Ischemic stroke

This study tested whether repeatedly inflating and deflating a blood pressure cuff on the arm (remote ischemic conditioning) could improve recovery in 458 people who had a severe stroke caused by a blocked artery in the brain. The goal was to see if this simple, non-drug treatmen…

This study aimed to find the best dose of MCI-186 for people who had an acute ischemic stroke. It compared a new way of giving the drug (a bolus followed by continuous infusion) with the standard twice-daily dosing for 14 days. The trial was terminated early and included only 17 …

This study tested a new device called Envi™-SR for removing blood clots in people having a severe ischemic stroke. The goal was to see if it works as well as devices already approved by the FDA. However, the trial was stopped early after enrolling only 12 people, so we don't have…

This study tested a drug called CardiolRx in 90 hospitalized COVID-19 patients who also had heart disease or risk factors like diabetes or high blood pressure. The goal was to see if the drug could lower the chance of death, needing intensive care, or having heart problems. The t…

This study tested whether taking people with severe stroke symptoms directly to the angio-suite for clot removal, instead of first doing a CT or MRI scan, leads to better recovery at 3 months. About 120 adults aged 18-85 with severe stroke were randomly assigned to either direct …

This study aimed to see if the antibiotic minocycline could improve outcomes after a stroke. Participants were to receive either standard care plus minocycline pills for five days, or standard care alone. However, the trial was stopped early after enrolling only 2 people, so no m…

This study tested whether a cone beam CT scan, done right after a stroke procedure called thrombectomy, could tell the difference between a brain hemorrhage and harmless contrast dye buildup. Only 5 adults were enrolled before the study was stopped early. The goal was to see if t…

This study tested a new imaging method to detect inflammation in fatty plaques that cause strokes. It involved 3 men who had a recent stroke and were scheduled for surgery to remove a plaque in their neck artery. The goal was to see if a special PET scan tracer could highlight in…

This study tested a device called CoolStat that is placed in the nose to cool down brain-injured patients with fever in the ICU. The goal was to see if it could safely and quickly bring their temperature to normal. Only 9 patients were enrolled before the study was stopped early,…

This study tested whether a magnetic device (rTMS) placed on the scalp could help people who had a stroke regain movement in their arm. The trial planned to include 60 adults with recent ischemic stroke. However, the study was terminated early, so the results are not complete.

This study aimed to identify brain areas outside the main motor region that help arm recovery after a severe stroke. Researchers followed 28 patients over time, using MRI and movement tracking to see which brain areas became active as arm function improved. The goal was to find n…

This study compared two breathing techniques (CPAP and eSigh) in 18 patients with brain injury and acute respiratory distress syndrome (ARDS). The goal was to see which method better maintains oxygen levels in the brain without causing harm. The trial was terminated early, so fin…

This study looked at how two common pain relievers—celecoxib (a Coxib) and naproxen (an NSAID)—affect blood clotting in people with rheumatoid arthritis who also have heart disease or are at high risk for it. All participants took low-dose aspirin daily. The goal was to see if on…