Ischemic stroke

This trial investigates whether a procedure to remove a blood clot from the basilar artery—a major vessel at the back of the brain—can improve recovery in people with severe stroke. Participants are adults aged 18 to 80 who have a large area of brain damage and can be treated wit…

This study compares two methods to remove large blood clots from the brain during a stroke: using a super large suction catheter versus a stent retriever. About 708 adults with acute ischemic stroke will be randomly assigned to one of the two techniques. The goal is to see which …

This phase 3 trial tests whether a new emergency stroke unit, equipped with a hybrid CT and X-ray machine (NeuAngio-CT), can speed up clot removal in people having a severe stroke. About 232 adults aged 18-60 with acute ischemic stroke will be randomly assigned to either the new …

This phase 3 trial tests whether giving clot-busting drugs directly into the blocked brain artery (intra-arterial thrombolysis) helps people recover better from a medium-vessel stroke. About 306 adults aged 18-80 with acute stroke will be randomly assigned to receive either the d…

This study tests whether a single daily polypill (combining blood pressure, cholesterol, and anti-clotting drugs) can help recent stroke survivors in Ghana avoid future strokes or heart attacks. About 500 participants will take the polypill or receive usual care for 24 months. Th…

This phase 2 trial tests whether taking a probiotic supplement (OMNi-BiOTiC® SR-9) twice daily for 90 days can improve gut health and recovery in people aged 60 and older who have had an acute ischemic stroke. The study will compare the probiotic to a placebo in 220 participants,…

This study tests a specially designed suction tube that cleans deep throat secretions under direct laryngoscope guidance. The goal is to see if it reduces pneumonia within 28 days in stroke patients who have trouble swallowing or coughing. Participants are adults with acute ische…

This study tests whether a non-invasive brain stimulation technique called cTBS, guided by each patient's brain scan, can improve arm and leg movement after a stroke. About 584 adults who had a stroke within the past two weeks will receive either real or sham stimulation alongsid…

This study tests a personalized brain stimulation technique called cTBS to help people recover movement after a stroke. Researchers use each patient's brain scan to target the stimulation precisely. Sixty participants will receive either real or sham stimulation alongside standar…

This study tests whether people who have had a minor stroke or a high-risk mini-stroke can safely stop one of their two blood thinners earlier than usual. About 3,800 participants will have their blood tested to see how they respond to the drug clopidogrel. Those who are sensitiv…

This pilot study tests whether an active smartwatch that gives real-time feedback, combined with regular nurse coaching, can help people who had a minor stroke or TIA walk more each day. Fifty participants will be randomly assigned to either an active smartwatch or a passive one …

This study tests whether a care model led by rural doctors and supported by telemedicine can reduce strokes, heart failure, and heart-related deaths in adults aged 65 and older who are at high risk of stroke in rural China. About 2,500 participants from 39 village clinics will be…

This study tests a new, simple procedure done right after doctors remove a blood clot from the brain in severe stroke patients. The procedure involves briefly inflating and deflating a tiny balloon to gently restore blood flow, which may prevent extra brain damage. About 288 to 4…

This early-stage trial tests whether stem cells from human umbilical cords are safe and might help people recover from a severe stroke. About 35 adults who had a stroke within the last 48 hours will receive either the stem cells or a placebo. The study will check for side effects…

This study tests a drug called pro-urokinase in people who have had a stroke in the back part of the brain (posterior circulation) and can be treated within 4.5 to 24 hours after symptoms start. About 586 participants will receive either the drug or a placebo, along with standard…

This study tests whether the clot-busting drug tenecteplase is safe and effective for people having a stroke who took a blood thinner (DOAC) within the last 48 hours. About 660 adults will receive either tenecteplase or a placebo within 4.5 hours of stroke symptoms. The goal is t…

This study looks at whether doing a balloon angioplasty or placing a stent right after removing a blood clot from the brain can help people who have a stroke caused by a hardened artery. About 420 adults will be in the study. The goal is to see if this extra step improves recover…

This study tests a new device, the SOFIA Flow 88 Aspiration Catheter, to treat acute ischemic stroke caused by a large blocked artery. About 200 adults with moderate to severe stroke will be enrolled. The goal is to safely restore blood flow to the brain using only this catheter,…

This study tests whether a set of simple treatments—daily blood pressure checks, dietitian visits, hearing and vision tests, and mood screening—can help preserve thinking and memory after a stroke. About 50 adults who recently had a mild stroke will either receive this care bundl…

This study looks at whether starting blood thinners (DOACs) is safe and effective for people who have had a stroke, but also have a history of a brain bleed and an irregular heartbeat (atrial fibrillation). About 852 participants will be randomly assigned to receive either a bloo…

This study looks at 2,000 people who had a stroke to see which blood-thinning medicine works best to stop another stroke. The drugs being compared are indobufen, aspirin, cilostazol, and clopidogrel, used alone or in pairs. Researchers will track strokes and bleeding problems for…

This study tests whether giving a clot-busting drug called tenecteplase before a mechanical clot removal procedure helps people with large ischemic strokes recover better than the procedure alone. About 486 adults with large-vessel occlusion strokes will be randomly assigned to o…

This study compares two ways to remove blood clots from the brain during a stroke. About 500 adults who have a stroke from a large blocked artery will be randomly assigned to one of two standard techniques: a cyclic 'plunger' method or a steady suction method. The goal is to see …

This study tests whether a personalized weaning strategy can help adults with chronic heart, brain, or lung conditions leave ventilators earlier. The strategy tailors care based on the main reason a patient struggles to breathe on their own, such as heart or muscle problems. Rese…

This small pilot study will test a program where nurses and general practitioners help breast cancer survivors who also have heart disease make healthy lifestyle changes. The program includes exercise, diet changes, quitting smoking, and stress-reducing activities like yoga. The …

This study tests two traditional Chinese medicines, Dengzhan Xixin and Dengzhan Shengmai, in 358 adults who recently had an ischemic stroke. The goal is to see if these treatments improve recovery and reduce disability at 3 months. Researchers will also study how the medicines wo…

This study tests whether the drug vericiguat can prevent serious heart and organ problems in people undergoing heart surgery. About 600 high-risk patients will receive either vericiguat plus standard care or standard care alone. The goal is to see if vericiguat reduces early comp…

This study tests a new device called the iNstroke 5F catheter to remove blood clots in people having an acute ischemic stroke. The goal is to see if it can safely restore blood flow to the brain within 24 hours of symptoms starting. About 45 adults with moderate to severe strokes…

This study looks at whether giving a low-dose aspirin just 2 hours after clot-busting treatment for stroke is better than waiting the standard 24 hours. About 210 adults aged 18-65 who had a stroke will be randomly assigned to get aspirin early or at the usual time. The goal is t…

This study tests a new, drug-free treatment for people having an ischemic stroke (a clot blocking blood flow to the brain). The treatment uses blood pressure cuffs on the arms and inflatable leg sleeves to temporarily reduce blood flow in the limbs, which may trigger the body to …

This study tests whether a smartphone-supported care program can improve health outcomes for stroke patients who have trouble swallowing. The program includes diet monitoring, doctor communication, and education. Researchers will compare 600 patients who receive this enhanced sup…

This trial tests whether the Adacolumn device, which filters certain white blood cells from the blood, can reduce brain swelling in people who have had a severe stroke. Ten patients will receive the treatment within 24 hours of their stroke. The goal is to see if it prevents wors…

This study tests a device called I-NIC that uses low-frequency magnetic pulses to treat people who have had a stroke. The goal is to see if it helps improve recovery when used alongside standard care. About 364 participants will receive either the real device or a placebo for 5 d…

This early-stage study tests the safety of a drug called pegcetacoplan (Empaveli) in 20 adults who have had a stroke from a large clot and already had a procedure to remove it. The drug aims to reduce swelling and inflammation that can occur when blood flow returns. Participants …

This study tests whether giving a drug called tirofiban directly into the artery right after a clot is removed can help people recover better from a severe stroke. About 344 adults who had a large-vessel blockage stroke will be randomly assigned to receive the drug or not. The ma…

This study tests whether giving a large amount of IV saline (about 2-2.5 liters) right after clot-busting treatment helps people recover from a stroke better than giving only a small amount. The trial will enroll 752 adults aged 18-80 who had an ischemic stroke and received throm…

This study tests whether managing blood pressure based on the brain's collateral circulation (backup blood flow) after stroke treatment leads to better recovery. About 544 adults who had a stroke due to a large artery blockage and received endovascular therapy will be enrolled. P…

This pilot study tests whether giving semaglutide (Ozempic) to 100 stroke patients who had a clot-removal procedure can improve recovery. Patients are randomly assigned to receive weekly injections for 12 weeks or no drug. The main goal is to see if a larger, definitive trial is …

This study tests whether the clot-busting drug tenecteplase can improve recovery in people with acute ischemic stroke when given 4.5 to 9 hours after symptoms start. It uses a special MRI pattern (DWI-FLAIR mismatch) to identify patients who might still benefit. About 564 adults …

This study tests a simple, non-invasive treatment called remote ischemic conditioning (RIC) for people who have had a stroke and also developed heart muscle injury. RIC involves using a blood pressure cuff on the arm to briefly restrict blood flow, which may trigger the body's ow…

This Phase 3 trial tests a new injectable drug, ongericimab, in about 4,800 people who recently had a stroke due to narrowed arteries. The goal is to see if lowering LDL cholesterol more than current standard care can prevent future strokes, heart attacks, or death from heart dis…

This study looks at stroke patients who have small clots remaining in smaller brain arteries after the main clot has been removed. Half will get an extra procedure to remove those leftover clots, while the other half will receive standard care without extra intervention. The goal…

This study tests whether a drug called edaravone dexborneol can help people who have a stroke while also having active cancer. The drug is given by IV twice a day for 10-14 days. Researchers will check if it improves recovery and is safe. About 144 adults aged 18-80 will take par…

This study tests whether the drug butylphthalide can reduce brain swelling in people who have had a severe stroke and undergone a procedure to reopen a blocked artery. About 100 adults will receive either the drug or a placebo for up to 14 days. Researchers will measure changes i…

This study tests a new method for closing the breastbone after coronary artery bypass graft (CABG) surgery using special knotless barbed sutures and a skin adhesive. Researchers will compare 401 adults who receive this new closure to past patients who had standard closure. The go…

This study tests whether cooling the head (using a special cap) during emergency stroke treatment can reduce the amount of brain tissue that dies. About 182 adults having a major stroke and undergoing a clot-removal procedure will be randomly assigned to receive either standard c…

This study will compare the safety of two clot-dissolving drugs, rhTNK-tPA and rt-PA, in 4500 adults having an acute ischemic stroke. Researchers will track how often each drug causes serious bleeding in the brain within 36 hours. The goal is to see if the newer drug, rhTNK-tPA, …

This study looks at whether using a continuous glucose monitor (CGM) can help manage high blood sugar better than standard finger-prick tests in people with type 2 diabetes who have had a stroke. High blood sugar after a stroke can lead to worse outcomes. The study will involve 8…

This early study tests whether a drug called RK-4 can be safely injected through the skull into the brain of people having a severe stroke. Only 6 participants will receive the injection once a day for 3 days, using a special device. The main goal is to see if the procedure is fe…

This phase 2 trial tests whether the drug J147, given by IV after clot removal, helps people recover from an acute ischemic stroke. About 196 participants will receive either J147 or a placebo. Researchers will measure brain function and safety through MRI scans and blood tests o…

This study tests a smartphone app called StrokeApp designed to support people after a stroke or mini-stroke. The app provides educational content, medication reminders, and tools to track health. Researchers will compare quality of life and other health measures between 500 patie…

This study tests whether canagliflozin, a diabetes drug, can reduce dangerous brain swelling and bleeding in people who have had a severe stroke and are receiving clot-removal therapy. About 150 adults will be randomly assigned to take the drug for 14 days or receive standard car…

This study tests whether adding a drug called human urinary kallidinogenase to standard clot-busting therapy can improve recovery after a stroke. About 220 adults who have had a moderate stroke will be randomly assigned to receive the combination or standard care alone. The main …

This study looks at whether starting insulin to lower high blood sugar on day 4 after a severe stroke is better than starting on day 1. About 200 adults with severe stroke and high blood sugar will be randomly assigned to early or delayed treatment. The goal is to see if delaying…

This study compares two approaches for people who have had a stroke or mini-stroke due to a blocked brain artery that hasn't opened on its own. One group gets a procedure to reopen the artery plus medication, while the other gets medication alone. The goal is to see which approac…

This study compares two medical devices used to close a small hole in the heart called a PFO, which can cause strokes. About 1,260 adults who have had a stroke or mini-stroke in the past year will be randomly assigned to receive either the Cocoon PFO Occluder or the Amplatzer PFO…

This study tests whether giving the drug tenecteplase directly into the brain's arteries, along with standard care, helps people recover better after a stroke caused by a medium-sized blood clot. About 488 adults with stroke symptoms starting within 24 hours will take part. The g…

This study tests a wireless brain-computer interface implanted in the skull to help people who had a stroke regain arm movement. Ten participants will undergo intensive rehabilitation with and without the device. The main goal is to check safety, but researchers will also measure…

This study is testing whether the clot-busting drug tenecteplase is safe and effective for people aged 80 and older who have had a stroke. Researchers will track 392 patients to see how well they recover and if there are any serious side effects. The goal is to find out if this t…

This study tests whether a clot-dissolving drug called tenecteplase works better than standard antiplatelet pills for people who have a mild but disabling stroke caused by a large blocked artery. About 864 adults who arrive at the hospital 4.5 to 24 hours after symptoms start wil…

This study tests a medicine called tenecteplase for people who have a stroke but don't know exactly when it started, like waking up with symptoms. About 352 adults will get either tenecteplase or standard care after a simple CT scan. The goal is to see if the drug helps them reco…

This study tests whether sending people with suspected severe stroke directly to the angiography suite (instead of first getting a CT or MRI) can speed up treatment and improve recovery. About 568 adults with stroke symptoms within 6 hours will be randomly assigned to the direct …

This study tests whether a single injection of Recaticimab, a cholesterol-lowering drug, can help people recover better after a stroke caused by narrowed brain arteries. About 1,200 participants will receive either the drug or a placebo, plus standard care. The main goal is to se…

This study tests whether adding the anti-inflammatory drug baricitinib to standard clot-removal treatment helps people recover better after a severe stroke caused by a blocked artery in the front of the brain. About 750 adults will receive either baricitinib or a placebo for five…

This study will test a mobile brain-computer interface (iBCI) that lets people with severe paralysis control computers and mobile devices using only their thoughts. Two veterans with conditions like spinal cord injury or ALS will use the device at home. The goal is to see if the …

This study tests whether a special clinic where heart, kidney, diabetes, and liver doctors work together can help people with type 2 diabetes and heart disease get better control of their blood pressure and cholesterol. About 150 adults will be randomly assigned to either usual c…

This study tests whether the drug anakinra can limit brain damage in people who have had a severe stroke and have already undergone a procedure to remove a blood clot. About 159 adults aged 18-80 will receive either standard care or anakinra at different doses. The main goal is t…

This study tests whether adding two common medicines—colchicine (an anti-inflammatory) and low-dose rivaroxaban (a blood thinner)—to standard care can prevent future heart attacks, strokes, or death in people who recently had a stroke. About 4,500 adults who had a stroke within t…

This study tests a new device called SSMD, which uses non-invasive stimulation to help people with movement problems after stroke, traumatic brain injury, spinal cord injury, or peripheral nerve damage. 120 adults aged 18-80 with moderate to severe arm impairment will receive eit…

This study tests whether adding butylphthalide (a neuroprotective drug) to standard clot-busting tenecteplase helps people with mild but disabling stroke recover better. About 1,062 adults aged 18-80 who can be treated within 4.5 hours of symptoms will receive either the combo or…

This early-stage trial tests a nasal spray made from human stem cell exosomes in 60 people who recently had a stroke. The spray is given once or daily for 14 days, alongside standard care. The main goal is to see if it is safe, and researchers will also check if it helps improve …

This study tests a community-based exercise program for people aged 50 and older who have at least two chronic conditions, such as heart disease, diabetes, arthritis, or obesity. The program is designed to improve muscle strength, heart and lung fitness, and overall well-being. R…

This phase 3 trial tests whether giving a clot-busting drug called rhPro-UK before a mechanical clot removal procedure improves recovery for people with severe stroke. About 820 participants who had a stroke 4.5 to 24 hours earlier will receive either the drug or a placebo, follo…

This study tests a new device called the iNstroke catheter, designed to remove blood clots from the brain in people having an acute ischemic stroke. About 160 participants will undergo a procedure where the catheter is used to suction out the clot. The main goal is to see how oft…

This Phase 2 trial tests whether giving human albumin directly into the artery supplying the brain, right after a clot is removed, can improve recovery in people with severe stroke. About 306 participants will be randomly assigned to receive either standard clot removal alone or …

This study looks at 518 adults with a severe stroke caused by a blockage in the main artery at the back of the brain. It compares two standard treatments: a procedure to remove the clot (endovascular therapy) versus medication alone. The goal is to see which approach leads to bet…

This study tests whether adding a drug called Tafolecimab to standard cholesterol-lowering therapy can reduce the risk of another stroke in people who have had a recent stroke or mini-stroke and have high levels of Lp(a), a type of fat in the blood. About 242 participants will re…

This study tests whether taking vitamin B supplements before and after heart surgery can lower the chance of serious problems like heart attack, stroke, or irregular heartbeat. About 1,000 adults having heart surgery will take either vitamin B or a placebo daily for 6 months afte…

This study tests whether adding the drug eptifibatide after standard clot-dissolving treatment can help people with acute ischemic stroke recover better. It includes 786 adults who arrive at the hospital 4.5 to 24 hours after stroke symptoms start. The goal is to see if this comb…

This study looks at how well certain drugs protect the brain after a mild to moderate stroke. Researchers will follow 600 adults who had a stroke within the last 48 hours and received edaravone or dexrazoxane. The goal is to see if these drugs help patients recover better and are…

This study tests whether adding the blood thinner tirofiban after standard stroke treatment helps people recover better from a severe type of stroke caused by a blocked large artery in the brain. About 564 adults in China will receive either tirofiban or usual care after their in…

This trial tests a new device called Supernova that removes blood clots from large brain arteries in people having a stroke. The goal is to restore blood flow within 24 hours of symptoms starting. The study will include 3,000 participants and measure how well the device works and…

This study tests whether a procedure to remove blood clots from the brain can help people who have had a severe stroke. The trial will include 308 adults aged 18 to 80 with a large area of brain damage. Doctors will use special tools to clear the blocked artery and then check how…

This study looks at the best way to manage high blood pressure in people having a stroke who are eligible for clot-busting medication. Currently, doctors lower blood pressure first, then give the drug, which can delay treatment. The trial will compare this step-by-step approach t…

This study will test whether Vojta therapy, a technique that uses reflex movements to activate muscles, helps people who have had an ischemic stroke regain functional independence better than standard conservative therapy. 150 participants who had a stroke within the last 3 years…

This study looks at whether a medical-grade smartwatch (CardioWatch 287-2) can improve a 13-week virtual cardiac rehab program for people with heart disease. About 216 participants will either use the watch or not, and researchers will compare their progress in areas like exercis…

This study tests whether breathing pure oxygen in a pressurized chamber (hyperbaric oxygen therapy) helps people recover better after a stroke. About 424 adults aged 35-75 who had a stroke and received endovascular treatment will be randomly assigned to get either hyperbaric oxyg…

This study tests a new biodegradable device that closes a common heart hole (PFO) in people who have already had a stroke or mini-stroke. The device is placed through a tube in the leg and dissolves over time, leaving no permanent implant. The trial will check if it safely and ef…

This study tests whether giving a protein called albumin directly into the artery during a stroke procedure can reduce brain damage. Sixty adults with a severe stroke will receive either standard treatment alone or standard treatment plus albumin. The goal is to see if albumin he…

This study tests a traditional Chinese medicine called Bovis Calculus Stativus (cultivated bezoar) in 220 adults who had a stroke and are now unconscious or barely responsive. Participants receive either the medicine or a placebo for 5 days, and are followed for 90 days. The goal…

This study tests whether two medicines, isosorbide mononitrate and butylphthalide, can reduce disability in people who recently had a lacunar stroke (a small stroke deep in the brain). About 3,156 adults aged 30 and older will receive one or both drugs or placebos for up to a yea…

This study tests whether a diabetes drug called sentagliptin (a DPP4 inhibitor) can improve thinking and memory in people who have had a mild stroke and also have type 2 diabetes. About 312 participants will receive either the drug or a placebo daily for 180 days. Researchers wil…

This early study tests whether nasal drops containing tiny particles from umbilical cord stem cells are safe for people who had an ischemic stroke. Nine patients will receive the drops four times over two weeks, alongside standard care. The main goal is to check for serious side …

This Phase 3 trial tests whether butylphthalide, a compound from celery seed, can improve long-term recovery in people who have had a minor ischemic stroke. 1,200 participants aged 40–80 will take either the drug or a placebo for 12 months. Researchers will measure survival, stro…

This study tests whether adding WhatsApp-based education and counseling to standard care helps stroke patients with type 2 diabetes improve their lifestyle, blood sugar control, and disease knowledge. 84 participants will be split into two groups: one gets routine education, the …

This early-phase study tests a new drug called RK-4 for people with a severe type of stroke (large hemispheric infarction) who cannot have standard clot-removal treatment. The drug is injected directly into the skull bone marrow once daily for three days. The main goals are to ch…

This study tests a new drug called RK-4, injected directly into the skull bone marrow, for people with a severe type of stroke (large hemispheric infarction) who cannot have standard blood vessel treatments. About 194 participants will either get the RK-4 injection daily for 3 da…

This study tests a new surgical technique called Expansion-floating Craniotomy (EC) for people with life-threatening brain swelling after a massive stroke. The standard surgery removes a piece of skull to relieve pressure, but requires a second surgery months later to replace the…

This study tests whether stem cells from umbilical cords can help people recover movement after a stroke. About 86 adults who had a stroke 2 weeks to 3 months ago will receive either the stem cells or a placebo. The main goal is to see if the treatment improves motor function and…

This study compares cilostazol, aspirin, and clopidogrel in 632 people who recently had a stroke due to cerebral small vessel disease. The goal is to see if cilostazol is better at preventing another stroke and slowing disease progression, with fewer bleeding risks. Participants …

This study tests whether adding the steroid methylprednisolone to standard clot-removal treatment helps people recover from severe stroke. About 912 adults aged 18–85 with a large clot in the front part of the brain will receive either the steroid or a placebo for three days. The…

This study tests Mobili®, a portable digital dispenser that automatically gives the right pills at the right time. Researchers will enroll 96 adults with diabetes or heart disease who take at least two daily medications. Participants use the device for a period, and the study mea…

This study tests whether adding a PCSK9 inhibitor (a cholesterol-lowering drug) to standard care helps people recover better after a stroke caused by a blocked artery. About 478 adults who had a stroke and received a procedure to reopen the blocked vessel will be randomly assigne…

This study tests whether the clot-busting drug tenecteplase can improve recovery in people who have a major stroke caused by a large blocked artery, but who cannot have a procedure to remove the clot. The trial includes 794 adults who arrive at the hospital 4.5 to 24 hours after …

This study tests a traditional Chinese herbal medicine called Xinglou Chengqi Granule for people who recently had a stroke. Researchers want to find the best dose and see if it helps improve recovery. Sixty adults aged 18-70 with moderate stroke symptoms will receive either a hig…

This large study will test whether giving stroke survivors personalized temperature warnings through a smartphone app can lower their chance of having another stroke. About 5,000 people who recently had an ischemic stroke will be split into two groups: one gets the app alerts and…

This study tests whether a mobile app that sends personalized temperature health warnings and risk management tips can reduce the chance of a second stroke. Over 10,000 people who recently had a stroke will use the app for one year. Researchers will track how many have another st…

This study tests a new radioactive tracer called 18F-FAPI-74 that may help detect scar tissue (fibrosis) in the heart and lungs earlier than current methods. Researchers will compare this new PET/CT scan to standard imaging in 210 adults with conditions like lung disease or heart…

This study will test a new radioactive tracer called FBFP in 30 stroke patients and 20 healthy volunteers. The tracer is used with a PET/MR scanner to take detailed pictures of the brain. The goal is to see if FBFP can help doctors diagnose and understand stroke better. Participa…

This study tests whether using artificial intelligence (AI) along with a smartwatch and a heart monitor patch can find a hidden heart rhythm problem called atrial fibrillation (AF) in people who have had a stroke. AF can cause strokes, but it often comes and goes without symptoms…

This study will check if an artificial intelligence (AI) system can accurately score stroke severity as well as a trained doctor. About 297 adults with a recent stroke will have their speech and facial movements recorded. The AI will analyze these recordings to produce a G-FAST s…

This study will test a new rapid blood test that can be done at the bedside to help doctors quickly tell if a child is having a stroke. About 250 children with stroke symptoms will give a small blood sample, and the test's accuracy will be compared to standard brain scans. The go…

This study looks at whether a detailed MRI of the blood vessel wall can help doctors tell the difference between two common causes of stroke: hardening of the arteries (plaque buildup) and inflammation of the vessel wall (vasculitis). About 46 people who recently had a stroke wil…

This study will check if an artificial intelligence (AI) tool can help less experienced doctors read MRI scans of stroke patients as accurately as a brain scan specialist. About 500 adults who are being evaluated for a stroke will have their MRI results compared. The goal is to s…

This study will check if a non-invasive device can accurately detect high pressure inside the skull in 300 adults with traumatic brain injury or stroke. The device uses a sensor placed on the head to measure brain pressure and pulse waves. If successful, it could help doctors mak…

This pilot study tests two non-invasive methods to keep the airways clear in adults who are unconscious or severely ill and need a breathing tube. One method uses a special tube with continuous low-pressure suction, and the other delivers a programmed 'artificial cough' through t…

This study tests whether the drug cilostazol can prevent recurrent strokes and heart problems in 1100 recent stroke survivors in Ghana. Participants take either cilostazol or a placebo twice daily for 24 months. The goal is to see if this affordable drug, already used in Asia, ca…

This study compares two ways of feeding patients with severe ischemic stroke who have trouble swallowing. The goal is to see if feeding through a tube placed past the stomach (post-pyloric) reduces the chance of developing pneumonia compared to standard stomach feeding. About 174…

This study tests whether a tablet called edaravone dexborneol can prevent epilepsy in people who have had a stroke and are at high risk. About 160 adults will receive either the tablet or a placebo for three months, starting within 48 hours of their stroke. Researchers will track…

This phase 3 trial will test whether a low dose of the blood thinner rivaroxaban plus aspirin can prevent recurrent strokes better than the standard clopidogrel plus aspirin in people with narrowed brain arteries. About 1,172 participants who recently had a stroke or high-risk TI…

This study tests whether adding a very low dose (15 mg) of the blood thinner edoxaban to standard aspirin or clopidogrel can prevent repeat strokes in people aged 75 and older who have already had an ischemic stroke. About 1,200 participants will be randomly assigned to receive e…

This study tests whether closing the left atrial appendage (a small pouch in the heart) during valve surgery can prevent silent brain injuries in 100 adults without atrial fibrillation. Participants will have brain scans after surgery to check for hidden strokes. The goal is to f…

This study compares apixaban alone versus apixaban plus clopidogrel for 30 days in people who have had a stroke and have both atrial fibrillation and atherosclerosis. About 586 participants will be randomly assigned to one of the two treatments. The goal is to see if the combinat…

This study tests whether adding cilostazol, a drug that improves blood flow, to standard aspirin or clopidogrel therapy can prevent another stroke or heart attack in people who have recently had a stroke or mini-stroke. About 2,000 participants will take either cilostazol or a pl…

This study tests whether a smartphone app that gives personalized tips on managing stroke risk factors can reduce the chance of having another stroke. Over 5,000 people who recently had a mild-to-moderate stroke will use the app for one year. Researchers will track how many have …

This pilot study explores whether non-drug strategies like virtual reality or relaxing soundscapes can reduce anxiety and pain in adults undergoing scheduled coronary angiography or angioplasty. Participants will be assigned to listen to calming sounds, experience a virtual reali…

This study tests whether a non-invasive technique called transcranial focused ultrasound can help stroke survivors recover movement and thinking skills. Researchers will use brain scans and EEG to guide stimulation to specific areas. 60 adults who had a first stroke within the la…

This study looks at whether combining Frenkel exercises (repetitive movements to retrain the brain) with electrical muscle stimulation can improve balance, coordination, and body awareness in people who have had a stroke. About 38 adults aged 50-65 who can walk independently will…

This study tests if a non-invasive device that stimulates the vagus nerve can improve blood flow in the brain and thinking skills in people who had a stroke 6-12 months ago. Forty participants aged 50-60 with mild cognitive issues will receive the stimulation. Researchers will me…

This study tests whether combining neuromuscular electrical stimulation with upper limb nerve exercises can improve hand grip strength and range of motion in people who have had a stroke. The trial will include 44 adults who had an ischemic stroke at least 3 months ago and have s…

This study tests whether using a virtual reality (VR) system during cycling exercise makes rehabilitation more motivating for adults with conditions like stroke, Parkinson's, multiple sclerosis, or frailty. About 70 participants will try cycling with and without VR over 4 weeks. …

This study tests a new way to improve vision loss caused by a stroke. It combines low-intensity focused ultrasound (LIFUS) with virtual reality therapy to stimulate the brain's vision areas. The study will enroll 28 adults who had a stroke 6 to 24 months ago and now have partial …

This study tests whether a virtual home rehabilitation program helps stroke survivors in underserved Texas communities recover better than standard care alone. About 80 adults who recently had a stroke and are returning home will take part. The program uses video sessions to guid…

This study tests whether low-intensity focused ultrasound (LIFU) applied to a nerve cluster in the neck can improve sleep quality and heart rate control in people recovering from heart surgery. 200 participants will receive either real or sham ultrasound daily for 3-7 days after …

This study tests whether adding brain-computer interface (BCI) training to standard early rehabilitation helps people recover arm and leg movement after an acute ischemic stroke. Sixty adults aged 18 to 80 with one-sided limb weakness will receive either standard rehab alone or s…

This early-phase trial aims to see if taking a combination of three common drugs (Telmisartan, Metformin, and Cilostazol) can help chronic stroke survivors gain more movement in their arms and hands during robot-assisted therapy. Fifty adults who had an ischemic stroke at least s…

This study tests whether a special smartwatch can improve sleep in warfighters who have trouble sleeping due to PTSD, traumatic brain injury, or stress. The watch detects signs of stress during sleep, like a fast heart rate, and gives gentle vibrations to calm the body without wa…

This study will test a new type of rehabilitation robot that uses brain signals and mirror therapy to help stroke patients with arm weakness. The robot is non-invasive and designed to encourage the brain to re-learn movement. Researchers will enroll 40 adults aged 30 to 80 who ha…

This trial tests whether an intensive, personalized speech therapy program (ICAP) helps people with post-stroke aphasia communicate better and feel better. 334 adults who had a stroke at least 3 months ago will be randomly assigned to either ICAP (100 hours over 4 weeks) or stand…

This study looks at whether a supplement called Neurofast® can help people who have both anxiety and heart problems. 80 adults aged 18-70 will take the supplement or no extra treatment for 12 weeks. Researchers will measure changes in anxiety, heart rate, and blood pressure.

This study will test whether different frequencies of electroacupuncture (low, medium, or high) can improve swallowing problems in 90 stroke survivors. Participants will receive daily 30-minute sessions over several weeks. The goal is to find the best frequency and understand how…

This study tests a personalized brain stimulation technique called IAF-rTMS to help people recover movement after a stroke. Thirty-four adults who had a first ischemic stroke will receive either real or sham stimulation for two weeks each, in a crossover design. Researchers will …

This study tests whether a mild electrical current applied to the scalp (tDCS) can improve naming ability in people who have trouble speaking after a recent stroke. Twenty-eight adults with aphasia will receive either real or sham stimulation over five days. The goal is to see if…

This study tests whether a feeding tube placed in the upper esophagus (oro-esophageal) helps stroke patients with swallowing difficulties recover faster than the standard nasogastric tube (through the nose). The trial will include 422 adults who recently had a first ischemic stro…

This study tests whether playing interactive games on a smart tablet can improve hand dexterity and strength in people who have had a stroke. Forty chronic stroke patients will either do tablet hand exercises plus standard physical therapy, or standard therapy alone. The goal is …

This study compares a new 'one-stop' emergency stroke unit that combines CT scanning and treatment in one room to the usual process where scans and treatment happen in separate places. The goal is to see if this faster approach helps more people recover with little or no disabili…

This study tests a safe, non-invasive therapy that uses gentle pressure on the arms to improve sleep and mood in people who have had a stroke and suffer from insomnia. The treatment, called remote ischemic adaptation, aims to help the brain recover by briefly restricting and rest…

This study tests whether adding a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) to standard physical therapy can improve arm and hand function in people who have had a first ischemic stroke. Sixty-six adults aged 18 to 80 with…

This early-phase study tests whether a combination of two drugs (chlorpromazine and promethazine) can safely put stroke patients into a hibernation-like state to protect the brain. The trial will enroll 57 adults with acute ischemic stroke who are eligible for clot-removal therap…

This study looks at whether a nurse-led health education program can improve quality of life, reduce depression, and help daily functioning in people who have had an ischemic stroke. About 70 participants will be split into two groups: one gets the education program, the other ge…

This study tests whether applying vibration to a specific muscle or the whole arm can reduce spasticity (stiffness) and improve arm control in people who had a stroke 3 to 6 months ago. Fifty-four participants will receive either focal muscle vibration or whole upper limb vibrati…

This study tests whether adding a short, guided mindfulness meditation session to standard cardiac rehabilitation can help heart patients feel better and control their blood pressure. Eighty adults with heart disease will be split into two groups: one gets standard rehab plus med…

This study compares early task-oriented rehabilitation (practicing daily-life activities) to traditional physiotherapy in 158 adults who had a stroke within the past 48 hours. The goal is to see which approach leads to better motor function and quality of life after 3 months. Par…

This study will compare cannabis, opioids, and two non-drug therapies (MIRE and TENS) in 1,000 people with chronic pain or circulatory disorders. The goal is to find safer, less addictive pain relief options. Researchers will measure changes in pain and nerve function using objec…

This study looks at two ways to feed stroke patients who have trouble swallowing: a standard nasogastric tube (through the nose) and an oro-esophageal tube (through the mouth). The goal is to see which method better protects the airway and improves swallowing function. About 156 …

This study will test if a low-intensity leg workout using blood flow restriction cuffs can improve strength and balance in stroke survivors as well as traditional high-intensity exercises. Eighty people who had an ischemic stroke 3 to 12 months ago will take part. The goal is to …

This study tests whether taking probiotics can improve quality of life, daily activities, and anxiety in people who have had a moderate stroke. Researchers will enroll 110 adults aged 18 to 80 who had a stroke within the past 3 months. Participants will take probiotics and be mon…

This study tests whether an artificial intelligence system can help therapists set better rehab exercises for a robotic arm trainer used by stroke patients. One hundred adults who had a stroke within the last six months will receive either AI-guided or therapist-guided robotic th…

This study will test a six-week rehabilitation program in one person who had a stroke more than six months ago. The program combines a special glove and electrical stimulation device (SaeboStim GO and Saebo Glove) with ultrasound therapy and balance exercises. The goal is to see …

This study tests whether listening to music for 30 minutes a day for 8 weeks can improve attention, language, and quality of life in people with aphasia after a stroke. Researchers will compare music listening to audiobook listening and a control group. The trial involves 45 adul…

This study tests whether adding occupation-based bilateral arm training (OBBT) to standard therapy helps stroke survivors improve arm movement and daily activities. 150 participants in inpatient rehab will either get OBBT plus standard care or standard care alone for 6 weeks. The…

This study will test whether using smart technologies like brain-computer interfaces and robotic hand therapy can improve recovery in people who recently had a stroke. 200 participants will be split into four groups: three using different high-tech devices and one receiving stand…

This study uses advanced 4D MRI scans to measure blood flow and heart function in adults with heart disease or cancer. Researchers aim to see if these detailed images can help predict how these diseases will progress. The study involves 1,000 participants who are already schedule…

This study will interview 15 people from ethnic minority backgrounds in the UK who have heart disease. The goal is to understand their views on the diet and lifestyle advice they get from doctors, and whether it fits their cultural and religious customs. Researchers hope to learn…

This trial tests an AI tool called MIDI that quickly spots problems in brain MRI scans. The goal is to see if it helps doctors report urgent scans faster, so patients get treatment sooner. Over 100,000 adults will take part across multiple NHS sites in the UK.

This study tests whether having a neurologist consult via video during ambulance transport helps decide the best hospital for suspected stroke patients. About 484 adults with stroke symptoms will be randomly assigned to standard care or standard care plus a telemedicine consultat…

This study aims to learn how patients with severe stroke move during their hospital stay. Fifty adults will wear a small activity tracker (activPAL) that records lying, sitting, standing, and stepping. Researchers will compare this data with standard mobility goals to understand …

This study tests whether a 6-week program that combines a pedometer with phone or video coaching is practical for people who had a stroke at least 6 months ago. 24 participants will track their steps and set goals with an occupational therapist. The main goal is to see if people …

This study tests whether it is possible to run a larger trial comparing two ways of using a breathing machine (ventilator) in critically ill heart patients who need help breathing. The two modes are volume-controlled (delivers a set amount of air each breath) and pressure-control…

This observational study at a French hospital will ask 20 heart rehab patients and their care teams about what stops them from getting or offering psychological and social support. The goal is to understand these barriers so that hospitals can better help patients return to work …

This study aims to see if a quicker MRI scan can produce images of blood vessel walls that are just as good as the standard, longer scan. Researchers will enroll 15 adults who already need a vessel wall MRI as part of their care. The faster scan will be compared to the regular on…

This study tests a computer system called LingBao that helps doctors decide the best treatment for people having a stroke. About 3,000 adults from 20 stroke centers will take part. The system uses patient data to give treatment suggestions, but doctors make the final call. The go…

This study looks at whether a substance in the blood called BDNF is linked to strokes caused by heart conditions like atrial fibrillation. Researchers will measure BDNF levels in 150 people who recently had a stroke and compare it with heart and brain scans. The goal is to better…

This study explores why stroke survivors often feel extreme muscle fatigue. Researchers will use a gentle, non-invasive brain stimulation technique called tACS to temporarily change brain activity in 120 stroke survivors. Participants will do leg exercises until tired while their…

This study tests if a non-invasive device called Electrical Impedance Tomography (EIT) can safely monitor brain blood flow in 100 ICU patients with conditions like stroke or brain bleeding. Currently, doctors must insert a probe into the skull to check this, which can cause infec…

This study adapts and tests a Spanish version of eTIPS, an early home-based therapy program for infants at risk of unilateral cerebral palsy after perinatal stroke. The program involves parent-delivered activities integrated into daily routines. The study will enroll 20 families …

This study looks at two common anesthetics used during carotid artery surgery to see which one better protects the brain from small areas of damage. About 160 adults having planned carotid surgery will get either an intravenous or inhaled anesthetic. Researchers will compare brai…

This study will test a new tool called the Stroke Mimics Score (SMS) in 1000 adults who come to the emergency room with stroke-like symptoms. The goal is to see if the SMS can accurately tell the difference between a real stroke and a condition that looks like a stroke but isn't …

This observational study aims to understand how neuromuscular fatigue develops in stroke survivors compared to healthy individuals. Researchers will measure brain activity (EEG) and muscle activity (EMG) in 120 participants while they perform repeated leg exercises until fatigue.…

This pilot study will use advanced MRI scans to create detailed maps of brain connections in 10 people who have had a stroke in the middle cerebral artery. The goal is to understand how stroke disrupts the brain's network and whether these maps can help predict recovery and guide…

This study will observe 300 adults in the intensive care unit with serious brain conditions like bleeding, stroke, or injury. Researchers will use noninvasive monitors to track brain activity and blood flow, linking this data to patients' recovery. The goal is to better understan…

This study tests a new way to recruit women into stroke research using easy-to-understand materials like brochures and videos. Researchers will compare this approach to usual recruitment methods with 1,600 participants. The goal is to make stroke studies more inclusive so treatme…

This study will follow up to 12,750 stroke patients in Germany to learn how care is given from the moment symptoms start through hospital treatment, rehab, and long-term recovery. It includes both adults and children with ischemic stroke or brain bleeding. The goal is to collect …

This pilot study will test whether a women-focused education program, called Cardiac College for Women, helps women with heart disease learn more about their condition and feel better. About 50 women in cardiac rehab across Canada will either get the program plus usual care or us…

This study will follow 1,000 children under 18 who have had a stroke to see which treatments work best in everyday hospitals. Researchers will check their recovery, brain scans, and daily life over 6 months. The goal is to learn what helps children recover the most after a stroke…

This study will look at how consistently nearly 6,000 adults in Italy take three newer cholesterol-lowering drugs (inclisiran, evolocumab, and alirocumab) over the long term. Researchers will analyze prescription records to measure adherence and persistence in everyday medical pr…

This study compares two ways to perform brain angiography: accessing an artery through the wrist (transradial) versus the groin (transfemoral). Over 2,400 people needing this imaging test will be randomly assigned to one method. Researchers will measure success rates, complicatio…

This study examines whether blood electrolyte levels are linked to kidney damage in people who have a stroke and undergo a clot-removal procedure. Researchers will review medical records from 250 patients treated between 2018 and 2026. The goal is to identify risk factors that co…

This study looks at whether a clot-dissolving medicine called tenecteplase is safe and effective for people having a stroke when given more than 4.5 hours after symptoms began. Researchers will follow 3000 patients in China to see how many recover with little or no disability aft…

This study will track 3,000 stroke patients in China who received clot-busting medication more than 4.5 hours after their symptoms began. Researchers want to see if this later treatment is still safe and helps reduce disability. The study is observational, meaning it simply watch…

This study tests whether a one-on-one nursing education session just before a stroke patient goes home can improve how well they follow their medication and care plan. Researchers will enroll 300 stroke survivors who are returning home and randomly assign half to receive the extr…

This study aims to find brain activity markers that can predict how well people recover after an ischemic stroke. Researchers will first study healthy volunteers to establish normal brain patterns, then test 120 stroke patients. Patients will receive either real or sham brain sti…

This study tests whether a program called PEER-HOMEcare is practical and helpful for people recovering from stroke at home. The program involves therapists and family members working together to adapt the home environment and use wearable sensors to track movement. Researchers wi…

This study will follow 30 adults who have had a stroke and have arm weakness. Researchers will use functional MRI scans at several time points over six months to see how the brain reorganizes itself. The goal is to link different patterns of brain activity to different levels of …

This study aims to develop a new EEG-based technique to detect 'cognitive-motor dissociation'—where a patient is aware but cannot move. Researchers will stimulate the median nerve (in the wrist) and analyze brain signals in 50 comatose ICU patients. The goal is to identify those …

This study compares two common head positions—lying flat (0°) versus raising the head 30°—for the first 24 hours after a severe ischemic stroke. Researchers want to see which position leads to better recovery and fewer complications. About 1,500 adults with severe stroke will be …

This study will look at brain scans (MRI/CT) and symptoms of over 1,100 people with cerebrovascular disease. The goal is to find patterns linking specific scan findings to different types of the disease. This could help doctors diagnose and treat these conditions more accurately …

This study will test new MRI methods to find early signs of heart disease in 1000 adults. Researchers want to see if these scans can detect tiny changes in heart muscle before standard tests do. Participants will have MRI scans and blood work, but no treatment is given. The goal …

This study looks at whether certain blood test results can help predict how severe a stroke is and how well a person might recover. Researchers will check three different ratios in the blood of 60 adults with acute ischemic stroke. The goal is to see if these simple, routine test…

This study compares two approaches to help people with chronic traumatic brain injury (TBI) become more engaged and confident in managing their health. One approach focuses on what matters most to the patient, while the other provides general health education. The trial will invo…

This study tests a 5-week support program for stroke survivors after they leave the hospital. The goal is to see if the program helps them feel more confident and independent in managing their daily health. Researchers will compare participants who get the program plus usual care…

This study will follow 400 people who come to the emergency room with sudden vertigo or dizziness that might be caused by a mini-stroke in the back of the brain. Researchers will track their symptoms, treatments, and outcomes over a year to learn how to better diagnose and manage…

This study will test whether mild electrical brain stimulation, combined with physical therapy, changes brain activity in people who had a stroke. Sixty participants will receive either direct or alternating current stimulation during rehab sessions. Researchers will measure bloo…

This observational study will follow 180 stroke patients who had a clot-removal procedure. Researchers will measure brain blood flow and electrical activity at days 1-3 and day 7 after treatment. The goal is to see if early changes in brain function can predict how well patients …

This study will collect detailed information from 200 adults with severe brain injuries treated at Örebro University Hospital. Researchers will track their recovery, including brain function and healthcare needs, for up to a year. No new treatments are being tested—the goal is to…

This large registry study will follow over 2,700 postmenopausal women aged 45-75 who use newer forms of hormone replacement therapy (creams, gels, sprays). The goal is to see if these modern delivery methods lower the risk of heart attacks, strokes, and other cardiovascular event…

This study looks at whether lying flat (0 degrees) or with the head raised (30 degrees or more) after a stroke clot removal procedure helps people recover better. About 2240 adults who had a stroke from a large blood vessel blockage will be randomly assigned to one of the two hea…

This study looks at blood clots removed from 500 stroke patients to understand their composition and how they relate to blood markers, treatment success, and patient recovery. The goal is to learn more about stroke causes and find new ways to dissolve clots. Participants are adul…

This study looks at blood markers related to inflammation and clotting in people who have had a stroke or a brain bleed. Researchers want to see how these markers change over time and differ between patients with complications. About 499 adults will give blood samples at five tim…

This study will follow 4,000 intensive care patients aged 80 and older to see how chronic and acute heart conditions impact their survival, daily function, and quality of life. Researchers will use simple tests to measure frailty and independence. The goal is to help doctors bett…

This study will follow 500 Beijing residents aged 60 and older to see how urinary function (like bladder and kidney health) relates to the development of multiple chronic conditions such as diabetes, heart disease, and Alzheimer's. Participants will have regular health checks, bl…

This study looks at whether a CT scan measurement called net water uptake (NWU) can predict how well people recover from a stroke after receiving clot-busting medication. Researchers will review medical records from 200 stroke patients across multiple hospitals. They want to see …

This study looks at immune activity in the brain of people who had a severe stroke and needed surgery to relieve pressure. Researchers will compare these patients to others having brain surgery for different reasons. The goal is to better understand the body's inflammatory respon…

This study looks at how the body's immune and inflammatory systems change in people having a stroke who receive clot-busting drugs or mechanical clot removal. Researchers will take blood samples at several time points over a year to measure inflammation markers. The goal is to se…

This study tests whether a personalized video platform called MyStroke can improve stroke knowledge and reduce hospital use after discharge. About 690 stroke patients and their caregivers will either get standard education or also access to tailored videos. Researchers will check…

This study will look at 300 adults with acute ischemic stroke to find out how many have a large vessel occlusion (a big clot in a major brain artery). Researchers at Assiut University Hospitals will use CT or MRI scans to identify these patients and describe their characteristics…

This large study in China will follow 5,400 people with minor ischemic stroke to see if clot-busting drugs or mechanical clot removal (reperfusion therapy) leads to better recovery than standard medications. Participants are treated based on their doctor's choice, and researchers…

This study will check how common thinking and memory problems are in people who have had their first stroke. Researchers will evaluate 400 adults aged 18 to 60 within three months of their stroke. The goal is to better understand the impact of stroke on the brain, not to test a n…

This study will observe 400 adults who have a stroke within 28 days of a heart procedure, such as a stent or valve replacement. The goal is to learn more about these strokes, including how severe they are and how well current treatments work. No new drugs or devices are being tes…

This study reviews past medical records of 462 people who had a stroke caused by branch atheromatous disease (BAD), a blockage in a small, deep brain artery. Researchers want to see if clot-busting drugs (intravenous thrombolysis) work better than antiplatelet medicines (like asp…

This study looks at whether giving different amounts of protein early on can help people with serious brain injuries or strokes recover better in the ICU. 216 adults will be split into three groups, each receiving a different protein dose through a feeding tube. The main goal is …

This study looks at 150 adults having emergency clot removal for a stroke. Researchers will measure substances in the blood that show blood vessel damage and inflammation. The goal is to learn how these changes relate to recovery, not to test a new treatment.

This study will test a new robotic and virtual reality system called NeglectARm 3D in 15 people who have spatial neglect after a stroke. The system uses a robot arm and VR headset to measure how well patients notice objects in 3D space. Researchers want to see if the device is ea…

This study will ask 380 heart patients and healthcare workers at Assiut University Heart Hospital to fill out questionnaires about depression, anxiety, stress, and burnout. No treatments or changes are given—the goal is simply to find out how common these mental health problems a…

This study looks at how changes in the GGCX gene relate to recovery after an ischemic stroke. Researchers will collect blood samples from 1,500 stroke patients and follow them for 12 months to track strokes, bleeding, and deaths. The goal is to understand if this gene can help pr…

This study will follow 500 people who recently had a stroke or mini-stroke to see how well they stick with cholesterol-lowering treatments like statins and diet changes. Researchers want to learn how many patients reach their LDL cholesterol goals and whether better control reduc…

This study will use transcranial Doppler (TCD) ultrasound to measure blood flow in the brains of 100 people who had a stroke and underwent endovascular therapy (clot removal). The goal is to see if TCD readings can predict complications like bleeding or brain swelling in the days…

This study looks at 958 people having a severe stroke to find out if general anesthesia (being fully asleep) or procedural sedation (being drowsy but breathing on your own) leads to better recovery after a procedure to remove a blood clot from the brain. Participants will be rand…

This study follows 120 adults who had a stroke and underwent a procedure to remove a blood clot from a large brain artery. Researchers will test their thinking and memory at 3 and 6 months after the procedure. The goal is to find out which patients are more likely to develop cogn…

This study will compare how quickly stroke-related brain damage worsens in 135 Afro-Caribbean patients in Guadeloupe versus patients from mainland France. Researchers will use brain scans to track blood flow and collateral circulation. The goal is to learn if stroke progression d…

This study looks at whether waiting until day 3 after a stroke to start physical therapy is better for patients with a persistent blocked artery. Researchers will test if this delayed approach is feasible and if it helps prevent further brain damage. The study involves 50 adults …

This study looks at whether people who have had a transient ischemic attack (TIA or mini-stroke) experience subtle, long-term speech difficulties, even when they seem fully recovered. Researchers will test 30 TIA patients and 60 comparison volunteers using speaking tasks and ques…

This study will observe 125 adults with confirmed stroke to see how factors like symptom awareness, calling emergency services, and transport time affect their recovery. No new treatment is given; instead, researchers will measure stroke knowledge and care pathways to find ways t…

This pilot study tests a new, faster MRI technique called Magnetic Resonance Fingerprinting (MRF) for people who have had an ischemic stroke. Standard MRI scans take 20-25 minutes, but for stroke, every minute matters. The study will enroll 10 adults with subacute stroke to see i…

This study will test whether an artificial intelligence (AI) system can detect pulmonary hypertension and other heart diseases using a smart stethoscope. Researchers will collect heart sound and ECG recordings from 1,000 adults already scheduled for routine echocardiography. The …

This study looks at how sleep disorders and problems with the body's automatic functions (like heart rate control) are linked in elderly people with heart disease. Researchers will study 210 patients aged 65 and older to find out how common sleep issues are and how they affect he…

This study will look at the genes of 1,000 people in Brazil—half who had a stroke and half who did not—to find genetic differences that may increase stroke risk. Researchers will use whole genome sequencing to analyze DNA and compare it with international data. The goal is to bet…

This study looks at whether a non-invasive ultrasound test, done within 24 hours of a stroke, can predict how well patients recover. Researchers will measure blood flow in the brain and compare it to neurological improvement over 72 hours. The study involves 50 adults with acute …

This study looks at how tightness in the ankle muscles (spasticity) after a stroke affects a person's balance, risk of falling, and ability to move around. Researchers will study 68 people who had a stroke at least six months ago, comparing those with mild versus moderate-to-seve…

This trial tests whether a community education and training campaign can reduce the time it takes for stroke patients to get to the hospital. Over 1.6 million people in 16 communities across China will be involved. The goal is to increase the number of patients arriving within th…

This study tests a new way to use magnetic stimulation (TMS) to help stroke survivors recover thinking and memory. Instead of a one-size-fits-all approach, researchers will use brain scans to find the exact spot to stimulate for each person. The study will include 10 healthy peop…