Could a daily pill ease leg pain and swelling from vein disease?

NCT ID NCT07684833

Not yet recruiting Disease control Sponsor: Barbara Maglione Source: ClinicalTrials.gov ↗

First seen Jul 06, 2026 · Last updated Jul 07, 2026 · Updated 1 time

Summary

This phase 3 trial tests whether a daily tablet of CLR-07-23 (heparan sulfate) can reduce symptoms of chronic venous disease, such as leg pain, itching, swelling, and night cramps. The study includes adults aged 18 to 80 with mild to moderate vein disease. Participants take either the active tablet or a placebo for one year, and researchers measure changes in symptom severity using a standard clinical score.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: heparan sulfate (CLR-07-23) prolonged-release tablets
What this could lead to: If effective, this treatment could reduce common symptoms of chronic venous disease, such as leg pain, swelling, and cramps, improving daily comfort and mobility.
What could go wrong: This is a phase 3 trial, but the drug may not prove more effective than placebo. Possible side effects are not yet fully known, and results may not apply to all patients with venous disease.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

chronic venous insufficiency vein disorder venous insufficiency

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC VENOUS DISEASE VEIN DISEASE VENOUS INSUFFICIENCY OF LEG

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