Could a lower dose of stroke drug be safer for seniors?

NCT ID NCT07294209

Recruiting now Disease control Sponsor: Southwest Hospital, China Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is testing whether a lower dose of the clot-busting drug tenecteplase is safer and just as effective as the standard dose for treating acute ischemic stroke in people aged 70 and older. About 798 participants will receive either a low dose (0.175 mg/kg) or the standard dose (0.25 mg/kg) within 4.5 hours of stroke symptoms starting. The goal is to see if the lower dose reduces disability and bleeding risks while still improving recovery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: tenecteplase (a clot-busting drug given intravenously)
What this could lead to: If successful, this could show that a lower dose of tenecteplase is safer for elderly stroke patients while still being effective, potentially reducing bleeding risks.
What could go wrong: This is a Phase 4 trial, but it focuses on a specific age group and a lower dose, so results may not apply to all stroke patients. There is still a risk of bleeding or that the lower dose may be less effective.

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Conditions

The condition(s) this trial relates to.

ischemic stroke

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE ISCHEMIC STROKE PATIENTS

Contacts and locations

Locations

Anshan Changda Hospital
NOT_YET_RECRUITING

Anshan, China
Anyang People's Hospital
RECRUITING

Anyang, China
Baoshan People's Hospital
NOT_YET_RECRUITING

Baoshan, China
Bishan Hospital
NOT_YET_RECRUITING

Chongqing, China
Chongqing Emergency Medical Center
RECRUITING

Chongqing, China
Chongqing University Fuling Hospital
RECRUITING

Chongqing, China
Chongqing University Jiangjin Hospital
RECRUITING

Chongqing, China
Chongqing University Three Gorges Hospital
NOT_YET_RECRUITING

Chongqing, China
Dali Bai Autonomous Prefecture People's Hospital
NOT_YET_RECRUITING

Dali, China
Dazhou Central Hospital
RECRUITING

Dazhou, China
Dianjiang People's Hospital OF Chongqing
RECRUITING

Chongqing, China
Guang an People's Hospital
NOT_YET_RECRUITING

Guang’an, China
Guizhou Provincial People's Hospital
NOT_YET_RECRUITING

Guiyang, China
Heyuan People's Hospital
NOT_YET_RECRUITING

Heyuan, China
Huaxian People's Hospital of Henan
RECRUITING

Anyang, China
Laixi People's Hospital
NOT_YET_RECRUITING

Laixi, China
Leshan Geriatric Specialized Hospital
RECRUITING

Leshan, China
Luoyang Mengjin People's Hospital
RECRUITING

Luoyang, China
Nanbu People's Hospital
RECRUITING

Nanchong, China
People's Hospital Of Xiushan County
NOT_YET_RECRUITING

Chongqing, China
People's Hospital of Leshan
NOT_YET_RECRUITING

Leshan, China
People's Hospital of Ningling County
RECRUITING

Shangqiu, China
People's Hospital of Zhijin County
NOT_YET_RECRUITING

Bijie, China
Puyang People's Hospital
NOT_YET_RECRUITING

Pujiang, China
Qichun People's Hosiptal
RECRUITING

Huanggang, China
Shenqiu County People's Hospital
RECRUITING

Zhoukou, Henan, 466300, China
Southwest Hospital, Chongqing, China
RECRUITING

Chongqing, Chongqing Municipality, 400038, China
The First Affiliated Hospital of Harbin Medical University
NOT_YET_RECRUITING

Ha’erbin, China
The First People ' S Hospital of Shao Yang
RECRUITING

Shaoyang, China
The First People's Hospital of Shangqiu
RECRUITING

Shangqiu, China
The People's Hospital Of Jianyang City
NOT_YET_RECRUITING

Jianyang, China
The People's Hospital of Dazu Chongqing
NOT_YET_RECRUITING

Chongqing, China
The People's Hospital of Gaocheng
RECRUITING

Shijiazhuang, China
The People's Hospital of HeChuan, Chongqing
RECRUITING

Chongqing, China
The People's Hospital of Nan Le Xian
RECRUITING

Pujiang, China
The People's Hospital of Rongchang Chongqing
RECRUITING

Chongqing, China
The People's Hospital of Tongnan District Chongqing City
RECRUITING

Chongqing, China
The People's Hospital of Zhongjiang
NOT_YET_RECRUITING

Deyang, China
The Second People's Hospital of Guiyang（Guiyang Jinyang Hospital）
RECRUITING

Guiyang, China
The Seventh People's Hospital of Chongqing
RECRUITING

Chongqing, China
The second people's hospital of Yibin
RECRUITING

Yibin, China
Tongliang Hospital
RECRUITING

Chongqing, China
Wuchang People's Hospital
RECRUITING

Harbin, Heilongjiang, 150200, China
Wuhan Puren Hospital
RECRUITING

Wuhan, China
Xiangyang NO.1 People's Hospital
RECRUITING

Xiangyang, China
Xunxian People's Hospital
RECRUITING

Hebi, China
Yunyang County People's Hospital
RECRUITING

Chongqing, China
Zhumadian Central Hospital
RECRUITING

Zhumadian, China
Zhuzhou Central Hospital
NOT_YET_RECRUITING

Zhuzhou, China
Zigong Third People's Hospital
RECRUITING

Zigong, China
Ziyang Central Hospital
NOT_YET_RECRUITING

Ziyang, China

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