Can closing a heart hole stop strokes in seniors? new trial aims to find out
NCT ID NCT05907694
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether closing a small hole in the heart (called a PFO) plus medication is better than medication alone at preventing repeat strokes in people over 60 who have had a cryptogenic stroke (a stroke with no clear cause). About 714 participants will be randomly assigned to either get the closure procedure or just medical treatment. The goal is to see if the procedure reduces the risk of another stroke in this older population, who have been left out of most previous studies.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Transcatheter PFO closure procedure plus antithrombotic medication
What this could lead to
If successful, this could provide an effective way to prevent recurrent strokes in older adults with a PFO, expanding treatment options beyond medication alone.
What could go wrong
This is an early-stage trial with no phase designation, and results may not confirm benefit. The procedure carries risks like bleeding, new atrial fibrillation, or device complications.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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IUCPQ
RECRUITINGQuébec, Quebec, G2E4G9, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
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IUCPQ-UL
ACTIVE_NOT_RECRUITINGQuébec, Quebec, G1V 4G5, Canada