Vascular disorder

This trial tests whether giving defibrotide before and after a stem cell transplant can prevent a serious liver condition called sinusoidal obstructive syndrome (SOS) in children and young adults with sickle cell disease or beta thalassemia. Participants receive defibrotide start…

This study will test a device called EkoSonic in 30 Chinese patients with acute pulmonary embolism (blood clots in the lungs). The device uses ultrasound to help break up clots while delivering clot-busting medicine. The main goal is to see if it improves heart function within 48…

This trial tests whether inhaling a sedative called dexmedetomidine can reduce the brain's oversensitivity that drives chronic migraine. Researchers will measure changes in pain-related biomarkers and nerve signals in people with early chronic migraine. The goal is to see if this…

This early-phase trial tests giving radiation therapy before surgery to people whose adrenal cancer has come back. The goal is to find a safe radiation dose and see if it helps shrink tumors before removal. About 32 adults with resectable recurrent ACC will receive daily radiatio…

This trial tests whether a new transcatheter heart valve (Myval) works as safely and effectively as two existing valves (Sapien and Evolut) in people with severe aortic stenosis, a condition where the heart's main valve narrows. About 768 patients who are eligible for valve repla…

This study tests an experimental drug called ATV-1601 in people with moderate to severe HHT, a condition that causes frequent nosebleeds and anemia. The trial has two parts: first, participants receive either the drug or a placebo to check safety and effectiveness; then, all elig…

This phase 2 study tests whether spironolactone, a drug already used for fluid retention, can improve exercise capacity and blood vessel function in people with pulmonary arterial hypertension (PAH). About 70 adults with PAH will receive either spironolactone or a placebo for 24 …

This early-stage trial tests an experimental drug called RO7663498, given as an injection into the eye, for people with diabetic retinopathy. The main goal is to check safety and how the drug moves through the body. About 30 participants will receive multiple doses to see if it i…

This study looks at whether taking just one blood thinner (a P2Y12 inhibitor) is as safe and effective as taking two blood thinners (dual antiplatelet therapy) for people with stable heart disease who have a drug-coated balloon procedure without a stent. About 2,170 adults will b…

This trial tests whether planning coronary artery bypass grafting (CABG) using a non-invasive CT scan (CCTA) works as well as the standard invasive angiography (CAG). About 826 people with blocked heart arteries will be randomly assigned to have their surgery planned with one of …

This study follows 125 people who received a special stent graft (GORE TAG TBE) to treat a tear or bulge in the main artery near the heart (aortic arch). The goal is to see how well the device works and how safe it is over 5 to 10 years. Participants are treated as part of their …

This study tests a new virtual reality (VR) walking therapy for people who have had a stroke within the past 1 to 6 months. Participants will use either a fully immersive VR system that lets them walk over ground in realistic environments, or a semi-immersive VR system on a tread…

This trial is testing an experimental drug called HS235 in obese adults who have both pulmonary hypertension and heart failure with preserved ejection fraction. The study aims to see if the drug is safe, how it moves through the body, and whether it can improve heart and lung fun…

This trial is testing an experimental drug called HS235, given as a shot under the skin, in adults with pulmonary arterial hypertension (PAH), a condition where high blood pressure in the lungs makes it hard to breathe and can strain the heart. The study aims to see if adding HS2…

This first-in-human study tests a new device called Pulse IVL that uses sound waves to break up calcium buildup in heart arteries. Up to 15 people with coronary artery disease will receive the treatment before getting a stent. The goal is to see if the device is safe and helps op…

This study tests whether exercise using electrical stimulation can improve muscle strength and endurance in people with lower limb paralysis from conditions like spinal cord injury, stroke, or multiple sclerosis. Participants will use devices that send electrical signals to their…

This study tests whether inclisiran, a twice-yearly injection that lowers cholesterol, can prevent major heart and limb events in 6,000 people who recently had artery-opening procedures. Participants receive either inclisiran or a placebo shot at the start, at 90 days, and every …

This trial is investigating whether adding a clot-removal procedure, called endovascular treatment, to standard medical care can improve outcomes for people who have had a severe stroke caused by a blockage in the basilar artery, a major vessel at the back of the brain. The study…

This trial tests whether a computer-based rehabilitation system called NeuroTechR3 can help people improve arm and hand function after a stroke. Participants will play upper extremity rehabilitation games on a computer for 30 minutes, three times a week. The study measures change…

This study tests a new device called the VDyne System, which is placed inside the heart through a tube in a blood vessel to replace a leaky tricuspid valve. The trial will include 730 people with severe symptoms who have not improved with medication. Researchers will compare the …

This study looks at whether doing a small surgery early to remove blood from a deep brain bleed helps patients more than standard medical care. About 600 adults aged 18 to 70 with a specific type of brain bleed will take part. The goal is to see which approach leads to better rec…

This trial is testing two different ways to perform varicocele embolization, a procedure that blocks off enlarged veins in the scrotum to relieve pain and improve fertility. Thirty men with varicocele will receive the procedure either through a vein in the neck (transjugular) or …

This phase 3 trial is testing atogepant, a daily pill already approved for adults, to prevent episodic migraines in children aged 6 to 17. About 450 participants will receive either a low or high dose of the drug or a placebo for 12 weeks. The goal is to see if it safely reduces …

This study explores whether a robotic device that amplifies a person's own walking movements can help improve balance in people who have had a stroke. Participants with chronic stroke (more than 6 months ago) will do two treadmill walking sessions—one in a normal environment and …

This study tests a one-time gene therapy called surabgene lomparvovec (Sura-vec) for diabetic retinopathy, a common eye problem from diabetes that can lead to blindness. About 576 adults with moderate-to-severe non-proliferative diabetic retinopathy will receive either the gene t…

This study looks at whether a gentle laser treatment (SLT) works as well as the standard version for people with glaucoma or high eye pressure. It also tests if getting the gentle laser once a year can delay or prevent the need for daily eye drops. About 790 adults will take part…

This study is checking how well a new drug-coated stent (Coroflex ISAR NEO) works in people with coronary artery disease. Researchers will follow 3,000 patients who get the stent during a routine procedure to see if it keeps arteries open safely. The goal is to confirm the stent …

This study is testing a device that uses sound waves to break up calcium buildup in the leg arteries of people with peripheral artery disease. The goal is to improve blood flow, reduce pain, and help people walk better. About 50 participants will be followed for one year to see i…

This early-stage trial tests an experimental drug called RO7823653, given as an eye injection alone or with an approved drug (faricimab), for people with diabetic macular edema—a condition where diabetes causes fluid buildup and vision loss in the center of the eye. The study wil…

This study is checking the long-term safety of a drug called avacopan for people with ANCA-associated vasculitis, a rare disease where the immune system attacks blood vessels. About 300 adults who need treatment for a new diagnosis or flare-up will take avacopan or a placebo. The…

This study compares two standard procedures—minimally invasive TAVR and open-heart surgery (SAVR)—for replacing a diseased aortic valve in people with a bicuspid aortic valve. About 1,200 participants aged 50 and older with severe aortic stenosis will be randomly assigned to one …

This study tests a stem cell transplant using the patient's own blood cells to treat severe scleroderma (systemic sclerosis) that hasn't improved with standard drugs. The goal is to see if this high-dose therapy is safe and can stop the disease from getting worse. The trial enrol…

This study tests the drug acalabrutinib in people with chronic lymphocytic leukemia (CLL) who also have moderate to severe heart failure. Researchers want to see if acalabrutinib causes fewer heart-related side effects compared to other standard treatments. About 60 adults will t…

This phase 2 trial is testing whether TAK-755, a lab-made protein that helps break up blood clots, is safe and effective for people who have had an acute ischemic stroke. About 222 adults aged 18 to 80 will receive either TAK-755 or a placebo, along with standard stroke care, and…

This trial tests whether placing a stent in a narrowed or blocked neck artery during emergency stroke treatment helps people recover better than just removing the clot in the brain. About 15-20% of severe strokes involve both a brain clot and a neck artery blockage. The study wil…

This Phase 2 trial tests whether adding ALE.F02 to standard therapy can protect kidney function in people with ANCA-associated vasculitis, an autoimmune disease that attacks small blood vessels, often damaging the kidneys. About 80 participants will receive either a low, high, or…

This study tests a single dose of an experimental drug called ALN-AGT01 in adults with mild to moderate high blood pressure who have already been treated with another drug, zilebesiran. The goal is to see if it safely helps control blood pressure by measuring changes in blood pre…

This phase 3 trial tests an inhaled drug called treprostinil palmitil in 344 adults with pulmonary hypertension caused by interstitial lung disease. Participants take the drug or a placebo once daily for 24 weeks. The main goal is to see if the drug helps them walk farther in six…

This study follows 550 patients whose first TAVI heart valve has failed. Researchers will compare a second TAVI procedure (redo TAVI) with open-heart surgery or medication alone. The goal is to see which approach works best and why, helping doctors make better decisions for futur…

This study follows 1,500 people who received a GORE® TAG® stent graft to treat aortic conditions like aneurysms or dissections. Researchers will monitor device performance and patient outcomes for up to 10 years. The goal is to confirm that this minimally invasive procedure remai…

This study tests whether empagliflozin, a diabetes medicine, can improve right heart function in 78 adults with pulmonary arterial hypertension (PAH). Participants continue their usual PAH treatments and receive either empagliflozin or a placebo. The main goal is to see if the dr…

This study tests a new device called the VDyne System, which is placed through a tube in a blood vessel to replace the tricuspid valve in the heart. It is for people with severe tricuspid regurgitation, a condition where the valve does not close properly, causing blood to leak ba…

This trial is testing whether a higher dose of adenosine, a drug used during cardiac MRI to stress the heart, improves blood flow imaging compared to the standard dose. The study includes 180 adults with suspected or known coronary artery disease or heart failure. By comparing th…

This study tests a single injection of stem cells (B2065) given within 36 hours of a stroke. The goal is to see if it is safe and might help patients recover better. Fifty-four adults with moderate to severe stroke will receive either the stem cells or a placebo, and be followed …

This trial tests whether combining aerobic exercise with a targeted reading therapy, called Phono-Motor Therapy, can improve reading skills in people who have reading difficulties after a stroke. Participants will receive both interventions, and researchers will measure changes i…

This phase 3 study tests the long-term safety of an inhaled drug called treprostinil palmitil for people with pulmonary hypertension caused by interstitial lung disease. About 344 adults who completed an earlier trial will take the drug for up to 2 years. Researchers will track s…

This study tests whether placing a stent in a blocked pelvic vein can help heal chronic leg ulcers in people with post-thrombotic syndrome, a complication of deep vein thrombosis. Twenty adults with non-healing venous ulcers will receive the stenting procedure plus standard ulcer…

This Phase 3 trial is testing whether adding BDB-001 to standard treatments (cyclophosphamide, azathioprine, rituximab, or prednisone) helps more people with ANCA-associated vasculitis achieve remission. The study plans to enroll 300 adults with active GPA or MPA. Participants wi…

This study is testing a device called FlowTriever that removes blood clots from the lungs in people with a severe, high-risk pulmonary embolism. About 200 participants will be randomly assigned to get either the device or standard care. The goal is to see if the device reduces de…

This study tests whether a personalized blood-thinner plan can reduce bleeding in people with coronary artery disease who have received a heart stent. About 3,944 participants will either get the usual dual antiplatelet therapy (two blood thinners) or a shorter course followed by…

This study tests a stent graft that doctors modify to fit each patient's unique aneurysm in the chest and abdomen. The goal is to see if this less invasive approach is as safe and effective as traditional open surgery. About 80 people aged 50 and older with large aneurysms will t…

This study looks at whether taking melatonin for 12 weeks can help lower blood pressure in women going through menopause who already have high blood pressure. Researchers will measure nighttime blood pressure and check for changes in stress markers. The goal is to find a simple, …

This study is a registry that follows about 960 people with coronary artery disease who are treated with a special balloon coated with a drug called sirolimus. The balloon is used to open blocked heart arteries. Researchers will track heart-related events like death, heart attack…

This study tests whether starting inclisiran early during a hospital stay for a heart attack can lower bad cholesterol more than a placebo, when both are added to standard care. About 300 adults hospitalized for a heart attack will receive either inclisiran or a placebo shot at t…

This trial tests whether nurse-led motivational interviewing—a counseling style that helps people find their own motivation to change—can improve blood pressure control in adults with hypertension. Participants are randomly assigned to usual care, individual counseling, or counse…

This study looks at whether successfully restoring blood flow in the brain using the Tigertriever device, a tool that removes clots during a stroke, may also help protect cognitive abilities like memory and attention. Researchers will follow 424 adults aged 18 to 75 who had a lar…

This trial tests a 9-month program for women who had preeclampsia during their first pregnancy. The program includes online screening, group meetings, and a smartphone app to help monitor blood pressure and weight. Researchers want to see if it improves heart health and promotes …

This study compares different ways to give blood pressure cuffs and training to adults with uncontrolled high blood pressure during routine primary care visits. Participants receive a cuff either in the clinic or by mail, and training either hands-on or through written instructio…

This trial tests whether starting respiratory physiotherapy within one hour of breathing tube removal after elective coronary artery bypass surgery improves lung function and reduces complications compared to waiting until the next day. Forty adults undergoing planned heart surge…

This study tests a new digital tool called P3-EX that helps doctors create personalized exercise plans for patients with heart disease risk factors like high blood pressure, diabetes, and obesity. Researchers will recruit 24 doctors and 48 patients to compare the new tool with a …

This study follows 118 people getting a special device called Pipeline Vantage to treat brain aneurysms. The device is placed inside the blood vessel to block the aneurysm and prevent rupture. Researchers will check how well it works and if there are any problems one year after t…

This early-phase study tests a new treatment called MQ710, a modified virus injected directly into tumors, alone or with the immunotherapy drug pembrolizumab. It is for people with advanced solid tumors (like skin cancer or head and neck cancer) that have not responded to standar…

This study tests whether a newer, less invasive procedure called transcatheter aortic valve replacement (TAVR) using the J-VALVE device is as safe and effective as traditional open-heart surgery for people with severe aortic regurgitation (a leaky heart valve). About 1,250 adults…

This trial tests an implantable device called the Shockwave Reducer for people with severe, persistent chest pain (refractory angina) who cannot have standard treatments like stents or bypass surgery. About 380 participants will either receive the device or a sham procedure. The …

This early trial tests a new device called the iHub stent-graft in 10 adults with iliac artery aneurysms. The device is placed through a small incision to seal off the aneurysm while keeping blood flowing to the internal iliac artery. Researchers will check for serious problems w…

This program provides access to an experimental oral medication called deucrictibant for people with hereditary angioedema (HAE) who have no satisfactory alternative treatments for acute attacks. Eligible participants, aged 12 to 75, take the capsule as needed to manage swelling …

This trial tests whether a gentle electrical stimulation applied to the ear—called transcutaneous auricular vagus nerve stimulation—can help people recover consciousness after surgery for a spontaneous brain hemorrhage. The study will include 160 adults aged 18 to 75 who remain i…

This study is tracking 1,000 patients with high blood pressure who receive the Paradise Ultrasound Renal Denervation treatment. The procedure uses ultrasound energy to calm overactive nerves near the kidneys, which can help lower blood pressure. Researchers are monitoring blood p…

This study compares a new balloon coated with everolimus to standard paclitaxel-coated balloons for opening blocked leg arteries in people with peripheral artery disease. About 410 participants will be randomly assigned to one of the two balloons. The goal is to see if the new ba…

This study follows 255 patients of any age (weighing over 3 kg) who receive a device called the Occlutech PDA Occluder to close a common heart defect called patent ductus arteriosus (PDA). The device is inserted through a blood vessel, avoiding open-heart surgery. Researchers wil…

This Phase 2 study tests an oral drug called RLY-2608 in adults and children with overgrowth conditions (like CLOVES or Klippel-Trenaunay syndrome) caused by PIK3CA gene mutations. The drug is designed to block the faulty protein driving abnormal tissue growth. The trial will enr…

This study looks at whether spinal cord stimulation, a device already used for chronic pain, can also reduce blood pressure in people with hypertension and low back pain. Researchers will measure blood pressure changes and pain levels, and explore how different stimulation patter…

This trial tests whether adding metacognitive training—exercises that help people think about their own thinking—to standard word-finding rehabilitation can improve language skills in people with chronic aphasia after a stroke. The study involves 18 participants who will receive …

This study compares standard medical care to a new, less invasive surgery for people with a severe bleeding stroke. The surgery uses a small tube to drain the blood clot and delivers clot-busting medicine directly into the brain. Researchers want to see if this approach helps pat…

This phase 3 trial compares a once-weekly growth hormone injection (lonapegsomatropin) to a daily one (somatropin) in 186 prepubertal children with growth failure due to Turner syndrome, SHOX deficiency, being small for gestational age, or idiopathic short stature. The goal is to…

This trial investigates whether giving a low dose of the clot-busting drug alteplase directly into the brain artery, right after successful mechanical clot removal, can improve recovery in people with a severe stroke caused by a large vessel blockage. About 416 adults who have ha…

This trial is testing a new heart valve called SAPIEN X4/X4S in over 1,200 people with severe aortic stenosis, a condition where the heart's aortic valve narrows. The valve is inserted through a catheter, avoiding open-heart surgery. Researchers are measuring how many patients di…

This study tests a drug called mirivadelgat in people with high blood pressure in the lungs caused by lung scarring (PH-ILD). The goal is to see if it improves blood flow in the lungs, exercise ability, and overall well-being. About 126 participants will take the drug or a placeb…

This trial tests an experimental therapy called CTX340, which uses CRISPR gene editing to disable a gene in the liver that regulates blood pressure. It is designed for adults with uncontrolled hypertension despite taking multiple blood pressure medications. The study will first a…

This trial tests whether adding self-administered hand therapy at home, using a videogame controller called the Twirlstone, can improve hand dexterity and coordination in stroke survivors. Participants, who are within six weeks of a stroke and have arm or hand weakness, will eith…

This study tests whether treating mild high blood pressure (stage 1 hypertension) during pregnancy can improve baby birth weight. 74 pregnant people with blood pressure between 130-139/80-89 mmHg will be randomly assigned to either active treatment with blood pressure medication …

This study tests a drug called CSL300 in people with end-stage kidney disease who are on dialysis and have signs of inflammation. The goal is to see if it can reduce the risk of heart attacks or heart-related death. About 3110 adults will take part, and half will get the drug whi…

This trial tests whether a non-invasive device that stimulates the vagus nerve through the ear can reduce harmful spasms in brain arteries that often occur days after an aneurysm rupture. The study will enroll 10 adults who have had this type of bleeding in the brain and will rec…

This study will screen 1,500 people with early signs of heart disease (plaque in arteries) to see if two common drugs—rosuvastatin and colchicine—can reduce or stabilize that plaque over two years. Participants will take pills daily and get heart-healthy lifestyle advice. The goa…

This study tests a new device called the RevCore Thrombectomy Catheter to treat blocked stents in the leg veins. About 100 adults with stents that have been in place for at least 6 weeks will be enrolled. The device is inserted into the vein to remove the blockage and restore blo…

This study tests a new drug, BBD-1, against standard steroids for IgA vasculitis, a disease that causes purple spots on the skin, joint pain, and can damage the kidneys. The trial will enroll 30 adults with confirmed IgA vasculitis. The goal is to see if BBD-1 can clear skin spot…

This trial tests whether adding a low-dose blood thinner (rivaroxaban) to standard antiplatelet therapy for the first three months after a heart stent procedure can reduce the risk of future heart attacks, strokes, and other cardiovascular events in high-risk patients. Participan…

This study tests two blood-thinning strategies in people with severe aortic regurgitation who have had a new heart valve placed without open surgery. Participants receive either daily aspirin for a year or warfarin for six months followed by aspirin. The goal is to see which appr…

This study tests whether a structured rehabilitation program called HABIT-ILE, which combines intensive arm, hand, and leg exercises, can improve balance and coordination in people recovering from a stroke. The trial will include 44 stroke survivors aged 40 to 60, who will be ran…

This study looks at whether people with giant cell arteritis (GCA) who are in remission can safely stop or lower their dose of tocilizumab (Actemra). About 78 adults who have been on high-dose tocilizumab for at least a year and off steroids for three months will either stop the …

This study compares two procedures used to treat unruptured wide-neck brain aneurysms: flow diverter stents and stent-assisted coiling. Researchers will follow 274 adults from three centers in China who receive one of these treatments as part of routine care. The main question is…

This long-term study follows people with pulmonary arterial hypertension (PAH) who previously took part in sotatercept trials. Sotatercept is a targeted therapy that aims to stop PAH from getting worse. Researchers will monitor safety, side effects, and how well patients tolerate…

This study is testing a device called a flow modulator to treat wide-necked brain aneurysms. The device is placed inside the artery to redirect blood flow away from the aneurysm, helping it close off. Researchers will check if the device is safe and effective in 214 adults over 1…

This trial compares two blood thinners, edoxaban and apixaban, in people who have both atrial fibrillation (an irregular heartbeat) and coronary artery disease (narrowed heart arteries). Both drugs help prevent blood clots, but they are taken differently and may have different ri…

This study looks at how a special balloon called the OPN balloon is used to open severely hardened or blocked heart arteries. Researchers will track 300 adults who need this procedure to see how well it works and what problems might happen. The goal is to learn the best ways to u…

This study tests whether a personalized, home-based exercise program can help people who have had a moderate-to-severe pulmonary embolism (a blood clot in the lungs) improve their physical capacity and quality of life. Participants will be randomly assigned to receive the exercis…

This study compares two medicated stents (tiny mesh tubes) used to open blocked heart arteries in people having a heart attack or unstable angina. About 2,100 participants will receive either a sirolimus-eluting stent (ihtDEStiny) or an everolimus-eluting stent (Xience). Research…

This study tests whether vestibular-oriented balance training or motor dual-task training, added to standard physiotherapy, better improves balance and reduces fall risk in people who had a stroke at least six months ago. About 50 participants will be randomly assigned to one of …

This trial compares two blood pressure medications—midodrine and droxidopa—against compression stockings and a placebo to see which best stabilizes blood pressure in people with spinal cord injury. Participants have a traumatic injury between C1 and T6, are at least a year post-i…

This study tests whether using a CT scan to guide heart stent placement is better than the current standard (IVUS ultrasound) for people with hardened, calcified coronary arteries. About 700 adults with evidence of reduced blood flow to the heart will be randomly assigned to one …

This study tests an experimental oral drug called ROC-101 in 40 adults with pulmonary arterial hypertension (PAH) or pulmonary hypertension linked to interstitial lung disease (ILD-PH). Participants take the drug alongside their standard care for 24 weeks, with a long-term follow…

This early study tests a new device called HyperQure that uses a keyhole surgery to disable certain nerves around the kidneys. The goal is to help people with resistant hypertension—high blood pressure that stays high despite taking three or more medications. The study will enrol…

This study investigates whether aggressive lipid-lowering therapy can reduce plaque buildup in the heart arteries of melanoma patients starting immune checkpoint inhibitors (ICIs). Participants with plaque detected on a heart CT scan are randomly assigned to either usual care or …

This study tests whether doing strength exercises one limb at a time (unilateral) or both limbs together (bilateral) makes a bigger difference in heart rate variability, muscle strength, and daily function for adults with high blood pressure. Adults aged 40-75 with hypertension w…

This study tests a drug called lepodisiran in 252 adults with high levels of Lp(a), a protein linked to heart disease. Participants must have heart disease or be at risk for a first heart event. The drug is given as an injection and compared to a placebo to see if it reduces plaq…

This large phase 3 trial is testing whether adding vicadrostat to the existing drug empagliflozin can reduce the risk of heart problems in adults with type 2 diabetes, high blood pressure, and heart disease. About 11,800 participants will take either the combination or a placebo …

This Phase 3 trial tests an oral drug called muvalaplin in over 10,000 adults with high levels of lipoprotein(a), a genetic risk factor for heart disease and stroke. Participants either have had a prior cardiovascular event or are at high risk for a first one. The study measures …

This study is testing a device called the Indigo Aspiration System to remove blood clots from leg arteries in people with acute limb ischemia, a condition where a clot suddenly blocks blood flow. About 300 participants will undergo a procedure where the device sucks out the clot.…

This study tests a device called the Artix Thrombectomy System to remove blood clots from leg arteries in people with sudden blockages. About 250 adults with symptoms lasting up to 14 days will be enrolled. The goal is to see if the device can safely restore blood flow and preven…

This trial is testing a device designed to remove blood clots from the deep veins of the legs, a condition called deep vein thrombosis (DVT). The study will enroll about 167 adults with acute or subacute DVT to see if the device can safely and effectively clear the blockage. Part…

This study tests a new device and technique (ADAPT 2.0) for removing blood clots in people having an acute ischemic stroke. The goal is to see if it can restore blood flow more completely and safely than current methods. About 750 adults who are already scheduled for clot removal…

This study tests whether adding pelacarsen to inclisiran can further lower a type of cholesterol called Lp(a) in people with heart disease. About 340 adults with high Lp(a) and LDL-C will receive either pelacarsen or a placebo, plus inclisiran. The main goal is to see if Lp(a) le…

This study compares catheter ablation (a procedure to fix irregular heartbeats) with standard medical care in 646 adults who have both atrial fibrillation and a recent brain bleed. The goal is to see if ablation reduces the risk of death, stroke, or blood clots. Participants must…

This early-stage study tests whether a drug called anisodine hydrobromide is safe for people having a stroke caused by a blocked large artery in the brain. About 92 adults aged 18 to 80 who are already scheduled for a clot-removal procedure will receive the drug. The main goal is…

This trial tests whether using a supraglottic airway (a mask-like device) instead of a breathing tube during heart surgery can reduce lung complications and speed recovery. Adults having elective heart valve surgery or bypass will be randomly assigned to either the nonintubated a…

This phase 3 trial tests whether metformin, a diabetes drug, can safely prolong pregnancy in women with preterm preeclampsia. Currently, the only treatment is early delivery, which risks the baby's health. The study will enroll 294 women across Nordic countries, giving them metfo…

This trial tests a new model of care called PEN-Plus, which brings specialized treatment for severe chronic diseases like diabetes, heart conditions, and sickle cell disease to first-level hospitals in Zambia. The goal is to train local health workers and set up clinics to manage…

This phase II trial tests whether adding the immunotherapy cemiplimab to the targeted drug cabozantinib works better than cabozantinib alone for advanced adrenocortical cancer. About 48 adolescents and adults whose cancer has spread or cannot be removed will take part. The study …

This study tests whether the drug clevidipine can lower blood pressure quickly and steadily in people having a bleeding stroke (intracerebral hemorrhage). High blood pressure can make the bleeding worse, so getting it under control fast is critical. The trial will compare clevidi…

This study compares two approaches for people with mild-to-moderate carotid artery stenosis (narrowing of the neck arteries): a standard statin regimen versus a statin plus a PCSK9 inhibitor (evolocumab) given as biweekly injections. The main goal is to see whether the combinatio…

This study tests a new treatment called NKX019 for people with autoimmune diseases like systemic sclerosis, rheumatoid arthritis, and vasculitis. NKX019 uses specially engineered immune cells to target and calm overactive B cells that cause the disease. The goal is to see if it i…

This study tests a daily pill called orforglipron to see if it can prevent major heart problems (like heart attacks or strokes) and slow kidney disease in people who already have heart or kidney disease. About 7,140 adults will take either the drug or a placebo for up to 5 years.…

This study tests whether closing a small pouch in the heart (the left atrial appendage) with a device is safer and as effective as long-term blood thinners for people with atrial fibrillation who have already had a brain bleed. About 530 participants will be randomly assigned to …

This study looks at two ways to treat a type of stroke caused by a blockage in a smaller branch of a brain artery. One group receives a procedure to remove the clot (thrombectomy) plus standard medical care, while the other group receives medical care alone. The goal is to see if…

This study tests a lab-made human protein called CYT107 in 55 people with HIV and Kaposi sarcoma. The protein aims to boost T cells, which may help shrink cancer tumors. Participants receive weekly injections for up to 4 weeks, with follow-up for 3 years.

This phase 3 study tests an intravenous C1 esterase inhibitor (C1-INH) in people with hereditary angioedema (HAE) to treat acute attacks and prevent attacks before medical procedures. About 124 participants, aged 2 and older, will receive either the drug or a placebo. The main go…

This study tests an oral medication called BI 1815368 in 300 adults with center-involved diabetic macular edema, a common cause of vision loss in diabetes. Participants take tablets twice daily for about 11 months, and doctors compare vision changes between those on the drug and …

This study tests an experimental drug, REGN7508, to see if it works better than the standard blood thinner apixaban for treating and preventing blood clots in people with cancer. The trial will include about 1,600 participants with or without cancer who have deep vein thrombosis …

This early study tests whether a liquid form of the drug avacopan can be safely given through a feeding tube to critically ill patients with ANCA vasculitis who have severe lung bleeding and need a ventilator. The main goal is to measure how the drug levels change in the blood ov…

This trial tests whether vericiguat, a drug that relaxes blood vessels, can protect the body during heart surgery. About 170 adults scheduled for open-heart surgery will receive either vericiguat or a placebo starting two days before the operation. Researchers will measure blood …

This study tests a new type of stent (a small mesh tube) for people with heart disease who also take blood thinners. These patients have a high risk of bleeding when they also need anti-clotting drugs after stent placement. The new stent is designed to allow a shorter course of a…

This study looks at whether giving enalapril, a standard blood pressure medicine, to women who had preeclampsia during pregnancy can help control their blood pressure after childbirth. Researchers will enroll 60 postpartum women and randomly assign them to enalapril or usual care…

This study looks at two ways to treat blocked large heart arteries (≥3.5 mm) in people with coronary artery disease. One method uses a drug-coated balloon, the other a drug-releasing stent. The goal is to see which helps the artery relax and function better 8 months after treatme…

This study is testing whether it is safe and effective to perform two heart procedures at the same time in people with atrial fibrillation (AF). The first procedure uses pulsed field ablation to correct the heart's rhythm, and the second closes off a small pouch in the heart to r…

This study tests if delivering oxygen directly into the gut through a thin tube can help people with ischemic-hypoxic bowel disease, a condition where the bowel doesn't get enough oxygen. About 90 adults with symptoms like belly pain, bloating, and trouble pooping will receive ei…

This program allows doctors to request NanO₂, an investigational drug that may help deliver oxygen to tissues, for patients with serious or life-threatening conditions like glioblastoma, respiratory distress, or ischemic stroke. It is for patients who have exhausted other treatme…

This study will track 100 people with severe aortic stenosis who receive the Hydra THV heart valve through a less invasive procedure (TAVR). The goal is to see how well the valve works and how safe it is in everyday practice. Participants will be followed for short- and mid-term …

This program provides access to an investigational drug called donidalorsen for people with hereditary angioedema (HAE), a genetic condition that causes sudden, painful swelling in various body parts. The drug is given as a monthly or every-other-month injection under the skin. I…

This study tests an experimental drug called REGN13335 in 99 adults with pulmonary arterial hypertension (PAH), a condition where high blood pressure in the lungs makes the heart work harder. Participants will receive either the drug or a placebo, on top of their usual PAH medica…

This study is a registry that will follow about 200 people with brain aneurysms who are treated with a flow diverter device (p64, p64 MW, or p48 MW). The goal is to see how safe and effective these devices are in real-world practice across France. Participants will be monitored f…

This study tests a drug called donidalorsen in 20 children aged 2 to 12 with hereditary angioedema (HAE), a condition that causes sudden, painful swelling. The goal is to see if the drug is safe and how it works in young bodies. Researchers will monitor side effects and measure h…

This study tests two experimental drugs, REGN7508 and REGN9933, in about 1,200 people with atrial fibrillation (an irregular heartbeat). The goal is to see if these drugs can prevent blood clots and strokes with less bleeding compared to the standard blood thinner apixaban. Parti…

This study looks at the best time to start blood thinners in people with atrial fibrillation who had a stroke and emergency treatment to open a blocked artery. About 438 participants will be randomly assigned to start blood thinners within 4 days or between 5-14 days after the st…

This program gives children with brain disorders like cerebral palsy or stroke access to umbilical cord blood infusions. The treatment uses donated cord blood cells to help repair brain damage. Kids up to age 26 with normal immune function may qualify. The goal is to improve symp…

This trial tests whether a 5-microgram or 10-microgram bolus of norepinephrine is better at quickly raising dangerously low blood pressure during emergency abdominal surgery. Low blood pressure after anesthesia is common in these surgeries and can harm organs if not treated fast.…

This phase 3 trial is testing two experimental drugs, REGN7508 and REGN9933, to prevent serious blood clots in people with peripheral artery disease who recently had leg surgery to improve blood flow. The study will enroll about 7,050 participants and compare the drugs to a place…

This trial investigates whether combining repetitive transcranial magnetic stimulation (rTMS) with aerobic exercise can treat depression and improve walking in people who have had a stroke. Participants will receive either real or sham rTMS along with exercise sessions over 12 we…

This study tests two ways to treat hardened calcium deposits in heart arteries. After using sound waves to break up the calcium, doctors will either place a drug-coated balloon or a drug-coated stent. The trial will follow 128 patients for 9 months to see which approach keeps art…

This study compares two treatments for small ischemic strokes (lacunar strokes): a combination of antiplatelet drugs (pills) versus the standard clot-busting drug tPA given through an IV. The goal is to see if the pill combo works just as well but causes fewer bleeding problems. …

This study tests a new medicine, EYP-1901, given as an eye injection to people with diabetic macular edema (DME), a condition that causes blurry vision in people with diabetes. The goal is to see if EYP-1901 works as well as the standard treatment (aflibercept) but with fewer inj…

This study tests a drug called YN001 in 456 adults with coronary atherosclerosis (plaque buildup in heart arteries). Participants receive weekly injections of YN001 or a placebo for 13 weeks. The main goal is to see if YN001 reduces plaque volume in the arteries, as measured by a…

This phase 3 trial tests EYP-1901, a new eye injection, against the standard treatment aflibercept for diabetic macular edema (DME), a condition that causes vision loss in people with diabetes. The study will enroll 240 participants and compare how well each drug improves vision …

This trial investigates whether giving clot-busting drugs (tenecteplase or alteplase) to people who have an ischemic stroke while taking direct oral anticoagulants (blood thinners) is safe and effective. About 906 adults who had a stroke within 48 hours of taking a DOAC will be r…

This study tests a new device that uses sound waves to break up calcium deposits in heart arteries before placing a stent. About 408 adults with coronary artery disease will receive this treatment. The goal is to see if the device is safe and effective at clearing blockages to im…

This study is checking how safe and well a device called TriClip works for people with a leaky heart valve (tricuspid regurgitation). The device is already approved for use, and this study will watch 1000 adults who get it to see how they do. The goal is to make sure the device w…

This study tests whether adding butylphthalide (a neuroprotective drug) to standard clot-busting tenecteplase helps people with mild but disabling stroke recover better. About 1,062 adults aged 18-80 who can be treated within 4.5 hours of symptoms will receive either the combo or…

This trial tests whether an eight-week digital cardiac rehabilitation program using the Peloton app can improve physical activity and recovery in people who have had a transcatheter aortic valve replacement (TAVR). Participants are randomly assigned to either the digital rehab pr…

This study tests whether a combination of nifedipine and enalapril controls high blood pressure after childbirth better than nifedipine and labetalol. It involves 200 postpartum women with persistent hypertension. The goal is to reduce hospital stays, readmissions, and severe blo…

This Phase 2 trial tests an inhaled drug called LAM-001 (sirolimus) in 85 adults who have pulmonary hypertension (high blood pressure in the lungs) along with interstitial lung disease (lung scarring). The study compares the drug to a placebo to see if it improves blood flow in t…

This study tests whether pemafibrate, a drug that lowers triglycerides, can prevent the worsening of narrowed brain arteries in people who have already had a stroke or mini-stroke. About 270 participants will be randomly assigned to receive either pemafibrate plus standard care o…

This trial tests whether a wrist-hand rehabilitation robot that uses both brain and muscle signals can help people with chronic stroke recover better than one using muscle signals alone. Forty-eight participants will receive 20 training sessions with the robot, which provides ele…

This study looks at a newly recognized disease called KSHV Inflammatory Cytokine Syndrome (KICS), caused by a virus that can also lead to certain cancers. Researchers aim to learn more about the disease and test experimental treatments, including antiviral and chemotherapy drugs,…

This early-phase trial tests an experimental antibody called DIAG723 in 93 adults with hereditary hemorrhagic telangiectasia (HHT), a condition that causes abnormal blood vessels and frequent nosebleeds. The study will check if the drug is safe and how the body processes it, with…

This trial is testing a new coronary extension catheter designed to help doctors deliver balloons and stents more easily during percutaneous coronary intervention (PCI) for coronary artery disease. The study will enroll about 69 adults who need PCI and for whom the catheter is pl…

This study investigates whether changes in retinal blood vessels can serve as a marker for cerebral small vessel disease (SVD), a common condition in older adults that increases stroke and dementia risk. The trial includes people with SVD-related conditions like CADASIL, sporadic…

This study is for children and young adults (up to age 30) with a rare type of soft tissue cancer called non-rhabdomyosarcoma. It tests whether adding the drugs pazopanib and selinexor to standard chemotherapy can improve outcomes. Participants receive treatment tailored to their…

This study tests whether giving thiamine (vitamin B1) during coronary artery bypass surgery can reduce the memory and thinking problems that sometimes follow the procedure. Older adults with coronary heart disease who are scheduled for bypass surgery and have low thiamine levels …

This early-stage trial tests a single IV dose of VERVE-102, a gene-editing drug designed to permanently lower LDL (bad) cholesterol by turning off a specific gene in the liver. It involves 85 adults with inherited high cholesterol or early heart disease who still need lower chole…

This early-stage study tests a new treatment called RD06-05, a universal CAR-T cell therapy, in up to 84 adults with autoimmune diseases like lupus, vasculitis, and scleroderma. The therapy targets and removes faulty immune cells to help control the disease. The main goal is to c…

This phase 3 trial is testing whether a blood pressure treatment plan that focuses on diuretics (water pills) works better than usual care for people with moderate to severe chronic kidney disease and uncontrolled high blood pressure. The study will include 720 participants and t…

This study tests whether doing wall squats at home, along with lifestyle advice, is a practical and acceptable way for people with high blood pressure to manage their condition. Seventy adults with hypertension will do supervised wall squat exercises three times a week for 12 wee…

This trial compares two rehabilitation approaches—neurodevelopmental technique (NDT) and mirror therapy—to see which better improves coordination, leg function, and walking ability in people recovering from a sub-acute stroke. Forty adults aged 45 to 65 with hemiplegia (weakness …

This study tests a device that uses ultrasound to calm overactive nerves in the kidneys, which can drive high blood pressure. About 261 adults with hypertension will either get the real procedure or a sham (fake) one. The goal is to see if this approach safely lowers blood pressu…

This trial tests whether a smartphone app called HeartCheck can help people who have recently survived a heart attack better manage their blood pressure, cholesterol, blood sugar, and smoking habits. The app provides education, reminders, and easy-to-understand goals to support m…

This trial is testing whether vitamin D supplements can improve bone density, body composition, strength, walking speed, and physical performance in people hospitalized with neurological disorders like stroke, spinal cord injury, or traumatic brain injury. Participants will recei…

This study tests an implanted electrical stimulation device designed to improve movement, standing, and walking in people with paralysis from spinal cord injury, stroke, multiple sclerosis, or traumatic brain injury. The device sends electrical signals to muscles in the trunk and…

This study follows over 500 people with chronic venous disease who are taking Ruscus aculeatus L., a plant extract also known as butcher's broom, as part of their routine care. Researchers will track changes in vein-related symptoms, pain, and quality of life over 90 days. The go…

This trial tests whether low-dose colchicine, an anti-inflammatory drug typically used for gout, can reduce stroke risk and artery plaque in people with intracranial atherosclerotic disease (ICAD). ICAD is a leading cause of stroke in Asia, and even with standard treatment, the r…

This study compares two ways to intensify treatment for people with pulmonary arterial hypertension (PAH) who are not doing well enough on standard dual therapy. One group adds a third type of medication (a prostacyclin pathway agent), while the other group increases the dose of …

This study follows 3,000 ischemic stroke patients who also have cerebral microbleeds — tiny spots of old blood in the brain. Researchers are tracking how different antithrombotic drugs (blood thinners) affect the number of microbleeds and the risk of future strokes or brain bleed…

This trial investigates whether a low dose of the drug conbercept can effectively treat retinopathy of prematurity (ROP), an eye disease that can cause blindness in preterm infants. The study will enroll 146 preterm babies with type 1 ROP and compare the low-dose treatment agains…

This trial tests a new implant that slowly releases the glaucoma drug timolol inside the eye. It is for people with open-angle glaucoma or ocular hypertension who are already having cataract surgery. The study compares three doses of the implant against standard timolol eye drops…

This trial tests whether a community health worker-led education program, called Heart Health and Nutrition for Life (HHNL), can help people with high blood pressure lower their numbers. The program covers healthy eating, physical activity, medication adherence, stress reduction,…

This registry tracks 5,000 people with coronary artery disease who receive one of three drug-eluting stents during angioplasty: Biolimus, Everolimus, or Zotarolimus. Researchers will compare rates of heart-related death, heart attack, and repeat procedures over two years. The goa…

This trial tests whether flushing a stent-graft with carbon dioxide before implanting it in the aorta can reduce the number of tiny air bubbles that travel to the brain during the procedure. These bubbles are a major cause of stroke and silent brain damage in patients undergoing …

This study tests whether a simple isometric wall squat exercise can lower blood pressure in adults with both hypertension and obstructive sleep apnea treated with CPAP. Each participant will complete one session of wall squats and one rest-only session, with blood pressure monito…

After a cardiac arrest, some patients develop seizures that do not respond to standard treatment. This trial tests whether putting the brain into a deeper state of electrical silence — called burst suppression — can stop those seizures better than the usual approach of only suppr…

This trial compares two single antiplatelet therapies—ticagrelor versus aspirin—in people who have just undergone transcatheter aortic valve implantation (TAVI) for severe aortic stenosis. The goal is to see which drug better prevents serious complications like stroke, heart atta…

This trial tests whether a device called remote ischemic conditioning can safely help lower blood pressure in people with essential hypertension. The treatment involves inflating a blood pressure cuff on the upper arm to briefly stop blood flow, then releasing it, in repeated cyc…

This pilot trial tests whether a substance made from stem cells — called mesenchymal stem cell secretome — can improve cognitive recovery in people who have had an ischemic stroke. Participants aged 40 to 75 with mild-to-moderate cognitive impairment will receive either standard …

This trial tests whether a diet adapted to Puerto Rican culture can lower the risk of heart disease, type 2 diabetes, and obesity. Researchers will compare culturally tailored nutrition advice—emphasizing traditional healthy foods and limiting unhealthy ones—with standard healthy…

This phase III trial tests whether vicagrel, an experimental antiplatelet drug, can prevent major heart-related events better than the standard drug clopidogrel in people with acute coronary syndrome (such as a heart attack or unstable angina) who are undergoing a stent procedure…

This trial tests whether a 12-week supervised treadmill exercise program can improve blood flow and walking distance in people with peripheral artery disease (PAD). It also explores whether adding nitrate-rich beetroot juice helps those who don't respond to exercise alone. Two hu…

This trial tests whether a new high-power short-duration radiofrequency ablation technique (90 watts for 4 seconds) is safer and more effective than the standard low-power approach (35 watts for 10-15 seconds) for treating atrial fibrillation. The study includes adults with parox…

This trial tests whether adding rhythmic auditory stimulation (like a metronome) to task-oriented training improves lower limb function, balance, and motivation in people recovering from a stroke. Participants, aged 40 to 60 with a first-time stroke within the past six months, wi…

This trial tests whether using a handgrip device for isometric exercise can lower blood pressure in people with elevated blood pressure or hypertension who are not on medication. Half the participants will use the Zona Plus handgrip device, while the other half will listen to rel…

This trial tests whether a digital health tool that uses artificial intelligence can help people with high blood pressure lower their numbers. The AI analyzes daily habits and blood pressure readings to give each person personalized lifestyle suggestions. Researchers will compare…

This trial tests whether practicing walking while doing a second task — like talking or carrying something — improves balance and reduces fall risk more than simply repeating walking exercises. The study enrolls adults aged 40 to 70 who had a stroke 6 months to 1 year ago and sti…

This trial investigates whether adding deep, slow breathing exercises and a gentle neck-release technique to standard physical therapy can improve heart rate control, movement, thinking, and mood in people who have had a stroke. The study includes 54 adults who had a first stroke…

This trial tests whether a structured physiotherapy program started at least two days before coronary artery bypass grafting (CABG) and continued after surgery can improve recovery in high-risk patients. Participants are adults scheduled for elective CABG who meet at least three …

This large trial compares robot-assisted rehabilitation to traditional one-on-one physiotherapy for people who have had a stroke. Researchers are measuring how well each approach helps patients regain independence in daily activities, as well as costs and patient satisfaction. Th…

This study compares two types of telerehabilitation for stroke survivors: a motor relearning program that focuses on retraining specific tasks versus conventional physical therapy delivered remotely. Researchers will measure changes in motor function and balance in adults aged 40…

This trial compares two minimally invasive procedures for treating incompetent perforating veins—veins that fail to close properly and can cause leg swelling, skin changes, or ulcers. One method uses a needle to deliver an electric current to seal the vein, while the other inject…

This trial compares two rehabilitation approaches — task-oriented training and hand-arm bimanual intensive therapy — in stroke survivors with mild to moderate arm weakness. The goal is to see which method better improves gross and fine motor skills and the ability to perform dail…

This trial tests a new device, the Laplace Transcatheter Tricuspid Valve Replacement (TTVR) System, designed to replace the tricuspid valve in people with severe, symptomatic tricuspid regurgitation. The procedure is done through a catheter, avoiding open-heart surgery. The study…

This pilot trial tests whether using placental tissue analysis from a prior complicated pregnancy can guide treatment with the blood thinner enoxaparin to reduce the risk of recurrent adverse outcomes. The study enrolls women who had a previous pregnancy affected by early deliver…

This study tests a metaverse-based surgical platform that uses extended reality (XR) to help surgeons precisely locate blood vessels during brain bypass surgery. The trial includes 30 adults with moyamoya disease or chronic cerebral ischemia who need an extracranial-intracranial …

This phase 2 trial tests whether pioglitazone, a drug used for diabetes, can improve how cells use oxygen in people with pulmonary hypertension caused by chronic lung disease. Participants take pioglitazone or a placebo daily for 28 days, then switch after a 2-week break. The stu…

This trial tests whether a structured arm therapy program delivered through video calls can improve upper limb function in people who had a stroke at least six months ago, compared with the same therapy given in a clinic. Sixty-eight participants will receive modified Constraint-…

This phase 3 trial tests whether incobotulinumtoxinA (Xeomin), a botulinum toxin that does not require refrigeration, works as well as onabotulinumtoxinA (Botox) for preventing chronic migraine. Adults with 15 or more headache days per month will receive injections of either drug…

This trial tests whether adding electrical muscle stimulation to a standard motor relearning program improves arm function more than the program alone in people recovering from a subacute stroke. Thirty-six participants will receive either the combined therapy or the program only…

This study tests whether a filter device called the Sentinel Cerebral Protection System can prevent stroke and brain injury during ablation for atrial fibrillation (an irregular heartbeat). The device is placed in the arteries to catch debris that might break loose during the pro…

This trial tests whether a hip-assisted wearable robot can help stroke survivors improve their walking through at-home training sessions. Eight adults who have had a stroke and walk with a spastic hemiplegic gait will use the robot during four 30-minute sessions over two weeks, g…

This study tests whether a structured nutrition counselling program can improve diet, blood sugar, blood pressure, and quality of life in adults who have both type 2 diabetes and hypertension. About 308 participants from 14 hospitals in Ethiopia will either receive six individual…

This study tests whether taking atorvastatin (a widely used cholesterol-lowering drug) every day for 12 weeks can reduce the number of migraine days in people with chronic migraine. About 300 adults aged 18–64 with chronic migraine will receive either atorvastatin or a placebo pi…

This study tests whether combining aerobic exercise with strength training helps people recover better after coronary artery bypass graft (CABG) surgery. Participants, aged 30 to 60 and cleared for phase II cardiac rehab, are randomly assigned to aerobic exercise alone or aerobic…

This trial tests whether gentle massage and palm-to-fist tapping near an IV insertion site can reduce the risk of phlebitis, a painful inflammation of the vein. Hospitalized adults with a peripheral IV in their arm are randomly assigned to receive standard care or add these simpl…

This study tests whether a robot can help people who had a stroke 1 to 12 months ago improve movement and feeling in their arm and hand. Participants first receive gentle, robot-guided stretching, then practice active movements with the robot, which can assist or resist as needed…

This study tests a new version of the clot-dissolving drug tenecteplase, coated with platelet membranes, to see if it targets blood clots more effectively. Researchers will apply the coated drug to blood clots made from samples taken from people with coronary artery disease and h…

This trial tests whether an experienced doctor's eye, guided by standard X-ray images, can place a heart stent as well as using a special ultrasound probe inside the artery. The study focuses on the left main coronary artery, a critical vessel. All patients receive the same type …

This trial tests whether apixaban, a newer blood thinner with fixed dosing, works as well as warfarin for dissolving dangerous blood clots in the heart's main pumping chamber. Adults with a confirmed left ventricular thrombus are randomly assigned to receive either apixaban or wa…

This phase 3 trial tests a single injection of SMO1, a dexamethasone implant placed inside the eye, for people with macular edema (swelling) caused by a blocked retinal vein. The study compares SMO1 to an existing dexamethasone implant to see which better improves vision and redu…

This trial tests whether a 'care champion' — a person who calls patients after they leave the hospital following a heart attack or stent procedure — can help them get their LDL cholesterol to a healthy level. Participants also receive education for their doctors. The study compar…

This trial compares two endovascular procedures for treating unruptured wide-neck brain aneurysms: a flow diverter device (Pipeline) versus traditional stent-assisted coiling. About 266 adults aged 18–75 with these aneurysms will be randomly assigned to one treatment and followed…

This trial tests whether colchicine, an anti-inflammatory drug used for gout, can reduce inflammation in the coronary arteries of people with HIV who have high cardiovascular risk. Participants take either colchicine or a placebo daily for 96 weeks, and changes in artery inflamma…

This trial compares two strategies to prevent another stroke in people with severe narrowing of a major brain artery. One group receives a drug-eluting stent (a mesh tube that releases medication to keep the artery open) along with aggressive blood-thinning medication. The other …

This study tests whether an AI-powered digital health platform can help people manage their blood pressure better than support from a human case manager. Adults aged 18 to 75 with high blood pressure use the platform to get reminders, health education, and alerts for abnormal rea…

This study tests whether a bedside monitoring device, placed on the head right after a mechanical thrombectomy for acute ischemic stroke, can predict which patients will have poor neurological outcomes. The device uses near-infrared spectroscopy to measure brain oxygen levels and…

This study tests a new radioactive tracer called 18F-FAPI-74 that may help detect scar tissue (fibrosis) in the heart and lungs earlier than current methods. Researchers will compare this new PET/CT scan to standard imaging in 210 adults with conditions like lung disease or heart…

This study tests whether a special ultrasound technique (SHAPE) can detect high blood pressure in the liver without using a needle. Portal hypertension is a serious condition that can lead to severe liver damage and death. The standard test requires inserting a catheter into a ve…

This study is testing new, lower-radiation CT scan methods for taking pictures of the heart and blood vessels. Researchers want to see if these scans are accurate at finding blocked arteries and predicting future heart problems like heart attacks. About 5,000 adults who need a he…

This study will test a portable, low-field MRI machine to see how well it detects brain injuries from lack of oxygen or blood flow in children. About 200 kids in intensive care will get both a portable and a standard MRI. The goal is to find out if the portable version is accurat…

This study is testing whether a new type of CT scan, called photon-counting CT, can do it all in one go for people who have had a coronary stent placed. The scan aims to check the stent and arteries, measure blood flow to the heart muscle, and assess heart function in a single ex…

This study compares two types of CT scans for imaging the buildup of plaque in the carotid arteries, which supply blood to the brain. The newer photon-counting detector CT (PCD-CTA) will be compared with the standard energy-integrating detector CT (EID-CTA) in 100 people with car…

This Phase 3 trial tests whether a new contrast agent called gadopiclenol works as well as the standard agent (Dotarem) for MRI scans to find blocked arteries in the neck, legs, or abdomen. About 315 adults with suspected vascular disease will receive both agents in random order …

This study is testing a chest-patch that uses light to measure blood pressure without a traditional arm cuff. Researchers will compare its readings over 24 hours to the standard cuff-based method in 600 adults with or without high blood pressure. The goal is to see if the patch i…

This study will check how common peripheral artery disease (PAD) is in people who need surgery for lumbar spinal stenosis (LSS). Both conditions can cause leg pain, making PAD hard to spot. Researchers will use a special CT scan to find PAD and compare it with simpler tests like …

This study explores whether performing a cardiac MRI (CMR) before the standard invasive coronary angiography (ICA) can accurately diagnose the cause of a suspected non-ST-elevation heart attack (NSTEMI). Currently, patients with NSTEMI often undergo an invasive angiogram, and if …

This study looks at 200 adults who have had an ischemic stroke or transient ischemic attack (TIA). Each participant will receive two types of imaging: a non-contrast magnetic resonance angiography (NC-MRA) and a carotid Doppler ultrasound. The goal is to see how well these two me…

This trial evaluates an artificial intelligence system designed to automatically detect signs of diabetic retinopathy in retinal photographs. Researchers will compare the AI's performance against experienced ophthalmologists using a large set of eye images from adults with the co…

This study tests whether a portable, low-field MRI machine can detect brain injuries in children who are on ECMO (a heart-lung bypass machine). The MRI is brought to the bedside, avoiding the need to move critically ill children. Researchers will scan children at several time poi…

This study explored whether a special type of MRI using inhaled xenon gas could detect changes in the small blood vessels of the lungs in people with pulmonary hypertension. The goal was to see if this imaging method could track disease progression or response to treatment. Howev…

This observational study is testing whether a combination of non-invasive measurements—including blood pressure monitoring, ultrasound, blood and urine tests, and a light-based technique called photoplethysmography—can detect early damage to blood vessels and organs in adults at …

This study is testing whether a noninvasive imaging technique called pulsatile electrical impedance tomography (EIT) can accurately diagnose acute pulmonary embolism — a life-threatening blood clot in the lungs. Researchers will compare EIT readings with standard CT scans in 275 …

This study tests whether an artificial intelligence (AI) tool that analyzes a simple ECG can help doctors find undiagnosed pulmonary hypertension (high blood pressure in the lungs) in people with interstitial lung disease. About 900 adults with severe lung scarring will be random…

This study is testing a new, noninvasive imaging device called HH-SECTR to see inside the eyes of premature infants with retinopathy of prematurity (ROP), a condition that can affect vision. The goal is to see if this technology can provide clearer, more detailed images of the re…

This trial tests a new portable brain scanner designed to quickly detect bleeding in the brain (hemorrhagic stroke) using harmless radio waves. The helmet-like device could offer a faster, more accessible alternative to CT or MRI scans in emergency settings. Researchers will enro…

This study tests whether a lab technique called polyethylene glycol (PEG) precipitation can tell the difference between a true heart attack and a harmless condition called macrotroponin, where troponin molecules clump together and falsely signal heart damage. Researchers will com…

This trial tests whether an artificial intelligence system called VeriSee can help doctors diagnose age-related macular degeneration and diabetic retinopathy from standard eye photos. The AI analyzes the images and provides instant results for the ophthalmologist to consider. Res…

This study aims to create a non-invasive diagnostic algorithm using PET imaging and CT scans to identify microvascular angina in patients who have chest pain and signs of ischemia but no blocked coronary arteries. About 70 participants with symptoms of angina or shortness of brea…

This study investigates whether a blood test measuring clotting and clot-busting markers can predict complications in patients undergoing aortic valve replacement. Researchers will follow 750 adults with aortic stenosis who receive either surgical or catheter-based valve replacem…

This study tests whether taking progesterone early in pregnancy can prevent preeclampsia, a condition that causes high blood pressure and organ damage. Over 600 low-risk pregnant women will either receive nightly vaginal progesterone or standard care. Researchers will track who d…

This Phase 2 study tests whether a daily pill called EVO756 can prevent migraines in adults who have not had success with other preventive treatments. About 330 participants will receive either EVO756 or a placebo, and researchers will track how many migraine days they have each …

This study tests whether adding a daily pill (amitriptyline) to online cognitive behavioral therapy (CBT) helps prevent migraines in children better than online therapy alone. About 400 kids with frequent migraines will be followed for months to see if headache days drop by half …

This study looks at whether patients and doctors in a family planning clinic find it acceptable to discuss and start PrEP, a daily pill that prevents HIV. About 83 English- or Spanish-speaking patients aged 16 and older, along with their doctors, will take part. Patients will rec…

This trial tests whether a single polypill combining three medications—finerenone, empagliflozin, and losartan—can help prevent heart failure and maintain exercise capacity in people with type 2 diabetes who are at high risk. Participants will take either the polypill or the same…

This study looks at whether a diet rich in whole white potatoes can improve blood sugar control and blood pressure in adults aged 50-70 who are at risk for type 2 diabetes. Participants will eat either a potato-rich healthy diet or a typical Western diet for 12 weeks. Researchers…

This trial tests whether taking a low-dose aspirin pill every day for six weeks after delivery can prevent dangerous blood clots in the legs or lungs as effectively as the standard daily heparin injections. The study enrolls people who have given birth and have one or more risk f…

This trial compares two blood-thinning drugs—aspirin and cilostazol—to see which one better prevents major heart and blood vessel events in people with type 2 diabetes who are already at high risk. About 1,200 participants will be randomly assigned to take one of the two medicati…

This trial tests whether starting intensive blood pressure medication soon after childbirth can prevent chronic hypertension in women who had preeclampsia. Participants are randomly assigned to receive nifedipine ER when their blood pressure reaches different thresholds during th…

This trial looks at whether pregnant women at high risk for preeclampsia can safely stop taking daily aspirin at 24-28 weeks instead of continuing until 36 weeks. Around 300 women will be randomly assigned to either stop or continue aspirin. The goal is to see if stopping early l…

This study tests whether using shockwave therapy on the leg artery before a TAVR heart valve procedure can reduce bleeding and other complications. It involves 100 adults with severe aortic stenosis and heavily calcified arteries. The goal is to make the procedure safer by prepar…

This study tests whether daily leg heat therapy can improve walking ability and quality of life in people with peripheral artery disease (PAD). About 106 adults over 50 with PAD will use special heated trousers for 90 minutes a day at home for 12 weeks. Researchers will measure c…

This study tests whether Acceptance and Commitment Therapy (ACT), delivered through a smartphone app, can help caregivers of children with RASopathies (like Neurofibromatosis type 1 and Noonan syndrome) cope with parenting stress. The trial is fully remote and involves 70 adult c…

This study explores whether hypnosis can help people with stroke, traumatic brain injury, or multiple sclerosis improve their attention and reduce fatigue. About 48 participants will receive hypnosis sessions alongside standard care, while researchers monitor brain activity with …

This study tests the long-term safety of rimegepant, a migraine medication taken as a dissolving tablet, in children and adolescents aged 6 to 18. About 600 participants with a history of migraine will take the drug as needed for up to one year. The main goal is to check for side…

This study tests whether a smarter electrical stimulation device can help people recover arm and hand movement after a stroke. Participants with moderate arm weakness will be randomly assigned to receive either standard cyclic stimulation or a new EMG-triggered stimulation that r…

This study tests whether rimegepant, a fast-dissolving tablet, can safely relieve migraine pain in children and adolescents aged 6 to 18. About 2,100 participants will receive either the drug or a placebo during a migraine attack. The main goal is to see if more kids become pain-…

This trial tests whether a 24-week personalized program called MICROFIT—combining high-intensity interval training with a personal trainer and Mediterranean-style dietary advice—is feasible for people with microvascular coronary dysfunction, a condition where small heart blood ve…

This trial investigates whether an experimental, unapproved medical device can help relieve symptoms in people with a specific condition. Researchers are enrolling participants to test the device's effects and safety. The goal is to see if this new approach could offer a drug-fre…

This study tests whether extra support—like personalized mask fitting, monthly phone calls, and a tracking app—helps stroke patients with sleep apnea use their CPAP machine more consistently during rehab. About 250 participants will be randomly assigned to either this intensive s…

This study tests two advanced rehabilitation methods—robot-assisted walking training and visual feedback balance training—to see which better improves balance and walking in people who have had a stroke. About 60 adults with subacute or chronic stroke will participate in 4 weeks …

This study explores whether listening to music on purpose, for one hour a day, can improve mental health in people who had a stroke at least six months ago. Sixty participants will be randomly assigned to listen to either music or an audiobook at home for four weeks. Researchers …

This trial tests a device called the Pedal Pump, which moves the feet for 10 minutes to help reduce lower leg swelling (edema) in hospitalized patients. The study includes 60 adults with edema due to conditions like heart failure, kidney disease, or chronic venous insufficiency. …

This trial tests whether Occupational Performance Coaching (OPC) can help adults who have had a stroke and finished rehabilitation get back to activities they value. Participants are randomly assigned to receive OPC or an attention control, both delivered virtually. The study mea…

This phase 3 study evaluates the long-term safety of elismetrep (K-304), an oral medication taken as needed for migraine attacks. About 1,000 adults who previously took elismetrep in an earlier trial will continue using it intermittently. Researchers will track side effects over …

This study tests whether adding a mild brain stimulation technique (tDCS) to a standard arm therapy (constraint-induced therapy) helps people who had a stroke more than therapy alone. Forty adults with chronic stroke and mild-to-moderate arm weakness will be randomly assigned to …

This study tests whether a digital program called Sleepio, which uses cognitive behavioral therapy for insomnia, can improve sleep in stroke survivors. Researchers will also see if better sleep helps with learning motor skills overnight. About 100 adults who have had a stroke and…

This study tests whether a gentle electrical current applied to the scalp (tDCS) combined with computer-based cognitive training can improve memory, attention, and thinking in people who had a mild stroke. About 60 participants will receive either real tDCS or a sham (fake) versi…

This study tests whether virtual reality (VR) training in a simulated home environment can improve arm and hand function in people recovering from a stroke. Researchers will compare VR-based task-oriented training to standard therapy in 86 participants. They will also use brain s…

This study will compare three surgical treatments for severe internal hemorrhoids: laser, energy therapy, and traditional surgery. About 60 adults with grade III hemorrhoids will choose their preferred treatment. The goal is to see which method provides less pain after surgery an…

This study tests a device called the PRIMUS System that uses mild electrical pulses to stimulate nerves in the head and neck. It is for people with chronic or frequent migraine who have not gotten relief from at least three preventive medicines. The goal is to see if the device s…

This study tests a once-daily pill called orforglipron in about 1205 people with peripheral artery disease (PAD) who have leg pain when walking. The goal is to see if the drug helps them walk farther without pain and improves their quality of life. Participants will be followed f…

This study compares two methods of releasing a tourniquet (a tight band that stops blood flow) during arm surgery in patients with high blood pressure. The goal is to see which method causes less of a sudden drop in blood pressure. The trial will include 68 adults whose blood pre…

This study tests a new drug, elismetrep, to see if it can quickly stop migraine pain and bothersome symptoms like nausea or light sensitivity. About 1800 adults with frequent migraines will receive either the drug or a placebo. The main goal is to measure how many people are pain…

This trial tests whether a new method of clearing mucus from the airways—using intermittent suction through a breathing tube—works better than the standard continuous suction method in comatose patients who have had a stroke. About 600 participants will be randomly assigned to on…

This study tests whether adding action observation (watching movements) and motor imagery (imagining movements) to standard physical therapy can improve balance, daily function, and quality of life in people who had a stroke within the last year. About 56 participants will be ass…

This study compares two types of nerve blocks (ESPB and SPSIPB) to see which provides better pain relief after coronary artery bypass surgery. About 64 adults aged 45-85 will receive one of the blocks before surgery, and their pain levels, opioid use, and recovery speed will be t…

This study tests whether a home-based telerehabilitation program, using games, exercises, and video calls with therapists, can improve arm function and reduce disability in people who had a stroke 90-150 days ago. 202 participants will be randomly assigned to receive telerehabili…

This study is testing a mobile app called MAYA that provides cognitive behavioral therapy (CBT) to help adults who have had a stroke manage anxiety and depression. About 10 participants aged 40-79 will use the app and provide feedback on how easy and helpful it is. The goal is to…

This trial tests whether a non-invasive electrical stimulation applied to specific acupoints on the fingers can improve memory, attention, and decision-making in people who have had a stroke. Adults aged 35 to 80 with mild to moderate cognitive impairment after an ischemic stroke…

This phase 2 trial tests whether an oral drug called BMS-986368 can reduce spasticity—muscle tightness and spasms—in adults who had a stroke 4 to 18 months ago. The drug works by boosting natural compounds in the body that calm overactive nerves. Researchers will measure changes …

This pilot study tests whether taking melatonin at night can increase REM sleep and improve cognitive function in people with cirrhosis who have a complication called hepatic encephalopathy (HE). Participants take melatonin for one month and a control supplement (thiamine) for an…

This trial tests a partially self-supervised version of constraint-induced movement therapy (sCIMT) for adults with arm and hand weakness after a stroke. Over two weeks, participants complete up to 30 hours of therapy, with about one-third guided by a therapist and two-thirds don…

This trial tests whether six months of group singing can improve mood, quality of life, and language recovery in stroke survivors with aphasia, while also supporting their personal caregivers. Half of the participants will attend weekly singing sessions; the other half will recei…

This pilot trial tests whether a six-week behavioral program focused on morning activation can improve mood and daily functioning in adults who have had a stroke and struggle with depressive symptoms. Participants are randomly assigned to either the morning activation program or …

This study tests whether giving caregivers of palliative care patients a single training session on using a PEG feeding tube before the patient leaves the hospital can lower the caregivers' burden, stress, and improve their quality of life. Researchers will compare trained caregi…

This study is collecting long-term safety and effectiveness data on treatments for various blood disorders, including hemophilia, sickle cell disease, and clotting disorders. It aims to enroll 3000 people of any age with these conditions. Researchers will monitor side effects, co…

This large observational study in Mali is following up to 15,000 pregnant women and children to understand why some get malaria and others don't. Researchers are looking at immune responses, parasite features, and other factors that influence infection and disease severity. The g…

This study is testing a new type of MRI scanner that uses less energy than standard machines. The goal is to see if it can still take clear pictures of the heart, which could help people with metal devices in their body. Healthy volunteers and people with heart disease will have …

This study collects tissue and blood samples from adults with HIV, other immune disorders, or cancers thought to be caused by viruses. Researchers will compare genes in cancer tissue to normal tissue to find genetic changes that drive these cancers. The goal is to better understa…

This study is for adults 18 and older who have had a stroke or a transient ischemic attack (TIA), often called a mini-stroke. The goal is to collect information from standard medical tests and some extra research tests, like blood draws and brain scans, to better understand how t…

This study is collecting medical data and biological samples from people with genetic conditions affecting the heart and blood vessels, their relatives, and healthy volunteers. The goal is to better understand these diseases, improve diagnosis, and lay the groundwork for future t…

This study looks at how social and lifestyle factors—like education, race, and income—affect a person's thinking and memory after a stroke. Researchers will interview 450 adults who had a stroke and review their brain scans and medical records. The goal is to understand why some …

This study follows up to 4,000 people with vasculitis (a group of diseases that cause blood vessel inflammation) and healthy volunteers over many years. Researchers collect blood, urine, imaging, and genetic samples to learn how the disease develops and changes. The goal is to fi…

This study aims to learn more about heart and blood vessel diseases by observing people who have them or are at risk. Researchers will collect samples and perform tests like imaging and stress tests on up to 5,000 participants, including healthy volunteers and relatives of affect…

This natural history study follows 270 adults with pulmonary arterial hypertension (PAH) and healthy volunteers to track how the disease changes over time. Researchers will use blood tests, heart and lung imaging, and a six-minute walk test to find new markers of disease severity…

This study looks at how certain white blood cells, called monocytes, react to injury from a heart attack or ischemic stroke. Researchers want to learn how these cells sense danger signals and produce substances that might help heart muscle and brain tissue heal. The study involve…

This study follows up to 3,500 people with sickle cell disease to learn more about how the condition progresses and what complications arise. Participants receive their usual medical care outside the hospital and visit the clinic for check-ups and research tests. No experimental …

This study looks at how obesity and body fat affect heart disease risk in 2,000 healthy African American men and women. Researchers will measure body fat, blood fats, and insulin function to see if risk factors differ by sex. The goal is to understand why heart disease rates are …

This study aims to uncover genetic changes that cause autoimmune diseases in people native to Peru. Researchers will collect blood, urine, and stool samples from 300 participants, including patients with conditions like lupus and rheumatoid arthritis, their family members, and he…

This study is testing a smart device called CONNECTDROP® that clips onto eye drop bottles to track how often glaucoma patients use their medication. About 200 adults with open-angle glaucoma will use the device and a smartphone app for one year. The goal is to see if the technolo…

This study investigates why arteries stiffen and harden faster in children and young people with chronic kidney disease (CKD) and high blood pressure. Researchers will use non-invasive tests to compare arterial stiffness between those with CKD and matched controls, including heal…

This study looks at whether two proteins released when heart muscle is damaged can be detected in the blood during a heart attack. Researchers want to see if higher levels of these proteins are linked to a greater chance of developing heart failure afterward. The study includes a…

This study explores whether a simple, radiation-free scan of the nailbeds—called nailfold capillaroscopy—can help diagnose and monitor pulmonary hypertension (PH), a condition of high blood pressure in the lungs. Researchers will compare nailbed blood vessel measurements with inv…

This study aims to develop a standardized questionnaire that lets patients with venous malformations report their own symptoms and treatment outcomes. Venous malformations are abnormal veins that can cause pain, swelling, and emotional distress, and current assessments may miss w…

This study looks at whether liver function and blood clotting tests can help doctors better understand and monitor cardiac transthyretin amyloidosis (ATTR-CA), a condition where abnormal protein builds up in the heart. Researchers will compare these tests in people with ATTR-CA a…

This study tests whether simple reminders—called nudges—sent to doctors and patients can increase the use of genetic testing for people with certain conditions like Parkinson's disease, ALS, or heart problems. The trial will compare different ways of prompting genetic testing, su…

This study looks at how physical activity, sleep, and light exposure relate to mood in people with bipolar disorder, major depression, or no mood disorder. Over two years, participants wear activity monitors and complete smartphone diaries for up to 20 days at a time. The goal is…

This study investigates whether sarcopenia—age-related muscle loss—is common in older adults during the acute phase of ischemic stroke and whether it influences recovery. Researchers will assess muscle mass and function in 400 patients aged 50 and older within 72 hours of stroke …

This study looks at how shoulder pain on the paralyzed side after a stroke affects arm movement, trunk control, fear of falling, mobility, and independence. Researchers will assess 62 stroke survivors using standard tests and ultrasound. The goal is to better understand the relat…

This study looks at how partial sleep deprivation affects blood pressure in healthy young adults whose parents have high blood pressure compared to those whose parents have normal blood pressure. Participants will spend 10 days in a sleep lab, with some nights allowing only 5 hou…

This study aims to learn more about RASopathies, a group of genetic conditions that can cause developmental issues, birth defects, and increased cancer risk. Researchers will follow up to 500 people of any age who have or may have a RASopathy, along with their family members, for…

This study is checking if a computer model can accurately predict why some people have a prolonged blood clotting time (APTT). The model uses data from routine blood tests to tell if the cause is harmless or a sign of a clotting disorder. Researchers will test it on 1,500 patient…

This study looks back at the medical records of 1,000 people with coronary artery aneurysms—bulges in the heart's blood vessels. Researchers want to understand how these aneurysms change over time, what factors increase the risk of progression, and whether different treatment str…

This study tracks 500 adults with stable coronary artery disease or unstable angina who are undergoing a heart procedure called percutaneous coronary intervention (PCI) using a drug-coated balloon. Researchers are looking at how procedural details—specifically how long the balloo…

This study tests whether a new type of CT scan, called ultra-high-resolution photon-counting CT angiography, can accurately check whether stents placed in the brain's venous sinuses are still open. It compares this new scan to the standard CT method and to the more invasive DSA p…

This study collects blood and urine samples from healthy adults and patients with heart, lung, or blood vessel conditions. Researchers will use these samples to study genes, proteins, and other substances in the lab. The goal is to support basic and translational research that co…

This study investigates how a recent stroke affects the ability to learn new motor skills that require using both arms or hands together. Researchers will use robotic devices to measure learning and brain imaging to see which brain areas are involved. The goal is to understand wh…

This study will enroll 5,000 adults with chronic heart conditions like heart failure, high blood pressure, or aortic stenosis. Participants will wear a Prolaio digital health patch that monitors heart rate, breathing, and other vital signs. The goal is to observe how these condit…

This study tests whether a wearable Holter monitor can detect early signs of fainting in people with orthostatic hypotension or reflex syncope. Forty adults who have already had a tilt-table test will wear the monitor for up to 21 days. The goal is to see if the device can pick u…

This study tests whether a clinical decision support (CDS) system can help doctors follow best-practice guidelines for preventing venous thromboembolism (blood clots) in adults with traumatic brain injury. Researchers will compare hospitals that use the CDS system with those that…

This study looks at whether a special CT scan (CT-FFR) can help doctors predict heart attacks and other serious events in people with chronic coronary syndrome. About 3,000 participants in China will be followed for up to 5 years. The goal is to see if abnormal CT-FFR results are…

This study investigates whether people who recently had a stroke (within 21 days) can learn new arm movements using a rehabilitation robot called REAplan. Researchers will compare their learning ability with healthy individuals and those who had a stroke long ago. The goal is to …

This study is creating a decision aid for people with a rare heart condition called right anomalous aortic origin of a coronary artery (R-AAOCA). The condition raises the risk of sudden cardiac death, but the best management—surgery or careful observation—isn't clear. The aid wil…

This registry will follow 1000 adults with pulmonary embolism (blood clots in the lungs) who are treated with Inari Medical devices. Researchers will track device-related complications and deaths to understand how safe these tools are in everyday use. The study is observational, …

This study looks at how much of the migraine drug galcanezumab (Emgality) appears in breastmilk after a mother receives her usual injections. Researchers will measure drug levels in milk samples from 30 women with migraine who are breastfeeding, and also track infant growth, deve…

This study checks whether a free smartphone app called PhysioMaster can reliably measure posture and range of motion in people who have had a stroke. Researchers will compare the app's measurements to those from standard tools like the universal goniometer. Sixty stroke survivors…

This study is an early-stage trial to check the safety of a new drug called RO7763505. It involves 196 participants, first in healthy volunteers and then in people with stable coronary artery disease. The main goal is to see if the drug is safe and how the body processes it, not …

This study surveys doctors who use the Liberant system to remove fresh blood clots from leg arteries and veins. About 50 patients aged 22 or older will be treated within 72 hours of their procedure. The goal is to confirm the device is safe and works as intended.

This study looks at whether a simple, non-invasive measure called the perfusion index (PI) can predict a sudden drop in blood pressure (hypotension) that often happens during spinal anesthesia for knee surgery. The PI, measured with a standard pulse oximeter on the finger, reflec…

This study explores whether a measure called perfusion index (PI), taken from a pulse oximeter on the ear, finger, or toe, can reliably predict changes in blood pressure in people with spinal cord injury (SCI) during a cool temperature challenge. Participants with SCI and healthy…

This study tests whether it is possible to run a larger trial comparing two ways of using a breathing machine (ventilator) in critically ill heart patients who need help breathing. The two modes are volume-controlled (delivers a set amount of air each breath) and pressure-control…

This study aims to learn more about rare disorders that affect how the body processes chemicals called pyrimidines and purines. These disorders can cause problems in the brain, blood, kidneys, and immune system, ranging from mild to life-threatening. Researchers will compare test…

This study looks at whether giving antibiotics for just 24 hours around the time of placing a special antibiotic-coated brain drain works as well as giving them for the whole time the drain is in place. The goal is to find the best way to prevent serious brain infections in peopl…

This study is building a large online registry of US adults who experience sinus, ear, dizziness, and headache symptoms, with or without a migraine diagnosis. Participants answer questions about their symptoms, how these affect daily life, and which treatments they have tried. Th…

This study looks at whether advanced imaging can detect a hidden heart condition called cardiac amyloidosis in people with severe aortic valve stenosis. The condition can complicate treatment and recovery. Researchers will use echocardiography, CT, and SPECT/CT scans to check for…

This study collects blood, bone marrow, and tissue samples from people with HIV, KSHV, or certain cancers to help researchers learn more about these diseases. Participants must be 18 or older and may have HIV, KSHV, or related conditions. No treatment is given; the goal is to gat…

This study is testing whether a special MRI technique, called 4D Flow MRI, can better detect and predict the growth of unruptured brain aneurysms. Researchers will follow adults with these aneurysms, using the advanced imaging to measure changes in the aneurysm's shape over time.…

This study looks at how blood pressure changes when standing affect thinking and brain blood flow in people with Parkinson's disease. About 60 participants, with and without orthostatic hypotension (low blood pressure on standing), will take thinking tests while lying down and st…

This study looks at how the body's innate immune system responds to certain environmental exposures by measuring inflammation markers in blood. Researchers will collect blood samples from up to 725 healthy volunteers aged 18-45 to analyze how specific genes and proteins react. Th…

This study investigates whether high-resolution MRI can identify dangerous plaque features in the middle cerebral artery that might predict a second stroke. Researchers will follow 75 patients who had a first stroke due to significant narrowing of this artery, tracking which plaq…

This study aims to learn more about how diseases related to blood clots, the immune system, and blood vessels start and change over time. Researchers will enroll up to 1,000 people aged 5 and older, including those with these conditions, their healthy relatives, and healthy volun…

This study looks back at medical records of 105 people who had a minimally invasive surgery called BEVAR to treat complex aortic aneurysms. Researchers want to see if two types of stent grafts (TUVA BX and iCover) are safe and work well. No new treatments are given; the study jus…

This natural history study aims to collect data from 1,200 people with lymphatic anomalies—rare conditions affecting the body's lymph system—over many years. Researchers will track symptoms, perform genetic testing, and gather biospecimens to better understand why these condition…

This study follows adults who have had a stroke caused by a blockage in a medium-sized blood vessel in the brain. Researchers will track the treatments patients receive and their recovery over time. The goal is to learn which approaches work best in everyday practice, helping doc…

This study will compare two types of heart-lung machines used during coronary bypass surgery to see how they affect blood flow to the brain. Researchers will measure brain pressure using an eye ultrasound and brain oxygen levels with a forehead sensor in 70 patients. The goal is …

This study uses a special eye imaging technique called OCT angiography to look at tiny blood vessels in the retina of people with diabetic retinopathy. Researchers will measure vessel density and other vascular features, then check whether these relate to visual sharpness and blo…

This study aims to gather crucial information about stroke in Uganda, where the disease is on the rise. Researchers will look at how common stroke is, what factors increase the risk, and how it affects people's quality of life. The goal is to identify what rehabilitation support …

This study looks at whether stopping certain blood pressure medications (ACE inhibitors or ARBs) before colorectal cancer surgery can reduce the risk of heart injury. Researchers will monitor 156 adults for signs of heart damage after surgery. The goal is to find the safest way t…

This study is testing new magnetic resonance imaging (MRI) techniques to get clearer pictures of the heart and blood vessels without using radiation. Researchers will compare these new MRI methods to standard tests like angiography and CT scans. Up to 4,000 adults—including healt…

This study looks at how well a rapid blood test called TEG 6s measures clotting in healthy children. About 125 kids having planned surgery will give a small blood sample for the test. The goal is to find normal values for children and compare them to existing ranges. No treatment…

This study investigates whether certain progesterone receptors in the placenta are linked to preeclampsia, a serious pregnancy condition marked by high blood pressure. Researchers will compare placental tissue from women with preeclampsia to that from healthy pregnant women, meas…

This study aims to find the genetic causes of primary aldosteronism, a condition where adrenal tumors cause high blood pressure, in Black individuals. Researchers will enroll 1150 participants, including those with difficult-to-control blood pressure or known primary aldosteronis…

This study aims to better understand and treat people with certain inherited metabolic or genetic disorders. Researchers will use standard medical tests like blood work and imaging to diagnose and care for participants, who may also join other related studies. The goal is to expa…

This study follows 155 adults with CADASIL, a genetic condition that narrows small blood vessels and raises the risk of strokes and dementia, over nine years. Researchers will use brain scans, blood tests, and other exams to track how the disease changes blood vessels and thinkin…

This study aims to develop better MRI methods for imaging the heart and brain, and to describe heart diseases using these new techniques. It will also investigate whether gadolinium, a common MRI contrast agent, stays in the body long after use. Up to 5,000 healthy volunteers and…

This observational study collects data from UK preterm babies with retinopathy of prematurity (ROP) who are treated with the drug aflibercept (Eylea) using a paediatric dosing device. The main goal is to count how many babies receive this treatment and decide if there are enough …

This study is collecting blood samples and health data from 15,000 symptom-free adults over 40 to understand what healthy aging looks like at the molecular level. By tracking participants over time, researchers hope to establish normal ranges for thousands of blood markers and id…

This study explores whether work-related frustration and stress are linked to higher-risk blood pressure patterns, such as masked or white-coat hypertension. Researchers will monitor the blood pressure of working adults aged 40 to 65 over 24 hours and compare it with their percei…

This study investigates whether physical exam findings called somatic dysfunction — impaired function of the body's framework — can be linked to energy expenditure, heart rate variability, and quality of life in people who have had a stroke. Researchers will assess 100 chronic st…

This study looks at how blood levels of common blood thinners (apixaban, dabigatran, edoxaban, and rivaroxaban) change over time in Chinese patients with atrial fibrillation. Researchers will take blood samples before and after stopping the medication for medical procedures. The …

This study creates a detailed registry of people with hereditary hemorrhagic telangiectasia (HHT), a condition that causes abnormal blood vessels and bleeding. Researchers will track participants over time to collect information on symptoms, treatments, and disease progression. T…

Women who had preeclampsia are at higher risk for both depression and heart disease later in life. This study investigates whether antidepressant medication can improve blood vessel function in these women. Researchers will measure skin blood vessel responses in 40 women, compari…

This study examines whether a structured cardiac rehabilitation program — including exercise, education, and lifestyle changes — can influence ferroptosis, a form of regulated cell death, in people with coronary artery disease. Researchers will compare gene expression and blood m…

This study investigates whether ultrasound measurements of thigh muscle thickness can help detect sarcopenia (muscle loss) and fear of movement in people who have had an ischemic stroke. Researchers will compare ultrasound results with standard tests like handgrip strength and a …

This study tests whether a wireless sensor placed on the forehead can accurately measure oxygen levels in the brains of infants in the neonatal intensive care unit (NICU). The wireless device is compared side-by-side with the standard wired monitor in 20 newborns with conditions …

This observational study uses a painless, non-invasive eye scan called iris OCTA to measure blood flow in the iris of people with type 2 diabetes. Researchers want to see if blood-flow patterns differ between healthy eyes, diabetic eyes without complications, and those with diabe…

This study tests whether measuring the optic nerve sheath diameter with ultrasound can predict post-dural puncture headache (PDPH) in women undergoing elective cesarean delivery under spinal anesthesia. Researchers will also monitor brain oxygen levels to see if drops in oxygen r…

This study investigates whether microscopic particles shed from blood vessels, called endothelial extracellular vesicles, can serve as early warning signs of blood vessel damage in children with newly diagnosed, untreated high blood pressure. Researchers will compare these partic…

This study investigates whether testicular cancer survivors who received cisplatin-based chemotherapy and bone marrow transplant have hidden heart disease that standard checkups might miss. Researchers will use advanced blood tests and CT scans to measure cholesterol, plaque in t…

This study looks at whether tiny particles shed from blood vessels, called endothelial extracellular vesicles, can serve as early warning signs for hypertensive disorders of pregnancy, such as preeclampsia. Researchers will compare levels of these particles in pregnant women with…

This study compares levels of tiny particles shed from blood vessels in people with newly diagnosed, untreated high blood pressure versus those with normal blood pressure. Researchers want to see if these particles can serve as early, non-invasive markers of blood-vessel injury. …

This study uses transvaginal ultrasound to examine the uterine scar in women who have had a single cesarean section. Researchers aim to identify factors linked to a condition called a 'niche'—a small pocket in the scar that can cause symptoms like pelvic pain or abnormal bleeding…

This study tests whether a machine learning model can predict the outcome of a common heart procedure — placing a stent to open a hardened, calcified artery. Researchers will measure blood flow and pressure before and after the procedure in 100 adults with coronary artery disease…

This study follows 5,000 people with mild cognitive impairment or mild-to-moderate dementia living at home in Bavaria, along with their family caregivers. Researchers collect detailed information on health, daily function, care needs, and quality of life over several years. The g…

This study tracks 400 people who had a procedure to close a patent foramen ovale (PFO), a small hole between the heart's upper chambers that can raise stroke risk. Researchers want to see how often strokes or mini-strokes return, whether a residual shunt persists, and what factor…

This study investigates whether gut bacteria and the chemicals they produce influence inflammation in people with autoinflammatory diseases such as FMF, CAPS, and MKD. Researchers will analyze stool and blood samples from 300 patients to measure gut-derived metabolites and assess…

This study is testing whether a non-invasive eye scan called optical coherence tomography (OCT) can help track neurological diseases like multiple sclerosis, Alzheimer's, Parkinson's, and migraine. Over two years, researchers will measure the thickness of retinal layers in 840 pa…

This study examines whether the duration a patient spends on cardiopulmonary bypass (heart-lung machine) and with the aorta clamped during coronary artery bypass surgery is linked to how long they stay in the intensive care unit afterward. Researchers will review medical records …

This study aims to create a better way to predict stroke risk in people with atrial fibrillation (an irregular heartbeat) who are already taking direct oral anticoagulants (DOACs), a type of blood thinner. Even with these medications, some patients still have strokes. Researchers…

This study is a large registry that collects data from thousands of patients across Asia who have undergone transcatheter aortic valve replacement (TAVR) for severe aortic stenosis. Researchers will analyze medical records to see how well the valves perform over time and what fac…

This study uses a special robot called IntelliArm to measure how arm stiffness, spasticity, and movement change during recovery from a first stroke. Researchers will track 56 people who had a stroke less than a month ago, measuring their arm function with standard tests and robot…

This study tracks how fast the 'halo sign' — a key ultrasound marker of inflamed arteries — disappears after starting steroid treatment in people with giant cell arteritis, a rare disease that can cause blindness. Researchers will scan the temporal arteries of 64 newly diagnosed …

This study creates a large registry of people diagnosed with hereditary hemorrhagic telangiectasia (HHT), a condition causing abnormal blood vessels and bleeding. Researchers will collect medical records and annual health updates for up to 10 years to understand how the disease c…

This study tests whether artificial intelligence can predict muscle loss (sarcopenia) in intensive care patients with serious brain conditions like stroke, bleeding, or tumors. Researchers will measure thigh muscle thickness with ultrasound and track nutrition markers over the fi…

This study looks at whether special MRI scans can help predict which people with severe narrowing of brain arteries (70-99% stenosis) are most likely to have another stroke. Participants have already had a minor stroke and are enrolled in a larger treatment trial. They will get a…

This study follows 100 stroke survivors over six months to understand how sitting balance, standing balance, and walking recover. Using wearable sensors and an interactive assessment game, researchers measure movement, coordination, and reaction time. The goal is to identify reco…

This study investigates how two types of assistive devices—exotendon and end-effector—affect finger extension and muscle coordination in 15 chronic stroke survivors and 15 healthy adults. Participants perform finger movements with and without assistance while muscle activity is r…

This study follows people with chronic thromboembolic disease (CTD) or chronic thromboembolic pulmonary hypertension (CTEPH) — conditions where blood clots scar the lungs' blood vessels. Researchers track survival, exercise ability, oxygen use, and quality of life over time using…