by stroke. One therapy, called Semantic Feature Analysis (SFA), helps people name objects by describing their features. The other adds metacognitive strategy training (SFA+MS…

This trial tests a wearable robot called ENMS-BSF that combines soft muscles, electrical stimulation, and balance feedback to correct foot drop and foot inversion after a stroke. Sixty people who had a stroke at least six months ago and have mild-to-moderate walking problems will…

This study tests whether a gentle, non-invasive nerve stimulation (called tVNS) applied to the ear or neck can improve arm movement, thinking, and quality of life when paired with standard therapy in people who had a stroke 3–6 months ago. About 54 adults who had their first isch…

This study tests whether a non-invasive brain stimulation technique called TMS, combined with language therapy, can improve speech in people who have aphasia after a stroke. Researchers will compare real TMS to a sham (fake) version in 63 participants who had a stroke 2 to 6 week…

This study looks at whether a regular exercise program can improve the benefits of botulinum toxin (Botox) injections for arm stiffness after a stroke. About 70 stroke survivors with arm spasticity will receive Botox and then be randomly assigned to either a prescribed exercise r…

This study looks at urinary problems in people recovering from a stroke. Researchers compare patients with and without bladder issues and test two simple behavioral approaches: for those with thinking difficulties, training to go to the toilet immediately when they feel the urge;…

This study tests whether adding telerehabilitation (home-based, supervised and independent arm exercises) to usual care improves arm function and reduces disability after a stroke. Twenty adults in Brazil who had a stroke about 4 months ago will participate. The goal is to see if…

This study tests a smartphone app designed to help people prepare for heart surgery through exercise, nutrition tips, and telehealth check-ins. About 40 adults awaiting surgery will either use the app or receive standard care. Researchers want to see if the app is easy to use, ac…

This study tests whether vagus nerve stimulation (VNS) paired with rehabilitation can improve leg and walking function in people who have had an ischemic stroke. Researchers will enroll 24 adults who are already approved for VNS therapy for arm problems. The goal is to see if thi…

This study tests two different stitch materials (PDS and Vicryl) for closing groin incisions after planned vascular surgery. About 259 adults will be randomly assigned to one stitch type or the other. The goal is to see which material leads to fewer wound problems.

This study tests whether a noninvasive brain stimulation technique, timed to the patient's own brain waves, can improve arm and hand movement after an ischemic stroke. Researchers will enroll 144 adults who had a stroke 1-14 days ago and have significant arm weakness. Participant…

This study is testing whether combining a special movement therapy with mild electrical stimulation can help people who had a stroke regain arm function. Forty participants who had an ischemic stroke 3 to 6 months ago will receive either the combo therapy or standard rehab. The g…

This study tests a new virtual reality system that uses motion-tracking games to help stroke survivors improve arm and hand function. 56 people who had a stroke within the last 2 to 6 months will either get this VR therapy or standard rehab for 8 weeks. Researchers will measure a…

This study tests whether a daily movement program led by a kinesiologist can reduce frailty in 60 hospitalized heart patients. Frailty makes people weaker and more likely to have longer hospital stays or be readmitted. The program encourages simple activities like standing, walki…

This study tests whether a special brain-training game can help people who have had a stroke regain movement in their hand. The game uses a headband to measure brain activity and rewards concentration by moving a virtual hand. The study will include 30 people who had a stroke wit…

This study tests whether ginkgo biloba tablets can help improve memory and thinking in people aged 55 and older who recently had a mild stroke. 400 participants will either take ginkgo biloba plus standard care or standard care alone for 12 months. Researchers will measure change…

This early-phase trial tests whether inhaled nitric oxide is safe for people having emergency clot removal after a stroke. It includes 36 adults with severe strokes. The main goal is to find the highest safe dose without causing brain bleeding.

This study tests a surgically implanted device called the CorTec Brain Interchange (BIC) System in 4 people who had an ischemic stroke at least 6 months ago and have lasting arm weakness. The device delivers electrical stimulation designed to encourage the brain to rewire itself …

This study tests whether a safe, non-invasive brain stimulation technique called theta burst stimulation (TBS) can boost language recovery in people with post-stroke aphasia. 45 adults with non-fluent aphasia will receive either real TBS (targeting the left or right brain) or a s…

This study tests whether extra support—like personalized mask fitting, monthly phone calls, and a tracking app—helps stroke patients with sleep apnea use their CPAP machine more consistently during rehab. About 250 participants will be randomly assigned to either this intensive s…

This study looks at whether high-intensity interval training (HIIT) is better than moderate continuous exercise for treating muscle loss (sarcopenia) in people who have had an ischemic stroke. Researchers will measure changes in thigh muscle thickness, grip strength, walking abil…

This pilot study tests whether a mild electrical stimulation applied to the spinal cord, combined with balance training, can improve stability and reduce fall risk in people who had a stroke over a year ago. Sixteen community-dwelling adults will be randomly assigned to receive e…

This pilot study tests whether a low-cost virtual reality (VR) system can help people recovering from a first-time stroke improve their arm movement. Researchers will compare VR therapy to standard care in 40 adults with moderate to severe arm weakness. Participants will use a Me…

This study tests whether a 12-week high-intensity exercise program can improve language, thinking, and physical health in 120 adults with aphasia (trouble speaking or understanding language) after a stroke. Participants are randomly assigned to either high-intensity or low-intens…

This study tests whether adding a program that targets sleep and stress (called RESST) to standard cardiac rehabilitation helps heart patients recover better. About 200 adults with heart conditions who also have poor sleep or high stress will take part. Researchers will measure s…

This study compares two types of anesthesia given during surgery to remove a blood clot from the brain after a stroke. One is inhaled (sevoflurane) and the other is given through a vein (propofol). Researchers want to see which method leads to better recovery and independence 90 …

This study tests a new rehabilitation method for people who lost part of their vision after a stroke. It combines gentle electrical brain stimulation with visual exercises, sometimes using virtual reality, to try to speed up recovery of sight in the blind area. The study involves…

This study tests whether combining Transcranial Magnetic Stimulation (TMS) with speech therapy can improve language in people with mild aphasia after a stroke. About 24 adults who had a left-brain stroke at least 6 months ago will receive either real or fake TMS along with 10 day…

This pilot study tests a 12-week workshop called STEP-Home-SP for veterans who recently left military service. The workshop teaches emotional regulation and problem-solving skills to help with reintegration and reduce suicide risk. Researchers will enroll 120 veterans to see if t…

This study tests whether using EEG neurofeedback — a way to train brain activity — can improve arm movement in people who recently had a stroke. Forty adults with a stroke within the past three weeks will either get real or fake (sham) neurofeedback, plus standard rehab. The goal…

This study tests whether a personalized form of brain stimulation (tDCS) can help people who had a stroke more than 3 months ago regain arm movement. Researchers will use brain scans to tailor the stimulation to each person and measure changes in brain connectivity and motor func…

This study tests whether a non-invasive nerve stimulation (taVNS) combined with occupational therapy can improve arm movement in people who had a stroke at least 6 months ago. 60 participants will receive the stimulation during therapy sessions. The goal is to see if this approac…

This study tests a hand exercise program for children aged 7 to 12 who have had a stroke and have trouble using their arm or hand. The program involves many repetitions of strength and coordination exercises. The goal is to see if these exercises improve how well children can use…

This study tests whether a gentle electrical current applied to the brain, combined with walking and thinking exercises, can improve movement and thinking in people who have had a stroke. Sixty adults who had a stroke between 2 weeks and 5 years ago will participate. The goal is …

This study tests a dissolvable oral film with a tiny dose of capsaicin (the hot part of chili peppers) in adults who had a stroke within the last 24 hours. The film aims to stimulate nerves in the mouth that may boost blood flow to the brain. 46 participants will receive either t…

This study tests whether balance exercises that challenge the senses (like closing eyes or standing on uneven surfaces) can improve balance and reduce fall risk in people who had a stroke over 6 months ago. 46 participants will be split into two groups: one doing these special ex…

This study tests whether adding real-time biofeedback (like visual or audio cues) to balance exercises helps people who had a stroke more than standard training alone. 66 chronic stroke patients in Lahore will be split into three groups: task-specific training with biofeedback, w…

This study tests whether psilocybin, a psychedelic substance, is safe for people who had a stroke at least a year ago. Researchers will monitor blood pressure and other vital signs in 20 participants. The goal is to see if psilocybin can help with lingering symptoms like weakness…

This study tests a web-based app called IAMABLE that provides evidence-based rehabilitation strategies for people with chronic conditions like heart disease, arthritis, or neurological disorders. Fifty adults aged 45 to 75 will use the app for 4 months to set goals and learn abou…

This study tests whether adding pelvic coordination exercises to standard core strengthening helps people recovering from a stroke improve their trunk control and balance. Researchers will compare this combined approach to standard trunk exercises alone in 38 adults aged 45-60 wh…

This study tests whether a virtual reality system that helps move a virtual hand using muscle signals, combined with mild brain stimulation, can improve arm function in stroke survivors. 45 people who had a mild to moderate stroke will try this approach. The goal is to see if thi…

This study is testing whether adding robotic exoskeletons and virtual or augmented reality to treadmill training can help people who have had a stroke walk better and feel more independent. Researchers will compare different training methods in 80 participants to see which works …

This study tests whether a painless brain stimulation technique called tDCS, combined with cognitive therapy, can improve thinking and memory in people who recently had a stroke. About 70 adults who had a stroke within the past month and have trouble thinking will receive either …

This study tests whether a type of talk therapy called Behavioral Activation, delivered via home-based telehealth, can improve social functioning and mood in veterans recently discharged from the hospital for a heart condition. About 132 veterans with depression will receive eith…

This study tests whether a telerehabilitation coaching program can help people who have had an ischemic stroke feel more confident managing their health, lower risk factors like high blood pressure and cholesterol, and avoid going back to the hospital. Sixty participants will eit…

This study tests whether a tongue endurance exercise program can improve swallowing in adults who have had a stroke. Seventy participants will be randomly assigned to either the tongue exercise group or a sham therapy group. They will do home-based exercises for 8 weeks and have …

This study tests two rehabilitation methods—mirror therapy (sensory augmentation) and mild brain stimulation (tDCS)—to improve arm and hand movement in stroke survivors. 36 adults aged 45-65 with chronic stroke will be split into three groups, each receiving different combination…

This study looks at whether a gentle nerve stimulation (tVNS) combined with hand therapy (mCIMT) can help people who had a stroke more than 6 months ago improve arm movement, thinking, and daily life. 50 adults with chronic stroke will be split into two groups: one gets both trea…

This study tests whether a daily dose of acetyl-leucine (a modified amino acid) can improve balance and coordination in people who have had a stroke affecting the back part of the brain. Two hundred adults who recently had a stroke and have trouble walking or staying steady will …

This study compares a women-only cardiac rehabilitation program to the standard mixed-gender program for women with heart disease. Sixty women aged 40-80 will attend 36 sessions over 12 weeks, with extra women-focused education. Researchers will measure attendance, completion rat…

This study tests a wrist-worn sensor system called StrokeWear that gives feedback and encourages stroke survivors to use their weaker arm more during daily activities. 88 people who had a stroke 1-6 months ago will either use the system plus a home exercise plan, or just the exer…

This study looks at whether Vojta therapy, a type of physical therapy that uses gentle pressure on specific body areas to trigger natural movement patterns, can improve posture and trunk control in people recovering from a stroke. Researchers will include 62 adults aged 45-65 who…

This small pilot study tests whether a brain-computer interface combined with electrical stimulation can improve swallowing difficulties and language problems in people who had a stroke at least three months ago. Ten participants will use the device for hand rehabilitation while …

This study looks at how social and lifestyle factors—like education, race, and income—affect a person's thinking and memory after a stroke. Researchers will interview 450 adults who had a stroke and review their brain scans and medical records. The goal is to understand why some …

This registry study will enroll 200,000 high-risk cardiac patients to see how well an AI platform called Willem can detect heart problems from standard ECGs. The AI's readings will be compared to expert cardiologist diagnoses, but the AI results won't be shared with doctors, so p…

This study follows 130 adults with moderate to severe traumatic brain injury to see if early problems with brain blood flow regulation are linked to thinking and memory problems one year later. Participants undergo brain scans and cognitive tests over the first year after injury.…

This study aims to learn more about how diseases related to blood clots, the immune system, and blood vessels start and change over time. Researchers will enroll up to 1,000 people aged 5 and older, including those with these conditions, their healthy relatives, and healthy volun…

This study aims to learn more about heart and blood vessel diseases by observing people who have them or are at risk. Researchers will collect samples and perform tests like imaging and stress tests on up to 5,000 participants, including healthy volunteers and relatives of affect…

This study creates a large database of about 12,000 people with and without heart disease. Researchers collect medical information and blood samples to analyze factors that influence heart conditions like coronary artery disease, heart failure, and stroke. The goal is to better u…

This study looks at medical records of 1,000 older heart patients in Russia to see if they were prescribed potentially harmful medications during the COVID-19 pandemic. Researchers will use a medical database to count how often these risky prescriptions happened and check for dan…

This study is translating and testing a French version of the Trunk Impairment Scale (TIS), a tool that measures trunk control and balance while sitting. Researchers will enroll 67 stroke patients to check if the scale is accurate and reliable. The goal is to give French-speaking…

This study is creating a large collection of blood, urine, stool, and heart tissue samples from 10,000 people with and without heart or metabolic conditions. The goal is to store these samples along with medical information to speed up future research into what causes these disea…

This study is testing whether simple nutritional checks before heart surgery can predict how well patients recover. Researchers will give 250 patients questionnaires, blood and urine tests, and measure grip strength and body composition. They will then see if these measures are l…

This study is collecting medical data and biological samples from people with genetic conditions affecting the heart and blood vessels, their relatives, and healthy volunteers. The goal is to better understand these diseases, improve diagnosis, and lay the groundwork for future t…

This study investigates the specific cognitive strengths and weaknesses of children and adults with Sturge-Weber Syndrome (SWS), a rare condition affecting blood vessels in the brain, skin, and eyes. Participants complete a series of tests measuring memory, attention, language, a…

This study is a registry that will follow 1500 adults treated for acute ischemic stroke with Medtronic devices. Researchers will track safety, how well the devices restore blood flow, and whether patients regain independence after 90 days. The goal is to see how these devices wor…

This study is for adults 18 and older who have had a stroke or a transient ischemic attack (TIA), often called a mini-stroke. The goal is to collect information from standard medical tests and some extra research tests, like blood draws and brain scans, to better understand how t…

This study tests how Tizanidine, a drug used for muscle stiffness, changes arm movement in people who have had a stroke. Researchers will measure brain activity, muscle responses, and movement patterns in 64 participants. The goal is to understand what limits movement after strok…

This study is observing tiny energy-producing parts of cells, called mitochondria, in the spinal fluid of people who have had a stroke or have Alzheimer's disease. Researchers want to see if these markers relate to how well patients recover after a stroke. The study does not give…

This study looks at whether people with type 2 diabetes, COPD, or heart disease who join a health program in Halsnaes Municipality improve their physical function and well-being. About 194 adults will be tracked before and after the program using tests and questionnaires. The goa…

This observational study is looking at 250 people who have had a stroke or mini-stroke due to narrowing of arteries in the brain. Researchers want to see if a specific platelet protein (FcγRIIa) and blood flow patterns on MRI can help predict who will have another stroke within a…

This early-stage study tests a technique that uses electrical stimulation to help stroke survivors improve arm movement. The idea is to correct mismatched sensory signals between vision and body awareness, which can interfere with motor learning. Only 3 people with chronic stroke…

This study uses a brain imaging technique called MEG to look at how the brain recovers after a minor stroke. Researchers will scan 40 stroke survivors and 15 healthy older adults at 1, 6, and 12 months after the stroke while they perform a naming task. The goal is to understand w…

This study follows 300 people who had hospital-acquired pneumonia to see how it affects their heart and lungs over 18 months. Researchers will take blood samples, swabs, and perform heart and lung tests to understand the link between pneumonia and later cardiovascular problems li…

This study follows 2000 adults who are in a coma or have disorders of consciousness after serious brain injuries like stroke, cardiac arrest, or trauma. Researchers collect medical records and later interview survivors or their caregivers about physical and emotional recovery. No…

This study is testing a comprehensive MRI scan to see if it can better diagnose different heart conditions. Researchers will scan 2,000 adults with suspected or confirmed heart disease. The goal is to create a standard imaging method that improves early detection and risk predict…

This registry is following 4,000 people who have been treated with Medtronic devices for brain aneurysms or ischemic stroke. Researchers are tracking how well the devices work in everyday medical practice, including how often aneurysms are fully closed and how many patients regai…

This early-stage study tests a brain implant called BrainGate in just 3 people with severe paralysis or speech loss from conditions like ALS or spinal cord injury. The goal is to see if the device is safe and can let users control a computer cursor or other tools by thought alone…

This study follows 180 adults with cerebral small vessel disease to see how their condition changes over time after a stroke. Researchers will use MRI scans and blood tests to track disease progression and look for links to thinking skills, daily function, and stroke recurrence. …

This study tests whether adding immersive virtual reality (VR) to standard physical therapy helps people who recently had a stroke regain arm movement and improve quality of life. Researchers will also look at blood markers and genes that might predict recovery. About 120 adults …

This study looks at whether getting people moving early after a stroke, with the help of a special ultrasound to check blood flow in the brain, leads to better recovery than standard care. About 1,300 adults who have had an ischemic stroke will take part. The goal is to see if th…

This study looks at 50 adults who had a stroke caused by a blocked middle brain artery and were treated with a clot-removal procedure called thrombectomy. Researchers will use special MRI scans to measure brain activity and metabolism in the damaged area. The goal is to find earl…

This observational study at Yale University will follow 150 people who have had an ischemic stroke to see how changes in blood pressure affect their recovery. Researchers will use brain scans and thinking tests to understand the connection. The goal is to find better ways to mana…

This study tests a new set of procedures called the HI-SPEED Protocol, designed to help hospitals evaluate stroke patients faster and decide who needs to be transferred for advanced care. The goal is to reduce the time patients spend in the first hospital before being moved to a …

This study is testing whether artificial intelligence can predict if someone will develop one of five common diseases: diabetes, heart disease, breast cancer, back pain, or arthritis. Researchers will collect health data from 1,000 adults aged 30 to 60, including medical records,…

This study aims to find early warning signs for major chronic diseases like stroke, heart disease, and cancer by following 4,500 healthy adults aged 30-80 in Lishui. Participants will receive regular check-ups and long-term monitoring. The goal is to improve prevention and care a…

This pilot study tests whether a special wire can safely measure blood flow in the brain's smallest blood vessels right after a stroke clot is removed. The goal is to understand why some patients still have disability even when the main artery is reopened. Fifteen adults who had …

This study looks at sleep problems like sleep apnea and insomnia in 226 people who have had a stroke. Researchers want to see how these sleep issues affect recovery, daily activities, and quality of life. Participants will use a home sleep test and a smartwatch to track sleep and…

This study uses advanced heart MRI to see how bariatric surgery and cardiac rehabilitation change the heart's structure and function. Researchers will scan 150 adults before and 6-12 months after these metabolic treatments. The goal is to understand how the heart adapts to these …

This study looks at how a stroke can disrupt the body's automatic functions, like heart rate and blood pressure control. Researchers will compare 100 people who had a stroke or a mini-stroke using brain scans, blood tests, and heart function tests. The goal is to understand why t…

This study follows 24 people who had a stroke and were recently diagnosed with atrial fibrillation (AF), a heart rhythm problem. Researchers want to see how AF changes over two years by monitoring heart activity, blood markers, and heart structure. The goal is to better understan…

This study compares how well stroke neurologists and a deep learning AI model predict recovery in 250 stroke patients. Researchers will track actual disability at 24 hours and 3 months, then compare those results to predictions made by doctors and the AI. The goal is to understan…

This study will use a new type of cardiac MRI to look at the heart's microscopic structure in 1,000 people—both healthy volunteers and those with various heart conditions. The goal is to see if this advanced imaging can detect early signs of heart damage better than standard test…

This study follows 600 adults who have had their first stroke to see how their thinking and memory change over time. Researchers will look at factors like brain reserve and daily habits to understand why some people get worse while others stay stable. The goal is to better predic…

This study tests a fast genetic test done in the hospital to see if it helps doctors pick the best blood thinner for stroke patients. Some people have a gene variation that makes the common drug clopidogrel less effective. The test checks for 11 known gene variants and alerts the…

This study is testing a new, non-invasive brain monitor (Neurosteer) in 100 ICU patients who are on breathing machines and sedatives. The monitor is a small device placed on the forehead that measures brain activity. Researchers want to see if it can accurately track levels of se…

This early study tests whether a brain implant can help people with severe paralysis from conditions like ALS, spinal cord injury, or stroke control devices using their thoughts. The implant records brain signals to decode text or synthesized speech. Only 3 adults will participat…

This study tests whether brain-computer interfaces (BCIs) can be used at home by children aged 5-18 with severe physical disabilities, such as cerebral palsy or brain injury. Families receive a BCI kit and participate in 12 virtual coaching sessions over 3-6 months. The goal is t…

This study tests a new brain scanning method called fNIRS to see if it can predict recovery in unconscious ICU patients with severe stroke or brain injury. Researchers will compare fNIRS results with standard tests in 30 patients and healthy volunteers. If successful, fNIRS could…

This study is building a huge database of up to 800,000 Korean patients with heart or brain vascular disease. By tracking their health over many years, researchers hope to understand the unique patterns and risk factors in this population. The goal is to create a platform that ca…

This study looks at how different types of anesthesia change blood flow and oxygen use in the brains of children. Up to 1,000 kids having an MRI scan will be asked to join. The goal is to learn more, not to test a new treatment.

This study follows 1,875 people who have had an ischemic stroke and are taking blood thinners to prevent another one. Researchers use MRI scans to see if these medications increase the risk of tiny brain bleeds or major bleeding. The goal is to help doctors choose safer treatment…

This study is creating a large biobank of blood, DNA, plasma, and tissue samples from 15,000 people with and without heart and aortic diseases. Researchers will use this information to better understand conditions like aortic aneurysm, heart failure, and bicuspid aortic valve. Th…

This study compares a standardized swallow test (MASA) with the usual non-standardized test to see which better detects swallowing problems and risk of food or liquid entering the lungs in stroke patients. Researchers will test 50 adults recently hospitalized after an ischemic st…

This study aims to develop better MRI methods for imaging the heart and brain, and to describe heart diseases using these new techniques. It will also investigate whether gadolinium, a common MRI contrast agent, stays in the body long after use. Up to 5,000 healthy volunteers and…

This study looks at whether an imbalance in gut bacteria is linked to stroke risk and recovery in young adults (ages 18-45). Researchers will analyze stool and blood samples from 60 stroke patients to find patterns that could help predict strokes earlier. The goal is to understan…

This study looks at whether a fast genetic test can help doctors pick the best blood-thinning medication for people who have had a minor stroke or a high-risk mini-stroke (TIA). The test checks a gene called CYP2C19, which affects how the body processes certain antiplatelet drugs…

This study looks at whether low magnesium in the blood is linked to memory, attention, and other thinking problems after a stroke. Researchers will measure magnesium levels and give cognitive tests to 80 stroke patients over several weeks. The goal is to understand if magnesium d…

This study will use advanced heart MRI scans on up to 100,000 people with known or suspected heart disease. The goal is to learn how these scans can help doctors better understand, diagnose, and treat different heart conditions. Researchers will track participants' health over ti…

This study is creating a biological bank of blood samples from 1,000 people with atrial fibrillation (AF) and stroke. Researchers will collect DNA and plasma to study the genetic roots of these conditions. The goal is to better understand why AF leads to stroke and find new drug …

This study looks at why about half of stroke patients don't recover well even after doctors successfully remove a blood clot from their brain. Researchers will use special MRI scans to measure blood flow changes in the brain at 3 days, 7 days, and 90 days after the procedure. The…

This study tests whether a gentle electrical current applied to the brain (tACS) can improve hand movement in people who had a stroke more than 6 months ago. Researchers will use brain scans and EEG to see how the stimulation changes brain activity. 45 participants (including hea…

This study is analyzing blood samples from 500 people who recently had a stroke and comparing them to healthy volunteers. Researchers are looking for specific RNA molecules that could serve as biomarkers to detect stroke and predict how well patients will recover. The goal is to …

This study is testing whether a gentle electrical stimulation of a nerve in the ear (the vagus nerve) can reduce brain injury and inflammation after a severe stroke. Researchers will measure brain damage markers in the blood of 65 participants over a week. The goal is to see if t…

This study collects data from 336 adults aged 18-85 who had an acute ischemic stroke and received a new clot-busting drug called non-immune staphylokinase. Researchers will check how often bleeding in the brain occurs and compare results to the standard drug alteplase. The goal i…

This study examines blood samples from 300 adults who had a stroke and received a procedure to remove the clot. Researchers look for specific RNA molecules that change before and after treatment. The goal is to find markers that can help predict how well patients will recover and…

This study is collecting information from 5,000 people hospitalized for ischemic stroke to see how different treatments affect their recovery. Researchers will track outcomes like disability and stroke recurrence over up to 24 months. The goal is to build models that help predict…

This study creates a large collection of blood, tissue, and medical information from up to 5,000 people with or at risk for pediatric heart disease. Researchers will use these samples to better understand the disease and find new ways to diagnose or treat it in the future. Partic…

This study tests a new camera tool that watches how stroke survivors move their arms during robot-assisted therapy and gives feedback. The goal is to see if group therapy sessions (up to 3 people) work as well as one-on-one sessions. About 42 adults who had a stroke 6 months to 6…

This study is testing a tool called B-COMPASS that uses a 22-question survey to predict whether people will follow their prescribed treatments. Researchers will enroll 3100 adults with cardiovascular, endocrine, immune, nerve, cancer, or rare diseases across Europe. The goal is t…

This study is looking for 250 stroke survivors to understand why many feel overwhelming tiredness after a stroke, known as post-stroke fatigue. Researchers will measure heart rate variability, heart function, and blood markers to see if problems with the autonomic nervous system …

This study is testing whether giving probiotics after heart surgery can improve recovery by changing the bacteria in the gut. Researchers will measure certain chemicals in the blood that come from gut bacteria. The trial involves 30 adults scheduled for heart surgery, who will re…

This early-stage study tests a new drug called LWP779 in 76 healthy adults to see if it is safe and how the body processes it. The drug is being developed for future use in people who have had an ischemic stroke. Participants will receive either the drug or a placebo, and researc…

This study collects blood samples from 1500 adults at risk for heart disease to discover new biomarkers that can predict future heart attacks, strokes, or blocked leg arteries. Participants are seen at a specialized prevention center and provide samples and health data at the sta…

This study tracks 350 stroke patients across the Asia-Pacific to see how well a proven clot-removal procedure (endovascular thrombectomy) works in everyday hospitals, not just in controlled trials. Researchers will analyze patient outcomes, imaging, and even the removed clots to …

This study compares a new, data-driven method for emergency responders to decide which hospital to take a stroke patient to, versus the current standard method. The goal is to see if the new approach helps rural patients get to a hospital that can perform specialized clot-removal…

This study tests whether a single PET tracer (FDG) can measure both blood flow and sugar use in the heart, instead of needing two separate tracers. Researchers will compare results from FDG with a dedicated flow tracer in 60 healthy adults and people with heart disease. The goal …

The PREVENT study is a large, worldwide registry that will track 1,000 stroke patients who undergo a clot-removal procedure called thrombectomy. Researchers want to understand why a blood vessel sometimes gets poked during the procedure, causing dangerous bleeding. By studying me…

This study tests whether a 3D image overlay (fusion imaging) helps doctors reach and remove blood clots in the brain faster during a standard stroke procedure. About 300 adults having emergency clot removal will be randomly assigned to get the extra imaging or not. The goal is to…

This study collects blood, clots, and tissue from up to 1000 people having procedures for stroke or other blood vessel problems in the brain. Researchers will analyze these samples to find biological markers and understand inflammation. The goal is to learn more about how stroke …

This study at Johns Hopkins University will follow 50 people who have had a stroke and have risk factors like high blood pressure, high cholesterol, or diabetes. Researchers will use repeated MRI scans over about 15 months to track changes in the brain's white matter. The goal is…

This study tests a program called Heart-to-Heart, where community health workers help low-income patients make informed choices about cardiac rehab after a heart event. About 50 adults from Johns Hopkins Hospital will take part. The goal is to see if the program is practical and …

This study is following 500 adults who had an ischemic stroke (a clot blocking blood flow in the brain). Researchers are collecting blood samples, brain scans, and health data to find new markers that can predict how well someone will recover and whether they will develop heart p…

This study aims to see if blood markers for Alzheimer's and brain injury can help predict death and hospital readmission in older patients. Researchers will follow 400 hospitalized seniors, including those with neurological issues or dementia. The goal is to develop a tool that u…

This study looks at whether caregivers' expectations for stroke patients' recovery match what physical therapists think is achievable. Researchers will compare goals set by caregivers and therapists for 58 subacute stroke patients. The aim is to improve how rehabilitation goals a…

This study aims to find early signs that predict quality of life more than four years after a minor ischemic stroke. Researchers will analyze data from 1,000 patients, including MRI scans, saliva samples, and questionnaires. The goal is to build a model that helps doctors underst…

This study uses advanced 3D-rotational angiography to track how fatty plaques in brain arteries change over one year in 140 people who have had a stroke or mini-stroke. Participants will have two scans 12 months apart while managing heart risk factors. The goal is to understand p…

This study aims to understand if COVID-19 vaccines have any impact on brain health in healthy people. Researchers will use MRI scans to look for changes in the brain's blood vessels and structure. The study will follow 500 adults from Hong Kong who have already had a baseline bra…

This study compares bone density in 84 stroke patients at different recovery stages (1 week to 6 months, or over 1 year) to understand osteoporosis risk. Researchers will also look at factors like muscle strength and vitamin D levels. The goal is to identify high-risk patients wh…

This study looks at fatty buildup in brain arteries that can break off and cause strokes. Researchers want to see if high-risk plaques look different from harmless ones. They will use special imaging to compare plaques in 140 people who have had a stroke with those who have not.

This long-term study is tracking 5,000 adults in Hong Kong who either have a brain disease (like stroke or dementia) or are at high risk due to family history or early signs. Researchers will collect medical records and questionnaires every 6 months to find what factors lead to b…

This study is building a biobank of blood, spinal fluid, and tissue samples from 500 Chinese adults, including stroke patients, their families, and healthy volunteers. Researchers will analyze the samples to find genetic markers linked to stroke and its complications. The goal is…

This study is looking back at medical records of 2,600 stroke patients who received clot-busting drugs between 4.5 and 24 hours after their stroke started. The goal is to see if giving the drug later than the usual 4.5-hour window can still lead to good recovery. The study does n…

This study looks at a condition called augmented renal clearance (ARC), where the kidneys work too fast and flush out medications before they can help. It involves 512 adults in intensive care with severe brain injuries, strokes, seizures, or meningitis. Researchers will measure …

This study will enroll 5,000 adults with chronic heart conditions like heart failure, high blood pressure, or aortic stenosis. Participants will wear a Prolaio digital health patch that monitors heart rate, breathing, and other vital signs. The goal is to observe how these condit…

This study tests a virtual coaching program for stroke survivors and their family members. The goal is to see if it can help lower the risk of another stroke and keep the brain healthy. About 40 people will take part in this early-stage research.

This study is reviewing medical records from 5,000 heart and blood vessel surgery patients to find factors that influence recovery and survival. Researchers are looking at data from 2001 to 2013 to identify what leads to complications or death after surgery. The goal is to improv…

This study is collecting information from 1,000 people who have been treated for brain aneurysms or stroke using MicroVention devices. The goal is to see how well these treatments work in real life, not just in controlled trials. No new treatments are being tested—just data gathe…

This study aims to create a tool that predicts if someone will develop depression after an ischemic stroke. Researchers will use machine learning to analyze data from 488 participants. The goal is to help doctors identify at-risk patients early and improve recovery.

This study looks at whether giving antibiotics for just 24 hours around the time of placing a special antibiotic-coated brain drain works as well as giving them for the whole time the drain is in place. The goal is to find the best way to prevent serious brain infections in peopl…

This study collects small heart tissue samples from 400 adults undergoing heart procedures. Researchers will analyze these samples to find new markers that could help diagnose heart diseases earlier and better understand how the heart works in health and disease. The goal is to i…

This study follows 1,300 people who had a stroke or mini-stroke and completed a 1-year exercise program. Researchers will track them for 3 more years to see if the exercise helped prevent future strokes or improve daily function. No new treatments are given—this is purely observa…

This study is testing a new type of MRI scanner, called Field-Cycling Imaging (FCI), to see if it can detect brain changes within the first day of a stroke. Researchers will compare FCI scans with standard MRI scans in 40 acute stroke patients. Participants will also provide bloo…

This study looks at how the immune system and blood clotting change in the first day after a stroke treated with a clot-removal procedure called thrombectomy. Researchers will collect blood samples from 1,200 participants to find markers that might predict how well people recover…

This study looks at brain tissue and MRI scans from 15 people who had a severe stroke and needed surgery. Researchers want to understand if certain dark spots on MRI are caused by tiny blood clots or bleeding. The goal is to learn more about what happens in the brain after a stro…

This study tests a special microscope attachment called GLOW800 that helps surgeons see blood flow and tissues in real time during brain and reconstructive surgery. About 29 adults will take part, and surgeons will rate how well the tool works. The goal is to confirm the device i…

This study looks at blood clots removed from stroke patients during a procedure called thrombectomy. Researchers will also take a small blood sample. They want to see if the clot's makeup and blood markers can tell us more about what caused the stroke, how well treatment worked, …

This study looks at blood markers related to inflammation and clotting in people with brain oxygen deprivation from stroke or bleeding. Researchers will compare these markers between patients with brain hypoxia and those without. The goal is to see if these markers are linked to …

This study uses a special eye scan called OCTA to measure the density of tiny blood vessels in the retina. Researchers will compare results from 64 people—half with cardiovascular disease and half healthy—to see if the scan can reliably detect vessel changes linked to heart probl…

This study is collecting data from 5,000 people who had a stroke caused by a blood clot and received endovascular treatment (a procedure to remove the clot). The goal is to measure how well patients recover neurologically three months later. This information is rarely collected b…

This study is testing whether a special heart MRI can measure scarring in the left atrium, which might lead to atrial fibrillation. Researchers will enroll 100 people who had a stroke with no clear cause and who are already scheduled to get an implantable heart monitor. The goal …

This study uses special ultrasound techniques to look at blood flow and tissue stiffness in the brains of newborn babies. Researchers will scan about 100 infants who are less than 7 months old and being treated in the hospital for conditions like lack of oxygen or stroke. The goa…

This study is testing whether sending a portable ECG monitor to people with elevated NT-proBNP (a heart stress marker) can catch hidden atrial fibrillation and reduce strokes. 4,000 adults aged 40+ without known AF will be randomly assigned to either 7 days of home monitoring or …

This study is testing whether adding genetic and imaging information to standard risk assessments can better predict heart disease in 30,000 healthy Italian adults aged 40-80. Participants will have their risk calculated using traditional methods and then again with the added dat…

This study looks at 92 people who had a stroke with no clear cause and received a small heart monitor. Researchers will use an artificial intelligence program called SmartECG-AF to analyze their ECGs and predict who might develop atrial fibrillation (an irregular heartbeat) in th…

This study is looking at whether certain gene changes (variants) in a protein called annexin A2 are linked to strokes that happen for no clear reason, especially in younger adults. Researchers will compare blood samples from 240 people who have had a stroke with no known cause. T…

This study looks at how emergency departments handle patients who have had a transient ischemic attack (TIA), also known as a mini-stroke. Researchers will review records of 300 adults diagnosed with TIA in 2024 to see if the care they received—like tests and treatments—matched t…

This study uses powerful 3T and 7T MRI scanners to create detailed maps of brain activity and connections in 100 stroke patients and 10 healthy volunteers. The goal is to understand how the brain reorganizes after a stroke and to identify patterns linked to motor deficits. Findin…

This study is observing 800 people who recently had an ischemic stroke or have significant artery narrowing. All are taking high doses of statins (atorvastatin or rosuvastatin) for at least a week. Researchers want to see how much their cholesterol drops and what factors influenc…

This early study is testing whether a robot can help doctors perform delicate brain blood vessel procedures, such as angiography, embolization, and thrombectomy. Ten patients scheduled for these standard procedures will have them done using a robotic system instead. The main goal…

This study is testing a virtual patient navigation program for 260 English, Chinese, or Spanish speakers with breast cancer or heart disease. The goal is to see if a phone-based portal can help underserved people get the support they need, even though it won't fully replace in-pe…

This study uses a virtual reality driving simulator to see how people with vision loss from a stroke steer a car. Researchers will compare driving accuracy between 40 participants with and without vision loss. The goal is to understand how the brain adapts to missing parts of the…

This study is testing whether a non-invasive ultrasound scan, combined with artificial intelligence (AI), can quickly identify bleeding in the brain (intracerebral hemorrhage) in people having a stroke. Researchers will enroll 500 adults with acute stroke and perform a standard C…

This study looks at whether a heart ultrasound technique called left atrial strain can predict stroke risk in people who had a stroke with no known cause. Researchers will measure heart function in 900 adults and track who has another stroke. The goal is to find a safe, low-cost …

This study looks at whether a nurse-led transitional care program helps stroke survivors and their caregivers after leaving the hospital. About 130 stroke survivors, their caregivers, and healthcare workers in Tanzania will take part. The program includes face-to-face sessions an…

This study will track 10,000 adults who receive tenecteplase for a stroke caused by a blood clot. Researchers want to see how well patients recover and if there are any safety issues when the drug is used in everyday hospital care. The goal is to improve stroke treatment across C…

This study is for people who have had a very large stroke caused by a blocked artery in the brain. Doctors want to see if a procedure to remove the clot (called thrombectomy) can help them recover better. The study will track 1000 patients for 90 days to measure their level of di…

This study is testing a new, noninvasive MRI technique to see if it can better predict stroke risk in people with narrowed arteries in the brain (ICAS). Researchers will measure blood flow pressure using a special MRI scan and follow 400 participants for one year to see who has a…

This study tests whether a simple CT scan (NCCT) works as well as advanced imaging (CTP/MRI) for choosing stroke patients who need emergency clot removal. About 1,846 adults with acute stroke arriving within 24 hours of symptoms will be enrolled. The goal is to see if the simpler…

This study tests different power levels and timing of low-intensity focused ultrasound (LIFUS) to see which best improves arm movement and motor learning in stroke survivors. 24 adults who had a stroke at least 6 months ago and have arm weakness will participate. The goal is to f…

This study aims to create an AI system that predicts which type of rehabilitation—like standard therapy, electrical stimulation, robotic training, or acupuncture—will help each stroke survivor recover the most movement in their arm. Researchers will collect data from 400 stroke s…

This observational study is testing whether advanced heart imaging (MRI or CT scans) can find blood clots in the heart that standard ultrasound might miss. It involves 125 people who had a stroke of unknown cause and have mild heart disease. The goal is to better understand strok…

This study follows over 10,000 Moroccan adults for 10 years after a heart screening. Researchers will track heart attacks, strokes, and heart-related deaths to build a risk score tailored to the Moroccan population. The goal is to better predict and prevent heart disease in Moroc…

This study is working to create better methods for evaluating how children with and without stroke or cerebral palsy use their arms and hands. Researchers will observe 80 children, including those with perinatal stroke and typically developing infants, using video and play-based …

This study is building a biobank of blood and tissue samples from 500 patients undergoing cardiac surgery. Researchers will analyze these samples to better understand the causes and progression of heart disease. The goal is to improve future diagnosis and treatment, but no new th…

This study follows 213 adults recovering from a first ischemic stroke to see if the intensity of inpatient rehabilitation (high vs. moderate) affects their functional recovery at six months. It also compares people whose stroke was linked to atrial fibrillation with those whose s…

This study looks at how gut bacteria and their byproducts affect recovery after an ischemic stroke. Researchers will compare 100 stroke patients and 100 healthy people to understand differences in gut microbes, inflammation, and immune function. The goal is to find new ways to im…

This study is looking for biological markers (biomarkers) in blood, urine, spinal fluid, and other samples that could help predict who will have a stroke and how they will recover. Researchers will follow 7,000 people with and without ischemic cerebrovascular disease for up to 4 …

This study follows 140 working-age stroke survivors in France to find out what factors help or hinder their return to work. Researchers will look at medical details, personal beliefs, and job-related issues. The goal is to create better support plans for people recovering from a …

This study is testing a new PET scan tracer called 18F-GP1 that sticks to activated platelets in blood clots. Researchers will scan 120 adults who recently had an ischemic stroke to see if they can find where clots are coming from. The goal is to better understand different types…

This study looks at how the brain changes after a stroke that causes vision loss. Researchers will use MRI scans to see which brain areas are damaged and how they respond to visual training. The goal is to better understand how the brain can adapt and restore some vision. About 1…

This study tests a brain implant that reads signals from the brain to help people who have lost the ability to speak fluently communicate through a computer just by trying to talk. It involves up to 2 participants with conditions like spinal cord injury or ALS. The main goal is t…