Is 'Safe' snus actually safe? 30,000-Person study aims to find out

NCT ID NCT07573319

Ongoing Knowledge-focused Sponsor: Karolinska Institutet Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study uses data from over 30,000 Swedish adults to see if using snus (including newer white nicotine pouches) is linked to heart disease, metabolic problems, and poor mental health, independent of smoking. Researchers will compare current, former, and never-users using advanced imaging and blood tests. The goal is to clarify the mixed evidence on snus safety.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: snus (including white nicotine pouches)
What this could lead to: If clear links are found, this could guide public health advice and regulation around snus use, especially for young people and women.
What could go wrong: This is an observational study, so it cannot prove cause and effect. Results may be influenced by other lifestyle factors not fully accounted for.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

atherosclerosis Depression metabolic disease nicotine dependence Psychological Well-Being

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARDIOVASCULAR (CV) RISK MENTAL HEALTH METABOLIC ABNORMALITIES NICOTINE

Contacts and locations

Locations

Göteborg Universitetssjukhus

Gothenburg, Sweden
Karolinska Institutet Danderyds Sjukhus

Stockholm, Sweden
Skanes Universitetssjukhus, Lund Universitet

Lund, Sweden
Umeå Universitetssjukhus

Umeå, Sweden
Uppsala Universitetssjukhus

Uppsala, Sweden

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