Can a new antiplatelet drug outperform clopidogrel after a heart attack?

NCT ID NCT06577519

First seen Jul 27, 2026 · Last updated Jul 28, 2026 · Updated 1 time

Summary

This phase III trial tests whether vicagrel, an experimental antiplatelet drug, can prevent major heart-related events better than the standard drug clopidogrel in people with acute coronary syndrome (such as a heart attack or unstable angina) who are undergoing a stent procedure. About 1,000 participants will receive either vicagrel or clopidogrel, and researchers will track the rate of heart attacks, strokes, and cardiovascular deaths over time. The goal is to see if vicagrel offers stronger protection without increasing dangerous bleeding.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
vicagrel, an experimental antiplatelet drug
What this could lead to
If vicagrel proves more effective than clopidogrel, it could offer a new option to prevent heart attacks and strokes in people with acute coronary syndrome who receive a stent.
What could go wrong
This is a phase III trial, but vicagrel is still experimental. It may not be safer or more effective than the standard drug, and like all antiplatelet agents, it carries a risk of bleeding.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • General Hospital of Northern Theater Command of Chinese PLA

    RECRUITING

    Shenyang, Liaoning, 110015, China

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