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Could the gut hold the key to calming autoinflammatory Flare-Ups?

NCT ID NCT07718555

Recruiting now Knowledge-focused Sponsor: Assistance Publique - Hôpitaux de Paris Source: ClinicalTrials.gov ↗

First seen Jul 22, 2026 · Last updated Jul 23, 2026 · Updated 1 time

Summary

This study investigates whether gut bacteria and the chemicals they produce influence inflammation in people with autoinflammatory diseases such as FMF, CAPS, and MKD. Researchers will analyze stool and blood samples from 300 patients to measure gut-derived metabolites and assess gut barrier function. The goal is to understand how imbalances in gut microbes might trigger or worsen symptoms in genetically predisposed individuals.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to
If links between gut microbes and inflammation are found, this could point toward new ways to manage autoinflammatory diseases through diet or probiotics.
What could go wrong
This is an observational study, not a treatment trial. It will not test any therapy, and findings may not lead to immediate changes in care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

A20 haploinsufficiency autoinflammatory syndrome cryopyrin-associated periodic syndrome deficiency of adenosine deaminase 2 familial Mediterranean fever juvenile arthritis due to defect in LACC1 mevalonate kinase deficiency

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AUTOINFLAMMATORY DISEASES

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Internal medicine, Tenon Hospital (APHP)

    RECRUITING

    Paris, 75020, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact Phone: •••-•••-•••• Email: •••••@•••••

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