Silent brain infarcts: new trial tests aspirin and statins to prevent stroke and dementia

NCT ID NCT07012629

Recruiting now Disease control Sponsor: Aarhus University Hospital Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether common stroke-preventing medications—aspirin, clopidogrel, and statins—can reduce the risk of future stroke, heart attack, and dementia in people who have small, symptomless areas of brain damage called covert brain infarcts (CBIs). These are often found by chance on MRI scans. The trial will enroll about 1,650 participants across Europe and follow them for up to 3 years to see if treatment lowers the chance of major cardiovascular events and dementia.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Aspirin, clopidogrel, rosuvastatin, or atorvastatin
What this could lead to: If successful, this could establish a standard treatment to prevent future strokes and dementia in people with silent brain infarcts.
What could go wrong: This is a large phase 3 trial, but the benefit of these medications for silent brain infarcts is unproven. There is a risk of bleeding or other side effects from the drugs.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cerebral infarction dementia MRI defined brain infarct stroke disorder prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COVERT BRAIN INFARCTION

Contacts and locations

Locations

Aalborg Universitetshospital
NOT_YET_RECRUITING

Aalborg, 9000, Denmark
Aarhus Universitetshospital
NOT_YET_RECRUITING

Aarhus, 8200, Denmark
Aarhus University Hospital
RECRUITING

Aarhus, 8200, Denmark
Bispebjerg og Frederiksberg Hospital
NOT_YET_RECRUITING

Copenhagen, 2400, Denmark
Herlev Hospital
NOT_YET_RECRUITING

Herlev, 2730, Denmark
Kolding Hospital
NOT_YET_RECRUITING

Kolding, 6000, Denmark
Odense Universitetshospital
NOT_YET_RECRUITING

Odense, 5000, Denmark
Oslo University Hospital
NOT_YET_RECRUITING

Oslo, 0450, Norway
Regionshospitalet Gødstrup
NOT_YET_RECRUITING

Herning, 7400, Denmark
Rigshospitalet
NOT_YET_RECRUITING

Copenhagen, 2100, Denmark
Roskilde Hospital
NOT_YET_RECRUITING

Roskilde, 4000, Denmark
Skånes Universitetssjukhus
NOT_YET_RECRUITING

Lund, 22242, Sweden
University Medical Center Hamburg-Eppendorf
NOT_YET_RECRUITING

Hamburg, 20246, Germany
Universitätsspital - Inselspital - University of Bern
NOT_YET_RECRUITING

Bern, 3010, Switzerland