Vascular disorder

This trial tests whether transplanting neural stem cells directly into the brain can help people who have had a chronic ischemic stroke. The study involves adults aged 18-75 who had a stroke 6 to 60 months prior. Participants receive a single dose of stem cells, and the trial eva…

This trial tests whether high-dose vitamin D supplements can improve cognitive function in people who have had a stroke and developed thinking or memory problems. Participants will receive either vitamin D or a placebo for six months, and researchers will measure changes in cogni…

This study tests whether a structured exercise program done at home can improve walking ability and overall recovery in people who recently had a stroke. About 208 adults who had a stroke within the past two weeks will be assigned to either the home exercise program or usual care…

This study tests a device called the Surpass Evolve Flow Diverter, a small mesh tube placed inside an artery to redirect blood flow away from a brain aneurysm. The goal is to safely close the aneurysm and prevent it from rupturing. About 248 adults with unruptured, wide-neck aneu…

This study tests a new laser procedure called Direct Selective Laser Trabeculoplasty (DSLT) in 40 ethnic Chinese patients with glaucoma or high eye pressure. The laser aims to improve fluid drainage in the eye and reduce pressure. Researchers will check if the treatment is safe a…

This study tests a device that uses radiofrequency energy to calm overactive kidney nerves, which can drive high blood pressure. About 1,900 adults with uncontrolled hypertension will receive the procedure and be followed for years. The goal is to see if this approach safely and …

This pilot trial is testing whether a device called the Coronary Sinus Reducer can help people with angina (chest pain) who have no significant blockages in their coronary arteries. The device, shaped like an hourglass, is placed into a vein in the heart to improve blood flow. Th…

This study tests whether adding an interleukin-6 receptor inhibitor (a drug that reduces inflammation) to standard emergency stroke treatment helps people recover better after a severe stroke caused by a large blood clot in the front part of the brain. About 692 adults who are el…

This study tests an experimental drug called QCZ484, given as an injection under the skin every 6 months, for people with mild to moderate high blood pressure. About 385 adults aged 18 to 75 are taking part. The goal is to see if the drug safely lowers blood pressure compared to …

This trial investigates the best way to treat people who have a heart attack and also have other narrowed arteries. It compares doing an immediate procedure to open those other arteries, guided by a pressure wire, versus waiting and using a heart scan to decide later. The goal is…

This trial tests an automated system called ADIVA that delivers two medications to control blood pressure during spinal anesthesia for cesarean delivery. Low blood pressure is a common side effect of spinal anesthesia and can cause problems for both mother and baby. The system ai…

This study tests whether the drug ubrogepant can prevent menstrual migraines when taken daily for a week around each period. About 496 women with regular cycles and a history of menstrual migraines will receive either ubrogepant or a placebo for three cycles, then all may receive…

This Phase I trial tests whether infusing specially trained immune cells, called TAA-T, can safely target and attack high-risk brain tumors in children and adults. The cells are made from the patient's own blood and are designed to recognize multiple tumor-related proteins, poten…

This study tests a new growth hormone medicine called somapacitan, given once a week, in 47 children who are very short due to being born small for gestational age, or having Turner syndrome, Noonan syndrome, or idiopathic short stature. The main goal is to see if it is safe and …

This study looks at the long-term safety of relacorilant, a drug for people with Cushing syndrome. It includes 125 adults who previously completed a relacorilant study and may benefit from continued treatment. Researchers will track side effects over time to see if the drug is sa…

This early-phase trial tested whether combining two anti-cancer drugs, pomalidomide (taken as a pill) and liposomal doxorubicin (given through an IV), is safe and tolerable for people with advanced or hard-to-treat Kaposi sarcoma. The study enrolled 62 adults, including those wit…

This study tests whether using a special camera (OCT) inside the heart's arteries during a heart attack procedure leads to better outcomes than the standard X-ray method. About 3000 people having a heart attack will be randomly assigned to one of the two approaches. The goal is t…

This study follows 284 people with blocked leg arteries (peripheral arterial disease) who are treated with a paclitaxel-coated balloon. The balloon is inflated inside the artery to open it and release a drug that helps prevent it from narrowing again. Researchers are tracking saf…

This study tests whether infusing a cold magnesium sulfate solution directly into the brain during emergency clot removal can improve outcomes for people with acute ischemic stroke. About 42 adults aged 18-80 with severe strokes will be randomly assigned to receive either standar…

This study tests whether a newer drug, benralizumab, works as well as the current standard, mepolizumab, for people with a rare disease called EGPA that inflames blood vessels. About 140 adults with active EGPA will receive either drug for a year, along with their usual steroids.…

This study tests a new approach called 'pill-in-pocket' anticoagulation for people with atrial fibrillation (AF), a heart rhythm condition that raises stroke risk. Instead of taking blood thinners every day, participants would stop them after a 30-day AF-free period and only rest…

This study follows 250 people with severe aortic stenosis who receive the SAPIEN 3 transcatheter heart valve as part of their standard care. The goal is to see how safe and effective the valve is over the long term in everyday clinical practice. Researchers will track how many pa…

This study tests a new medicine called ALN-6400 for people with hereditary hemorrhagic telangiectasia (HHT), a condition that causes abnormal blood vessels and frequent nosebleeds. First, healthy volunteers will receive a single dose to check safety. Then, HHT patients will recei…

This trial is testing a temporary stent system designed to open blocked arteries below the knee in people with peripheral arterial disease. The stent is used along with a drug-coated balloon to help keep the vessel open. The study will check how well the treated arteries stay ope…

This large study is testing whether a device called WATCHMAN FLX, which closes off a small pouch in the heart, can be a safe and effective alternative to daily blood thinners (NOACs) for preventing strokes in people with non-valvular atrial fibrillation. The trial involves 3,000 …

This study looks at whether game-like features and social rewards can help overweight veterans with high blood pressure become more physically active. About 725 veterans will take part in a 9-month program where they either compete or cooperate to increase their daily steps. The …

This study tests whether a special placental membrane called BR-AC, applied weekly, can help heal non-healing venous leg ulcers faster than standard care alone. About 60 adults with a leg ulcer between the knee and ankle will be randomly assigned to get either standard care plus …

This study tests a new medical device called the GORE VIAFORT stent, which is a small mesh tube placed inside a blocked or narrowed vein in the leg or pelvis to keep it open. The goal is to improve blood flow and reduce symptoms like pain, swelling, and leg ulcers. About 165 adul…

This trial tests whether losartan, a common blood pressure medication, can reduce scarring in the heart's main pumping chamber and improve exercise capacity in adults who had surgery to repair coarctation of the aorta. Participants will take losartan, amlodipine, or a placebo dai…

This study tests whether pharmacists can encourage doctors and patients to switch to a single pill that combines multiple blood pressure medicines. About 720 adults with high blood pressure will take part. The goal is to see if this approach helps lower blood pressure more effect…

This phase 2 study tests two drugs, sunitinib and temsirolimus, in 137 people with advanced rare tumors that have no cure. The goal is to see if these drugs can shrink tumors or slow their growth. Participants take one of the two drugs, and researchers measure how long the cancer…

This Phase 3 trial tests whether a daily pill called AZD0780 can safely lower LDL (bad) cholesterol in adults with heart disease or at high risk. About 3,100 participants will receive either AZD0780 or a placebo for 52 weeks, and neither they nor their doctors will know which the…

This trial is testing a specially modified stent graft—a small mesh tube—to repair complex aortic aneurysms in people who are too high-risk for open surgery. The graft is adjusted by the physician to keep blood flowing to the kidneys and other vital organs during the procedure. T…

This study follows 246 people who received the Pipeline Shield device to treat brain aneurysms. The device is a small mesh tube that blocks blood flow to the aneurysm, reducing rupture risk. Researchers are checking how well the aneurysm seals, whether the artery narrows, and if …

This study tests a new medicine called INZ-701 in babies up to 1 year old who have a rare genetic condition (ENPP1 deficiency) that causes severe hardening of the arteries and bone problems. The goal is to see if the drug can raise a key substance in the blood, improve survival, …

This early study is testing a new device called HyperQure that uses radiofrequency energy to disrupt nerves around the kidney arteries, which may help lower blood pressure. It involves 10 adults with resistant hypertension who are already taking 3 or more blood pressure medicatio…

This large phase 3 trial tests whether newer blood thinner combinations (ticagrelor plus aspirin or rivaroxaban plus aspirin) are better than the standard clopidogrel plus aspirin at preventing stroke, brain bleeding, or death from blood vessel disease. Over 1,600 participants wi…

This study tests whether taking potassium supplements can slow down kidney function loss in people with moderate-to-severe chronic kidney disease (CKD) and high blood pressure. About 532 adults with CKD stage 3b or 4 will receive potassium or a placebo. The goal is to see if pota…

This study tests whether people with atrial fibrillation who receive a WATCHMAN FLX Pro device can safely take just one blood thinner or aspirin instead of the usual two-drug plan. About 1,857 participants are being followed for six months to compare rates of death, stroke, major…

This study tests a new drug called INZ-701 in up to 16 infants (up to 1 year old) with rare genetic conditions (ENPP1 or ABCC6 deficiency) that cause dangerous calcium buildup in arteries and other problems. The main goal is to check the drug's safety and how the body handles it,…

This study tests a program to help control high blood pressure in adults aged 35 and older living in rural Pakistan. The program includes regular blood pressure checks, home health education, and referrals to doctors. Researchers want to see if this approach can be effectively us…

This study compares two methods for monitoring the blood thinner heparin in hospitalized patients with blood clots. One method uses a standard clotting test (PTT), while the other uses a newer test (anti-Xa). The goal is to see which method helps patients reach the right blood th…

This study tests whether implanted monitors can quickly show if a new PAH drug is working. About 40 adults with stable PAH will try two different approved drug plans while their heart and lung function are tracked. The goal is to see if this approach can help doctors choose the b…

This study tests a new device that replaces a leaky tricuspid heart valve using a thin tube inserted through a leg vein, avoiding open-heart surgery. It includes 150 people with severe tricuspid regurgitation who are too high-risk for surgery. The goal is to see if the device is …

This phase 2 trial tests an injectable drug called DII235 in 233 adults with high lipoprotein(a), a genetic condition that raises heart disease and stroke risk. Participants have heart disease or type 2 diabetes. The study compares different doses of DII235 against a placebo to s…

This phase 3 trial tests whether ziltivekimab, a drug that targets inflammation, can reduce swelling in the arteries of 40 people with coronary artery disease. Participants receive either the drug or a placebo, and researchers use advanced imaging and blood tests to measure chang…

This study looks at whether opening a completely blocked heart artery with a procedure called PCI, on top of taking standard heart medications, helps people live longer and feel better compared to medications alone. About 2000 adults with stable heart disease and symptoms like ch…

This study compares a device called FlowTriever (used with blood thinners) to blood thinners alone for people with intermediate-risk pulmonary embolism (blood clots in the lungs). About 1,200 adults with clots in major lung arteries and signs of heart strain will be randomly assi…

This trial tests whether an insomnia treatment can improve markers of heart health in adults with insomnia and risk factors for cardiovascular disease. Participants receive either a cognitive-behavioral therapy program for insomnia or a sleep education control. The study measures…

This study tests a small device, called the Coronary Sinus Reducer, in 35 people with a type of heart failure where the heart pumps well but still has trouble filling with blood. The device is placed in a vein of the heart to help lower pressure during exercise. The goal is to se…

This study looks at whether using a CPAP machine during pregnancy can reduce the chance of developing high blood pressure disorders like preeclampsia. About 1,500 pregnant women with mild to moderate sleep apnea will be randomly assigned to use CPAP or not. The goal is to see if …

This study is a long-term follow-up for people who previously received an injection of RGX-314, a gene therapy, for diabetic retinopathy (with or without diabetic macular edema). The purpose is to monitor the safety and effectiveness of the treatment over a total of five years af…

This study compares two community-based programs designed to reduce heart disease risk factors—like high blood pressure and obesity—in Black women after pregnancy. About 432 Black or African American women who are early in pregnancy and have obesity or high blood pressure will ta…

This phase II trial tests the drug pomalidomide in about 45 people with Kaposi sarcoma, a rare skin cancer. Pomalidomide works by stopping blood vessel growth and boosting the immune system to fight cancer cells. The study aims to see how long tumors shrink and how many people re…

This study asks whether wearing a small heart monitor for two weeks at a time, twice, can better detect hidden irregular heartbeats (atrial fibrillation) in older adults who recently had a stroke or mini-stroke, compared to the usual 1-2 day monitoring. Atrial fibrillation is a m…

This study looks at whether semaglutide, a medicine for type 2 diabetes, can slow or prevent diabetic eye disease over 5 years. About 1500 adults with type 2 diabetes will receive either semaglutide or a placebo injection once a week, in addition to their usual diabetes medicatio…

This study tests a device called Amulet 2 that is implanted in the heart to seal off a small pouch (the left atrial appendage) where blood clots can form in people with atrial fibrillation. The goal is to reduce the risk of stroke without needing long-term blood thinners. About 4…

This study follows 155 people in Japan with hereditary angioedema (HAE) who are taking TAKHZYRO (lanadelumab) injections every two weeks. Researchers will monitor side effects and check if the drug helps control swelling attacks over 12 months. The goal is to see how well TAKHZYR…

This trial tests whether a procedure called renal denervation can safely lower blood pressure in people with chronic kidney disease (stage 3) whose hypertension is not controlled by medication. The procedure uses ultrasound energy to calm overactive nerves in the kidney that may …

This study looks at how well the iCover stent works when used as a bridging stent during a procedure called fenestrated endovascular aneurysm repair (fEVAR) for complex abdominal aortic aneurysms. The goal is to see if the stent stays open and keeps the aneurysm sealed without co…

This study tests a new type of balance training for people who had a stroke within the past few weeks. The training uses controlled wobbles and shifts in the support surface to challenge patients' balance in a safe way, aiming to improve their ability to walk and perform daily ac…

This trial is testing whether a catheter that suctions out blood clots can restore blood flow to the intestine in people with acute mesenteric ischemia, a life-threatening blockage of the artery feeding the gut. Participants will undergo thrombus aspiration, and if needed, laparo…

This trial tests whether adding melatonin to the standard preventive drug propranolol can better reduce migraine attacks in children aged 5 to 15. Sixty children with moderate-to-severe migraine disability will receive either melatonin plus propranolol or propranolol alone for th…

This trial tests whether starting physical therapy early—while infants are still in the NICU and continuing until 12 months corrected age—can improve motor function and reduce the severity of motor delays in babies at high risk due to premature birth, brain injury, or other condi…

This study tests whether a focused, intensive stepping training program, called FIRST, can improve walking ability in people recovering from a recent stroke. Participants in inpatient rehabilitation receive physical therapy that prioritizes walking practice at higher cardiovascul…

This trial tests whether using optical coherence tomography (OCT) during a procedure to reopen a chronically blocked carotid artery is safe. The blockage can cause strokes, and doctors often need to see what's inside the artery after crossing the blockage. OCT provides high-resol…

This study tracks the safety and effectiveness of the GORE® TAG® Thoracic Branch Endoprosthesis, a stent-graft device used to treat aortic arch and descending aorta conditions such as aneurysms, dissections, and transections. Researchers will follow about 155 patients who receive…

This trial compares two common procedures—carotid endarterectomy (surgery to clean out the artery) and carotid stenting (placing a mesh tube to hold it open)—in people who have recently had an ischemic stroke caused by a blocked carotid artery. The goal is to see which approach l…

This trial tests whether a gentle electrical current applied to the brain — called transcranial direct current stimulation (tDCS) — can help older adults recover the ability to swallow after a stroke. Hospitalized patients aged 60 to 80 with swallowing difficulties will receive e…

This study looks at whether alirocumab, a drug that lowers cholesterol, can reduce the risk of heart attack, stroke, or death in people who have hardened arteries but have never had a heart attack or stroke before. Researchers will analyze data from routine medical care to compar…

This study compares two procedures for severe aortic valve stenosis: transcatheter aortic valve implantation (TAVI), a less invasive approach, and standard open-heart surgery. It will follow 4,000 high-risk patients for up to 24 months to see which method leads to fewer deaths, h…

This trial tests two methods of harvesting the left internal mammary artery for heart bypass surgery. One method strips the artery clean of surrounding tissue; the other leaves the tissue intact. Researchers want to know which approach keeps the graft open longer and reduces the …

This trial compares two types of transcatheter heart valves—one designed to sit above the natural valve opening (supra-annular) and one that sits within it (annular)—in people with severe aortic stenosis and a small aortic annulus (≤23 mm). The goal is to see which valve leads to…

This study tracks the safety of avacopan, a medication for ANCA-associated vasculitis, an autoimmune disease that causes blood vessel inflammation. Researchers will compare side effects like liver injury, heart problems, serious infections, and cancer in people taking avacopan ve…

This study tests whether a home-visit program called PAT+HEALTH can help pregnant women with obesity in Nigeria improve their heart health and manage weight. About 1,000 women will be randomly assigned to receive the program or standard care. Researchers will track weight, lifest…

This study looks at whether a special blood test (TEG-PM) can guide doctors in adjusting blood-thinning medications for people who have had leg artery surgery for peripheral artery disease. About 130 adults will have their blood tested before and up to 9 months after surgery, and…

This study tests a prototype smartphone app called Appet HEART, designed to support personalized care for people with coronary artery disease after they leave the hospital. Researchers want to see how often patients use the app, who benefits most, and whether it improves recovery…

This trial tests two rehabilitation techniques — synergy-based electrical stimulation and task-oriented training — to see which better improves leg movement and mobility in people who had a stroke 1 to 6 months ago. Participants, aged 40 to 60, will receive one of the two approac…

This study follows 100 adults with primary open-angle glaucoma who had a goniotomy procedure using the C-Rex surgical instrument. The goal is to see how well the surgery lowers intraocular pressure and reduces the need for glaucoma medications over 12 months. Researchers will als…

This study tests a next-generation heart valve (Navitor) in 333 people with severe aortic stenosis who are too high-risk for open-heart surgery. The goal is to see if the valve is safe and works well at 30 days, focusing on survival and reducing leaks around the valve. The valve …

This study investigates whether intensively lowering systolic blood pressure with FDA-approved medications can reduce the buildup of amyloid and tau proteins in the brain—hallmarks of Alzheimer's disease. The trial enrolls adults aged 60-85 with high blood pressure who are cognit…

This study tests whether adding a PCSK9 inhibitor (a powerful cholesterol-lowering drug) to high-intensity statin therapy can prevent future cardiovascular events in people who have recently had a heart attack or unstable angina and underwent a stent procedure. About 1,200 partic…

This study looks at people with idiopathic intracranial hypertension (IIH), a condition where high pressure inside the skull can damage vision. Researchers will track which patients need a surgical shunt to relieve pressure versus those who improve with weight loss and medication…

This trial tests a procedure called pulmonary arterial denervation (PADN) for people with heart failure who also have high blood pressure in the lungs. A special catheter delivers radiofrequency energy to nerves in the pulmonary artery, which may help lower pressure and improve h…

This study tests an experimental drug, NPI-001 (AT-001), in people with hereditary cystatin C amyloid angiopathy (HCCAA), a rare genetic condition that causes repeated brain bleeding and stroke. The trial includes about 15 participants aged 12 and older who carry the specific L68…

This trial tests whether a dietary supplement called Tertinat, containing epigallocatechin-3-gallate, can reduce major heart problems in people with atherosclerosis who have recently had bypass or stent surgery. Over two years, participants take either the supplement or a placebo…

This study investigates whether diagnosing and treating obstructive sleep apnea with CPAP therapy early, while patients are still in the hospital for heart problems, can reduce the chance of being readmitted within 30 days. The trial enrolls adults with heart failure, heart attac…

This study tests whether giving stroke patients real-time feedback on muscle activity—either through a visual display or sounds—can improve balance, walking, and daily independence when added to standard physical therapy. The trial enrolls adults aged 20-30 who have had a hemiple…

This study tests whether a procedure called spinal cord stimulation can reduce blood vessel spasms that often occur after a brain aneurysm rupture. Participants have already had standard treatment for their aneurysm and will receive either real or sham stimulation. The goal is to…

This trial investigates whether combining neuromuscular electrical stimulation (NMES) with therapeutic ultrasound can help stroke patients who also have sarcopenia—a condition of low muscle mass and strength. Participants receive four weeks of daily therapy, and researchers measu…

This study evaluates a special balloon coated with sirolimus, a drug that helps prevent arteries from narrowing again after angioplasty. The balloon is used during routine procedures to open blocked heart arteries in people with coronary artery disease. Researchers are tracking h…

This trial tests a device called the Edwards PASCAL system, which is used to repair a leaky tricuspid valve in the heart without open-heart surgery. The study includes 300 people with severe tricuspid regurgitation who are candidates for this procedure. Researchers are checking h…

This study investigates whether adding two common drugs—valsartan (for high blood pressure) and celecoxib (for arthritis pain)—to standard metformin therapy can improve blood sugar control in people with type 2 diabetes. The trial enrolls adults with obesity, high blood pressure,…

This study tests whether combining two drugs, droxidopa and pyridostigmine, can improve a sudden drop in blood pressure when standing up (orthostatic hypotension) without making high blood pressure worse when lying down. The trial enrolls people with neurogenic orthostatic hypote…

This trial tests a new artificial valve, called LuX-Valve Plus, for people with severe tricuspid regurgitation (a leaky heart valve) who are not candidates for open-heart surgery. Participants are randomly assigned to receive either the valve implant plus standard medical therapy…

This study tests whether a structured 5-part nursing care bundle can reduce dangerous blood clots (venous thromboembolism) after total hip replacement surgery. The bundle includes patient education, ankle exercises, early walking, fluid management, and compression stockings. Abou…

This trial tests whether using a special camera inside the arteries (optical coherence tomography, or OCT) is better than standard pressure-wire measurements for deciding which non-blocked arteries need stenting in people who have just had a heart attack. About 1,425 participants…

This study compares standard high-intensity gait training and gait training with electrical stimulation against a new approach that uses real-time feedback on how muscles work together (muscle synergies). The goal is to see if this biofeedback method helps people with chronic str…

This study tests a new way to control leg exoskeletons by reading muscle signals in real time. Researchers use high-density electrodes to capture nerve activity and predict a person's intended movement, then have the exoskeleton assist accordingly. The trial includes both healthy…

This study looks at whether people with an On-X mechanical aortic heart valve can safely take a lower dose of the blood thinner warfarin. The goal is to reduce bleeding complications while still preventing dangerous blood clots. Researchers will follow 510 adults for up to 5 year…

This trial tests whether a quick procedure called umbilical cord milking—pushing blood from the cord into the baby before clamping—can improve brain development in newborns who are limp or not breathing well at birth. The study follows over 3,400 infants from the earlier CORDMILK…

This study follows about 3000 people with complex coronary artery disease who receive the Ultimaster Nagomi stent, a device that slowly releases a drug to keep arteries open. The goal is to see how often the stent fails—meaning heart-related death, heart attack, or need for anoth…

This trial tests a drug called ivarmacitinib in people with Behçet's disease who have not improved with standard treatments. Ivarmacitinib blocks a key inflammation pathway (JAK-STAT) to reduce symptoms. Participants take the drug daily for 24 weeks, and researchers monitor their…

This study tests whether a gentle, targeted electrical stimulation to the brain (HD-tDCS) can safely improve how stroke survivors perceive vertical balance. Participants who have had a stroke affecting one side of the brain will receive either active or sham stimulation while per…

This clinical trial tests an implant called PA5108 that is placed inside the eye to lower pressure in adults with open-angle glaucoma or ocular hypertension. The implant is compared to standard latanoprost eye drops. The study aims to find the right dose that is both safe and eff…

This trial tests a long-acting injection of leuprolide acetate in children with central precocious puberty, a condition where puberty starts too early. The goal is to suppress puberty-related hormones, slowing or stopping early development. The study includes children aged 4 to 9…

This study tests whether a non-invasive brain stimulation technique called deep transcranial magnetic stimulation (dTMS), combined with paired associative stimulation (PAS), can improve arm and hand movement in people who have had a stroke. The trial includes 40 adults who experi…

This trial tests whether a special training that uses unexpected slips on a low-friction platform can help stroke survivors improve their balance and reduce falls. Participants will practice recovering from slips in a safe lab setting, and researchers will track whether these ski…

This study compares two versions of a three-drug combination eye drop for glaucoma: one with preservatives and one without. Researchers want to see if the preservative-free version is gentler on the eye surface and leads to better treatment adherence. Participants will also use a…

This trial looks at the best time to reopen other blocked arteries in people who have just had a major heart attack (STEMI) and have multiple narrowed heart arteries. Participants are randomly assigned to have all blockages fixed right away or in a separate procedure later. A spe…

This trial investigates whether using a device to continuously measure pressure inside the brain's fluid-filled spaces can improve outcomes for people who have had a bleeding stroke from a ruptured aneurysm. About 372 adults with moderate to severe bleeding will be randomly assig…

This study looks at whether starting daily low-dose aspirin in the first trimester (weeks 1–12) is safer and more effective than starting in the second trimester (weeks 13–27) for pregnant women with sickle cell disease. Researchers will track maternal deaths, preterm births, and…

This study tests a new non-invasive brain stimulation device called kTMP (kilohertz transcranial magnetic perturbation) to see if it can help improve arm and hand movement in people who have had a stroke. The trial involves 7 adults aged 18-80 who had a stroke at least 12 months …

This trial tests whether a chelation therapy infusion—a cocktail that removes toxic metals from the blood—can reduce the risk of heart attacks, strokes, and leg amputations in people with diabetes and critical limb ischemia (severe blockage in leg arteries). Half of the 50 partic…

This study tests whether injecting botulinum toxin (Botox) into fat pads around the heart's veins during cardiac surgery can prevent atrial fibrillation (AFib), a common and serious complication. About 220 adults undergoing heart surgery will receive either Botox or a placebo inj…

This study tests a new drug called TS23, a monoclonal antibody designed to help break down blood clots in the lungs. It is for people with intermediate-risk pulmonary embolism, a serious condition where clots block blood flow. The trial compares different doses of TS23 against a …

This study tests whether a reduced dose of the clot-dissolving drug alteplase, given alongside standard blood thinners, can improve outcomes for people with intermediate-high-risk pulmonary embolism (a serious blood clot in the lungs). About 800 adults with confirmed acute pulmon…

This trial tests whether a home-based tele-rehabilitation program is as effective as traditional center-based cardiac rehabilitation for people who have recently had a heart attack (acute coronary syndrome). Participants will either complete 20 sessions at a rehab center or 20 se…

This early study tests a new stent system designed to treat blockages at artery branch points in the heart. It involves 13 people with heart disease who need a procedure to open these blockages. The main goal is to see if the stent can be safely placed and work as intended.

This study tests a new drug called EYE103 (Restoret) against an existing treatment, ranibizumab (Lucentis), for people with diabetic macular edema, a condition that causes vision loss in diabetes. About 984 participants will receive injections into the eye every 4 weeks for a yea…

This study tests a new device called the DurAVR™ THV System, a replacement heart valve placed through a small tube in an artery, for people with severe aortic stenosis (a narrowed heart valve). The trial involves 150 participants and aims to see if the device is safe and works we…

This study tests a virtual clinic where pharmacists monitor blood pressure, adjust medications, and provide telehealth support to older adults (65+) with high blood pressure. The goal is to see if better blood pressure control can also help prevent cognitive decline. About 1,000 …

This Phase 2 trial tests whether delivering the anti-inflammatory drug dexamethasone directly around deep veins can prevent blood clots from returning after they are removed. The study involves 60 adults aged 18-89 who have had DVT symptoms for 14-60 days. Participants receive ei…

This study tests a 12-week home-based digital program called eCardiacRehab for people who have had a heart procedure (PCI). The program includes video messages, modules, and tracking to support recovery. Researchers want to see if patients will use it regularly and find it accept…

This study looks at whether starting a cardiac rehabilitation programme soon after leaving the hospital helps people with coronary artery disease live longer and avoid hospital stays for heart problems. The programme includes counseling, education, and exercise sessions three tim…

This study tests a new device called the MOTIV Sirolimus-Eluting Bioresorbable Vascular Scaffold for people with severe leg artery disease (critical limb ischemia). The scaffold slowly releases medicine to keep the artery open and then dissolves over time. Researchers compare it …

This study tests whether giving a fructose (a type of sugar) injection soon after a stroke, along with standard clot-busting treatment, can improve brain recovery. About 46 adults who have a stroke within the last 4.5 hours will be randomly assigned to receive either fructose plu…

This trial aimed to test whether anti-CD19 CAR-T cells could safely and effectively treat children with refractory ANCA-associated vasculitis, a rare autoimmune disease. The study was withdrawn before enrolling any participants, so no results are available. It was designed for ch…

This early study tests a special scaffold that dissolves over time in 10 people with severe leg artery disease (critical limb-threatening ischemia). The scaffold is placed in arteries below the knee to help keep them open after balloon treatment. Researchers check safety and how …

This study tests a smartphone app called Liebria designed to help people manage high blood pressure. 328 adults with high blood pressure used the app at home to track and lower their readings. The goal is to see if the app can help control blood pressure and improve daily life.

This study planned to test whether giving a child their own stored umbilical cord blood is safe for treating perinatal arterial ischemic stroke. It was designed for children aged 6 weeks to 6 years with MRI-confirmed stroke. The trial was withdrawn before enrolling any participan…

This study follows 116 people with open-angle glaucoma who already have a MINIject implant in their eye. Researchers will track them for up to 5 years to see if any serious device-related problems occur. No new treatment is given—this is a safety check to see how well the implant…

This study compares two types of weight-loss surgery (gastric bypass and gastric banding) with an intensive diet and exercise program for controlling type 2 diabetes in moderately obese adults aged 25 to 55. The goal is to see which approach works best for improving diabetes and …

This study tests a new coil device (Kaneka i-ED) in 50 people with wide-necked brain aneurysms. The coil is placed inside the aneurysm to block blood flow and prevent rupture. Researchers will check how well it works, how safe it is, and whether it saves money compared to standar…

This study tests a special balloon catheter coated with the drug paclitaxel to treat narrowed or re-narrowed brain arteries. The balloon is inflated inside the artery to open it and release the drug, which may help prevent the artery from closing again. The trial includes 281 adu…

This study compares a new stent (Supera) to standard surgery for treating blockages in the leg's main artery. About 286 people with moderate to severe leg pain or sores will be randomly assigned to get either the stent or surgery. Researchers will check if the stent keeps the art…

This trial tests whether a new device called OmniHeart 4.0 can safely support the heart during high-risk angioplasty, compared to the standard ECMO machine. About 254 patients will be randomly assigned to receive either the OmniHeart or ECMO. Researchers will track major heart an…

This study tests whether a new drug-coated balloon (Passeo-18 Lux) is as safe and effective as an existing one (IN.PACT Admiral) for opening blocked leg arteries in people with peripheral artery disease. About 302 participants with moderate to severe symptoms are randomly assigne…

This study tests whether Rhopressa eye drops can further lower eye pressure in people with glaucoma or high eye pressure who recently had laser surgery (SLT) in both eyes. About 70 adults will receive either Rhopressa or placebo drops daily for several weeks. The goal is to see i…

This study tests a mobile app called HyperCoach that provides health coaching to help people with high blood pressure manage their condition. Thirty-seven adults with hypertension who are already on medication will use the app to track blood pressure, weight, and steps, and set p…

This early-phase trial tests an investigational biologic called EA5 in adults with antiphospholipid syndrome (APS) who have had two or more blood clots despite standard blood-thinning therapy. The study enrolls about 12 participants and gives EA5 by intravenous infusion followed …

This phase 3 trial studies 1,200 people with severe coronary artery disease and a weak heart pump (ejection fraction 40% or less). Participants are randomly assigned to receive either guideline-directed medical therapy, bypass surgery, or stenting. The study tracks survival, hear…

This study tests whether a natural supplement called nicotinamide riboside can improve artery stiffness and lower blood pressure in people with moderate to severe chronic kidney disease. About 118 adults aged 35-80 will take either the supplement or a placebo for 3 months. The go…

This study looks at whether providing medically tailored groceries can help people with type 2 diabetes and high blood pressure keep up healthy eating habits and control their blood sugar and blood pressure. About 80 adults who already took part in a meal delivery study will rece…

This study looks at 3,500 unconscious patients who survived a cardiac arrest to find the best combination of sedation, fever control, and blood pressure management in the ICU. Each patient gets one of two levels for each factor (e.g., deep vs. light sedation, tight vs. loose feve…

This study tests a nurse-led program that uses home monitoring devices to help older adults with conditions like heart failure, diabetes, and depression manage their health after leaving the hospital. The goal is to improve care coordination and reduce hospital readmissions. Abou…

This study looks at whether giving people with PTSD a personalized mix of gut bacteria (called pharmabiotics) can help their mental health. The researchers will track changes in PTSD symptoms, anxiety, depression, and thinking skills over 14 days. The goal is to see if fixing the…

This study tests whether monthly home visits from trained health agents can help people in poor, high-altitude communities in Peru better control their high blood pressure and diabetes. Over 1,000 participants will either receive these visits for a year or get usual care. The goa…

This study tests whether the drug farcimab (Vabysmo), given as an injection before and after eye surgery, can reduce bleeding complications in people with diabetes who have bleeding inside the eye. About 100 adults will receive either farcimab or a sham injection. The goal is to …

This study compares two strategies for placing stents in people with multiple blocked heart arteries. One group gets standard guidance using a pressure wire (FFR), while the other also uses an imaging catheter (OCT) to spot unstable plaques. The goal is to see if the combined app…

This study compares two cholesterol-lowering strategies in adults aged 75 and older who have heart or blood vessel disease. One group aims for a very low LDL cholesterol target (below 55 mg/dL) using high-intensity statins, while the other receives standard moderate-intensity sta…

This early-phase study tests a single injection of ART101 in 16 adults with high blood pressure. The goal is to see if it is safe and how it affects blood pressure over 24 weeks. Participants receive either 600 mg or 800 mg of the drug and are closely monitored.

This study tests whether a drug-coated balloon is as safe and effective as a drug-eluting stent for people with large coronary artery disease. About 1,400 participants from multiple countries will be randomly assigned to one of the two treatments. The goal is to see which approac…

This study planned to test a special shockwave device that uses sound waves to crack calcium buildup in leg arteries before placing a stent. The goal was to improve stent fit and long-term blood flow in people with severe peripheral artery disease. However, the trial was withdraw…

This study tests a new eye injection called IBI302 for people with diabetic macular edema, a condition that causes vision loss due to diabetes. About 150 adults aged 18-80 with type 1 or 2 diabetes and swelling in the center of the retina will receive either IBI302 or an active c…

This study tests whether nurse-led health coaching can help adults with high blood pressure in Huayuan County, China, better manage their condition. About 78 participants will receive either standard care or additional coaching sessions over six months. The goal is to see if coac…

This study is following 147 people who have a bulge (aneurysm) or tear (dissection) in the main artery of the chest. All participants received the Ankura stent graft, a fabric-covered metal tube placed inside the artery to support it. Researchers are tracking how well the device …

This study looks at whether 10 weeks of regular exercise (on land or in water) can lower blood sugar and blood pressure in people aged 60 and older who have several health conditions like diabetes, high blood pressure, and arthritis. 63 volunteers will be split into two exercise …

This study tests whether adding cabergoline to osilodrostat works better than osilodrostat alone for controlling Cushing's disease. About 50 adults with active Cushing's disease will receive either the combination or the single drug. The goal is to see if the combo can lower cort…

This pilot study aimed to see if the oral drug trametinib could improve the structure of brain arteriovenous malformations (AVMs) in adults before their scheduled surgery. The goal was to shrink the AVM or reduce risky features. However, the trial was withdrawn before enrolling a…

This trial tests a 12-month lifestyle medicine program for 1000 adults with obesity and related conditions like diabetes or high blood pressure. Participants get regular visits with a dietitian and a doctor, plus optional behavioral health support. The goal is to see if the progr…

This phase 3 trial compares two laser wavelengths (1940 nm vs 1470 nm) for closing off faulty veins in people with symptomatic varicose veins. 220 adults will be randomly assigned to one laser or the other. The main goal is to see which laser achieves complete vein closure at 6 m…

This early study tests a new device called the Cook® Venous Valve System in just 4 people with chronic venous insufficiency (leg veins that don't pump blood back to the heart properly). The valve is implanted through a small tube into a deep leg vein to help blood flow one way. T…

This study aimed to test a drug called BAC in people with Alzheimer's disease or vascular dementia. The goal was to see if it could improve thinking and memory, and to check for side effects. However, the trial was withdrawn before any participants were enrolled, so no results ar…

This study is tracking 511 patients with severe tricuspid regurgitation who are treated with the Abbott TriClip device in real-world settings. The main goal is to see if the device can successfully reduce the valve leak by at least one grade at discharge. Researchers are also mon…

This study tests whether using a special imaging tool called OCT during stent placement leads to fewer heart problems over two years compared to standard methods. About 1,200 adults with blocked heart arteries that need complex stenting are taking part. The goal is to see if OCT …

This study compares two ways to replace a narrowed heart valve in people with severe aortic stenosis who are at intermediate risk for surgery. About 1,400 participants will be randomly assigned to get either a less invasive TAVI procedure or open-heart surgery (SAVR). The main go…

This phase 3 trial tests two things at once in 2312 people with coronary artery disease: a new drug-coated stent (Angiolite) versus a standard stent, and a shorter course of blood thinners versus the usual longer course. The goal is to see if the new stent works as well and if sh…

This study tests a new eye drop called DE-117B in 345 Chinese adults with open-angle glaucoma or high eye pressure. The goal is to see if it safely lowers eye pressure better than an existing drug. Participants use the drops once daily for at least 4 weeks, with long-term follow-…

This study looks at how well new, custom-made and off-the-shelf stent-grafts work for repairing complex aortic aneurysms (bulges in the main artery). About 750 people with aneurysms in the abdomen, chest, or arch will be treated using a less invasive procedure through blood vesse…

This study planned to test a new device called the Cardiovalve for people with severe tricuspid regurgitation (a leaky heart valve). The goal was to see if the device could safely replace the valve and reduce leakage. However, the study was withdrawn before any participants were …

This study is following 450 people with long blockages in their leg arteries who are treated with the DETOUR System, a device that creates a bypass inside the artery. The goal is to see how well it works and how safe it is in everyday medical practice. Participants are chosen by …

This study tests whether briefly inflating a blood-pressure cuff on the arm before non-cardiac surgery can reduce heart damage in high-risk patients. Over 1,200 participants will receive either the cuff procedure or no intervention. The goal is to see if this simple, low-cost tec…

This study tests whether a nurse-led smoking cessation program with free drugs and follow-up at healthy life centers helps heart patients quit smoking better than just giving them written information. About 221 daily smokers hospitalized for a heart event will be split into two g…

This study tests a community-based program to help Black and Latino adults with diabetes, prediabetes, high blood pressure, or obesity. Participants receive lifestyle coaching, help connecting to health and social services, and digital skills training. The goal is to see if this …

This study looks at 3,500 people with severe tricuspid regurgitation, a common heart valve problem in older adults. It compares medical therapy (diuretics), surgery, and a less invasive transcatheter procedure to see which works best and when to treat. The goal is to improve surv…

This study is testing a custom-made artificial heart valve, called TRICENTO, in 15 people with carcinoid heart disease who have severe leakage of the tricuspid valve and cannot have surgery. The valve is delivered through a catheter, avoiding open-heart surgery. The goal is to se…

This study looks at whether adding targeted laser treatment to the standard ranibizumab injections can help people with macular edema (swelling) from a central retinal vein occlusion need fewer injections over time. About 88 adults with this condition will receive either injectio…

This study tests whether showing people their own coronary CT scans can motivate them to lower their LDL cholesterol and reduce side effects from statins. 273 adults with non-obstructive coronary artery disease will be followed for 12 months. The goal is to see if visual feedback…

This study compares two treatments for complex blockages in the leg's main artery: one avoids stents by using a drug-coated balloon, the other uses a stent. About 120 people with peripheral arterial disease will be randomly assigned to one approach. The goal is to see which keeps…

This early study is testing a new device called the DurAVR™ THV System, which is a replacement heart valve placed through a small tube in the leg (TAVI procedure). The study includes 40 people with severe aortic stenosis or a failed surgical valve. The main goal is to see if the …

This phase 2 trial tests a procedure called transarterial chemoembolization (TACE) for people with uveal melanoma that has spread to the liver. Doctors inject a chemotherapy drug (carmustine) mixed with an oily contrast agent (Lipiodol) directly into the liver's blood supply, the…

This study tests a minimally invasive heart bypass surgery for people with blockages in multiple coronary arteries. Instead of opening the chest fully, surgeons work through a small incision on the left side. The goal is to see if this approach is safe and effective, with fewer c…

This study is testing a less invasive procedure using stent-grafts to treat various types of aortic disease, including aneurysms and dissections. It involves 170 participants who are considered too high-risk for traditional open surgery. The goal is to see if this endovascular ap…

This study tests a device that uses ultrasound to burn nerves around the kidney arteries, aiming to lower blood pressure in people with autosomal dominant polycystic kidney disease (ADPKD) whose blood pressure remains high despite medication. 44 participants will be randomly assi…

This study tests whether a bedside device called Quantra can help doctors decide when to give blood transfusions during complex heart surgery. The device measures how well a patient's blood clots in real time. Researchers hope this will reduce the number of blood products (like r…

This study looks at two treatment options for people who have both a leaky heart valve (ischemic mitral regurgitation) and blocked heart arteries. One option is open-heart surgery to fix the valve and bypass the blockages at the same time. The other is a less invasive procedure t…

This study aimed to see if removing additional small clots after the main blockage is cleared could help stroke patients recover better. It planned to compare standard care with extra mechanical or drug-based treatments. However, the trial was withdrawn and enrolled zero particip…

This trial is testing whether a new PET imaging tracer, 18F-flurpiridaz, can detect coronary artery disease as accurately as the current standard, 82Rb-chloride. The study will involve 60 adults scheduled for a clinically indicated PET scan. Researchers will compare the diagnosti…

This phase 3 trial is testing whether a special PET scan using radioactive water ([15-O]-H2O) can accurately detect coronary artery disease. About 215 adults with suspected heart disease will receive the injection at rest and during stress, then compare results to standard tests.…

This study tests whether a new MRI technique, called 5D flow, can measure blood flow and pressure in the heart as accurately as the standard invasive procedure, right-left heart catheterization. People with congenital heart conditions who already need a catheterization will also …

This study investigates how well different imaging methods—ultrasound, CT, and MRI—can identify the cause of neck swellings in children. Researchers will compare imaging results with the final diagnosis from biopsy, lab tests, or follow-up. The goal is to see if imaging can relia…

This trial is developing an artificial intelligence system that reads electrocardiograms (ECGs) to detect congenital heart disease in children. Researchers are collecting ECG data from thousands of children, including those with common and rare heart defects, to train a deep-lear…

This trial tests whether improving how clinics measure and record blood pressure, height, and weight can help identify people with undiagnosed hypertension or diabetes. About 800 adults visiting family medicine clinics will be part of a study where some clinics use the FOR-Care m…

This study tests whether a compact 3-lead ECG device can accurately detect acute coronary syndrome (heart attack) in adults arriving at the emergency department with chest pain. Participants receive a HeartBeam ECG recording within 10 minutes of the standard 12-lead ECG. The goal…

This study is developing and testing an artificial intelligence model that analyzes images of skin biopsies to tell the difference between malignant lymphomas (like mycosis fungoides) and benign conditions that look similar. The AI will be trained on hundreds of archived slides a…

This study offers voluntary screening for newborns in North Carolina to detect a wide range of rare health conditions early. Using a small blood sample already collected at birth, the program tests for dozens of disorders, including spinal muscular atrophy, cystic fibrosis, and m…

This study checks if a Withings smart scale can accurately spot signs of high blood pressure by looking at body measurements like weight and heart rate. Researchers compared the scale's results to a standard blood pressure cuff in 2,500 adults. The goal is to see if the scale wor…

This study uses special brain scans (PET imaging) to measure amyloid buildup—a protein linked to Alzheimer's—in healthy older adults, people with mild memory problems, and those with dementia. Participants receive scans every 2-3 years for up to 20 years to see how amyloid change…

This study evaluates RDX-Aneurysm, a computer-assisted detection software designed to help radiologists find saccular intracranial aneurysms (bulging blood vessels in the brain) on MRI scans. Researchers will analyze 550 past scans—half with confirmed aneurysms and half without—t…

This study looks at whether a detailed full-body scan called FDG PET/CT can find hidden cancers in people aged 50 and older who have had an unexplained blood clot. About 1,276 participants will get either the scan or standard cancer checks. The goal is to see if the scan catches …

This study is developing an artificial intelligence tool that can detect hidden plaque in arteries by analyzing photos of the retina (the back of the eye). About 884 adults without known heart disease will have eye photos taken and compared with ultrasound scans of their neck and…

This study tests a laser-based imaging method that shows blood flow in the brain in real time during surgery. It involves 20 adults having brain surgery for conditions like aneurysms. The goal is to see if this technique can give surgeons continuous feedback, unlike the current d…

This study tests a new urine test called CercaTest™ Red to predict preeclampsia in pregnant women who show signs of the condition. Preeclampsia is a serious complication involving high blood pressure and organ damage. The test is designed to be used at the point of care, giving q…

This study looks at people with Long COVID who have new chest pain but no blocked arteries. It tests whether a special heart function test can guide treatment to improve symptoms and quality of life. 108 participants will be randomly assigned to either treatment guided by the tes…

This study looks at better ways to find hidden atrial fibrillation (an irregular heartbeat) in people who have had a stroke. About 337 participants will use either a wearable patch for 72 hours or a handheld device three times a day to monitor their heart rhythm. The goal is to s…

This study is testing whether a special home blood pressure monitor that can detect atrial fibrillation (AFib) helps diagnose the condition faster in older adults with high blood pressure. About 1,900 participants aged 60 and older will take daily blood pressure readings and answ…

This study is developing an artificial intelligence system to analyze CT scans of the heart. The goal is to automatically detect and measure dangerous plaque that can cause heart attacks. Researchers will compare the AI's findings with detailed imaging tests and track patient out…

This study looks at two new methods to tell apart blockages in large versus tiny heart arteries. About 68 adults with known or suspected coronary artery disease will get a PET scan and a heart catheterization. Researchers will compare the new measurements with standard tests to s…

This study is testing a new finger-prick blood test that measures troponin levels in about 10 minutes, compared to the usual 2-hour lab test. Researchers hope it will help diagnose heart attacks faster and reassure patients who are not having one, allowing them to be discharged s…

This pilot study is testing whether a special ultrasound scope (EBUS) can diagnose acute pulmonary embolism (a blood clot in the lung) in critically ill patients in the ICU. These patients often cannot undergo standard CT scans because they are too unstable or have kidney problem…

This trial asks whether hydroxyurea, a daily oral medication, can reduce the risk of a first stroke in children with sickle cell anemia. Researchers will use transcranial Doppler (TCD) ultrasound to measure blood flow in the brain, a key indicator of stroke risk, in children aged…

This study will test a telehealth group prenatal care program called Centering HER in 72 low-income, predominantly Black pregnant women in Kansas who are at moderate or high risk for preeclampsia. Participants will receive routine care plus seven doula-led virtual group sessions,…

This trial is testing a device called the Vine™ Embolic Protection System, which is implanted in the carotid arteries to trap blood clots before they travel to the brain. It is designed for people with atrial fibrillation who are already taking blood thinners but still have a hig…

This study tests whether a music-inspired community campaign, called Music4Health, can help lower blood pressure and improve stroke awareness among 1,412 youth (ages 14-24) and their caregivers (ages 40+) in Nigeria. Participants will take part in listening sessions and activitie…

This study looks at whether clopidogrel, a blood thinner, can prevent new silent brain infarctions (small, unnoticed strokes) in people who recently had a stroke or mini-stroke. Researchers will track 134 participants over 24 months using MRI scans and cognitive tests. The goal i…

This study tests a co-created antenatal care program designed for busy urban clinics in Dar es Salaam, Tanzania, where climate risks like heat, flooding, and pollution add to pregnancy challenges. The program includes guidance for pregnant women and their families, provider train…

This study tests an investigational drug called OHB-607 to see if it can prevent bronchopulmonary dysplasia (BPD), a serious chronic lung disease, in extremely premature infants. About 338 babies will be randomly assigned to receive either the drug or standard care. The goal is t…

This trial tests whether a combination of lifestyle interventions—brain training, yoga, music therapy, and a special diet—can slow or reverse early signs of neurological disorders like dementia, stroke, epilepsy, and Parkinson's disease. Participants are healthy adults aged 50 an…

This study tests whether using a smartphone app and a home blood pressure monitor can help prevent heart disease in women who had high blood pressure during pregnancy. 120 women who gave birth at Northwestern Memorial Hospital will use these digital tools for 12 months after deli…

This trial tests whether spinal cord stimulation can reduce severe, treatment-resistant pain in people with erythromelalgia, a rare condition causing red, hot, and painful extremities. Participants receive either burst stimulation or sham (inactive) stimulation to see if the ther…

This trial investigates whether adding focused shock wave therapy to standard Botox injections can better ease foot stiffness and improve walking in people with post-stroke spastic equinovarus foot. Participants are randomly assigned to receive Botox alone, shock waves just befor…

This study tests a new exercise therapy called Progressive Abduction Loading Therapy for people who recently had a stroke. The goal is to reduce a common arm problem called 'flexion synergy' that makes it hard to reach outward. 86 participants will receive either the new therapy …

This study tests whether transcutaneous spinal cord stimulation (TSCS) — a gentle electrical current applied through the skin — can help veterans with chronic spinal cord injury (SCI) better regulate blood pressure during exercise and cold exposure. Participants will receive both…

This trial explores whether an affordable robot can help people with HIV who have had a stroke improve their arm and leg function. Participants will use the robot for rehabilitation exercises, and researchers will measure changes in movement, balance, and quality of life. The goa…

This trial explores whether five daily sessions of a gentle brain stimulation technique called transcranial direct current stimulation (tDCS) can reduce fatigue in people who have had a stroke. Participants will receive either real or sham stimulation, and their fatigue levels wi…

This study is testing a robotic lower-limb exoskeleton combined with functional electrical stimulation (FES) to help people with conditions like spinal cord injury, brain injury, or multiple sclerosis improve their walking. The device provides robotic support and electrical stimu…

This study tests whether combining virtual reality games with physical therapy can reduce chronic pain in children aged 7 to 21. Twenty participants with pain in the head, neck, or upper limbs will attend six weekly sessions. They will play VR games designed to encourage movement…

Slow-flow vascular malformations — abnormal clusters of veins, capillaries, or lymph vessels — can cause pain, swelling, and appearance concerns. This study follows 60 children and adults who receive bleomycin electrosclerotherapy (BEST), a procedure that injects the drug bleomyc…

This study investigates whether keeping a headache diary helps adults with migraine feel better and manage their condition. Participants track their headaches in a virtual diary, and researchers measure changes in quality of life and disability. The goal is to see if this low-cos…

This study tests whether adding home-based telerehabilitation via WhatsApp video calls to standard outpatient therapy improves hand function in people who had a stroke 1-6 months ago. Forty-eight participants will be split into two groups: one gets standard therapy plus daily 30-…

This study explores whether dry needling — a technique where thin needles are inserted into tight muscles to trigger a twitch — can reduce spasticity (stiffness) in people who have had a stroke. Researchers will measure changes in nerve pathways and movement over two visits. The …

This study tests whether a non-invasive electrical stimulation device placed on the skin over the spine can help veterans with spinal cord injury improve blood pressure, exercise capacity, and body temperature regulation. Twenty veterans with injuries between the neck and upper b…

This study compares two types of exercise—open kinetic chain (like leg raises) and closed kinetic chain (like squats)—to see which better reduces knee hyperextension in stroke survivors. Sixty adults who have had a stroke and can walk with some help will be randomly assigned to o…

This trial tests whether wearing compression stockings with a higher (32 mmHg) or lower (21 mmHg) pressure after radiofrequency ablation for varicose veins leads to less pain and swelling. About 64 adults with varicose veins and leg swelling will wear one of the two stocking type…

This study explores whether joining a weekly reading group can improve reading comprehension and communication confidence in adults with aphasia, a language disorder often caused by stroke. Participants read a book at home and then discuss it in a 90-minute group session each wee…

This study tests whether a smartphone-based stress management program can help Black men with hypertension lower their blood pressure and feel less stressed. About 135 participants will either use a culturally tailored app (m-CBSMi) or take a standard online stress course. Resear…

This study tests whether adding two ultrasound-guided nerve blocks to standard pain relief can lower opioid use and pain after coronary artery bypass grafting. 88 adults having elective bypass surgery will be randomly assigned to receive either the nerve blocks plus standard medi…

This study tests two different movement training methods—sprinter-style and skater-style—to see which better improves balance and coordination in people who had a stroke at least six months ago. Twenty-two participants will do 30-minute sessions three times a week for four weeks.…

This study tests whether taking extra salt (5 grams per day in capsules) can improve symptoms and quality of life in older adults (65+) who experience dizziness and falls due to orthostatic hypotension. The trial involves 42 participants and lasts 12 months, focusing on whether s…

This study tests whether an 8-week mindfulness meditation program (MBSR) can reduce anxiety and depression in heart patients who have completed cardiac rehab. About 74 participants will either take the meditation course or continue with standard rehab. Researchers will measure ch…

This study tests whether applying shockwave therapy to the calf muscles can improve blood flow and reduce pain in people with peripheral artery disease. About 138 adults with stable leg pain when walking will receive the treatment. The goal is to see if it helps them walk longer …

This study tests whether wearing a virtual reality headset during laser treatment for varicose veins can lower anxiety and pain. About 100 adults will use VR during the procedure, and researchers will measure their heart rate, blood pressure, and comfort levels. The goal is to se…

This study looks at whether progressive muscle relaxation and finger grip exercises can lower stress, anxiety, and fatigue while improving sleep in pregnant women with preeclampsia. About 90 women will be split into three groups: one doing relaxation exercises, one doing finger g…

This study tests whether using a far red light device on the legs for 10 minutes twice a day can improve walking distance in people with peripheral artery disease (PAD). The trial involves 32 adults aged 50 and older with PAD. Participants use the light at home for four months, a…

This study compares two types of hand and arm therapy for people who had a stroke 3 to 6 months ago. One therapy involves restraining the good arm to force use of the affected arm, while the other focuses on using both arms together. Both groups also receive standard physical the…

This study tests whether wearing inflatable leg cuffs (intermittent pneumatic compression) for six months can improve walking distance in people with peripheral artery disease (PAD). Some participants also combine the cuffs with walking exercise. The goal is to see if the cuffs h…

This study compares two treatments—Functional Electrical Stimulation (FES) and Whole Body Vibration Training (WBVT)—to see which better improves leg control, balance, and daily activities in people who had a stroke 6 months to 1 year ago. Thirty-four adults aged 35 to 70 will rec…

This study compares two physical therapy approaches—Rood's techniques (using touch, stretch, and ice) and PNF patterns (diagonal movements)—to improve arm and hand function in people who recently had a stroke. 28 adults aged 40-60 with a first-time stroke will receive one of the …

This study tests whether a virtual reality (VR) wellness program can help Black women with high blood pressure reduce stress and improve heart health. Sixty Black women in South Florida will either use a five-week VR program or receive standard educational materials. Researchers …

This study compares two physical therapy techniques—PNF and NDT—to see which better helps stroke survivors improve trunk control and balance. It will involve 32 people aged 40-65 who have had a recent stroke. Participants will receive electrical stimulation plus one of the two th…

This study tests whether using argon plasma coagulation during hemorrhoid surgery can reduce pain and complications compared to standard methods. About 100 adults with severe hemorrhoids will be randomly assigned to one of two surgical techniques. Pain levels and recovery will be…

This study tests whether early, intensive leg exercises, done by a physical therapist and a parent together, can improve walking and motor skills in children aged 8 months to 3 years who had a stroke around birth. The study compares this approach to usual care. The goal is to see…

This study compares two rehabilitation methods—somatosensory stimulation (using touch) and task-based mirror therapy (using a mirror to trick the brain)—to see which better improves arm and hand function in stroke survivors. About 24 adults who had a stroke 1 to 6 months ago will…

This study tests whether combining gentle touch stimulation with nerve exercises can improve arm movement and feeling in people who had a stroke 6-12 months ago. 53 adults aged 45-65 with lasting arm weakness and sensory loss are participating. The goal is to see if this therapy …

This study compares two types of exercise programs to see which one better improves balance and leg movement in people who have had a stroke. The study includes 52 adults aged 45 to 65 who had a stroke 6 to 10 months ago and have mild to moderate leg weakness. Participants will d…

This study compares two types of heart bypass surgery for people with blocked arteries: a minimally invasive approach using small incisions between the ribs versus the traditional method that opens the breastbone. Researchers want to see if the less invasive surgery leads to bett…

This study tests whether exercising both legs together (bilateral training) or just the affected leg (unilateral training) with visual feedback from mirrors and floor targets works better for improving balance, walking, and sensation in people who had a stroke. Fifty participants…

This small study tests whether a four-session program combining music and nature activities can improve wellbeing for people with acquired brain injuries and their care partners. Ten adult participants will complete surveys before and after the program. The goal is to see if this…

This study tests whether 10 weeks of supervised exercise training can improve heart function, oxygen use, and quality of life in people with heart failure and pulmonary hypertension. Forty participants will do three sessions per week at a cardiac rehab clinic. The goal is to see …

This study tests whether a non-invasive device that gently stimulates the vagus nerve through the ear can improve speech recovery in people with aphasia after stroke or brain injury. Twelve adults with apraxia of speech will receive either active or sham stimulation during 16 wee…

This study tests whether exercise delivered through immersive virtual reality can improve physical performance, muscle strength, fatigue, and quality of life in 32 adults with idiopathic pulmonary arterial hypertension. Participants will do virtual reality exercises and be measur…

This study follows 500 adults under 45 who have narrowing of a major brain artery, a condition that can raise stroke risk. Researchers will track participants over time to see how the narrowing progresses and who goes on to have a stroke. The goal is to better understand the natu…

This study looks at whether tiny RNA particles called exosomal microRNAs in the blood can act as a 'stroke clock' for people with a severe type of stroke caused by a blocked large artery in the front of the brain. Researchers will compare blood samples from stroke patients to hea…

This study follows 46 people with gyrate atrophy, a rare genetic condition that causes vision loss, over 4 years. Researchers measure ornithine levels in the blood and track changes in the retina using eye scans and photos. The goal is to learn how the disease progresses under st…

This study is sequencing the genes of 1665 people aged 45 to 65 to learn how genetic changes relate to health, especially heart disease. Participants provide blood samples and undergo heart tests. The goal is to improve methods for interpreting genetic data and understand how res…

This study looks at whether measuring the arm or finger can help choose the right blood pressure cuff size for pregnant women. Accurate blood pressure readings are vital during pregnancy and childbirth, but the current method of sizing cuffs may not always be correct. Researchers…

This study looks at how caffeine is processed in newborns with hypoxic-ischemic encephalopathy (HIE), a brain injury caused by lack of oxygen, who are receiving cooling therapy. Researchers will test different doses of caffeine in 16 babies to find the safest and most effective a…

This study tests a new imaging device called OCT-NIRAF that takes detailed pictures inside heart arteries during a standard heart procedure. Researchers want to see if the images can predict which plaques (fatty buildups) will grow and become dangerous. Forty adults with heart di…

This study follows 800 adults who have had their first ischemic stroke in Central Norway for up to 10 years. Researchers will track how physical activity, medication use, and control of blood pressure and cholesterol affect the risk of death, another stroke, or severe disability.…

This study collects blood and other samples from people with sickle cell disease and healthy volunteers to help researchers understand how inflammation affects blood vessels. Up to 2,000 adults aged 18 and older will take part. The samples will be used in lab tests to support fut…

This study follows 100 adults aged 35-70 with mildly elevated blood pressure to see how their aldosterone hormone system changes over time. Participants will eat special high-salt or low-salt diets for a few days each year to test how their body responds. The goal is to better un…

This study follows 250 male endurance athletes who were part of an earlier study to see how their heart arteries have changed over time. Researchers will use CT scans and AI to examine plaque buildup and determine if it is stable and harmless or likely to cause heart attacks. The…

This study looks back at 10 years of medical records from a scoliosis referral center to see how frequently adults with scoliosis who had surgery also develop restrictive breathing problems or signs of pulmonary hypertension on echocardiography. By analyzing data from 174 patient…

This trial investigates whether increasing or decreasing salty food intake for just six days changes how pleasant, desirable, or salty foods taste. Healthy young adults aged 18–35 are randomly assigned to eat more salty foods, fewer salty foods, or stick to their usual diet. Rese…

This trial tests whether a treadmill that automatically adjusts its speed to the walker can help people with weakness on one side of the body take more even steps. Participants with hemiparesis from a stroke or traumatic brain injury will walk on both a self-pacing and a fixed-pa…

This study surveys doctors who use Concerto Versa detachable coils to treat various blood vessel conditions like aneurysms and varicose veins. About 30 patients will be included, and doctors report how well the coils work and any problems within 72 hours. The goal is to collect e…

This study looks at how a soft robotic exosuit can help people who have had a stroke walk better. Researchers will measure muscle activity and walking patterns in 22 adults who are at least six months past their stroke. The goal is to see if customizing the exosuit's assistance b…

This study looks at whether data from wearable devices like smartwatches can track and even predict migraine headaches. Twenty adults with chronic migraine will use a phone app and a smart device to record heart rate and movement. The goal is to see if this information can help f…

This study investigates whether people with neurodegenerative diseases—like Alzheimer's, Parkinson's, or ALS—show changes in behavior, social circumstances, or health before and after their diagnosis. Researchers will compare the records of over 61,000 patients with those of matc…

This study at Mayo Clinic looks at how renin, a protein in the blood, changes when patients are on the heart-lung machine during open heart surgery. Researchers want to see if renin levels can help guide treatments for low blood pressure. The study will enroll 100 adults having e…

This study follows 1,000 patients in China who are already receiving faricimab for diabetic macular edema, retinal vein occlusion, or wet age-related macular degeneration. Researchers will collect data from routine clinic visits over one year to see how well the drug works and ho…

This study looks at balance and movement problems in people with stroke, Parkinson's disease, or multiple sclerosis. Researchers will use special devices to measure how well participants can keep their balance and walk. The goal is to learn more about these issues so that rehabil…

This study looks at how eating mostly ultra-processed foods (like packaged snacks) compared to less-processed foods (like whole fruits and vegetables) affects blood pressure and other heart health markers. About 79 overweight adults will follow special diets to see the difference…

This 5-year study follows 250 people with von Hippel-Lindau disease who have brain or spinal cord tumors. Researchers use regular MRI scans and blood tests to see how fast tumors grow and what factors like hormones might affect growth. The goal is to better understand which tumor…

This observational study follows about 198 patients in Spain who are already taking inclisiran (Leqvio) for high cholesterol linked to heart disease or a genetic condition. Researchers will check if patients reach their LDL cholesterol goals after 6 and 12 months. The goal is to …

This observational study looks at why some untreated coronary artery blockages get worse over time in people who have already had a stent or balloon procedure for heart disease. Researchers will follow 1,400 adults aged 18-80 who are scheduled for a repeat angiogram, tracking the…

This study tested a new MRI method to better predict stroke risk in people with intracranial atherosclerosis, a condition where arteries in the brain become narrowed. Researchers measured how well different parts of the brain responded to changes in blood flow. The goal was to fi…

This study compares two approaches to help people with chronic traumatic brain injury (TBI) become more engaged and confident in managing their health. One approach focuses on what matters most to the patient, while the other provides general health education. The trial will invo…

This study looks at whether stroke patients who do high-intensity rehab at home recover just as well as those who go to a rehab facility. Researchers will follow 500 patients who choose home rehab and compare their progress to patients who went to inpatient rehab. The goal is to …

This study follows 60 people with abdominal aortic aneurysm who are scheduled for endovascular repair (EVAR). Researchers will measure artery stiffness, heart structure and function, and certain blood markers before the procedure and at several points afterward. The goal is to un…

This study aims to build a research group of 100 people with neurological diseases like stroke, Parkinson's, epilepsy, or dementia. Researchers will use overnight sleep tests and questionnaires to measure sleep patterns, breathing, and heart rate during sleep. The goal is to bett…

This study follows 50 people who previously received an INSPIRIS RESILIA aortic valve and now need a valve-in-valve procedure because their original valve is not working well. Researchers will track complications like death, stroke, bleeding, and valve movement, as well as how we…

This study tests whether everyday rehabilitation therapy sessions can be recorded and measured more objectively using wrist-worn sensors, a video camera, and an audio recorder. Adults with neurological conditions like stroke, Parkinson's disease, or spinal cord injury will wear t…

This registry follows 500 people receiving a specific type of surgical aortic valve replacement (the INSPIRIS RESILIA valve) for up to five years. Researchers are tracking how pre-existing conditions like kidney disease, diabetes, and high blood pressure affect survival and valve…

This study looks at whether measuring lactate in stool can help doctors predict how well critically ill patients with low blood flow will respond to treatment. About 40 adults in the ICU will provide a stool sample within 24 hours of admission. Researchers will check if high stoo…

This study tests whether a new scoring system, called PRO-ICH, can accurately predict how well people will recover after a spontaneous brain hemorrhage. Researchers will also check if adding certain blood markers improves the score's accuracy. The goal is to give doctors a reliab…

This trial tests whether wearable devices can measure how the body responds to everyday challenges like changes in salt intake, meals, fasting, and exercise in adults with endocrine or metabolic disorders. Participants wear home monitoring devices and follow different diet and ac…

This study follows about 400 adults with liver cirrhosis admitted to internal medicine wards across Italy. Researchers will track how doctors manage hepatic encephalopathy—a brain complication of liver disease—during hospitalization and after discharge. The goal is to identify pr…

This pilot study is testing whether a specialized blood test called thromboelastography (TEG) can better evaluate clotting problems in people with severe burns. Researchers will track clotting patterns over the first four weeks after injury and see if they relate to burn size or …

This study aims to create and test a new scoring system called HeQAS that uses a microscope to evaluate the technical quality of hemorrhoid removal surgery. Researchers will check if the score is reliable and whether a newer, less invasive surgical method causes less tissue damag…

This study tests whether pairing vagus nerve stimulation (VNS) with language training can improve memory and learning in people who have already used VNS for movement recovery after a stroke. Participants, who already have a VNS implant, will try learning a new language while the…

This study explores whether a special 3D ultrasound technique, called vector flow imaging, can predict where blood clots form inside abdominal aortic aneurysms. Researchers will scan 14 people with small aneurysms (under 5.5 cm), half with existing clots and half without. They wi…

This long-term study follows over 121,000 female nurses to explore how hormones, diet, lifestyle, and genetics affect the risk of heart disease and stroke. Researchers are analyzing blood samples to create a 'metabolomic risk score' that could help predict coronary heart disease.…

This trial is testing a medical device that has not been approved or cleared by the U.S. FDA. The study is small and early-stage, focused on understanding how the device works and whether it is safe. No results are available yet, and the device is not ready for widespread use.

This observational study looks at how inserting a central venous catheter into the neck affects pressure inside the skull in patients with acute brain injury. Researchers will monitor brain pressure, blood flow, and oxygen levels during and after the procedure in about 120 ICU pa…

This study uses a non-invasive eye scan called OCTA to examine tiny blood vessels in the retina of adults with type 1 diabetes. The goal is to detect early signs of diabetic retinopathy, a leading cause of vision loss, before symptoms appear. Researchers will measure vessel densi…

This pilot study looks at whether spinal cord stimulation can improve nerve health in people with small fiber neuropathy, a condition that causes chronic pain. Researchers will measure changes in nerve fiber density from skin biopsies taken before and after 12 months of routine c…

This study investigates how people physically interact with each other during tasks like collaboration, competition, and cooperation. The goal is to design robot controllers that mimic these human behaviors, which could then be used in devices like exoskeletons to improve motor l…

This study scans over 16,000 adults aged 18 to 70 without known heart disease to find hidden (silent) plaque in their arteries using ultrasound and CT scans. The goal is to measure how common silent atherosclerosis is and build a risk calculator that combines imaging, lifestyle, …

This study collects blood and tissue samples from up to 500,000 adults, including heart patients, their family members, and healthy individuals. Researchers will analyze these samples to find molecular and genetic markers linked to heart disease. The goal is to improve understand…

This study investigates how the brain coordinates muscle activity during walking rehabilitation in people recovering from a stroke. Researchers use high-density electromyography (HD-EMG) to track neural synergies—groups of muscles that receive common signals from the brain—over t…

This study examines how ankle impairments affect walking ability in people who had a stroke at least six months ago. Researchers use a robotic device to measure ankle control and sensation, comparing results with standard walking tests and clinical scales. The goal is to develop …

This study from Mayo Clinic is testing whether a 12-week progressive barbell strength training program can lower blood pressure and improve cholesterol in 200 sedentary adults. Participants will train three times a week with certified coaches. The goal is to see if this type of e…

This study uses a non-invasive ultrasound device to monitor blood flow and detect tiny clots traveling to the brain during placement of a specialized stent-graft for thoracic aortic aneurysms or dissections. Researchers aim to understand how often these microemboli occur and how …

This study investigates whether a drug called XBD173, which targets a protein (TSPO) on blood vessel lining cells, can help understand how these cells contribute to pulmonary artery hypertension (PAH). PAH is a rare condition where narrowed lung blood vessels strain the heart. Si…

This study compares two procedures—rotational atherectomy and intravascular lithotripsy—used to treat severe calcium deposits in heart arteries. The goal is to see how each technique affects the tiny blood vessels (microcirculation) of the heart and whether one leads to better lo…

This study looks at whether pausing sedation each day in mechanically ventilated ICU patients can reduce the amount of blood pressure medication they need. Researchers will compare medication doses before and during these daily awakening trials. The goal is to see if this simple …

This study looks at how a stroke affects the jaw joint and chewing muscles. Researchers will use ultrasound to measure jaw structures in 70 stroke survivors and see if these measurements relate to their recovery. The goal is to better understand jaw problems after a stroke, which…

This pilot study tests whether keeping the lungs gently ventilated during cardiopulmonary bypass (heart-lung machine) reduces lung collapse after heart surgery. Adults having elective coronary artery bypass surgery will be randomly assigned to receive ventilation or not during by…

This study uses a new, child-friendly brain imaging technique called OPM-MEG to understand how immune-related brain diseases (like autoimmune encephalitis and multiple sclerosis) and other brain conditions affect children aged 2 to 25. Standard scans often miss problems with memo…

This study tests a new non-invasive blood pressure (NIBP) measurement method in adults who already have an arterial line in place. The goal is to see how well the cuff-based readings match the direct arterial measurements. Participants must be 18 or older and have an arm or thigh…

This study evaluates whether artificial intelligence models can accurately interpret ROTEM blood clotting tests and recommend treatments for coagulopathy. Researchers will compare AI decisions to those of a panel of clinical experts using data from adults undergoing elective card…

This study looks for biological markers in the blood and tissue of adults with Marfan syndrome that could signal when an aortic aneurysm is dangerous enough to require surgery. Researchers will compare three groups of Marfan patients: those without aortic aneurysms, those with st…

This study looks at how often pelvic congestion syndrome (a condition where veins in the pelvis become enlarged and painful) occurs in women who are about to have a standard procedure for leg varicose veins. Researchers want to know if having this pelvic condition affects how muc…

This study follows 250 people who had a type of stroke called intracerebral hemorrhage (ICH) to understand why some experience progressive cognitive decline. Participants undergo advanced brain scans and tests of thinking and movement at 12–24 months after their stroke, with foll…

This trial investigates whether measuring high-sensitive troponin, a protein released during heart injury, can predict heart complications in people undergoing surgery to open a narrowed carotid artery. About 527 participants will have their troponin levels checked before and aft…

This study tests whether combining standard monitoring tools with new light-based sensors can better detect a dangerous narrowing of the aorta in newborns. Infants under one month old with suspected aortic arch obstruction will be monitored using resonance Raman spectroscopy, pul…

This study follows 100 people with and without varicose veins to see how often the condition appears and how it changes over time. Participants get yearly checkups including ultrasound exams. The goal is to learn what factors make vein disease worse and how it naturally progresse…

This study examines health data from about 800,000 Korean adults to see how often conditions like obesity, type 2 diabetes, heart disease, chronic kidney disease, and fatty liver occur together. Researchers will analyze national survey and insurance records from 2013 to 2023. No …

This study looks at whether bosentan, a drug that blocks a natural vessel-constricting substance, can improve blood flow in the tiny heart vessels of people with angina who have no major blockages. About 45 participants will get bosentan for 4 weeks and have MRI scans before and …

This study looks at how a brain procedure called embolization affects the immune system. Researchers will take blood samples from 78 patients before and after the procedure to measure immune markers. They want to understand why patients with brain arteriovenous malformations (AVM…

This study follows over 3,400 adults who have had a heart stent procedure to understand how continuity of care, health literacy, and medication adherence influence their long-term health. Researchers will track hospital readmissions, medication use, and patient-reported outcomes …

This study looks at how high blood pressure changes the heart's structure in people who work rotating shifts in the Arctic. Researchers will track 550 workers over a year using heart ultrasounds and blood tests. The goal is to understand why some develop heart failure, not to tes…

This study looks at whether an ultrasound measurement of a large vein near the heart (the inferior vena cava) can predict when a patient's blood pressure will drop dangerously during hip replacement surgery. Researchers will measure this vein's flexibility before cement is used t…

This study tests a short guide called the 'Jumpstart Guide' to help doctors have better conversations with dementia patients and their families about healthcare goals. Over 1,800 patients and their caregivers are taking part. Researchers will compare whether those whose doctors u…

This long-running study follows nearly 100,000 French women, mostly teachers, since 1990 to understand what factors influence their risk of cancer, heart disease, diabetes, and other major illnesses. Participants fill out questionnaires every few years about their lifestyle, medi…

This study tests whether a newer, less invasive heart-lung machine (MiECC) reduces brain swelling and stroke risk compared to the standard machine used during open heart surgery. Researchers will measure optic nerve sheath diameter (a marker of brain pressure) and track strokes o…

This observational study tracks 5,000 people taking common blood thinners (like rivaroxaban or apixaban) or antiplatelet drugs (like aspirin). Researchers regularly measure drug levels in the blood to see how they relate to clots or bleeding events. The goal is to find the best d…

This study follows 214 men treated for prostate cancer to see how many develop lower limb lymphedema (leg swelling) and who is most at risk. Participants attend check-ups every three months for 18 months. The goal is to better understand this side effect and its impact on quality…

This study looks at 90 people who recently had a heart attack and have other artery narrowings that may or may not be dangerous. Researchers will use two types of scans—optical coherence tomography (OCT) and magnetic resonance angiography (MRA)—to see if they can tell which narro…

This study compares a new X-ray system (Azurion R4.0) to an older version during heart procedures like angiography. The goal is to see if the new system lowers the radiation dose patients receive while still allowing doctors to work effectively. About 824 adults from several coun…

This study looks at how blood flow in the feet changes during a 12-week heart and blood vessel rehab program for people with narrowed arteries. Researchers will track 80 adults with conditions like peripheral artery disease or coronary artery disease. The goal is to better unders…

This study looks at how a common glaucoma eye drop (latanoprost with preservatives) changes the natural bacteria living on the eye's surface. Researchers will compare the eye bacteria of 45 newly diagnosed glaucoma patients before and after at least 6 months of treatment. The goa…

This study aims to create a tool that predicts which patients with inflammatory rheumatic diseases (like rheumatoid arthritis, vasculitis, or polymyalgia rheumatica) will develop serious side effects from long-term steroid use. Researchers will collect routine medical data—such a…

This study follows 350 people who survived a brain bleed (intracerebral hemorrhage) and were part of earlier trials. Researchers will test memory, thinking, and movement skills over time, and collect blood samples to look for signs of ongoing inflammation. The goal is to see if s…

This study collects tissue samples from 1,000 people having heart valve surgery to find genetic causes of calcific aortic valve disease. Researchers will compare normal and diseased tissue to understand why the disease develops. Participants must be at least 20 years old and have…

This study was designed to see if a device called AirGlove, which applies heat, could improve blood flow in the legs of people with peripheral arterial disease (PAD). It planned to include healthy volunteers and people with PAD who experience leg pain when walking. However, the s…

This study reviewed medical records of 1000 people who received a special balloon treatment (drug-coated balloon angioplasty) for blocked heart arteries between 2009 and 2015. Researchers tracked major heart problems like death, heart attacks, or need for repeat procedures for up…

This study looks at women who have had a heart attack or unstable angina but do not have major blockages in their heart arteries. Doctors will use special imaging techniques, like IVUS and MRI, to find hidden causes such as cholesterol plaque in artery walls or problems with tiny…

This study looks at 1,000 patients on blood thinners who had a minor head injury and a normal first CT scan. Researchers want to see if a second CT scan 24 hours later finds any delayed brain bleeding. The goal is to understand whether the extra scan is needed and how often it le…

This study uses advanced CT scans to look for fat and scar tissue inside the heart. Researchers want to see if these findings can help predict who is at risk for dangerous heart rhythms. About 110 adults with heart disease who already have a defibrillator or need one will get a C…

This study is enrolling 15,000 adults who are already scheduled for a coronary CT angiography (CCTA) scan. Researchers will analyze the scan images along with participants' health outcomes over time. The goal is to see if detailed information from the scans can help doctors more …

This study examines how different hospital treatments—sedation, temperature control, and blood pressure management—after a cardiac arrest impact kidney function. Researchers will follow 3500 adults who were resuscitated from a heart attack outside the hospital. The goal is to und…

This study looks at whether adding a stress CT scan that checks blood flow to the heart muscle helps doctors decide the best treatment for people with known or suspected heart disease. About 2000 adults will be followed to see if this extra test reduces the need for more tests an…

This study looks at whether using a mobile health app (called Penelope) is a cost-effective way to manage high blood pressure disorders during pregnancy. About 250 pregnant women at risk for conditions like preeclampsia will either use the app or track their health on paper. Rese…

This study looks for tiny plastic particles in brain tissue removed during surgery for spontaneous bleeding. Researchers will test if these plastics are linked to more inflammation and worse recovery in 150 patients. No new treatment is given; the goal is to understand if environ…

This study looks at whether a new care plan can help more people with pulmonary embolism (a blood clot in the lungs) go home from the emergency room instead of being admitted to the hospital. Researchers are working with 14 hospital ERs in Michigan to track changes in how often l…

This study tests a web-based tool called gp-multitool.de that helps general practitioners follow guidelines for older patients with multiple chronic conditions. About 659 patients from GP practices in Germany are taking part. The tool lets patients fill out questionnaires online …

This study aims to help adults aged 40 and older in Upper Manhattan get better eye care. It will offer free eye screenings at local health centers and senior centers, and provide support like scheduling appointments and transportation. The goal is to see if this extra help leads …

This study looks at 320 people with complex coronary artery disease who need a stent. It compares using a special camera (OCT) versus standard X-ray (angiography) to guide the stent placement. The goal is to see which method leads to better blood flow after the procedure.

This study looks at whether having a rehabilitation doctor see stroke patients early in their hospital stay can shorten how long they stay and reduce the chance of coming back. Researchers are tracking 3,000 stroke patients to see if this coordinated care approach improves recove…

This study looks at why people with antiphospholipid syndrome (APS) — a condition that raises blood clot risk — may have narrowed brain arteries. Researchers will use advanced MRI scans on 60 APS patients to check for artery narrowing and plaque buildup. The goal is to better und…

This study looks at whether low blood pressure during major noncardiac surgery harms organs like the heart and kidneys. Researchers are using a non-invasive brain monitor to see if a personalized blood pressure target can be set. 650 patients at cardiovascular risk are being obse…

This study looks at whether special imaging features from scans can help predict serious outcomes like amputation or death in people with peripheral artery disease (PAD) after they have had a procedure to open blocked leg arteries. Researchers will analyze 200 patients' scans to …

This registry follows 63 patients with choroidal melanoma or early eye lesions who were treated with the experimental drug bel-sar in earlier studies. The goal is to monitor long-term safety, side effects, and any spread of the disease over time. Participants are not receiving ne…

This study looks at how newer diabetes medications (SGLT2 inhibitors and GLP-1 receptor agonists) affect the eyes of people with type 2 diabetes. Researchers will monitor 40 adults who take metformin and are starting these newer drugs. The goal is to see if these drugs cause any …

This study collects data from 1,200 patients undergoing surgery for aortic dissection, a life-threatening tear in the heart's main artery. Researchers will track death rates, strokes, and other complications to identify the safest surgical strategies. The goal is to improve outco…

This study looks at whether brain scans can help predict which people with migraine will respond to a class of drugs called CGRP antibodies. Researchers used MRI to measure brain structure, activity, and blood flow in 219 adults with frequent migraine before and after 12 weeks of…

This study aimed to see if music therapy and mindfulness meditation could help people who had coronary artery bypass surgery improve their blood pressure, heart rate, anxiety, and depression. It planned to enroll 48 adults who had the surgery and were stable. However, the study w…

This study follows 500 people with peripheral artery disease (PAD) who undergo a procedure to open blocked leg arteries. Researchers check blood and heart ultrasound before and after the procedure to find hidden heart injury. The goal is to see if certain markers can predict futu…

This study looks at whether a special MRI scan can detect early scarring in the heart muscle of people with leaky heart valves. The goal is to find a way to predict when the heart might start to fail, so doctors can decide on surgery sooner. About 316 adults with moderate to seve…

This study follows 200 adults with high blood pressure and gum disease to see how gum health affects blood pressure and cholesterol levels over 6 to 12 months. Researchers will measure triglycerides and LDL cholesterol to understand the link. The goal is to learn whether treating…

This study uses brain scans to see how the brainstem and other brain areas respond to mild electrical pulses on the face and arm in 40 healthy volunteers. The goal is to better understand the brain circuits involved in facial pain and touch, which could help future research on mi…

This study looks at whether a program called I-SITE can help rural health clinics use teleophthalmology (remote eye exams) to screen more diabetic patients for eye problems. Up to 10 health systems and 10,000 patients will take part. The goal is to see if screening rates improve …

This study tests whether a swallowable camera capsule, controlled by magnets from outside the body, can safely and effectively examine the stomach and esophagus in 30 people preparing for weight loss surgery. Participants swallow the capsule after fasting, and a surgeon guides it…

This study is looking at whether an artificial intelligence tool can help doctors decide which heart surgery patients might benefit from a drug called ulinastatin. Ulinastatin is used to reduce inflammation after surgery, but it doesn't work for everyone. Researchers will analyze…

This study looks at 45 people having carotid artery surgery to see if special brain scans can predict improvements in thinking and memory. Researchers will use PET/CT scans to measure inflammation in the brain and MRI to examine plaque in the carotid artery. The goal is to find i…

This study tracks over 1,700 heart patients who had hip or knee replacement surgery. Researchers want to see how often bleeding or blood clots happen in the months after surgery. The goal is to find better ways to prevent these complications.

This study uses a special imaging device called optical coherence tomography (OCT) to look at blood vessels in vascular stains (a type of birthmark). Researchers want to see if the size and depth of these vessels relate to the birthmark's genetics. About 73 people with vascular s…

This study tests whether a tablet-based decision support system helps frontline health workers in India and Nepal provide better antenatal care. About 1,320 pregnant women will take part. The tool guides workers to check blood pressure, blood sugar, urine protein, and hemoglobin,…

This study uses data from over 30,000 Swedish adults to see if using snus (including newer white nicotine pouches) is linked to heart disease, metabolic problems, and poor mental health, independent of smoking. Researchers will compare current, former, and never-users using advan…

This study looks at how high-protein drinks affect certain blood cells (monocytes and platelets) that may play a role in heart disease. Ten healthy adults will drink either a low-protein, high-protein, or leucine-added meal, and researchers will check their blood for changes in c…

This study follows 2000 people who received the AFX2 system, a device to repair abdominal aortic aneurysms. Researchers will track complications like rupture, need for further procedures, and death over 5 to 10 years. The goal is to see how well the device performs in real-world …

This study looks at whether giving a personalized dose of a radioactive tracer (rubidium-82) based on a patient's weight can improve the quality of PET heart scans. Researchers will enroll 48 adults with known or suspected heart disease and divide them into four weight groups. Th…

This study collects movement data from 250 people with stroke, Parkinson's disease, or leg amputations using wearable sensors and video. The goal is to build an online database that researchers can use to study how people move and recover. No treatments are being tested—this is p…

This study looks at whether brothers, sisters, and children of people who have had an abdominal aortic aneurysm are more likely to develop one themselves. Researchers will analyze health records from nearly one million people in Sweden. The goal is to better understand how family…

This study is not testing a new drug, but rather doing the early science needed to develop one. Researchers are looking for the right targets (antigens) on adrenocortical carcinoma cells and studying how the tumor suppresses the immune system. The goal is to find a way to create …

This study looks at whether blood flow restriction training (using tight bands on the legs during exercise) can improve walking in people who had a stroke at least 6 months ago. 40 participants, aged 40-65 with mild leg stiffness, will do resistance exercises with or without bloo…

This study looks at whether two simple, non-invasive tests can predict when a patient's blood pressure will drop dangerously during shoulder surgery performed in the 'beach chair' position (sitting upright). The tests are a finger sensor that measures blood flow and an ultrasound…

This study follows 400 people with adrenocortical carcinoma who are taking mitotane as their first treatment. The goal is to carefully record all side effects, including ones that are not well understood. By collecting this data, researchers hope to improve how side effects are m…

Most stroke survivors struggle to stay physically active after rehab, raising their risk of another stroke. This study works with survivors, carers, and staff to design a program that supports long-term activity. 34 participants will help shape and test the program.

This study looks at whether giving extra support to community health centers helps them screen patients for non-medical needs like food or housing and refer them to community resources. Twenty health centers will be randomly assigned to get this support or not. The goal is to see…

This study looks at whether a computer model can predict heart injury after major orthopedic surgery in patients 65 and older. Researchers will combine blood tests, frailty scores, and other health data to build a machine learning tool. The goal is to help doctors spot high-risk …

This study looks at how a special heart device (BackBeat CNT) affects nerve activity in 15 people with high blood pressure who already have the device implanted. Researchers measure nerve signals and blood pressure with and without the device turned on. The goal is to understand …

This study is closely watching heart and lung changes in extremely low birth weight babies (under 1000 grams) during their first week of life. Researchers want to understand why some preemies develop low blood pressure and related complications. By using standard and new monitori…

This international registry is collecting information from 2000 people who have had spontaneous coronary artery dissection (SCAD), a rare cause of heart attacks. Researchers will track participants' health over time to better understand the condition and develop best practices fo…

This study is a large international registry that will collect data from up to 130,000 people who have had a heart attack or unstable chest pain. Researchers will track treatments, outcomes, and safety to understand what works best in real-world care. No new drugs or devices are …

This study tests whether adding automatic reminders to echocardiogram (heart ultrasound) reports can increase the number of patients with heart valve disease who see a cardiologist within six months. Researchers will randomly assign 300 patients' reports to receive no prompt, a p…

This study looks at whether adding simple family history questions to a standard bleeding questionnaire can better identify children who truly have mild bleeding disorders. Researchers will review data from 1,000 children seen at a clinic since 2019. The goal is to see if this co…