Could a common blood pressure drug tame a rare brain artery disorder?
NCT ID NCT07634068
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This pilot study tests whether amiloride, a drug used for high blood pressure, can reduce inflammation in the walls of enlarged arteries at the base of the brain in people with vertebrobasilar dolichoectasia (VBD). Six adults with VBD will take amiloride for up to 12 months. Researchers will use a powerful 5.0 Tesla MRI to track changes in artery wall inflammation over time.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Amiloride hydrochlorothiazide
- What this could lead to
- If it works, this could point toward a treatment that slows or stops the progression of vertebrobasilar dolichoectasia.
- What could go wrong
- This is a very small pilot study with only 6 participants, so results may not apply broadly. Amiloride is generally safe but may cause side effects like electrolyte imbalances.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Huashan Hospital, Fudan University, Shanghai, Shanghai 200040
Shanghai, Shanghai Municipality, 200040, China
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Other studies related to the condition(s) this trial covers.