Vascular disorder

This trial tests whether a drug called carfilzomib, given directly to the liver through an implanted pump, is safe for people whose colon, adrenal, or bile duct cancer has spread to the liver and persists after prior pump therapy. Participants receive weekly infusions of the drug…

This study tests whether huperzine A, an injected drug, can help prevent or reduce memory and thinking problems that often follow surgery for a bleeding brain aneurysm. Adults aged 18-70 who had an aneurysm bleed and underwent endovascular or surgical treatment will receive eithe…

This Phase 3 trial is testing whether a microneedle pad delivering botulinum toxin A can improve symptoms of Raynaud's phenomenon and digital ulcers in people with systemic sclerosis. The study compares the microneedle treatment to a placebo, measuring changes in finger temperatu…

This trial tests whether a non-invasive brain stimulation technique, called transcranial temporal interference stimulation, can improve swallowing in adults who have difficulty swallowing after an ischemic stroke. Participants will receive either active or sham stimulation combin…

This trial tests whether epidural spinal cord stimulation can help people with severe brain injury breathe without a ventilator. Ten patients with stroke or traumatic brain injury who need mechanical ventilation will receive a surgically implanted electrode that delivers electric…

This trial is testing a new stent graft system designed to treat abdominal aortic aneurysms—a bulging, weakened area in the main artery. The device is placed inside the aorta to reinforce the wall and prevent rupture. The study includes adults with infrarenal abdominal aortic ane…

This trial is testing whether preparing a blocked leg artery with a special 'scoring' balloon before using a drug-coated balloon improves outcomes compared to using a standard balloon. The study involves people with severe leg artery disease (critical limb-threatening ischemia) w…

This trial investigates whether combining two behavioral therapies can help people with non-fluent aphasia—a condition where stroke damages the brain's language centers, making speech difficult. The approach uses Melodic Intonation Therapy (MIT), which uses singing-like intonatio…

This trial tests whether icosapent ethyl, a purified form of fish oil, can stabilize high-risk coronary plaques in people with heart disease. Participants have plaques that narrow a major heart artery by 30–70% and show at least one high-risk feature on a CT scan. Half will take …

This study tests whether a single infusion of eptinezumab, given within 8 weeks of a mild brain injury, can reduce headache days and prevent short-term post-traumatic headaches from becoming long-term. About 80 adults with migraine-like post-traumatic headaches will receive eithe…

This trial tests a 1-month nurse-led program designed to help older adults with coronary heart disease and frailty reduce their daily sitting time. Participants are randomly assigned to either the program or a control group, and the program uses education, goal setting, self-moni…

This trial tests whether adding lumbrokinase, an enzyme derived from earthworms, to standard aspirin treatment can improve recovery in people who have had a moderate-to-severe ischemic stroke. Participants receive either lumbrokinase capsules or a placebo, along with aspirin, for…

This trial tests whether citicoline, a compound that may support brain cell repair, can improve outcomes in newborns with hypoxic-ischemic encephalopathy (HIE) — brain injury from oxygen deprivation at birth. About 86 infants with signs of birth asphyxia will receive either citic…

This trial tests whether aspirin and a non-invasive physical therapy called ischemic conditioning can slow the progression of moyamoya disease, a rare brain vessel disorder that can cause strokes and cognitive decline. The study enrolls adults with moyamoya disease or syndrome wh…

This early-stage trial tests whether transplanting gut bacteria from healthy donors, along with antibiotics and fiber, is safe and feasible for people with pulmonary arterial hypertension (PAH), a condition of high blood pressure in the lungs. About 24 adults with PAH will be ran…

This study tests a new, drug-free treatment for people having an ischemic stroke (a clot blocking blood flow to the brain). The treatment uses blood pressure cuffs on the arms and inflatable leg sleeves to temporarily reduce blood flow in the limbs, which may trigger the body to …

This study tests a special stent (a small mesh tube) placed in veins to treat blockages, narrowing, or leg ulcers caused by poor blood flow. About 150 adults will receive the stent and be followed to see if it keeps the vein open and safe. The goal is to improve blood flow and re…

This study tests a 6-month program where patients work with a pharmacist and their primary care doctor to make shared decisions about medications and lifestyle. The goal is to see if this team-based approach improves heart and kidney health scores and medication adherence. The st…

This trial asks whether adding motor imagery—mentally rehearsing hand movements without physically moving—to robot-assisted hand rehabilitation can improve daily living skills in people recovering from stroke. Forty participants will be randomly assigned to receive either robot-a…

This study tests whether giving the seizure medicine levetiracetam right after a brain bleed (intracerebral hemorrhage) can prevent seizures and improve long-term recovery. About 580 adults will receive either the drug or a placebo for up to 7 days, and their level of disability …

This study tests whether adding stem cells to standard cooling therapy helps newborns with brain injury from lack of oxygen at birth. Forty infants will receive either stem cells from donated placentas or a placebo. Researchers will track death and developmental delays for up to …

This trial tests whether a low-sodium diet can improve blood pressure control in people who had a hypertensive disorder of pregnancy. Participants receive either a provided diet with less than 2000 mg of sodium per day or a standard diet with no salt restrictions for the first we…

This study looks at whether switching to a higher-dose eye injection called aflibercept 8 mg can allow people with neovascular age-related macular degeneration (nAMD) or diabetic macular oedema (DME) to go longer between treatments. It follows adults in Portugal who have already …

This trial tests whether a simple, non-invasive technique called remote ischemic preconditioning (RIPC) can reduce brain damage after an aneurysmal subarachnoid hemorrhage, a severe type of stroke. The procedure involves briefly inflating a blood pressure cuff on the leg to restr…

This trial tests whether adults with pulmonary arterial hypertension (PAH) can safely switch from selexipag, a pill taken by mouth, to LIQ861, an inhaled form of treprostinil. Participants stop selexipag on day one and start taking LIQ861 four times a day using a handheld inhaler…

This trial tests three experimental antibodies—REGN9933, REGN7508, and REGN9533—in people with end-stage kidney disease who are on hemodialysis. The goal is to see if these antibodies can safely reduce blood clot risk during dialysis, potentially offering an alternative to standa…

This trial is testing a new medical device called FRED X, designed to treat brain aneurysms—weak spots in blood vessels that can bulge and potentially rupture. The study will enroll about 15 people with a single untreated aneurysm to see if the device, used with blood-thinning me…

This study tracks the safety and effectiveness of J&J MedTech devices used to remove blood clots in people with acute ischemic stroke. It will follow about 5,000 adults who receive these devices as part of their routine care, measuring how well blood flow is restored and how pati…

This trial investigates whether adding tirofiban, a fast-acting anti-clotting drug, to standard aspirin treatment can improve recovery in people who have had a moderate ischemic stroke. Participants receive either tirofiban or a placebo, both with aspirin, within 24 hours of stro…

This pilot study tests a 6-session lifestyle program for people with high blood pressure, where each participant brings a supportive partner. The program covers heart-healthy habits like diet, exercise, stress management, and sleep, along with communication skills to help partner…

This trial tests whether an experimental drug called CS1, taken as a daily pill, can improve blood vessel function in people with pulmonary arterial hypertension (PAH), a condition where high blood pressure in the lungs makes the heart work harder. Participants will receive CS1 o…

This trial tests whether giving praziquantel three times a year, instead of the standard once a year, can improve liver fibrosis (scarring) caused by schistosomiasis in people aged 15-40 in Uganda. Participants with liver fibrosis will be randomly assigned to one of two treatment…

This trial tests whether using a portable ultrasound device during coronary artery bypass surgery can improve outcomes by letting surgeons see blood flow through the new grafts in real time. About 380 adults scheduled for elective bypass surgery will be randomly assigned to eithe…

This trial compares three different embolic materials—particles, liquid embolics, and coils—used during a procedure called middle meningeal artery embolization to treat chronic subdural hematoma, a type of bleeding on the brain's surface. The study will enroll 30 adults undergoin…

This phase 2 trial tests whether propranolol, a drug usually used for high blood pressure, can treat Kaposi sarcoma. About 25 children and adults will take propranolol pills for up to 24 weeks. Researchers will measure how many participants see their tumors shrink or disappear, a…

This trial tests whether combining nurse-delivered care with text message check-ins and support can help adults with uncontrolled high blood pressure lower their blood pressure and improve diabetes management. Participants receive either usual care or the enhanced support, which …

This study tests whether motor cortex stimulation – a device that sends mild electrical pulses to the brain's movement area – can reduce chronic pain after a stroke that affects the thalamus. Participants who do not get relief from standard pain treatments will have electrodes te…

This trial tests whether Cerebrolysin, given after a procedure to remove a blood clot from the brain, can reduce tissue damage and improve recovery in people with acute ischemic stroke. The study involves 100 adults aged 18 to 80 who undergo successful clot removal within 6 to 24…

This phase II trial is testing whether an experimental drug called LT3001 can help people who have had an acute ischemic stroke, which happens when a blood clot blocks blood flow to the brain. The study will include about 300 participants who receive either a high or low dose of …

This study tests whether giving creatine monohydrate, a popular sports supplement, twice a day for 12 weeks is safe and practical for children and teenagers recovering from a moderate-to-severe brain injury, including traumatic brain injury or stroke. The trial will enroll 46 par…

This trial is testing a device called the Heli-FX EndoAnchor system, which is used during minimally invasive repair of abdominal aortic aneurysms (a bulging, weakened area in the main artery). The device helps secure the stent graft in place, potentially preventing leaks or movem…

This trial tests whether a powered leg exoskeleton called ZEPU AI9 can safely and effectively help people with walking difficulties caused by stroke, incomplete spinal cord injury, or orthopedic surgery. Participants will be randomly assigned to receive either exoskeleton-assiste…

This pilot trial is testing a smartphone app that acts like a personal coach to help adults with uncontrolled high blood pressure improve their self-care. The app provides education and interactive coaching to encourage medication adherence and healthy habits. The study will enro…

This study tests whether a procedure called proximal splenic artery embolization (PSAE) can reduce the need for repeated fluid drainage in adults with cirrhosis and ascites that no longer responds to water pills and diet. Participants will undergo a one-time procedure where small…

This study tests NeoMayor, a smartphone app that gives personalized advice on exercise, diet, sleep, and mood to improve heart health. Researchers will enroll 240 adults aged 55 to 75 in Chile who are at risk for heart problems. Participants use the app for 4 months, and some als…

This observational study is looking at whether Ferretab comp., an oral iron and folic acid supplement, can improve anemia and heart-related symptoms in adults who also have coronary artery disease or heart failure. Participants take the supplement for 12 weeks as part of their us…

This trial is testing whether a new heart valve device, called Myval, can safely and effectively treat people with severe aortic regurgitation—a condition where the heart's aortic valve doesn't close properly, causing blood to leak backward. The study involves about 164 adults wh…

This study tests the safety of a new medicine called sotatercept for adults in India with pulmonary arterial hypertension (PAH), a condition where blood vessels in the lungs become narrow, making breathing hard. About 30 people will receive sotatercept along with their usual trea…

This phase 3 trial is testing whether Angong Niuhuang, a traditional Chinese medicine, can improve recovery in people who have had a bleeding stroke (intracerebral hemorrhage). About 1,100 adults who are eligible for non-surgical management will receive either the herbal pill or …

This study tests a new laser system designed to vaporize plaque in blocked coronary arteries before doctors place a stent. The trial compares the new laser device to an existing one in about 218 people with severe heart artery narrowing. The main goal is to see if the new system …

This trial tests whether faricimab, an eye injection, can improve vision and reduce swelling in South Asian patients with diabetic macular edema (DMO), a complication of diabetes that can lead to blindness. Previous studies mostly included Caucasian or East Asian participants, le…

This Phase 3 trial will test whether a combination of three cholesterol-lowering drugs—bempedoic acid, ezetimibe, and a high-intensity statin—can reduce and stabilize plaque buildup in the coronary arteries. The study enrolls 103 adults with coronary atherosclerosis who have neve…

This trial tests whether the Adacolumn device, which filters certain white blood cells from the blood, can reduce brain swelling in people who have had a severe stroke. Ten patients will receive the treatment within 24 hours of their stroke. The goal is to see if it prevents wors…

This trial tests whether rimegepant, a newer migraine medication, works as well as flunarizine, an older preventive, for reducing days with moderate-to-severe dizziness in people with vestibular migraine. About 400 adults aged 18 to 75 will take one of the two drugs daily for 12 …

This study tests whether a special clinic where heart, kidney, diabetes, and liver doctors work together can help people with type 2 diabetes and heart disease get better control of their blood pressure and cholesterol. About 150 adults will be randomly assigned to either usual c…

This trial is testing two experimental versions of a blood pressure drug, called D311 and D107, against the original medication, CKD-339. Healthy adults aged 19 to 55 will receive a single dose of each version in a random order to compare how the drug is absorbed and processed in…

This trial tests whether giving empagliflozin before or after a procedure to open a blocked heart artery (primary PCI) reduces heart muscle injury during a heart attack. Adults aged 18-75 of South Asian origin having their first heart attack will be randomly assigned to receive e…

This trial tests whether robotic devices that guide arm and leg movements can safely improve strength, coordination, and daily function in adults with movement problems from stroke, spinal cord injury, brain injury, or orthopedic conditions. Participants will use the devices thre…

This trial tests whether giving adolescent girls a daily multiple micronutrient supplement (with or without extra nutrients) improves their growth, brain function, bone health, and overall well-being compared to the standard weekly iron-folic acid pill. About 3,000 girls aged 10–…

This trial tests whether adding robotic rehabilitation devices to standard physiotherapy can improve arm and leg function in adults with movement problems from stroke, spinal cord injury, traumatic brain injury, or orthopedic surgery. Participants will receive robotic-assisted se…

This phase 3 trial is testing whether giving a clot-busting drug before mechanical thrombectomy (a procedure to physically remove a blood clot) improves outcomes for people with severe strokes caused by large vessel occlusion. Participants are randomly assigned to receive tenecte…

This study looks at whether giving people with high blood pressure and food insecurity $100 a month for fruits and vegetables can improve their health. It focuses on Native Hawaiian and Pacific Islander adults in Hawaii. Some participants will also get one-on-one help from a comm…

This trial tests whether treating high blood pressure in pregnancy to a stricter target (below 140/90) is better than the usual approach (below 160/110) for women with gestational hypertension or preeclampsia without severe features. About 4,120 pregnant women will be randomly as…

This trial tests whether a minimally invasive heart bypass surgery, done through a small incision on the left side of the chest, helps frail adults aged 60 and older recover better than the traditional approach of opening the breastbone. Participants are randomly assigned to one …

This phase 3 trial tests whether an experimental oral drug called engasertib can reduce the number of nosebleeds in adults with moderate to severe hereditary hemorrhagic telangiectasia (HHT), a genetic condition that causes abnormal blood vessels and frequent bleeding. About 240 …

This trial tests a new device called the Angimis Atherectomy System, which uses laser energy to break up plaque in coronary arteries that are too narrow or hardened for standard balloon or stent procedures. The study enrolls adults with coronary artery disease who have at least o…

This trial compares two methods for closing the main artery in the leg after a TAVI procedure, which replaces a heart valve without open surgery. Half of the participants will have the artery closed with a single suture device, while the other half will receive a hybrid approach …

This phase 2 trial is testing whether a new drug called obinutuzumab beta, combined with a short course of steroids, can help people with newly diagnosed ANCA-associated glomerulonephritis—a rare autoimmune disease that causes kidney inflammation and damage. The study will enroll…

This study tests a device called TricValve for people with severe tricuspid regurgitation, a condition where a heart valve leaks. The device is implanted in the veins to help blood flow better. About 780 participants will be randomly assigned to get the device plus standard medic…

This trial tests whether dapagliflozin, a drug used for diabetes, can improve blood flow in the tiny vessels of the heart in people with angina (chest pain) but no blocked coronary arteries. Participants will take either dapagliflozin or a placebo daily for 180 days. The study me…

This trial is testing an experimental drug called NTS-521, given as an intravenous infusion, to see if it can help people recover better after an acute ischemic stroke. The study will include about 140 adults aged 45 to 80 who have moderate to severe weakness on one side of the b…

This phase 2 trial is testing whether the drug ivonescimab can help control advanced or metastatic adrenal cancers, specifically adrenocortical carcinoma (ACC) and pheochromocytoma/paraganglioma (PPGL), that have not responded to prior treatment. About 20 adults with these rare c…

This trial compares two surgical implants—the Baerveldt Glaucoma Implant and the Paul Glaucoma Implant—in people with glaucoma that is not well controlled by eye drops. Both devices are tiny tubes placed in the eye to drain fluid and lower pressure. The study will track which imp…

This study tests a stent (Carotid WALLSTENT) used with a special brain protection system (ENROUTE NPS) in 60 Chinese patients with narrowed carotid arteries. The goal is to see if the combination can be safely delivered to prevent strokes. Patients must have significant artery na…

This pilot study tests whether a virtual-reality system controlled by muscle activity can help improve arm and hand movement in people recovering from stroke or spinal cord injury. Participants use a wearable device that detects muscle signals through sensors on the skin and prov…

This trial tests whether adding a robotic leg-training device (ZEPU-AI5) to standard rehab can safely improve walking, strength, and balance in adults aged 18–60 with lower-limb problems from stroke, incomplete spinal cord injury, or orthopedic surgery. Participants will receive …

This study tests a robotic device called ZEPU-AI1 that helps people with leg weakness practice standing and walking. The trial includes adults aged 19 to 60 who have walking problems from stroke, spinal cord injury, or orthopedic surgery. Half of the participants will use the rob…

This study tests whether combining a gentle nerve stimulation device worn on the ear (taVNS) with intensive arm therapy (CIMT) can help infants and toddlers (8–24 months) with perinatal brain injury improve movement in their weaker arm and hand. The therapy involves placing a mit…

This trial compares two ways of giving tranexamic acid, a drug that reduces bleeding, to adults undergoing off-pump coronary artery bypass surgery. Half receive the drug as a pill before surgery, while the other half get it through an IV during surgery. The goal is to see if the …

This trial is testing whether an experimental drug called HRS-4029 can improve outcomes for people who have had an acute ischemic stroke, which happens when a blood clot blocks blood flow to the brain. The study will compare the drug against a placebo in about 340 participants wh…

This pilot study tests whether adding dipyridamole, an approved drug that improves blood flow, to standard care is feasible and safe for pregnant women with early-onset preeclampsia. The trial will enroll 15 hospitalized women between 26 and 34 weeks of pregnancy with high levels…

This trial asks whether people with severe aortic stenosis can safely go home the same day after a minimally invasive heart valve replacement (TAVI) instead of staying in the hospital. About 764 patients who are stable six hours after the procedure will be randomly assigned to ei…

This trial tests whether wearing a portable heart monitor for two weeks after a TAVI procedure can reduce the risk of sudden death, dangerous heart rhythms, or stroke within the following year. People who have had a successful TAVI and show certain electrical abnormalities on the…

This pilot trial asks whether adding a robotic hand-training device to standard rehabilitation is safe, practical, and helpful for people with arm and hand motor problems caused by stroke, incomplete spinal cord injury, traumatic brain injury, or orthopedic conditions. Participan…

This trial investigates whether semaglutide, a GLP-1 agonist, can shift how the heart produces energy in people with pulmonary arterial hypertension (PAH). The heart in PAH often relies on inefficient fuel sources, and the drug may help it switch to a more efficient form. Researc…

This study tests whether a supervised group exercise program, called EINTER, can improve muscle strength and walking ability in adults recovering from stroke. The program combines cycling and strength training, tailored to each person, and runs for up to four weeks. Researchers w…

This trial tests whether heart attack patients who have had complete artery-opening procedures can safely stop aspirin after 3-6 months and continue with only a P2Y12 inhibitor. The goal is to see if this approach reduces bleeding problems without increasing the risk of another h…

This registry follows adults newly diagnosed with pulmonary arterial hypertension (PAH) who are starting treatment with parenteral treprostinil, a medication given as a continuous infusion under the skin or into a vein. Researchers will collect data from routine care—including do…

This trial investigates whether adding a PCSK9 inhibitor to a high-intensity statin can reduce liver fat—measured by a non-invasive FibroScan—in diabetic patients who have recently had a heart attack or unstable angina. Half the participants will receive the combination therapy, …

This study tests a new biological graft, LineMatrix®, for replacing or bypassing damaged arteries in the lower body. About 15 adults with peripheral artery disease or other artery damage will receive the graft during surgery. Researchers will track how well the graft stays open w…

This trial investigates whether tirzepatide, a drug approved for diabetes and obesity, can improve recovery in people who have had a severe stroke caused by a large artery blockage. Participants receive two injections of tirzepatide—one before a clot-removal procedure and another…

This trial tests whether a hybrid cardiac telerehabilitation program — combining in-person sessions, live video workouts, and remote monitoring — can improve adherence to exercise rehab in people with coronary artery disease or stable heart failure. Participants are randomly assi…

This trial tests whether a 3-month dietary program, called the Eastern Blood Pressure-Lowering Diet, can improve blood pressure in Chinese adults with hypertension. About 800 participants from workplace canteens will either receive standard hypertension care or also get specially…

This trial tests whether angiotensin receptor blockers (ARBs), a type of blood pressure medication, can reduce the risk of death or heart failure in people who have had a transcatheter aortic valve replacement (TAVR) for severe aortic stenosis and still have a thickened heart mus…

This phase 3 trial compares an experimental drug, tabirafusp tedromer, against the standard treatment aflibercept for people with diabetic macular edema (DME), a leading cause of vision loss in diabetes. About 910 adults with DME will receive injections into the eye and be follow…

This trial explores whether starting transdermal estradiol (a skin gel or patch) soon after menopause can protect the heart and brain in women who have hot flashes and at least one cardiovascular risk factor. One hundred women will be randomly assigned to receive the hormone ther…

This trial is testing a new device called the Crea Aortic Valve, a replacement heart valve that can be implanted through a catheter without open-heart surgery. It is designed for people aged 60 and older with severe aortic stenosis—a narrowing of the heart's main valve—who are co…

This trial tests whether a telemedicine program can help Black patients with high blood pressure get better control. The program includes home blood pressure monitoring, medication management, and support from pharmacists, nurses, community health workers, and social workers. Res…

This study tests whether a robotic device called ZEPU-AI3 can safely help people with lower limb weakness from stroke, spinal cord injury, or orthopedic surgery improve their walking. Participants receive either standard rehabilitation alone or standard rehab plus robot-assisted …

This trial tests whether a lab-grown, tissue-engineered blood vessel can be safely used as a bypass graft in people with coronary artery disease undergoing heart bypass surgery. Ten participants will receive the artificial vessel alongside a standard graft, and researchers will m…

This study compares two ways to guide a minimally invasive procedure that opens blocked arteries below the knee in people with chronic limb-threatening ischemia, a severe form of peripheral artery disease. One group receives standard X-ray guidance (angiography) alone; the other …

This pilot study tests the drug ivonescimab in people with advanced or metastatic cutaneous angiosarcoma, a rare and aggressive skin cancer. Participants must have already received chemotherapy with paclitaxel or docetaxel. The study aims to see if ivonescimab is safe and can shr…

This study tests whether adding a drug called firsekibart to the standard treatment (IVIG and aspirin) can better prevent coronary artery damage in children with Kawasaki disease. Kawasaki disease causes inflammation in blood vessels, especially those supplying the heart, and can…

This trial investigates whether a specific type of breathing exercise — functional inspiratory muscle training — can improve walking patterns in people who had a stroke more than six months ago. Sixty participants will be randomly assigned to either this new training or conventio…

This phase 2 trial tests whether an experimental oral drug, SAL0137, can safely lower high levels of lipoprotein(a) — a genetic risk factor for heart attacks and strokes that currently has no approved medication. About 120 adults with elevated Lp(a) and high cardiovascular risk w…

This trial tests whether adding either high-repetition task-oriented training or high-intensity gait training to standard neurodevelopmental therapy helps people with chronic stroke walk farther and move more easily. Forty-five participants who had a stroke at least six months ag…

This trial tests whether a 9-month program called STEP COACH can help people with coronary artery disease stay physically active after completing cardiac rehab. Participants use their own smartwatch or smartphone to track steps and receive coaching on increasing both step volume …

This pilot study is testing whether a smartphone app called HeartMate can help people with heart disease manage their condition from home. Over six weeks, participants use the app for daily heart checks, guided exercise, breathing training, and a mind program, with weekly coachin…

This study tests a new device called the Laplace Transcatheter Tricuspid Valve Replacement (TTVR) System for people with severe tricuspid regurgitation, a condition where the heart's tricuspid valve leaks blood backward. The device is placed through a catheter, avoiding open-hear…

This study looks at whether using a smartphone app to guide slow breathing, combined with aerobic exercise, can help lower blood pressure in people with essential hypertension. Seventy-five adults aged 40-50 with stage 1-2 hypertension will be split into three groups: breathing p…

This trial tests whether adding an oral Chinese herbal formula called Tongluo Huayu to standard care (eye injections and laser therapy) can improve vision and reduce retinal swelling in people with retinal vein occlusion. Eighty participants will receive either standard treatment…

This trial tests whether a TeleStroke network can help peripheral hospitals in Oman safely give clot-busting drugs (alteplase or tenecteplase) to people having an acute ischemic stroke. A remote neurologist will assess patients via video, review scans, and guide the local medical…

This study compares two blood-thinning medicines given after delivery to prevent dangerous blood clots: apixaban (a pill taken twice a day) and enoxaparin (a daily shot). The trial enrolls women at high risk for clots after vaginal or cesarean birth. The main goal is to see which…

This trial tests whether giving high-concentration oxygen during a clot-removal procedure can improve recovery for people having a major stroke who arrive at the hospital 6 to 24 hours after symptoms began. Participants are randomly assigned to receive either the oxygen therapy o…

This study tests whether the drug vericiguat can slow the buildup of calcium on the aortic valve in people with mild-to-moderate aortic valve stenosis. Participants take vericiguat or a placebo daily for 24 months, with regular heart scans to track valve calcium and function. The…

This study tests a new type of bypass graft made from a biodegradable polymer for people with peripheral artery disease who need leg bypass surgery. The graft is designed to restore blood flow and then gradually be replaced by the body's own tissue. The trial will enroll 15 parti…

This study tests whether sending patients home on the same day of surgery, with follow-up care via phone calls, home visits, and a mobile app, is as safe and less costly than keeping them in the hospital overnight. The trial includes adults in Uganda having low-risk procedures su…

This trial investigates whether maintaining a higher blood pressure (85 mmHg or above) during surgery can reduce the risk of postoperative delirium—a sudden confusion that can occur after surgery—in older adults (65+) with high blood pressure. About 3,400 participants having non-…

This study compares two innovative therapies—immersive virtual reality and proprioceptive neuromuscular facilitation (PNF)—against standard physical therapy for improving quality of life in people who had a stroke at least six months ago. Participants will complete 12 sessions ov…

People who have spine surgery for cancer that has spread are at high risk for dangerous blood clots in the legs or lungs. Currently, blood-thinning medicine is stopped when patients leave the hospital. This trial tests whether taking apixaban (Eliquis) by mouth for 30 days after …

People living with HIV have twice the risk of heart attacks and stroke compared to the general population. This trial tests whether integrating clinical pharmacists into HIV care can improve blood pressure control and reduce cardiovascular disease risk. The study enrolls 450 adul…

This study looks at whether a minimally invasive surgical procedure can help people with a spontaneous deep brain hemorrhage (bleeding in the basal ganglia) recover better than standard medical treatment alone. Researchers will follow 300 adults for 180 days, measuring survival, …

This study investigates whether two common vaccines—the shingles vaccine (RZV) and an RSV vaccine (RSVPreF3)—can slow the buildup of fatty plaque in the coronary arteries. The trial enrolls adults aged 50 and older who are at risk for cardiovascular events. Participants receive e…

This study compares two surgical techniques for hemorrhoids: Doppler-guided artery ligation alone versus the same procedure combined with mucopexy (stitching up the prolapsed tissue). Researchers will measure pain levels and the sensation of incomplete evacuation (tenesmus) in 15…

This phase 2b trial tests whether injecting allogeneic neural stem cells (CC-101) into the brain near a prior stroke lesion can improve motor function in adults with chronic ischemic stroke and lasting movement problems. About 36 participants will receive either stem cells plus s…

This study tests an experimental drug called HRS-1780 in people with uncontrolled or resistant hypertension—high blood pressure that stays high despite treatment. The trial compares three different doses of HRS-1780 against a placebo to see if it safely lowers blood pressure. Par…

This study tracks how well the FLOWRUNNER Aspiration System removes symptomatic blood clots from veins in the arms or legs during routine care. About 218 adults with deep-vein clots will be followed to see if the device safely restores blood flow and reduces clot-related disabili…

This trial tests whether the drug sebetralstat can prevent swelling attacks in people with hereditary angioedema (HAE) when taken before a medical procedure. Participants aged 12 and older with HAE type I or II will take sebetralstat just before their scheduled procedure. The mai…

This trial tests whether a liquid called Theravex can improve healing and stability when a dental implant is placed right after a tooth is pulled. Theravex is applied directly into the gap between the implant and the bone socket to stimulate bone growth. Researchers compare it to…

This study investigates whether Songling Xuemaikang capsules, a traditional Chinese herbal formula, can help people with both high blood pressure (hypertension) and insomnia. About 260 adults aged 18–79 with mild hypertension and sleep difficulties will take either the herbal cap…

This pilot study tests whether a program called GRIP—which combines a soft robotic glove with a virtual reality system—can help adults recovering from a recent stroke improve hand and arm function. About 20 participants in inpatient rehabilitation will be randomly assigned to rec…

This trial tests whether tocilizumab, an anti-inflammatory drug, can stop the progression of calciphylaxis—a rare condition where calcium buildup blocks skin blood vessels, causing painful, non-healing wounds. Ten adults with calciphylaxis and end-stage kidney disease will receiv…

This phase 3 trial tests whether an experimental drug called MK-8748 can treat diabetic macular edema (DME), a condition where fluid builds up in the retina and blurs vision. About 960 adults with DME will receive either MK-8748 or the standard treatment aflibercept via eye injec…

This study tests whether people with pulmonary arterial hypertension (PAH) who are doing well on the drug sotatercept can safely stop their background prostacyclin therapy. Prostacyclin drugs can cause side effects and are hard to manage. The trial compares patients who slowly st…

This study tests whether secukinumab, a drug that blocks inflammation, can reduce the risk of major heart problems and kidney decline in people with cardiorenal metabolic syndrome and hardened arteries. About 100 adults will receive either secukinumab injections plus standard car…

This phase 3 trial compares an experimental drug, MK-8748, to the standard treatment aflibercept for diabetic macular edema (DME), a condition where fluid buildup in the retina blurs vision. About 1,100 adults with diabetes and vision loss from DME receive either MK-8748 or aflib…

This study tests a 3-month home program for people aged 50+ who recently had a stroke and are returning home. The program combines guided stepping training with tips to reduce long periods of sitting. Researchers measure changes in daily steps, mobility, and disability over 12 mo…

This trial investigates whether AI-assisted written patient information, given alongside standard medical treatment, helps adults with mild to moderate hemorrhoids follow their treatment plan more completely. Participants receive either standard verbal counseling or an AI-generat…

This study tests a multilevel care model designed to help low-income adults with hard-to-control hypertension. The model combines patient education, electronic health record alerts for providers, and support from community health workers. Researchers will measure changes in blood…

This study tests whether a patient navigator — a trained staff member who helps connect people with health services — can improve long-term heart health for those who had high blood pressure disorders during pregnancy. About 60 participants will be randomly assigned to receive ei…

This study investigates whether a standardized microsurgical procedure can safely and effectively remove large spontaneous brain hemorrhages (bleeds) located near the brain's surface. The procedure uses a microscope and computer guidance to evacuate the clot, with the goal of lea…

This trial tests whether a wearable hand robot, used at home with remote therapist support, is a feasible way to deliver intensive hand therapy to people who had a stroke at least six months ago. Participants will either use the robot for 12 weeks or receive the same amount of st…

This study tests whether a specially formulated omega-3 supplement, with a high ratio of EPA to DHA, can reduce inflammation and improve blood vessel function in people with pulmonary arterial hypertension (PAH). Participants take four capsules daily for 12 weeks alongside their …

This trial investigates whether photobiomodulation—applying low-level laser light to the surgical wound—can improve healing and reduce complications after coronary artery bypass grafting (CABG). It compares two methods of harvesting the saphenous vein (the conventional technique …

This study explores whether measuring a hormone called renin can help doctors choose the best first medication for people with early-stage high blood pressure. Adults with low renin levels are randomly assigned to receive either spironolactone or a standard blood pressure drug fo…

This trial tests whether an absorbable gelatin sponge works as well as cyanoacrylate glue for closing off enlarged stomach veins that can bleed. Both treatments are delivered via endoscopy with small coils. Participants are adults with a history of bleeding from these veins, and …

This study explores whether a carefully designed, low-impact exercise program is safe and practical for people with vascular Ehlers-Danlos syndrome (vEDS), a rare condition that weakens blood vessels and organs. Researchers are working with patients and doctors to create a 12-wee…

This trial compares a procedure to reopen blocked brain arteries (using balloons and stents) against standard medical therapy in people with chronic blockages. The goal is to see if the procedure reduces the risk of stroke or death within a year. Participants have had symptoms fr…

This study tests two experimental drugs, REGN7508 and REGN9933, to see if they can prevent blood clots in people who have a peripherally inserted central catheter (PICC). People with PICCs are at higher risk for venous thromboembolism (VTE), which can be serious. The trial compar…

This study explores whether virtual group medical appointments focused on lifestyle changes can help people with high blood pressure lower their readings. Participants attend four online sessions over eight weeks, track their blood pressure at home, and get medication adjustments…

This study looks at different methods to restore blood flow to the left subclavian artery when it must be covered during aortic repair. Covering this artery can raise the risk of stroke and arm problems. The trial compares surgical bypass with newer endovascular techniques to see…

This trial tests whether using a detailed CT scan of the heart's arteries before a procedure to open blockages (PCI) can make the procedure more efficient. About 200 adults with coronary artery disease will be randomly assigned to either have their procedure guided by a pre-plann…

This trial tests whether ciprofol, a newer anesthetic, can keep blood pressure more stable than the standard drug propofol in people having general anesthesia for endovascular thrombectomy after an ischemic stroke. Stable blood pressure during the procedure may improve outcomes. …

This clinical trial is testing a new heart valve replacement system called Encantor, which uses software to guide placement of the valve. The study includes 150 adults with severe aortic stenosis who are candidates for a minimally invasive procedure. Researchers will track how ma…

This trial investigates whether giving two drugs—remifentanil and dexmedetomidine—soon after a spontaneous brain hemorrhage can safely lower blood pressure and improve recovery. The study includes adults with a brain bleed who have high blood pressure and are treated within six h…

This study tests whether extra support from a navigator can help pregnant people with high blood pressure use a home monitoring program (Connected MOM) and follow up after giving birth. The trial includes about 2,000 participants who have a smartphone and speak English or Spanish…

This trial investigates whether edaravone dexborneol sublingual tablets can improve blood-brain barrier function in people with CADASIL, a genetic condition that causes small strokes and cognitive decline. About 60 adults aged 18 to 80 with confirmed CADASIL will be observed for …

This study tracks the safety and effectiveness of a stent graft device used to treat aneurysms, dissections, or trauma in the aortic arch (the curved part of the main artery from the heart). Researchers will follow 75 patients in Japan who receive the device, monitoring for compl…

This study looks at how well atogepant, a daily pill, works to prevent migraines in adults treated in UK primary care. About 200 people with migraine will take atogepant as prescribed by their doctor and report their symptoms and healthcare use for up to 48 weeks. The goal is to …

This study develops and tests a standardized oral care protocol for stroke patients who have a breathing tube (orotracheal intubation). The goal is to see if this special mouth care plan can lower the risk of ventilator-associated pneumonia compared to usual care. The trial inclu…

This pilot study tests whether a three-week inpatient cardiovascular rehabilitation program, started three months after abdominal aortic aneurysm repair, improves cardiorespiratory fitness more than standard post-operative care. Researchers will measure changes in maximal oxygen …

This trial investigates whether adding Getong Tongluo Capsule, a traditional Chinese herbal medicine, to standard stroke care improves recovery in people who recently had an ischemic stroke. Researchers will also explore if the capsule works by affecting gut bacteria and brain co…

This trial tests whether a newer balloon-expandable heart valve with intermediate sizes (Myval) is as safe as a standard self-expanding valve (Evolut) in people with severe aortic stenosis whose valve measurements fall in a 'borderline' range. About 600 participants will be rando…

This trial tests whether giving a clot-busting drug directly into the brain arteries after mechanical clot removal can improve recovery in people having a severe stroke. About 1,500 adults with acute ischemic stroke who undergo endovascular thrombectomy will be randomly assigned …

This trial tests a new platinum coil system (i-ED Coil and EDG v4) used to block abnormal blood vessels in the brain, called arteriovenous malformations (AVMs). The study includes 36 adults aged 18 to 79 who need this procedure. Researchers will check how well the coils block the…

This study tests whether a new drug called baxdrostat can lower blood pressure in Chinese adults whose hypertension remains uncontrolled despite taking two or more blood pressure medications. Participants receive either baxdrostat or a placebo daily for 12 weeks, while continuing…

This study tests whether combining spinal cord stimulation with brain-computer interface training can improve arm function in people who had a stroke more than six months ago. Participants will either receive both treatments or the brain-computer training alone. The goal is to se…

This phase 2 trial tests a drug called nab-sirolimus in people with a rare cancer called epithelioid hemangioendothelioma (EHE) that is getting worse or causing symptoms. The drug is given through a vein and aims to shrink or control the tumors. The study will measure how many pa…

This trial tests whether applying sucralfate—a medication that forms a protective barrier over wounds—directly onto esophageal ulcers after variceal banding can speed healing and reduce rebleeding. The study includes adults with cirrhosis who have bleeding esophageal varices. Par…

This study tests a new device called the Vibrato Aspiration System, designed to remove blood clots from the lungs in people with acute pulmonary embolism (a sudden blockage in the lung artery). The trial includes up to 10 adults aged 18 to 75 who have had symptoms for 14 days or …

This study looks at whether two different combinations of blood pressure and cholesterol medications can help protect kidney function in people with both high blood pressure and high cholesterol. Researchers will track changes in urine protein levels and other kidney markers over…

This study tests whether adding an 8-week online mindfulness program, called Mindfulness in Motion, to usual care helps people with high blood pressure improve their blood pressure, weight, stress, sleep, and well-being. Participants will be randomly assigned to either the mindfu…

This phase 3 trial tests whether a daily tablet of CLR-07-23 (heparan sulfate) can reduce symptoms of chronic venous disease, such as leg pain, itching, swelling, and night cramps. The study includes adults aged 18 to 80 with mild to moderate vein disease. Participants take eithe…

This study tests whether montelukast, a common allergy medication, can reduce damage to the kidneys, eyes, and blood vessels in adults with type 2 diabetes and early kidney disease. The drug works by blocking inflammatory chemicals called leukotrienes, which are linked to diabete…

This trial investigates whether patients with acute coronary syndrome can safely stop taking aspirin soon after a heart stent procedure and continue with only a potent antiplatelet drug (ticagrelor or prasugrel). The standard approach is to take both aspirin and a P2Y12 inhibitor…

This study tests whether a nurse-led, community-based program can help lower blood pressure in adults aged 25 and older with uncontrolled hypertension in Monrovia, Liberia. Trained community health nurses provide medication and lifestyle counseling at mobile clinics in high-traff…

This study looks at how surgery to fix varicocele—enlarged veins in the scrotum—affects the number of immature sperm cells in semen. Infertile men aged 20 to 45 with varicocele will have a microsurgical procedure to tie off the abnormal veins. Their semen will be tested before su…

This study tests whether a proactive, pharmacist-led telephone program can help people who have had a heart attack reach safer cholesterol levels. Participants receive pharmacist calls, repeat blood tests, and medication adjustments based on national guidelines. The goal is to se…

This trial tests whether a sublingual (under-the-tongue) tablet of edaravone dexborneol, given within 6 hours of stroke onset during transfer between hospitals, can improve functional recovery in people with acute ischemic stroke. About 1,040 participants will receive either the …

This study tests whether adding a drug called inclisiran to standard cholesterol-lowering therapy (statins) helps people who recently had a heart attack or unstable angina lower their LDL ('bad') cholesterol more than statins alone. About 300 adults in Saudi Arabia will receive e…

This trial tests whether a less intensive antiplatelet therapy is safer and as effective as standard dual therapy for people with spontaneous coronary artery dissection (SCAD), a rare cause of heart attack in women aged 30–55. Unlike typical heart attacks, SCAD involves a tear in…

This trial investigates whether a procedure to remove a blood clot from the basilar artery—a major vessel at the back of the brain—can improve recovery in people with severe stroke. Participants are adults aged 18 to 80 who have a large area of brain damage and can be treated wit…

This study tests whether combining a gentle electrical brain stimulation (called FNS) with sling-based exercises can help people who have paralysis on one side after a stroke. The trial will enroll 54 adults aged 18-70 who had a stroke within the last 6 months. Participants will …

This pilot study tests a new catheter device designed to deliver clot-dissolving medication directly to blood clots in the lungs of adults with intermediate-risk pulmonary embolism. The goal is to see if the device can be used safely and as intended. All 20 participants will rece…

This trial tests whether using a balloon guide catheter along with a filter can better protect the brain during carotid artery stenting. People with narrowed neck arteries (carotid stenosis) who need stenting are randomly assigned to get either the balloon-plus-filter combo or a …

This study tests whether combining two medications, empagliflozin and finerenone, can lower blood pressure in adults with obesity and stage 1 hypertension. Participants take the drugs or a placebo daily for 12 weeks. The trial also measures effects on kidney function, inflammatio…

This study tests whether using a temporary heart pump (CorVad) during a procedure to open blocked arteries (PCI) can improve outcomes for people with complex coronary artery disease and a very weak heart (ejection fraction below 35%). Half of the 452 participants will receive the…

This trial tests whether a single daily pill that combines treatments for high blood pressure, high cholesterol, and type 2 diabetes can lower the risk of heart disease and dementia. The study involves over 8,000 adults aged 50 to 75 in China who have all three conditions. Partic…

This study tests an experimental drug called REGN22530 in people with primary open angle glaucoma or ocular hypertension. The drug is designed to block a protein in the eye that causes fluid buildup and high pressure. Researchers are checking for side effects, how the drug moves …

This trial compares a new temporary heart pump called VentriCure with standard ECMO support in people with coronary artery disease undergoing high-risk angioplasty. The study includes 220 patients whose hearts are weak or who have severe heart failure. The goal is to see if Ventr…

This phase 3 trial tests whether a new drug called HCP1803-4 can safely lower blood pressure in adults with essential hypertension. Participants are randomly assigned to receive either the new drug or a control drug. The study measures changes in sitting blood pressure over time …

This study explores whether applying mild electrical stimulation to the spinal cord through the skin can improve blood pressure control in people with spinal cord injury. Participants will undergo tilt-table tests to measure immediate effects, plus 20 stimulation sessions to see …

This study tests whether stroke survivors can safely use a robot called ReHandyBot to exercise their hand at home without a therapist present. Participants first learn how to use the device at a clinic, then take it home to train on their own. The goal is to see if unsupervised h…

This phase 3 trial tests whether a new emergency stroke unit, equipped with a hybrid CT and X-ray machine (NeuAngio-CT), can speed up clot removal in people having a severe stroke. About 232 adults aged 18-60 with acute ischemic stroke will be randomly assigned to either the new …

This phase 3 trial tests whether giving clot-busting drugs directly into the blocked brain artery (intra-arterial thrombolysis) helps people recover better from a medium-vessel stroke. About 306 adults aged 18-80 with acute stroke will be randomly assigned to receive either the d…

This early study tests whether a drug called sirolimus (rapamycin), given directly into the brain's fluid spaces, can prevent hydrocephalus after a severe brain hemorrhage. Hydrocephalus is a dangerous buildup of fluid that often requires a permanent surgical shunt. The trial wil…

This study tests a new procedure for people with a completely blocked main portal vein who have had at least two episodes of dangerous variceal bleeding. Doctors will use ultrasound to guide a needle into a vein in the gut, then try to reopen the blocked vein or create a new bypa…

This study looks at whether stopping propranolol suddenly or slowly is better for preventing hemangioma regrowth in infants. About 110 children who have taken propranolol for at least 6 months will be randomly assigned to either stop immediately or taper over 4 weeks. The goal is…

This study tests a simple balloon inflation technique to modify blood clots during emergency heart artery opening. 100 heart attack patients will either get the balloon procedure or standard care. The goal is to see if this reduces damage to the heart muscle and improves recovery…

This trial tests whether a newer anesthetic drug, ciprofol, causes fewer dangerous drops in blood pressure during anesthesia than the standard drug propofol in frail patients aged 60 and older having major abdominal surgery. Participants are randomly assigned to receive one of th…

This study tests whether a blood test measuring the sFlt-1/PlGF ratio can help doctors decide the best time to deliver babies in women with severe early-onset preeclampsia. The trial will include 386 pregnant women between 30 and 34 weeks of gestation. Half will have delivery tim…

This study tests whether a type of abdominal massage called visceral osteopathic manual therapy can improve sperm quality and blood flow in men with varicocele, a condition where veins in the scrotum become enlarged and can cause infertility. Thirty-two men aged 18-45 will either…

This trial will compare three drugs—dopamine, norepinephrine, and epinephrine—to see which works best for people experiencing a pulmonary hypertensive crisis, a life-threatening spike in blood pressure in the lungs. The study will enroll 75 adults with pulmonary arterial hyperten…

This study tests whether the drug vericiguat can improve right heart function and reduce tricuspid regurgitation in 100 adults with heart failure and reduced pumping ability. Participants take vericiguat daily for 9 months, with regular heart scans and walking tests to measure ef…

This trial tests whether giving blood pressure medication inside a mobile stroke unit—a special ambulance with a CT scanner—can improve outcomes for people having a brain bleed. About 706 adults with high blood pressure and a recent stroke will be randomly assigned to either the …

This study tests whether a 12-week tele-pulmonary rehabilitation program, done at home via an app with a physiotherapist, helps people with chronic lung diseases start and stick with rehab better than going to a center. 90 patients will be randomly assigned to either remote rehab…

This pilot study tests a new device that uses radiofrequency energy to calm overactive kidney nerves, which can drive high blood pressure. Twenty adults with untreated mild hypertension will either get the real procedure or a sham (fake) one. The main goal is to see if the real t…

This trial tests whether taking two inexpensive migraine prevention drugs together works better than taking either one alone. Adults aged 18 to 55 who have at least four migraines per month will receive propranolol, flunarizine, or both for 12 weeks. The goal is to see which appr…

This study tests whether mazdutide, a weekly injection that helps with weight loss, can slow the buildup of fatty plaque in the heart arteries of 116 overweight or obese adults with coronary heart disease. Participants will receive either the drug or a placebo for 52 weeks, and d…

This Phase 3 trial tests whether adding baxdrostat (Baxfendy) to standard care can improve heart structure and function in 286 adults with high blood pressure and thickened heart walls. Participants take either baxdrostat or a placebo daily for 12 months, with heart scans and reg…

This trial investigates whether a diet rich in polyphenols—including daily cocoa and extra fruits and vegetables—can reduce oxidative stress and improve blood vessel function in pregnant women. Researchers will randomly assign 60 pregnant women to receive dietary counseling and c…

This study tests whether a stellate ganglion block (a nerve block injection) can improve neurological outcomes in people who have had a bleeding stroke from a ruptured aneurysm. The procedure is done before surgery to reduce brain artery spasms and improve blood flow. Researchers…

This study tests a specially designed suction tube that cleans deep throat secretions under direct laryngoscope guidance. The goal is to see if it reduces pneumonia within 28 days in stroke patients who have trouble swallowing or coughing. Participants are adults with acute ische…

This trial tests whether a specialized scoring balloon, called Naviscore, can better prepare calcified coronary arteries before placing a drug-eluting stent. Hardened plaques often prevent stents from expanding fully, raising risks of re-narrowing or clots. About 200 adults with …

This study tests the safety and tolerability of sotatercept in Japanese children aged 1 to 18 with pulmonary arterial hypertension (PAH), a condition where blood vessels in the lungs narrow, making the heart work harder. Participants receive sotatercept injections every three wee…

This study tests whether adding 20 minutes of moderate-to-high intensity aerobic exercise before constraint-induced movement therapy helps stroke survivors walk better. Fifty adults who had a stroke at least 6 months ago will take part in a 4-week intensive program, followed by a…

This Phase 2 trial tests whether a fixed-dose combination of leucine, sildenafil, and metformin (NS-0200) can lower blood pressure in adults aged 18 to 75 with hypertension. About 150 participants receive one of two doses of the combination or a placebo for 12 weeks. The main goa…

This study tests whether a 12-week program of moderate aerobic exercise and inspiratory muscle training can improve breathing, exercise capacity, and quality of life in people with pulmonary hypertension caused by lung disease. Participants will walk on a treadmill and use a brea…

This study looks at whether icosapent ethyl, a purified fish oil medication, can reduce inflammation and improve heart structure in people with coronary artery disease. Researchers will follow 420 patients for one year, comparing those who receive standard care plus icosapent eth…

This study looks at people with a rare lung condition called CTEPH who have done well after a procedure (balloon angioplasty) and are taking a drug called riociguat. The goal is to see if stopping the drug is as safe as continuing it. About 150 participants will be randomly assig…

This study tests whether a set of dietary supplements taken at different phases of a migraine cycle can improve quality of life and reduce headache days in adults with migraine. Participants take a daily foundational supplement, with additional supplements during the luteal phase…

This pilot study tests whether amiloride, a drug used for high blood pressure, can reduce inflammation in the walls of enlarged arteries at the base of the brain in people with vertebrobasilar dolichoectasia (VBD). Six adults with VBD will take amiloride for up to 12 months. Rese…

This trial investigates whether adding early lumbar drainage to standard care (a drain in the head plus clot-dissolving medication) improves long-term outcomes for people with bleeding into the brain's fluid-filled spaces. The study includes adults aged 18 to 85 who have had a fi…

This study compares two supervised treadmill exercise programs for people recovering from coronary artery disease or a heart procedure. One group does high-intensity interval training (HIIT) — short, hard efforts with rest periods — while the other does moderate-intensity continu…

This study looks at whether a long-acting injectable HIV prevention drug (cabotegravir) can be delivered fairly and effectively in NHS sexual health clinics. Researchers will follow 200 people taking the drug for 12 months, along with 20 healthcare professionals, to see how well …

This trial tests whether an AI-guided handheld ultrasound, used during routine primary care or geriatrics visits, can detect serious heart valve disease and weak heart muscle in adults aged 65 to 85 who have no known heart problems. Half of the participants will receive this quic…

This trial asks whether adding artificial intelligence (AI) to radiologists' reading of liver CT scans can match or improve standard reporting. It involves 40,000 adults who had contrast-enhanced CT scans of the abdomen. On some days, radiologists first read scans on their own, t…

This trial evaluates a new device called the Photobionic IOP Tonometer (PIB) that measures eye pressure without touching the eye or using an air puff. It uses a low-power infrared light and a gentle sound to detect tiny movements on the eye's surface, which a computer analyzes to…

This trial tests whether a special ultrasound technique can detect heart muscle ischemia (reduced blood flow) in people with suspected acute coronary syndrome. The approach uses microbubbles that stick to activated immune cells and blood vessel linings, potentially revealing infl…

This study tests whether a computer algorithm can analyze standard EEG recordings from full-term newborns who experienced oxygen deprivation at birth to tell apart mild brain injury from moderate or severe forms. The algorithm's readings are compared against expert review of the …

This trial is testing whether an artificial intelligence-enhanced electrocardiogram (AI-ECG) can help doctors quickly and safely identify which people with non-cardiac chest pain are truly low risk. Half of the participants will receive the AI-ECG in addition to standard care, wh…

This trial tests whether a new device, Pro9000X, can measure spleen stiffness to detect esophageal varices—enlarged veins in the esophagus that can bleed dangerously—in people with chronic liver disease. Currently, the only reliable way to diagnose these varices is an invasive en…

This trial compares two blood-test strategies for diagnosing heart attacks in people with chest pain: the standard approach of testing at arrival and again 3 hours later, versus an accelerated approach testing at arrival and again after just 1 hour. The goal is to see whether the…

This trial tests whether two non-invasive tools can help paramedics detect dangerously high pressure inside the skull in patients with sudden brain injury, such as stroke or head trauma, before they reach the hospital. The tools are a wearable sensor placed on the head and an ult…

This study looks at whether measuring the collapsibility of the internal jugular vein in the neck using ultrasound can predict low blood pressure after general anesthesia. Researchers will measure the vein in 42 adults before gallbladder surgery and track blood pressure changes r…

This study tests whether a handheld, ultra-widefield eye scanner (OCT) can accurately identify preterm infants with severe retinopathy of prematurity (ROP), a condition that can harm vision. The scanner takes detailed images of the retina without touching the eye, potentially red…

This trial tests whether a smartphone app called Antshrike, paired with a smartwatch, can predict heart attacks or strokes within 3-4 days in people at high risk. Participants aged 40 to 79 with existing heart disease or elevated risk will wear the smartwatch for 18 months while …

This trial tests whether a 4-electrode tablet-based ECG (DigitalCardio) can record heart activity as quickly and clearly as the standard 10-electrode ECG. About 50 cardiology patients will undergo both methods in random order. Researchers will measure recording time and compare t…

This trial tests whether a portable handheld Doppler device can help nurses quickly detect arterial insufficiency in people with diabetes who have foot ulcers. The device checks for blood flow in the great toe, and the goal is to see if it can reliably flag patients who need furt…

This trial tests whether an accelerated heart MRI scan, taking only 15 to 20 minutes, can diagnose coronary artery disease as accurately as the standard 45- to 50-minute scan. About 2,000 adults with suspected coronary heart disease will be randomly assigned to receive either the…

This trial compares two imaging strategies—CT with CT angiography versus MRI with MR angiography—as the first test for people with suspected severe ischemic stroke. The goal is to see which approach is more cost-effective while still leading to good patient outcomes. Six hundred …

This study translates two standard questionnaires—the Hemorrhoidal Disease Symptom Score and the Short Health Scale for Hemorrhoidal Disease—into Mandarin Chinese and checks whether they are reliable and accurate for Chinese-speaking patients with hemorrhoids. About 115 adults di…

This study explores whether a newer type of SPECT/CT scan can accurately measure blood flow in the heart, similar to the more expensive and less available PET scan. Researchers will compare the two imaging methods in 30 adults with coronary artery disease who are already schedule…

This study tests a new ultrasound method called super-resolution ultrasound (SRUS) to see tiny blood vessels in liver tumors. Current scans show only larger vessels, but SRUS can detect vessels as small as 20 micrometers. Researchers will compare blood flow patterns in different …

This study tests whether an artificial intelligence system called AngioAI+ can accurately diagnose two types of coronary artery disease using standard angiogram images. The research involves 620 adults with suspected coronary artery disease who are already scheduled for an angiog…

This study tests whether oxygen-enhanced MRI (OE-MRI) can identify low-oxygen (hypoxic) regions in high-grade gliomas, the most common and aggressive adult brain cancers. Twenty-five patients will undergo OE-MRI scans before, during, and after standard radiotherapy. Researchers w…

This pilot study tests a lifestyle intervention called BASIC-S, which uses coaching, text messages, and video check-ins to help people improve blood pressure, activity, sleep, social connection, nutrition, and support. The goal is to see if this approach is feasible and acceptabl…

This trial tests whether cutting out a small fibrous structure called the Ligament of Marshall during minimally invasive heart bypass surgery can prevent new-onset atrial fibrillation (an irregular heartbeat) that often occurs after the operation. The study will include 628 adult…

This pilot study tests two non-invasive methods to keep the airways clear in adults who are unconscious or severely ill and need a breathing tube. One method uses a special tube with continuous low-pressure suction, and the other delivers a programmed 'artificial cough' through t…

This trial tests whether anticoagulant medications (like rivaroxaban or apixaban) are better than aspirin at preventing a second stroke in people who have had an ischemic stroke of unclear cause. Participants are adults who had a stroke within the past two weeks and show signs th…

This trial tests whether combining electroacupuncture with a sedative drug called dexmedetomidine can prevent depression in people who recently had an ischemic stroke. Participants at high risk for post-stroke depression will receive either the combined treatment, a sham version,…

This phase 3 trial tests whether zastaprazan, a stomach-acid-blocking drug, can prevent upper gastrointestinal bleeding in adults who have recently had a transient ischemic attack (TIA) or ischemic stroke and are taking antiplatelet or anticoagulant medications. Participants take…

This trial tests whether eplerenone, a drug that blocks the hormone aldosterone, can prevent the onset of high blood pressure in people aged 30–55 who have a mild, early form of primary aldosteronism but normal blood pressure. Participants will receive either eplerenone or a plac…

This phase 3 trial tests whether taking rimegepant once daily can prevent migraine attacks in people with chronic migraine (15 or more headache days per month). About 400 adults will receive either rimegepant or a placebo for 12 weeks, then all participants may receive rimegepant…

This trial tests whether offering a seasonal flu vaccine to heart patients while they are still in the hospital, along with active counseling, increases vaccination rates compared to counseling alone. The study enrolls adults hospitalized for acute coronary syndrome or heart fail…

This study explores whether offering HIV prevention medication (PrEP) through pharmacies can help more young women aged 18-24 in Tanzania access and consistently use it. Researchers compare four different pharmacy-based service models to standard care, and later test cost-sharing…

This study tests whether washing the surgical wound and the new prosthetic graft with a hypochlorous acid solution at the end of surgery can prevent infections. Participants are adults having open surgery to insert a synthetic bypass graft for narrowed or blocked arteries. The st…

This study looks at whether pregnant women at high risk for preeclampsia can safely stop taking daily aspirin at 24-28 weeks instead of continuing until 36 weeks. Over 15,000 women across Europe and Africa will be randomly assigned to stop or continue aspirin. The goal is to see …

This trial tests whether a gentle brain stimulation technique called transcranial direct current stimulation (tDCS) can improve bladder control in people who have had a stroke. Participants will receive either real or sham tDCS alongside standard pelvic floor muscle training, thr…

This study tests whether a new, fully immersive virtual reality walking program can help people with traumatic brain injury (TBI) improve their mobility and quality of life. Thirty participants will try two types of VR therapy: one on a treadmill with screens, and another using a…

This trial tests whether wearing a light-blocking eye mask at night can improve sleep quality and reduce delirium in patients recovering from coronary artery bypass graft (CABG) surgery. About 100 adults scheduled for elective CABG will wear the mask during nighttime sleep, and t…

This trial tests whether applying a numbing medicine (lidocaine) to a nerve cluster inside the nose can quickly relieve migraine headaches, facial pain, and neck pain. Adults who have frequent headaches and facial pressure will receive either lidocaine or a saltwater placebo duri…

This trial tests whether a neck-focused rehabilitation program can reduce the burden of chronic migraine. Adults aged 18-55 with chronic migraine will be randomly assigned to either an eight-week program of cervical sensorimotor exercises or conventional physiotherapy. The study …

This trial tests whether adding a second nerve block—targeting the greater auricular nerve—to the standard occipital nerve block provides better pain relief for people with chronic migraine. About 80 adults with chronic migraine will receive either the combined block or the stand…

This trial tests whether placing a small catheter near the breastbone to deliver local anesthetic can reduce pain after coronary artery bypass surgery. Half of the participants will receive this catheter-based pain relief, while the other half gets standard care. Researchers will…

This trial tests whether a single application of Kinesio Taping can quickly reduce symptoms and improve grip strength and hand dexterity in adults with thoracic outlet syndrome, a condition where nerves or blood vessels are compressed in the shoulder area. Participants are random…

This trial tests whether a set of self-help booklets, based on cognitive behavioural therapy for insomnia (CBT-I), can improve sleep quality in adults with pulmonary hypertension (PH). Participants will be randomly assigned to receive the booklets during the study or after a wait…

This study tests whether a fully virtual mindfulness program (BREATHE-HA) is feasible and acceptable for teens aged 12–17 with migraine. Participants will either join a 6-session mindfulness group or a headache education group, both delivered via telehealth. The goal is to see if…

This pilot trial tests whether NeuroEyeCoach, a computer-based eye movement training program, can help stroke survivors who have lost part of their visual field. Sixty participants will be randomly assigned to receive either the training plus usual care or usual care alone. The s…

This study tests an inhaled powder called LIQ861 (treprostinil) in adults with scleroderma who have frequent, painful Raynaud's attacks—episodes where fingers or toes turn color and become numb or tingly. About 75 participants will be randomly assigned to receive either a dose th…

This trial tests whether spinal cord stimulation (SCS) can reduce muscle spasticity in adults who have had a stroke. Participants will have a small device implanted that sends electrical pulses to the spinal cord. Half will receive active stimulation for six weeks, while the othe…

This trial tests whether a non-invasive brain stimulation technique called transcranial direct current stimulation (tDCS) can reduce the number of headache days in people with chronic migraine. Participants will receive either real or sham (inactive) stimulation over the motor co…

This study tests whether one session of laser acupuncture can lower blood pressure in people with hypertension who are on hemodialysis. Researchers will measure blood pressure changes in 60 adults aged 18-65. The goal is to find a non-drug way to help manage blood pressure during…

This trial tests whether gentle electrical stimulation of a nerve in the ankle, called posterior tibial nerve stimulation (PTNS), can reduce the sudden, urgent need to urinate that often follows a stroke. The study will include women aged 40 to 70 who have had a stroke at least s…

This trial tests whether an 8-week daily resistance exercise program can reduce chest pain and improve daily function in women who have angina without blocked coronary arteries (ANOCA). Around 76 to 152 women across 13 hospitals in the UK and Netherlands will be randomly assigned…

This trial tests whether a non-invasive device that gently stimulates the vagus nerve through the ear is tolerable for children who have had a stroke. One child will receive ear stimulation paired with occupational therapy sessions over four weeks. The goal is to see if the child…

This trial tests whether a targeted nerve block, called an adductor canal block, can reduce leg pain after coronary artery bypass grafting (CABG) when a leg vein is used as a graft. About 120 adults scheduled for CABG will receive either the block with a numbing medication or a s…

This trial is testing whether a bilingual (English and Urdu) mobile app can help stroke survivors improve movement in their affected arm and hand. The app guides users through structured exercises over eight weeks, starting with gentle range-of-motion activities and progressing t…

This trial tests whether a six-week personalized behavioral sleep program, called ISleepFAST, can improve sleep and daily functioning in adults who have had a stroke and still struggle with sleep or circadian problems. Forty participants will be randomly assigned to either the sl…

This trial investigates whether Benson Relaxation Technique (BRT), a 20-minute mind-body relaxation session, can reduce anxiety and depression in people who had an ischemic stroke 1-2 weeks earlier. Participants are randomly assigned to receive either BRT or health education twic…

Stroke survivors often face unmet needs long after the initial event, especially younger adults who must balance rehabilitation with work and family. This trial tests a 12-month digital education and peer support program, co-designed with patients and delivered through LINE commu…

This trial compares two adaptive indoor rowing seats designed for Veterans who have limited trunk stability due to spinal cord injury, stroke, or neurodegenerative conditions. Participants will try both seats during short rowing sessions, and researchers will measure trunk moveme…

This trial tests whether different types of pressure garments can improve touch sensation in the hand after a stroke. Adults aged 21 to 60 with hand stiffness will wear one of three garment designs for at least 12 hours daily over four weeks. Researchers will measure how the pres…

This study tests whether injecting a local anesthetic near the stellate ganglion in the neck, guided by ultrasound, can improve how patients feel after heart surgery. The block temporarily calms part of the nervous system, which may reduce pain, improve sleep, and lower the risk …

This study tests whether placing an ice pack inside the anal canal for one minute right after hemorrhoid removal surgery can reduce pain. Adults with severe (grade III or IV) hemorrhoids will be randomly assigned to receive either standard surgery alone or surgery plus this quick…

This study investigates whether a device called FREMS, which delivers rhythmic electrical pulses to the legs, can improve blood flow, reduce nerve pain and numbness, and enhance quality of life in people with type 2 diabetes who have peripheral neuropathy and poor leg circulation…

This pilot study tests whether zavegepant nasal spray can quickly relieve pain from episodic cluster headaches. About 40 adults with episodic cluster headaches will use the spray at the start of an attack. The main goal is to see how many achieve minimal or no pain within 30 minu…

This trial investigates whether adding radial shock wave therapy to standard botulinum toxin injections can further reduce ankle muscle stiffness and improve walking in people who have had a stroke. Participants receive either shock wave therapy plus physical therapy or physical …

This study tests the safety and tolerability of rimegepant 75 mg ODT for acute migraine treatment in adults in India who have had an insufficient response, intolerance, or contraindication to triptans. About 60 participants take the drug as needed at the start of a migraine attac…

This study tests whether taking oral nifedipine, a drug usually used for high blood pressure, can reduce pain and improve wound healing after hemorrhoid removal. One hundred adults in Yemen will receive either nifedipine or a placebo twice daily for two weeks after surgery. Resea…

This trial tests whether a fentanyl nasal spray can reduce pain during eye exams for retinopathy of prematurity (ROP) in preterm infants. About 58 babies born at or before 31 weeks will receive either fentanyl or a saltwater placebo before their routine exam, along with standard …

This study tests whether special attention exercises can improve focus and quality of life in people who have had a stroke. 46 participants will do either attention training or standard rehab for 4 weeks. Researchers will measure changes in attention and daily functioning.

This study tests whether a daily herbal capsule called Nimsai Herbal can shrink hemorrhoids and reduce symptoms like pain and itching. Fifty adults with grade 2-3 hemorrhoids will take either the herbal blend or a placebo for 10 days. The main goal is to see if the hemorrhoids im…

This study tests whether adding aspirin to a standard anti-inflammatory gel can reduce pain from blood clots in children aged 6 to 17 with superficial venous malformations. The trial will compare aspirin plus gel against a placebo plus gel over 14 days. Only 34 children will take…

This study will test two FDA-approved migraine drugs, rimegepant (a tablet that dissolves on the tongue) and zavegepant (a nasal spray), in 100 adults visiting the emergency department for a migraine. The goal is to see if these drugs provide pain relief within 2 hours without ne…

This study tests whether adding motivational interviewing (a type of counseling) to a home exercise program can improve pain and arm function in people with thoracic outlet syndrome (TOS). Seventy adults with TOS will be randomly assigned to either exercise alone or exercise plus…

This study tests whether neurofeedback—a type of brainwave training—can help adults with episodic migraine have fewer and less severe headaches. Participants will undergo 60 sessions over 12 weeks, learning to regulate their brain activity through real-time feedback. The goal is …

This study investigates whether sleeping on a gently rocking bed can improve sleep quality and memory in people undergoing neurorehabilitation after conditions like stroke, traumatic brain injury, or inflammatory diseases of the central nervous system. Participants will sleep on …

Many people with migraine also suffer from tinnitus, a persistent ringing in the ears. This trial will compare two types of migraine preventives—newer anti-CGRP drugs and older medications like antidepressants and blood pressure drugs—to see which better reduces tinnitus symptoms…

This study tests whether applying heat to the legs for 90 minutes each day at home can improve walking distance and leg function in adults over 50 with peripheral artery disease (PAD). Participants are randomly assigned to receive either active heat therapy or a sham (low-heat) v…

This study tests whether a common water pill (furosemide) can help women with severe preeclampsia recover faster after childbirth and leave the hospital sooner. About 186 women will receive either furosemide or a placebo starting 12 hours after delivery. The goal is to see if the…

This study tests whether an 8-session self-hypnosis program, delivered online in groups, can help adults with migraines reduce disability and improve well-being. Forty participants are randomly assigned to either the hypnosis training or a waitlist. The program teaches self-hypno…

This study gathers real-world data from medical records of patients with complex vascular anomalies treated with targeted therapies like mTOR inhibitors, MEK inhibitors, or PI3K inhibitors. Researchers will look at patient characteristics, treatment patterns, and side effects acr…

This study is a large international registry that will look back at the medical records of about 1,000 adults who were treated with the AngioVac system, a device that uses suction to remove blood clots, infected tissue, or other unwanted material from the heart and major blood ve…

This study is creating a large collection of blood samples and medical information from 1000 adults with or suspected of having pulmonary hypertension (PH). Researchers hope this resource will help them find new ways to diagnose and treat PH. Participants will provide a blood sam…

This study investigates whether tiny particles called extracellular vesicles, released by brain cells into the blood, can serve as reliable markers of nerve damage in people with multiple sclerosis or stroke. Researchers will measure these particles in blood samples from 60 parti…

This study looks at whether two simple bedside tests—the Passive Leg Raising (PLR) test and the Pleth Variability Index (PVI)—can predict a temporary drop in blood pressure that sometimes happens during a lung-opening procedure called an Alveolar Recruitment Maneuver (ARM). ARM i…

This study aims to develop and validate a questionnaire called the ProChange scale, designed to measure the barriers and facilitators to lifestyle changes in people at risk for chronic diseases. The scale will be tested in adults aged 45 and older who receive prevention advice on…

This study is a large, real-world registry that will include over 10,000 people with coronary artery disease from more than 50 hospitals across China. The goal is to see how often a software tool called QFR, which analyzes angiogram images to guide treatment decisions, is used in…

This study aims to build a specialized AI model, called CorAI, for coronary artery disease (CAD). Researchers will collect de-identified medical data from about 640 patients with suspected or confirmed CAD to create a rich dataset. Using this data, they will develop and test CorA…

This study tests whether a new device called Blood'up can help locate the radial artery in the wrist better than the traditional method of feeling for the pulse. Healthy volunteers will have arterial blood samples taken from both wrists, one using the device and the other using m…

This study looks at stroke survivors who have mild aphasia—a condition causing language difficulties. Researchers want to see if these individuals also struggle with 'executive control' of language, which helps us manage and switch between words and ideas. By testing 30 participa…

This study looks at whether a specific type of stroke called branch atheromatous disease (BAD) is linked to cognitive decline. Researchers will follow 60 adults aged 18-80 who had this stroke, tracking their thinking and memory over a year. They will also examine if early neurolo…

This study is a large, observational registry in Türkiye that will track the real-world practice and outcomes of a procedure called percutaneous coronary intervention (PCI) for chronic total occlusion (CTO) — a complete blockage of a coronary artery that has been present for at l…

This study uses imaging scans to measure the size and blood flow speed in three key arteries—the carotid, renal, and femoral—in adults with high blood pressure. The goal is to see how hypertension affects these blood vessels, both structurally and functionally. By comparing measu…

This study tests whether a non-invasive sensor placed on the back can detect early signs of kidney injury in adults undergoing off-pump coronary artery bypass surgery. Kidney injury is common after such surgery, but current detection relies on blood tests that rise days later. Th…

This study tests whether adding a technique called vascular deformation mapping (VDM) to standard CT scans can better predict liver failure after major liver surgery. Researchers will analyze routine preoperative CT images from over 1,000 adults undergoing removal of at least thr…

This study tests whether a small implanted sensor, called CardioMEMS, can continuously track blood pressure in the lung arteries after surgery for chronic thromboembolic pulmonary hypertension (CTEPH). The surgery, called pulmonary endarterectomy, can cure CTEPH, but some patient…

This study is building a biobank of blood samples and imaging data from 300 people with suspected inflammatory heart or autoimmune rheumatic diseases. Researchers aim to identify immune biomarkers that could predict major heart events like heart failure, stroke, or atrial fibrill…

This study looks at whether inflammation levels differ on either side of a blood clot in the brain during a stroke treatment called mechanical thrombectomy. Researchers will compare blood samples taken from before and after the clot to see if the difference is linked to how well …

This study looks at how blood test results change after delivery in people with severe preeclampsia. Participants are randomly assigned to receive magnesium for either 12 or 24 hours after birth. The goal is to see if a shorter treatment is safe and effective, and to understand h…

This study looks at how anticipated stigma and illness identity affect quality of life in men with hypogonadism (low testosterone). It compares these men to those with other chronic endocrine conditions like diabetes, hypothyroidism, or hypertension. The goal is to see if these p…

This study explores whether ultrasound can reliably measure aneurysms in the descending thoracic aorta, the part of the main artery that runs through the chest. Researchers will compare ultrasound measurements with standard CT scans in about 60 adults, including some with known a…

This study explores whether the type of symptoms a person has at the start of a stroke influences how quickly they get to the hospital and how well they recover. Researchers will follow 120 adults with a first-ever ischemic stroke, comparing those with classic, high-urgency sympt…

This study will examine 108 adults aged 30-65 to see if a gene called Klotho, certain mouth bacteria, and viruses are linked to gum disease and acute coronary syndrome (a type of heart attack). Researchers will measure gum health and collect samples to look for these markers. The…

This study looks at whether an AI-based tool that helps doctors shape a microcatheter can improve the safety and success of coil embolization, a procedure to treat brain aneurysms. Researchers will follow about 1,400 adults who are scheduled for this procedure, comparing cases wh…

This study reviews existing research to understand how aldosterone, a hormone that regulates blood pressure, contributes to hypertension. It looks at the proteins and genetic factors involved in aldosterone production and how the body's signals might be able to block its effects.…

This study looks at whether tiny plastic particles in the blood are linked to problems with the heart's small blood vessels. Researchers will measure microplastic levels in 184 people who are already having a heart procedure, and then check their heart vessel function and track t…

This study looks at whether patients recovering from a first acute stroke do better in a specialized stroke unit than in a conventional neurology ward. Researchers will follow 140 adults admitted within 48 hours of symptom onset, comparing outcomes like daily independence, disabi…

This study looks at a rare liver condition called porto-sinusoidal vascular disease (PSVD), which is diagnosed with a liver biopsy. The researchers are collecting detailed medical information from 150 patients to track their health over time, including survival and liver-related …

This observational study will track 87 people who are already scheduled to receive treatment with the Recana Thrombectomy Catheter System for blocked veins in their legs. The goal is to see how safe the device is and how well it works at clearing the blockages during the procedur…

This study looks back at medical records of about 350 people who had a specific stent graft placed during a complex aortic surgery called a frozen elephant trunk procedure, used to treat aortic aneurysms or dissections. The goal is to see how often major complications like stroke…

This study is testing whether a simple, non-invasive brain wave recording (EEG) taken within days of a stroke can help predict how well a person will recover. Researchers will record the brain activity of 400 stroke patients and track their recovery over three to six months. The …

This study compares two common prostate medications, tamsulosin and silodosin, to see how they affect pupil size and the thickness of a layer at the back of the eye called the choroid. Men aged 50 and older with benign prostatic hyperplasia (BPH) who have not used these drugs bef…

This study asks whether nurses in geriatric departments have the knowledge needed to properly screen for orthostatic hypotension—a sudden drop in blood pressure when standing that can cause falls and other serious problems in older adults. About 30 nurses will complete a question…

This trial tests whether a medical artificial intelligence (AI) tool can assist primary care doctors in managing chronic conditions like heart disease, atrial fibrillation, heart failure, and stroke. Doctors in the intervention group use the AI to help make decisions about assess…

After a severe brain injury, some patients survive but cannot communicate, and it is difficult to predict who will recover consciousness. This observational study in Cyprus is testing whether a brain-wave monitoring technique called the bispectral index (BIS) can improve predicti…

This study looks at people whose coronary arteries are abnormally widened (coronary artery ectasia). Researchers want to see if exercise stress tests and certain blood markers can detect when the heart muscle isn't getting enough blood. The goal is to better understand the link b…

This study tests whether occlusal splints (night guards) made using a fully digital workflow are as comfortable and effective as those made with a traditional wax bite registration. Healthy volunteers aged 18 to 45 will wear both types of splints overnight for three weeks each. T…

People with interstitial lung disease (ILD) can suddenly get much worse, but it is hard to tell if the cause is a lung flare-up or a blood clot in the lungs (pulmonary embolism). This observational study will follow 70 adults with ILD who come to the hospital with worsening breat…

This study uses a special eye scan called OCTA to examine how blood sugar control relates to tiny blood vessel changes in the retinas of people with diabetic retinopathy. Researchers will compare patients with well-controlled and poorly controlled blood sugar levels. The goal is …

This observational study examines how antiplatelet medications affect platelet function in people over 80 with atrial fibrillation who have received a Watchman implant. Researchers will measure various markers of platelet reactivity before and after treatment to see if clotting r…

This study investigates whether the speed at which blood sugar falls after starting a new diabetes medicine affects small blood vessels in the eye. Adults with type 2 diabetes who are beginning a GLP-1 receptor agonist or an SGLT2 inhibitor will undergo advanced eye scans and blo…

This study uses cone-beam CT scans to map the alveolar antral artery, a small blood vessel in the upper jaw that can be injured during dental implant or sinus lift procedures. Researchers will analyze 1,000 existing scans to document the artery's typical location, size, and varia…

This study tests a personalized, digitally supported prehabilitation program for adults waiting for elective cardiac surgery. Participants receive education, psychosocial support, nutritional advice, and home-based exercise guidance during the routine 6-10 week preoperative perio…

This observational study investigates whether cardiac autonomic neuropathy (nerve damage affecting the heart) changes the risk of death and cardiovascular events in people who have diabetes, coronary heart disease, and sleep apnea. Researchers will follow 326 participants, dividi…

This study investigates why some people develop long-term thinking and memory problems after surgery to repair a ruptured brain aneurysm. Researchers will review past medical records and then bring in 150 adult survivors for brain scans and cognitive tests. The goal is to identif…

This study tests whether measuring the optic nerve sheath diameter — the nerve that connects the eye to the brain — with a simple bedside ultrasound can predict a dangerous rise in brain pressure when a pressure-lowering drug (mannitol) is reduced or stopped. Researchers will fol…

This study looks at whether insurance claims data can be used to reliably identify two serious complications in people with Alzheimer's disease: brain hemorrhages larger than 1 cm and new-onset seizures. Researchers will analyze records from 600 Alzheimer's patients, linking insu…

This trial tests whether wearable devices like smartwatches can measure blood pressure as accurately as standard arm cuffs or invasive arterial lines. Hospitalized patients will wear multiple devices using light-based (PPG) and wrist-cuff methods, with readings compared to clinic…

This pilot study is investigating how quickly C-reactive protein (CRP), a key marker of inflammation, drops after starting steroid treatment in people newly diagnosed with giant cell arteritis. By measuring CRP levels daily, then weekly and monthly for up to a year, researchers h…

This study looks at whether a routine blood test measuring D-dimer levels can predict if the immunotherapy drug cemiplimab will control advanced cutaneous squamous cell carcinoma. Researchers will follow 116 patients starting cemiplimab in regular care, comparing disease control …

This study investigates whether erectile dysfunction (ED) in men being treated for high blood pressure is linked to a hidden heart condition called subendocardial ischemia, where the heart muscle doesn't get enough oxygen. Researchers will compare a noninvasive heart test called …

This observational registry study follows 2,250 adults with cardiovascular-kidney-metabolic syndrome (CKMS) at five hospitals in India. Researchers aim to understand how the condition progresses over 12 months, how it affects quality of life, and what treatments doctors prescribe…

This study looks at how tiny particles called extracellular vesicles travel through the bloodstream in people with systemic sclerosis, an autoimmune disease that affects blood vessels and organs. Researchers will take blood samples from different points in the circulation to see …

This observational study looks at whether heart rate variability — a measure of the nervous system's control over the heart — is linked to how well people with resistant hypertension take their medications. Researchers will use a blood test to objectively check drug levels and co…

This study looks at how well the right side of the heart works with the lungs in people who have high blood pressure in their lung arteries caused by schistosomiasis, a parasitic infection common in parts of Africa and South America. Researchers will use echocardiography to measu…

This study looks at children with Von Hippel-Lindau (VHL) disease, a rare genetic condition that causes tumors in the brain and spinal cord. Researchers want to understand how these tumors grow over time and what factors predict when a child will need surgery. By reviewing medica…

This study looks at whether intentionally lowering blood pressure during elective nose surgery (rhinoplasty) causes any stress to brain cells or affects thinking abilities. Researchers will measure a protein called GFAP in the blood, which can indicate brain cell stress, and test…

This study investigates genetic and molecular markers in pregnant women with severe preeclampsia, a dangerous condition involving high blood pressure and organ damage. Researchers will analyze blood, urine, and placental samples from 100 women to identify changes in genes and cel…

This study uses ultrasound to examine how the right side of the heart and the lungs' blood vessels work together during severe COPD flare-ups. Researchers will measure changes in heart-lung coupling in 115 patients admitted to intensive care, comparing readings during the acute e…

This study looks at how certain cancers develop in people with HIV and what factors might increase their risk. Researchers will analyze medical data from 1,000 HIV-positive adults to track which types of cancer occur most often and why. The goal is to improve early detection and …

Superficial vein thrombosis (SVT) is a painful but usually harmless blood clot just under the skin. However, about 4% of people develop more serious clots in deep veins or lungs. Current guidelines recommend ultrasound scans to decide if blood thinners are needed, but scans are o…

This study investigates whether biomarkers in tear fluid can help diagnose migraine and monitor response to anti-CGRP therapies. Researchers will compare tear and blood samples from 400 people with migraine and healthy controls. A subgroup will be followed over time to see how bi…

This study tracks how a pregnant person's heart and lungs change over the course of pregnancy and after childbirth. Researchers will use non-invasive tests to measure blood flow and airway function, aiming to understand how these changes relate to the development of preeclampsia,…

This study tests whether four popular AI chatbots — ChatGPT, DeepSeek, Gemini, and Claude — can correctly classify surgical risk using anonymous patient vignettes. Researchers compare the AI's risk scores to those given by a panel of senior anesthesiologists. If successful, AI co…

This study tests a new wearable system called M2VS that measures heart activity (ECG) and blood pressure continuously for 24 hours. Researchers want to see if it works as well as standard monitors like Holter ECG and ambulatory blood pressure monitors. The study involves 20 adult…

This study follows adults with severe, treatment-resistant migraines to see if preventive treatments—like Botox injections or Eptinezumab infusions—improve not only headache frequency but also cognitive skills such as attention and memory. Researchers will assess participants' th…

This study tests whether wearable devices and artificial intelligence can help personalize the timing of valve replacement in people with moderate to severe aortic stenosis who have no symptoms. Participants wear a smartwatch to track heart rate, activity, and blood pressure, and…

This study tests whether blood pressure readings taken over different layers of clothing are as reliable as those taken on bare skin. Researchers will compare measurements from 161 emergency department patients. The goal is to see if clothing affects accuracy, which could change …

This study will follow 150 infants with a type of birthmark called infantile hemangioma. Some have a less active form that barely grows, while others have the typical form. Doctors will assess each baby using standard guidelines and decide whether to recommend treatment or just w…

This study explores whether measuring how a woman's pupils react to light before spinal anesthesia can predict dangerous drops in blood pressure during planned cesarean sections. Researchers will observe 200 healthy pregnant women and track their pupil responses and blood pressur…

This study tests whether a large language model (LLM) — a type of AI — can help village doctors make better care plans for patients with type 2 diabetes and high blood pressure. About 20 rural doctors will review standardized patient cases, with half receiving AI-assisted decisio…

This study explores whether artificial intelligence can help perform high-field whole-body MRI scans faster while keeping image quality high. Researchers will compare standard MRI sequences with AI-accelerated versions in 600 adults undergoing screening for prostate, lung, or vas…

This study screens adults aged 18 and older in suburban and peri-urban areas of Faisalabad, Pakistan, for four major noncommunicable diseases: diabetes, hypertension, obesity, and high cholesterol. Participants who are found to have these conditions are referred to doctors for st…

This study investigates the role of the Sonic Hedgehog signaling pathway in brain arteriovenous malformations (AVMs), abnormal tangles of blood vessels that can cause bleeding or stroke. Researchers will analyze leftover brain tissue from 20–30 adults undergoing AVM surgery and c…

This study follows 3,000 adults in Qatar—both citizens and long-term residents—to track how cardiometabolic conditions like diabetes and heart disease develop over time. Participants are grouped by blood sugar status (normal, pre-diabetes, or diabetes) and monitored for major car…

This study follows 25,000 people referred to a specialized heart clinic with symptoms like chest pain or shortness of breath. Researchers will track which heart conditions are actually diagnosed and how patients are evaluated. The goal is to improve diagnostic accuracy and unders…

This study looks at why people with end-stage kidney disease on dialysis often develop high blood pressure in the lungs (pulmonary hypertension). Fluid buildup can make this condition seem worse than it is. Researchers will first correct fluid levels, then use heart ultrasound an…

This study will follow 5,500 first-time pregnant women to see if blood tests and eye scans can predict complications like preeclampsia, fetal growth restriction, and gestational diabetes. Researchers will collect samples and images at different points during pregnancy and compare…

This study will check blood pressure and ask about health habits in 500 adults who attend free public health screenings in Croatia. Researchers want to see how many people have high blood pressure, how many know they have it, and how many are taking medicine for it. No treatments…

This study will use ultrasound to measure the thickness and movement of breathing muscles between the ribs in 65 stroke patients. Researchers will compare the affected and unaffected sides and see how these measurements relate to breathing strength, movement, balance, and quality…

This trial tests an AI tool called MIDI that quickly spots problems in brain MRI scans. The goal is to see if it helps doctors report urgent scans faster, so patients get treatment sooner. Over 100,000 adults will take part across multiple NHS sites in the UK.

This study will follow 120 women having surgery for common anal conditions like fissures, hemorrhoids, or fistulas. Researchers want to see if their sexual function improves after surgery. Participants will fill out questionnaires before surgery and at 3 and 6 months after. The g…

This study will test a device that delivers gentle waist pulls during treadmill walking to improve balance in people who have had a stroke and in older adults with mild balance issues. Fifty participants will undergo nine training sessions over three weeks. The goal is to see if …

This study investigates why some chronic stroke survivors with slow walking speed improve after high-intensity interval training (HIIT) while others do not. Participants will undergo 12 weeks of supervised cycling sessions, along with MRI brain scans and walking tests before and …

This study looks at people with inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease, to better understand their risk of serious heart problems like stroke and heart attack. Researchers will collect information on therapy, disease activity, lifestyle…

This study will test whether using ultrasound to guide how a patient's head is tilted can improve blood flow to the brain. Researchers will measure brain pressure and blood flow in 30 ICU patients as they are moved from lying flat to a 30-degree angle. The goal is to find a perso…

This study checks whether an Apple Watch Series 9 can accurately measure key health indicators—like oxygen levels and exercise capacity—in adults with heart conditions such as congenital heart disease, heart failure, or coronary artery disease. Participants wear the smartwatch du…

This study tests a decision aid for people who have had a first blood clot and must decide whether to stop or continue blood thinners after at least 3 months of treatment. The aid provides balanced information on risks and benefits and helps clarify personal values. Researchers w…

This study will look at 60 adults with a type of high blood pressure in the lungs (pre-capillary pulmonary hypertension) to see if measurements from a CT scan match those from a standard invasive heart catheter test. If the CT scan proves reliable, it could offer a safer, less in…

This study looks at whether a hospital rehab and prosthetic training program helps people who lost a leg due to diabetes or blood vessel disease use their artificial limb regularly. Researchers will review past patient records and follow new patients for up to 6 months after they…

This study will follow 100 people with severe obesity who are starting a GLP-1 drug (like Ozempic or Wegovy) to see if it causes new anal or rectal problems within the first 3 months. Participants will have a check-up before starting the drug and again after 3 months to look for …

This study will measure certain proteins in the blood of people who have had a brain hemorrhage (bleeding in the brain) and compare them to healthy volunteers. The goal is to see if these proteins are linked to inflammation after the bleed. No drugs or treatments are being tested…

This trial tests whether remifentanil or esmolol is better at preventing dangerous pressure spikes in the brain when a breathing tube is inserted. Patients with unruptured brain aneurysms scheduled for coil embolization will receive one of the two drugs before intubation. Researc…

This study will look at how balance, arm movement, and body awareness are related in 53 people who had a stroke at least 6 months ago. Participants will complete tests like standing on a special platform, reaching tasks, and questionnaires. The goal is to understand these connect…

This study looks at how the sedative dexmedetomidine affects the smallest blood vessels in people with septic shock, a life-threatening condition caused by severe infection. Researchers will measure blood flow in the tongue's tiny vessels and other key blood pressure indicators b…

This observational study will follow 2,500 people who had a brain hemorrhage and received minimally invasive surgery. Researchers want to see how well patients recover in real-world settings. The study does not test a new drug or procedure, but gathers data to improve future care…

This study will test a new, noninvasive camera called XyCAM CRE that measures blood flow in the back of the eye. Researchers will compare its images with standard eye tests in 350 adults with retinal disorders. The goal is to see if this camera can provide extra information to he…

This study will examine how the heart-lung machine used during cardiac surgery changes platelet function and metabolism. Researchers will take blood samples from 100 adult heart surgery patients at several time points. The goal is to link these platelet changes to post-surgery in…