Arthritic joint disease

This study looked at how safe and effective two shingles vaccines (Zostavax and Shingrix) are in people with rheumatoid arthritis who are taking the drug abatacept. About 154 adults took part, and researchers measured their immune response and any side effects. The goal was to se…

This study compares two treatments for severe shoulder arthritis: total shoulder replacement surgery followed by rehab, versus a 12-week exercise program with a physiotherapist. Researchers want to see if surgery leads to better pain relief and function than exercise alone. The t…

This study tests whether a device called BB-02, which delivers pulsed electromagnetic fields, can slow cartilage damage in people with early knee osteoarthritis. Researchers will use MRI scans to measure changes in cartilage and track pain levels. The goal is to find a non-surgic…

This study tested a program to help people with opioid use disorder stay on their medication after being hospitalized for serious infections like endocarditis or bone infections. Forty adults took part to see if the program was practical and helpful. The goal is to improve long-t…

This study tests whether a mobile-friendly gamified app, called Game-App-KNEE, can improve functional outcomes and recovery for people who have had total knee replacement surgery. Participants use the app daily for three months after discharge, while a control group receives only…

This study tests whether whole-body vibration therapy, alone or combined with exercise, can improve bone health and physical function in women with low bone density who have had a total knee replacement. Forty-eight women will be randomly assigned to vibration only, vibration plu…

This study looks at how well the SAGITTA EVL R hip implant works over the long term—7 to 10 years after surgery. Researchers are checking how many implants survive without needing another revision, how satisfied patients are, and what complications arise. The study includes adult…

This study investigates whether changing diet can reduce disease activity in people with psoriatic arthritis. Participants are randomly assigned to one of two diets: one focusing on which foods are eaten, and another limiting daily calorie intake. The trial lasts 24 weeks and inc…

This completed Phase 4 study compared the safety of baricitinib (a daily pill) to TNF inhibitors (injections) in over 2,600 adults with rheumatoid arthritis. The main goal was to see if baricitinib had a higher risk of blood clots. Participants had to be at least 60, have a histo…

This study tested whether injecting bevacizumab (a drug that blocks blood vessel growth) into the joints of people with hemophilia can prevent repeated bleeding episodes. Eighteen participants with chronic synovitis (joint inflammation) received the injection. Researchers measure…

This completed study tested whether a 6-week cardiac rehabilitation program (aerobic and resistance exercises) could improve heart disease risk, blood pressure, and arthritis activity in 40 people with both rheumatoid arthritis and high blood pressure. Participants were randomly …

This trial compares two ways to deliver rehabilitation for women with knee osteoarthritis: in-person clinic visits versus tele-rehabilitation using a smartphone, tablet, or computer. Both groups receive hot packs and strengthening exercises. The study measures knee function, musc…

This phase 3 trial tested whether methotrexate, a drug used for other types of arthritis, can reduce pain and improve quality of life in people with erosive hand osteoarthritis. 64 participants received either methotrexate or a placebo once a week for 12 months. The study measure…

This Phase 1 study tested a single injection of SHR-3045 in 16 healthy adults to see if it is safe and how the body processes it. The drug is being developed as a potential treatment for rheumatoid arthritis, an autoimmune disease that causes joint pain and swelling. Because this…

This study looked at how safe and effective peficitinib is for people with rheumatoid arthritis (RA) in everyday medical practice. About 3,000 patients who were starting peficitinib for the first time took part. Researchers tracked side effects and measured disease activity using…

This study tested whether a single injection of a patient's own fat-derived stem cells can reduce pain and improve knee function in people with mild to moderate knee osteoarthritis that hasn't responded to other treatments. One hundred participants received either a low dose, a h…

This study looked at whether shining a special low-level laser on the gums after getting a dental implant can reduce swelling, pain, and help the implant stay stable. Fifty adults who needed implants took part. The laser was used right after surgery, and the team checked healing,…

This study followed 152 people who received the Sidus Stem-Free Shoulder implant for severe shoulder pain and disability due to arthritis or other joint diseases. The implant is designed to replace the shoulder joint without a long stem, potentially preserving more bone. Research…

This early-stage trial tested the safety of a new drug called SHR-3045 in 40 healthy adults. The study was randomized, double-blind, and placebo-controlled, meaning some participants got the drug and some got a dummy shot. The main goal was to see if the drug causes any side effe…

This study looked at the long-term safety and effectiveness of bimekizumab in adults with active psoriatic arthritis. Over 1,100 people who completed earlier studies received the drug and were monitored for side effects and disease symptoms. The goal was to see if bimekizumab rem…

This large Phase 3 trial tested a once-weekly injection called retatrutide in over 2,300 adults with obesity or overweight who do not have type 2 diabetes. The study also looked at how the drug affects knee osteoarthritis and obstructive sleep apnea. Participants received either …

This Phase 3 study tested guselkumab, a drug given by injection, in 741 adults with active psoriatic arthritis. The goal was to see if it reduces joint pain and swelling. Participants received either guselkumab or a placebo. The main measure was a 20% improvement in arthritis sym…

This pilot study tested whether a butyrate supplement, a type of short-chain fatty acid, could change the gut microbiome and immune responses in people with rheumatoid arthritis who didn't respond well to methotrexate. Twenty participants took the supplement for up to two months.…

This study looked at whether giving tranexamic acid (a medicine that reduces bleeding) both through an IV and directly into the hip joint during hip replacement surgery can safely lower blood loss. 58 adults having elective hip replacement took part. The goal was to see if the co…

This study tested a new technique to help women with primary ovarian insufficiency (early ovarian failure) become pregnant. Doctors removed one ovary, treated small pieces of it with drugs to wake up dormant eggs, and then transplanted the tissue back into the patient. After moni…

This study followed 155 French adults with moderate-to-severe rheumatoid arthritis who were prescribed filgotinib (Jyseleca) for the first time. Over two years, researchers measured how many patients stayed on the drug and how well it controlled their disease activity. The goal w…

This study tested an experimental oral drug called LY3871801 in 164 adults with moderately-to-severe rheumatoid arthritis. The goal was to see if it reduces joint swelling and pain better than a placebo. The trial is complete, and results will help decide if further testing is wa…

This study tested whether analyzing a patient's DNA and RNA could help doctors pick the right drug for inflammatory diseases that don't fit standard categories. 32 adults with at least two affected organs (including skin) received one of six targeted therapies based on their mole…

This study looked at whether taking NSAIDs every day, instead of only when needed, can prevent spine damage in people with ankylosing spondylitis who are also receiving anti-TNF therapy. 188 adults participated in this Phase 3 trial. The goal was to see if continuous NSAID use re…

This study looked at 351 people with knee arthritis and a torn meniscus to see if surgery or physical therapy works better. Participants were randomly assigned to have knee surgery or follow a physical therapy program. The main goal was to measure changes in knee function and pai…

This study compared two types of total knee replacements in 160 patients with medial knee arthritis. One group received a fixed-bearing implant, the other a mobile-bearing implant. Researchers measured knee function and X-ray results to see if one design leads to better outcomes.

This study tested whether a procedure called Subchondroplasty, which fills bone defects with a special material, plus standard knee arthroscopy works better than arthroscopy alone for treating bone marrow lesions in the knee. About 131 adults with knee pain and osteoarthritis too…

This study tested whether adding a weight-loss drug (tirzepatide) to a standard arthritis drug (ixekizumab) helps people with psoriatic arthritis who are overweight or obese. 279 adults with active psoriatic arthritis and a BMI of 27 or higher took part. The goal was to see if th…

This study looked at whether using a robotic system (ROSA) during knee replacement surgery leads to more accurate implant placement compared to traditional methods. It included 252 adults with knee pain, arthritis, or deformities who were already scheduled for knee replacement. R…

This study tested a plastic meniscus implant in 115 adults aged 30-75 who still had knee pain after having part of their meniscus removed. The goal was to see if the implant is safe and helps reduce pain and improve knee function. Participants were followed for up to 5 years afte…

This study tested the drug filgotinib (Jyseleca) in 118 Korean adults with rheumatoid arthritis. The goal was to see how many patients experienced at least a 20% improvement in symptoms after 12 weeks of treatment. The trial is complete, and results will help determine if filgoti…

This early-stage trial tested a new injection for wrist osteoarthritis that combines the patient's own fat (microfat) and platelet-rich plasma (PRP). The goal was to see if this mixture is safe and can reduce pain and improve wrist function, potentially delaying the need for surg…

This Phase 3 trial tested a single injection of TG-C, a cell-based treatment, in 531 people with moderate knee osteoarthritis. The goal was to see if it reduces pain and improves knee function compared to a placebo injection. Participants were followed for 24 months to check safe…

This phase 3 trial tested whether adding paroxetine, an antidepressant, to standard methotrexate therapy can better control rheumatoid arthritis. 100 adults with active RA took part. The main goal was to see if the combination lowers disease activity scores more than methotrexate…

This study tested whether a personalized surgical guide (TOKA) helps surgeons correct knee alignment more accurately than standard tools. 56 adults with medial knee osteoarthritis took part. The goal was to see if the custom approach leads to better bone alignment after surgery, …

This study compared four different knee replacement devices in 218 adults with knee arthritis to see which one patients 'forget' about most after surgery. The main goal was to measure how natural the joint feels using the Forgotten Joint Score. Results could help surgeons choose …

This study tracked over 2,300 adults in Korea who were prescribed Skyrizi (risankizumab) for moderate to severe plaque psoriasis or psoriatic arthritis. Researchers monitored side effects and symptom changes for 52 weeks during routine doctor visits. The goal was to confirm the d…

This study tested a device that delivers antibiotics directly to an infected hip or knee joint for 7 days after replacement surgery. 76 adults with joint infections were randomly assigned to get either the local antibiotic irrigation plus standard care, or standard care alone. Th…

This study tested an experimental protein called LNA043, given as injections into the knee, to see if it can help regrow cartilage in people with knee osteoarthritis or cartilage injuries. 142 adults participated in two parts: one for cartilage lesions and one for osteoarthritis.…

This study tested an injectable drug called CT-P13 in 192 adults with moderate-to-severe rheumatoid arthritis. The goal was to see if it reduces joint pain and swelling better than a placebo. Participants received either the drug or a dummy shot, and researchers measured improvem…

This early-phase study tested whether a single injection of donor bone-marrow stem cells (StromaForte) is safe for people with mild-to-moderate knee osteoarthritis. Twelve adults received the injection and were monitored for side effects over 24 weeks. The main goal was safety, n…

This study tested a new drug called bimekizumab in 567 adults with moderate to severe plaque psoriasis. Participants received either bimekizumab, a placebo, or another active drug. The main goal was to see how well bimekizumab cleared skin lesions after 16 weeks. Results showed s…

This phase 3 study tested bimekizumab, a drug given by injection, against a placebo in 435 adults with moderate to severe plaque psoriasis. The main goal was to see how many people achieved at least 90% skin clearing after 16 weeks. The trial also looked at complete clearing and …

This study tested whether ultrasound could detect signs of rheumatoid arthritis (RA) relapse before symptoms appear in patients treated with rituximab. Thirty adults with RA who had not responded to at least one TNF-blocking drug were included. Researchers used ultrasound to meas…

This study looked at the long-term safety and effectiveness of the Birmingham Hip Resurfacing System, a metal hip implant, in 329 adults with arthritis. The main goal was to see how many patients needed a revision (replacement or removal) within 10 years. The study also measured …

This early-stage trial tested the safety of a new drug called NTR-1011 in 36 healthy adults and people with lupus or rheumatoid arthritis. The study aimed to find a safe dose and see how the drug behaves in the body. It is a first step toward possibly developing a new treatment f…

This study tested whether combining two drugs (guselkumab and golimumab) works better than one drug alone for people with active psoriatic arthritis who didn't get enough relief from previous TNF-alpha blockers. 91 adults took part. The goal was to see if the combo could help mor…

This study tested whether people with rheumatoid arthritis, psoriatic arthritis, or spine arthritis could safely switch from receiving infliximab through an IV infusion at a clinic to giving themselves a simple shot under the skin at home. 22 adults who were already stable on IV …

This study tested a treatment for people with damaged knee cartilage caused by arthritis or injury. The treatment used the patient's own cartilage cells grown in a lab and then implanted into the knee. The goal was to see if it could reduce pain and improve knee function over 48 …

This completed trial tested Chondron, a treatment made from a patient's own cartilage cells, for knee cartilage defects caused by osteoarthritis or injury. Ten participants received the cells during arthroscopic surgery. The study measured pain and knee function over 96 weeks to …

This study tested a compound called 2-HOBA in 32 adults with rheumatoid arthritis. Participants took either 2-HOBA or a placebo three times a day for 4 weeks. The goal was to see if 2-HOBA is safe and reduces markers of inflammation. This early research helps plan larger future s…

This study tested whether taking a probiotic called VSL#3, alongside standard treatment, can reduce disease activity in children with juvenile idiopathic arthritis (JIA). Fifty-one children aged 1 to 7 with specific types of JIA took either the probiotic or a placebo. Researchers…

This study tested a treatment called Chondron, which uses a person's own cartilage cells grown in a lab, against a standard surgery called microfracture for knee cartilage damage. 21 adults who had either treatment at least 2 years ago were compared. The goal was to see which app…

This study looked at whether adding methotrexate to adalimumab (a biologic drug) reduces the chance that the body makes antibodies against adalimumab in people with ankylosing spondylitis. About 110 adults with active disease who did not respond well to NSAIDs took part. The goal…

This study tested canakinumab, an anti-inflammatory biologic, in 14 Japanese adults with Adult-Onset Still's Disease (AOSD), a rare condition causing fevers and joint pain. Participants received injections every 4 weeks for at least 48 weeks. The goal was to see if the drug could…

This study tested a new shoulder implant called the Catalyst CSR System in 87 people with shoulder arthritis or bone damage. The implant is designed to preserve more natural bone than traditional replacements. Researchers measured pain, movement, and implant safety over two years…

This early-stage trial tested a new biologic drug called KD6005 in 73 people: first in healthy volunteers, then in patients with rheumatoid arthritis. The main goal was to check safety and how the body processes the drug. It is too soon to know if KD6005 works, but this study is …

This Phase 2 trial tested whether an oral drug called RHH646 can help regrow cartilage in the knee for people with osteoarthritis. 82 adults aged 35 to 75 with knee osteoarthritis took either RHH646 or a placebo. The study measured changes in cartilage volume using MRI and tracke…

This completed study looked at whether the DASH diet, known for lowering blood pressure, can help people with rheumatoid arthritis. Forty-nine adults with active disease followed a personalized DASH diet for 12 weeks. Researchers measured changes in disease activity, pain, and in…

This Phase 3 trial tested a new drug called XKH004 in 323 adults with moderate-to-severe active ankylosing spondylitis, a type of arthritis that causes back pain and stiffness. The drug works by blocking two inflammatory proteins, IL-17A and IL-17F. Participants received either X…

This study looked at how well upadacitinib, an anti-inflammatory pill, controls pain in people with axial spondylarthritis (axSpA), a condition causing chronic back pain. Over 700 adults from 19 countries took the drug as prescribed by their doctors and were followed for 12 month…

This study followed 302 children with juvenile idiopathic arthritis (JIA) who had previously taken tofacitinib in earlier studies. The goal was to see how safe the drug is over the long term, by tracking side effects, lab results, and growth. Children took tofacitinib twice daily…

This study looked at 62 children with juvenile idiopathic arthritis whose disease was inactive. Researchers tested whether slowly reducing and then stopping their biologic medication was as safe and effective as staying on the full dose for 24 weeks. The goal was to see if taperi…

This study tested a drug called AK111 in 510 adults with active ankylosing spondylitis, a type of arthritis that causes back pain and stiffness. Participants received either AK111 or a placebo as a shot under the skin over 48 weeks. The main goal was to see if AK111 improves symp…

This study looked at how well a short stem hip replacement stays in place in people with a wider thigh bone canal (DORR Type C). 108 participants who had this surgery were followed to measure any sinking of the implant and to track their pain and function. The goal was to see if …

This study looked at whether a custom-made hip spacer can help people with infected hip replacements. 25 patients had their infected hip implant removed and replaced with a temporary custom spacer, followed by antibiotics. After the infection cleared, they received a new permanen…

This study followed 100 adults who received the Excia T hip prosthesis to see how the implant held up over 10 years. Researchers measured survival rate of the implant and tracked hip function using standard scores. The goal was to confirm the implant's long-term safety and perfor…

This study looked at whether weight-loss surgery (sleeve gastrectomy) is better than diet and medication for adults aged 65 and older with severe obesity and related health problems like type 2 diabetes, high blood pressure, sleep apnea, and knee arthritis. Sixty patients chose e…

This study looked at the safety and performance of the Journey II UNI partial knee replacement in 154 people with knee arthritis. The main goal was to see how many implants were still working well 5 years after surgery. Researchers also tracked any side effects and checked X-rays…

This study tested a daily pill called upadacitinib in 734 adults with axial spondyloarthritis, a type of arthritis that causes pain and stiffness in the spine. The drug was compared to a placebo to see if it could reduce symptoms and control the disease. Results showed that upada…

This study tested whether adding MegaCarti® to standard microfracture surgery improves knee cartilage repair in people aged 50-65 with knee cartilage injuries. 61 participants received either microfracture alone or microfracture plus MegaCarti®. The main goal was to see if MRI sc…

This study tested whether adding leflunomide to standard methotrexate treatment helps children with polyarticular juvenile idiopathic arthritis (JIA) that did not improve with methotrexate alone. Fifty children were randomly assigned to receive either the combination or methotrex…

This study tested whether a visual biofeedback program during squats can improve knee loading and prevent osteoarthritis after ACL reconstruction. 34 participants were assigned to either standard physical therapy or standard therapy plus real-time visual feedback on a screen duri…

This study tested the drug RINVOQ in 69 adults with ankylosing spondylitis, a type of arthritis that mainly affects the spine. Participants took RINVOQ as prescribed by their doctor and were followed for up to a year. The goal was to see how safe and effective the drug is in real…

This study tested a drug called anakinra in 24 children and young adults (ages 2-20) with severe systemic juvenile idiopathic arthritis that did not respond well to steroids. For the first month, half received anakinra and half received a placebo, then all received anakinra for 1…

This study tested whether adding vancomycin powder and a diluted povidone iodine wash during joint replacement surgery could prevent infections in high-risk patients. Over 2,100 adults with osteoarthritis who were at higher risk due to factors like obesity or smoking took part. T…

This study tested a drug called emapalumab in 33 children and adults with macrophage activation syndrome (MAS), a life-threatening immune overreaction, linked to Still's disease or lupus. The goal was to see if the drug could safely control the condition and reduce the need for h…

This study looked at how safe and effective upadacitinib is for Korean patients with rheumatoid arthritis, atopic dermatitis, ankylosing spondylitis, or psoriatic arthritis. Over 2,300 adults took the drug as prescribed by their doctor and were followed for about 28 weeks. Resear…

This study looked at how well a specific knee replacement (balanSys UNI) works over time. 116 people with knee arthritis got the implant and were followed for at least 2 years. Doctors measured knee function using the Knee Society Score and checked X-rays for any problems.

This study looked at 70 people with psoriatic arthritis to compare two drug types: upadacitinib and IL-17 inhibitors. Researchers tracked joint and skin symptoms over 24 weeks in routine care. The goal is to see which works better in real life, helping doctors personalize treatme…

This phase 2 trial tested an experimental drug called LRX712, given as injections into the knee, to see if it can help regrow cartilage in people with mild to moderate knee osteoarthritis. 45 participants received either the drug or a placebo over 8 weeks. The main goal was to me…

This study looked at how well a specific hip replacement system (the Allofit IT Shell with Longevity Liners) works over 10 years. 197 people with hip problems like arthritis or bone death received the implant. The main goal was to see how many implants were still in place without…

This study tested a drug called bimekizumab in 852 adults with active psoriatic arthritis, a condition causing joint pain, swelling, and skin patches. Participants received either bimekizumab, a placebo, or an existing treatment (adalimumab). The main goal was to see if bimekizum…

This early-phase trial tested a stem cell product called CARTISTEM in 12 adults with knee cartilage defects. The stem cells, derived from human umbilical cord blood, were implanted into the knee to see if they could safely help repair damaged cartilage. The study measured knee fu…

This Phase 3 trial tested bimekizumab, a drug given by injection, against a placebo in 400 adults with active psoriatic arthritis who had not responded well to TNF-alpha inhibitors. The study aimed to see if bimekizumab could reduce joint pain and swelling and improve daily funct…

This study tested whether a weekly injection of abatacept (Orencia) plus usual care could prevent juvenile idiopathic arthritis (JIA) from spreading to more joints or causing eye inflammation. 121 children with recent-onset JIA affecting 4 or fewer joints took part. The goal was …

This study looked at using a surgical approach from the back (posterior) to treat bacterial infections of the spine. 47 patients underwent the procedure, which involved removing infected tissue and stabilizing the spine. The researchers found no major complications and reported s…

This study looked at 300 adults with active rheumatoid arthritis whose first anti-TNF treatment stopped working. Researchers compared two strategies: switching to a different type of biologic drug or trying a second anti-TNF. The goal was to see which approach better controls the…

This study looked at how to best use antibiotics to prevent infections in people having knee replacement surgery. About 1,770 adults were split into groups that got antibiotics either just before surgery or for a full day after. The goal was to see if a single dose works as well …

This study followed 218 people who received a cementless POLARSTEM hip implant to treat osteoarthritis. Researchers tracked how well the implant worked and how long it lasted over up to 10 years. The goal was to see if this implant is a safe and effective option for hip replaceme…

This study tested what happens when patients with rheumatoid arthritis, Crohn's disease, or eye inflammation switch from the original drug Remicade to its lower-cost biosimilar Inflectra. Over 260 adults who had been on Remicade for at least 4 months were switched. The main goal …

This early study tested a new drug called EF-M2 (Immutalon) in 48 adults with moderate-to-severe rheumatoid arthritis. The drug is designed to shift immune cells from a pro-inflammatory to an anti-inflammatory state. Participants received injections for 4 weeks, and researchers m…

This study looked at how well a new, quick finger-prick test (LumiraDx CRP) measures CRP levels compared to a standard lab test. CRP is a marker of infection, inflammation, or tissue injury. 79 adults with symptoms of these conditions took part. The goal was to see if the new tes…

This study tested a new DNA-based technique called shotgun metagenomics to see if it can diagnose chronic infections in artificial joints better than standard lab cultures. Researchers took samples from 144 adults undergoing surgery for a suspected joint infection. The goal was t…

This study tests a new radioactive tracer called [F-18]MHF to see if it can detect infections around knee implants using PET scans. Researchers will compare the tracer's uptake in infected versus non-infected implants in 18 adults. The goal is to improve diagnosis and reduce unne…

This study tested whether a self-assessment questionnaire for the shoulder, knee, or ankle can help people decide if they need an orthopedic specialist visit. 150 adults who already requested an orthopedic exam filled out the questionnaire. Researchers will analyze the answers to…

This study looked at whether an MRI scan can help doctors diagnose rheumatoid arthritis (RA) sooner in people with joint swelling. 75 adults with early symptoms were given an MRI and followed for a year. The goal was to see if MRI findings could predict who would develop RA, allo…

This study tested a Turkish version of the Johns Hopkins In-Room Independence Scale, which measures a patient's ability to move, use the toilet, and think clearly while in their hospital room. Researchers worked with 100 adults who had conditions like stroke, Parkinson's, or ampu…

This clinical trial tests a gel called ABIO3419, injected into the knee joint, to see if it safely reduces pain and improves function in people with knee osteoarthritis. The study compares ABIO3419 to another treatment and measures pain relief over three months. Participants are …

This study tests whether adding hypnosis to standard care helps control pain and anxiety during a knee lavage procedure for people with knee osteoarthritis. About 100 participants will be randomly assigned to receive either usual care alone or usual care plus hypnosis. The main g…

This study tests whether injecting a concentrated sugar-water solution (dextrose) into the knee joint can reduce pain and improve function in people with knee osteoarthritis. Participants receive either the dextrose injection or a placebo (salt-water injection) under ultrasound g…

This study is testing a device called the CORI™ KNEE TENSIONER, which helps surgeons balance the knee during total knee replacement surgery. Fifty adults who need a knee replacement will have the surgery using this device, and their recovery and quality of life will be tracked fo…

This study tests a wearable device that delivers low-intensity ultrasound to the knee for 1-4 hours daily, combined with a diclofenac pain patch, to reduce pain and improve function in people with mild-to-moderate knee osteoarthritis. Participants aged 50-85 with frequent knee pa…

This study tests whether adding foot massage to standard cold therapy can reduce pain and improve satisfaction in people who have had knee replacement surgery. Sixty participants will be randomly assigned to receive either cold therapy alone or cold therapy plus foot massage for …

This study tests whether a prescription pain cream called Multiprofen-CC™ can help control pain and reduce the need for opioid painkillers after total knee replacement. About 288 adults having knee surgery will use either the cream or a placebo along with standard pain care. The …

This pilot study tested the Atlas Knee System, a device implanted outside the knee joint to reduce pressure on the inner knee, in 50 people with medial knee osteoarthritis. The goal was to see if it safely relieves pain and improves function over 24 months. Participants were foll…

This study tested two acupuncture methods—thread-embedding and electroacupuncture—in 60 adults with knee osteoarthritis. Participants received 4 weeks of treatment plus standard care. The goal was to see which approach better reduced pain and improved knee function. Results may h…

This study tested whether a supplement made from grape and olive extracts (Oléogrape®SEED) can reduce inflammation in people with knee osteoarthritis. Twelve patients took the supplement or a placebo for 7 days. Researchers then measured anti-inflammatory effects in blood and joi…

This study tested whether adding a special breathing therapy (intermittent hypoxia-hyperoxia) to standard physical therapy helps people with knee osteoarthritis. Sixty adults aged 45 and older with knee pain for at least 3 months took part. The breathing therapy involved short cy…

This study tested whether a higher concentration of ozone injected into the knee works better than a lower concentration for treating osteoarthritis. 159 patients received one of two ozone strengths and were followed for 3 months. Researchers measured pain, stiffness, and daily f…

This study tested a dietary supplement called INTOFINE-JOINT SUPPORT in 33 adults aged 40-60 with mild knee osteoarthritis. Participants took the supplement for 60 days, and researchers measured changes in pain, stiffness, and physical function using standard questionnaires and t…

This study tested a one-year support program (JASP-1) for children newly diagnosed with juvenile idiopathic arthritis (JIA). The program included seven structured visits with a focus on the child and family. Researchers compared registry data from 56 children who took part in the…

This study compares two treatments for knee osteoarthritis: a nerve block injection guided by ultrasound and standard physical therapy. Researchers want to see which method better reduces pain, improves mobility, and helps balance. The study will include 66 adults aged 40-70 with…

This study tested whether a gentle electrical current, called frequency specific microcurrent, can lower inflammation and pain in obese adults with osteoarthritis. Ten participants received one hour of treatment and had blood drawn to measure inflammatory markers. They also fille…

This study tested a self-guided online program for people with psoriasis. 348 adults were split into two groups: one got the app plus their regular treatment, the other got regular treatment alone. The main goal was to see if the app improved quality of life over 12 months.

This trial tests whether a program combining education with high-intensity interval training (HIIT) can improve knee osteoarthritis symptoms and reduce heart disease risk better than a standard neuromuscular exercise program. About 150 adults with knee osteoarthritis and at least…

This pilot study tested whether village doctors in rural China can effectively deliver an exercise program for people with knee osteoarthritis. Sixteen participants either received supervised exercise three times a week for 12 weeks followed by independent exercise, or usual care…

This study compares two ways to manage pain after total knee replacement: a continuous nerve block using a catheter near the femoral triangle versus tissue infiltration with a local anesthetic. The goal is to see which method better prevents long-term chronic pain and improves kn…

This study tested whether giving multiple doses of gabapentin before and after total knee replacement surgery can reduce the amount of morphine needed for pain. 101 adults having elective knee replacement took part. The goal was to see if gabapentin could lower pain and morphine-…

This study looked at 60 people having total knee replacement surgery to see which of two nerve blocks works better for pain control when added to a standard block. One block targets the space behind the knee (IPACK), the other targets a muscle plane (AMM). The goal was to reduce …

This study tested whether a device that gently stimulates the vagus nerve through the ear could help control rheumatoid arthritis in one patient who had their spleen removed. The patient used the device at home for 24 months and visited the clinic every two months for checkups. T…

This study tested whether nurse-led consultations can help people with rheumatoid arthritis become more independent in managing their subcutaneous biotherapy. Many patients struggle to recognize warning signs and delay seeking help. The study enrolled 71 adults with rheumatoid ar…

This study tested whether adding a resveratrol supplement to a low-calorie diet helps postmenopausal women with obesity and knee osteoarthritis. Ninety-seven women took either the diet alone or the diet plus 150 mg of resveratrol daily for 10 days. Researchers measured pain, func…

This study tested whether adding high-intensity laser therapy to exercise can reduce pain and improve muscle strength in people with knee osteoarthritis. 31 adults aged 45-77 with knee pain received either real laser or a sham laser alongside a standard exercise program for four …

This study looked at 20 people with severe hip arthritis who needed a hip replacement. They were randomly assigned to get either a short or a long stem implant. Researchers used 3D motion capture to measure walking patterns before surgery and at several points after, to see if on…

This study tested whether using a blue laser before a standard red laser can help reduce muscle and joint pain in 44 adults with chronic neck or shoulder pain. Participants received a 13-minute treatment combining both lasers. The goal was to see if at least 65% of people got a 3…

This completed trial tested a new device called the NEUROCUPLE™ patch, which uses nanotechnology to reduce pain after knee replacement surgery. 156 adults were randomly assigned to receive either the active patch or a placebo patch for 30 days. The goal was to see if the patch co…

This study tested whether a personalized, supervised home exercise program helps people recover better after total hip replacement compared to just receiving an exercise brochure. 44 people who had hip replacement surgery were split into two groups: one got a tailored exercise pl…

This study tested whether a non-invasive technique called transcranial direct current stimulation (tDCS) can reduce pain and improve daily function in people with knee osteoarthritis. 102 adults with chronic knee pain received either real or fake tDCS sessions over three weeks. R…

This study compares core stabilization exercises to a daily physical activity program in children aged 10-18 with juvenile spondyloarthropathy, a type of arthritis. The goal is to see if targeted core training can reduce pain, fatigue, and improve quality of life better than gene…

This study tested whether a J-shaped skin incision, instead of the usual straight cut, can reduce numbness and pain after total knee replacement. Sixty-two patients with severe knee arthritis were randomly assigned to get either the standard or the J-shaped incision. The research…

This study looked at whether using a forced-air warming blanket during knee replacement surgery helps prevent hypothermia (low body temperature) and related problems like shivering. Researchers compared 240 patients who either got the warming blanket or standard care. The goal wa…

This study tested whether adding exercise plans created by AI chatbots (ChatGPT-5, Gemini 2.5 Pro, or DeepSeek V3.1) to standard physical therapy helps people with degenerative knee disease feel better and move easier. 84 adults aged 40-65 took part in an 8-week program with supe…

This study tested whether a CBD oral solution (Epidiolex) can help manage pain and reduce the need for opioids in 37 adults undergoing double knee replacement. Participants received either a placebo or one of two CBD doses. The goal was to see if CBD could lower opioid use while …

This study tested whether surgeons can give a numbing shot (adductor canal block) during knee replacement surgery as effectively as an anesthesiologist does before surgery. 200 adults with knee osteoarthritis having same-day discharge were randomly assigned to one of the two meth…

This completed trial looked at whether giving dexamethasone through a nerve block or through a vein works better for pain and inflammation after total knee replacement. 90 older adults were randomly assigned to one of two groups. Researchers measured how long pain relief lasted, …

This study tested three different injections—platelet-rich plasma (PRP), stem cell secretome, and hyaluronic acid—in 45 people with knee osteoarthritis. The goal was to see which one reduces pain and improves function best. Participants received one of the three treatments, and o…

This study compared two minimally invasive procedures for knee osteoarthritis pain: genicular nerve radiofrequency ablation and intra-articular pulsed radiofrequency. Both use radiofrequency energy to reduce pain, but in different ways. Researchers enrolled 34 adults with knee os…

This completed pilot study tested an 8-week online mindfulness course in 38 people with rheumatoid arthritis. The goal was to see if patients liked the program, what barriers they faced, and how it might affect symptoms. Half the group took the course while the other half receive…

This study tested two different ways of preparing Platelet-Rich Plasma (PRP) injections for people with knee osteoarthritis. 96 participants received three injections over six weeks and were followed for six months. The goal was to see which method better reduces pain, improves f…

This completed study tested two different physical therapy programs in 84 adults aged 40-60 with grade II knee osteoarthritis. One group received the Macquarie injury management protocol (soft tissue work plus exercises), while the other did a targeted knee exercise program. Rese…

This study compares two common surgeries for thumb arthritis: total joint replacement (arthroplasty) and trapeziectomy (removing a small bone). Researchers will analyze data from 1,000 patients aged 45 and older in a Swedish registry, tracking pain, function, and complications fo…

This study tested two ways of applying radial pressure wave therapy to the knee in 82 people with knee osteoarthritis. The goal was to see if targeting specific joint lines works better than treating the most painful spots. Participants received three sessions and were followed f…

This study tested whether injecting a steroid (betamethasone) directly into the torn meniscus of the knee provides better pain relief and function than the standard injection into the joint space. 70 people with stable degenerative meniscal tears were randomly assigned to one of …

This study tested whether using a computer navigation system with special pre-surgery X-rays (EOS imaging) helps surgeons place a new hip joint more accurately. 78 adults with hip osteoarthritis who needed a total hip replacement took part. The goal was to see if this technology …

This study tested whether using virtual reality before or during total knee replacement surgery could help lower anxiety and improve recovery quality. 120 adults who had the surgery participated. The results showed that VR may be a simple, drug-free way to help patients feel calm…

This study tested whether holding a simple thigh muscle contraction for 5, 10, or 20 seconds best improves strength, pain, and daily function in people with knee osteoarthritis. 127 adults aged 40-65 with mild to moderate knee arthritis took part. All also received ultrasound and…

This early study tested a single injection of a new drug, LEO 158968, in 6 people having a gout flare. The goal was to see if it could reduce joint pain. The trial is complete, but results are not yet public.

This study tested whether adding video-call support to standard physical therapy helps people recover better after total knee replacement. 44 adults aged 50-75 with knee arthritis took part. The goal was to see if tele-rehab reduces pain, improves movement, and helps people get b…

This study tested whether taking oral hyaluronic acid supplements along with hyaluronic acid injections works better than injections alone for knee osteoarthritis. 44 people aged 60-75 with knee arthritis took part. The goal was to see if the combination improves pain, stiffness,…

This study compared two methods of pain relief after hip replacement surgery: a newer technique called erector spinae plane block (ESPB) and the standard epidural. 60 adults having hip replacement took part. Researchers measured pain levels, opioid use, muscle strength, and walki…

This study tested a gel containing diclofenac (a common pain reliever) applied once daily to the knee. 549 adults with knee osteoarthritis used either the gel or a placebo for 6 weeks. The goal was to see if the gel reduces pain and improves knee function better than a placebo.

This study tested whether applying a hot compress with black seed or ginger essential oil to the knees for 7 days could reduce pain and improve satisfaction in people with knee osteoarthritis. 120 adults with moderate knee OA were split into four groups: ginger oil plus heat, bla…

This pilot study tested whether adding group-based pain neuroscience education (PNE) to a community exercise program helps older women with knee osteoarthritis. Nineteen women aged 60+ were randomly assigned to 10 weeks of exercise plus PNE or exercise alone. Researchers measured…

This study compared two surgeries for severe thumb arthritis: simple removal of a small wrist bone (trapeziectomy) versus removal plus ligament reconstruction (the Weilby procedure). Sixty patients were randomly assigned to one surgery. The goal was to see which provides better p…

This study tested whether a home exercise program guided by the TRAK app could improve pain and function in people with knee osteoarthritis, compared to doing the same exercises without the app. Fifty patients over age 45 with knee pain took part. The goal was to see if telerehab…

This study tested two types of balance training—whole body vibration therapy and balance board exercises—in 44 obese adults with mild knee osteoarthritis. Over eight weeks, researchers measured pain, mobility, and quality of life to see which approach worked better. The goal was …

This study tested whether a short behavioral program called Acceptance and Commitment Therapy (ACT) could reduce pain and improve function in veterans at risk for persistent pain after knee replacement. 402 veterans were randomly assigned to ACT or an attention control group. Res…

This study tested three different injections for people with painful jaw arthritis: platelet-rich plasma (PRP), hyaluronic acid, and a steroid called triamcinolone acetonide. 64 adults received one of these or a placebo saline injection. Researchers measured pain and mouth openin…

This study tested a system that combines a wearable knee sensor with an exercise app to help people with knee osteoarthritis. The program provides personalized exercises and real-time feedback to ensure correct form. Thirty adults with knee osteoarthritis participated, and resear…

This study tested a new injection treatment called PIT (using a sugar-water solution) against TENS (a mild electrical stimulation device) for people with shoulder pain. Thirty-two adults with ongoing shoulder pain received either PIT or TENS, plus exercises, over two weeks. The g…

This study tested whether low-dose radiation therapy can reduce pain and improve function in people with knee osteoarthritis. 114 adults aged 50-85 with moderate knee arthritis received either low-dose radiation or a sham treatment. Researchers measured pain and function improvem…

This study tested whether a daily capsule combining etoricoxib and diacerein can reduce pain and improve function in adults with knee or hip osteoarthritis. Over 60 days, 123 participants took either the test combination or an active comparator (meloxicam plus diacerein). Researc…

This completed study tested two versions of a cooled radiofrequency procedure to relieve chronic knee pain from osteoarthritis. Ten adults with moderate to severe pain received either the standard or a revised nerve-targeting technique. Researchers measured pain, knee function, q…

This study tested whether applying cold to painful joints can reduce pain and improve quality of life in people with rheumatoid arthritis. 90 patients with active pain participated. The goal was to see if this simple, low-cost method could be a helpful addition to standard care.

This study tested whether transcutaneous electrical acupoint stimulation (TEAS) — a gentle electrical pulse applied to specific points on the body — could reduce period pain and inflammation in women with autoimmune diseases like rheumatoid arthritis or lupus. Fifty-two women rec…

This study tested whether a special type of exercise called isokinetic eccentric strengthening can improve knee function and reduce pain in people with knee osteoarthritis. 40 adults with one-sided knee osteoarthritis participated. The exercises focused on strengthening the quadr…

This study tested whether a single injection of amniotic suspension allograft (ASA) can reduce pain and improve function in adults with knee osteoarthritis who haven't found relief from other treatments. About 594 participants received either ASA or a placebo, and their pain and …

This study tested whether a food formula containing medium-chain triglycerides (MCTs) and vegetable fibers could improve quality of life in 72 adults with psoriatic arthritis and low disease activity. Participants took the formula for 3 months while continuing their usual medicat…

This study tested a new robot device that helps people with knee osteoarthritis do rehab exercises at home after surgery. Ten adults used the device for one month to see if it improved their leg strength and knee function. The goal was to make recovery easier and faster, especial…

This study tested whether injecting a collagen product called CartiZol into the knee can reduce pain in people with osteoarthritis, cartilage damage, or injury-related arthritis. 200 adults with knee pain received either the collagen injection or a placebo (saline). The main goal…

This study tested two drugs, colchicine and prednisone, to see which works better for sudden, severe joint pain caused by CPPD arthritis (a type of arthritis common in older adults). The trial involved 111 hospitalized patients aged 65 and older. Researchers measured pain relief …

This study tested whether injecting a sugar solution (dextrose) into the small joints of the lower back can reduce pain and improve function in people with chronic low back pain. Sixty adults aged 40-70 with facet joint arthritis were randomly assigned to receive dextrose, steroi…

This study compared two injections for sacroiliac joint pain: platelet-rich plasma (PRP) made from the patient's own blood, and a standard steroid/anesthetic mix. Fifty adults with confirmed sacroiliac joint pain received one of the two injections. Researchers measured pain level…

This study tested whether motivational interviewing, a counseling technique that helps people set and reach personal goals, could boost satisfaction in 149 patients undergoing knee replacement for osteoarthritis. Researchers measured how satisfied patients were with their rehabil…

This study tested a new treatment called CKD-981 to see if it can safely and temporarily ease knee pain in people with osteoarthritis. About 100 adults aged 40 to 80 with moderate knee pain took part. The treatment was compared to a fake procedure (sham) to measure its true effec…

This study tested a mobile app designed to help people with rheumatoid arthritis manage their condition. 90 adults with stable treatment used the app for 12 weeks, while a control group received usual care. Researchers measured changes in disease activity and quality of life to s…

This study tested a treatment called Dharasana Lep in 35 adults with mild to moderate muscle or joint pain, including rheumatoid arthritis. The goal was to see if it safely reduces pain and improves movement. Participants used the treatment and reported their pain levels using si…

This study tested whether a collagen injection into the knee could relieve pain and improve function better than a standard hyaluronic acid injection in 100 adults with knee osteoarthritis. Participants received one injection and were followed for up to 52 weeks. The goal was to …

This study looked at whether a numbing injection around knee nerves (genicular nerve block) can reduce pain and improve quality of life and joint position sense in people with chronic knee osteoarthritis. 40 adults aged 55-75 with moderate knee arthritis took part. The goal was t…

This study tested a step-by-step treatment plan for people with knee osteoarthritis pain. Participants first received duloxetine (Cymbalta), a drug that helps with pain, and then, if needed, an injection of hyaluronic acid mixed with a steroid into the knee joint. The goal was to…

This study tested whether giving the sedative drug dexmedetomidine during knee replacement surgery could lengthen the time before patients need additional painkillers. 94 adults having elective knee replacement under regional anesthesia received either the drug or a placebo. The …

This study tested whether adding a nerve block (adductor canal block) to standard local pain injections reduces pain after knee replacement surgery better than injections alone. 61 adults having knee replacement took part. The goal was to find a way to improve pain control and he…

This study looked at whether intermittent fasting (eating only during certain hours) can reduce disease severity and improve quality of life for people with psoriasis and psoriatic arthritis. Sixty overweight adults were randomly assigned to either follow an intermittent fasting …

This study tested whether a steroid injection into the thumb joint can reduce pain and improve hand function in people with thumb osteoarthritis. 61 adults received either a steroid shot or a placebo (salt water) and were followed for 6 months. The goal was to see if the steroid …

This study looked at 60 people having knee replacement surgery to compare two types of nerve blocks for pain relief: the adductor canal block and the pericapsular nerve group block. The goal was to see which one provides better pain control and helps patients feel more comfortabl…

This study looked at whether doing physical therapy online (telerehabilitation) works as well as going to a clinic in person after shoulder replacement surgery. 93 patients were randomly assigned to either online or in-person therapy. Researchers measured shoulder movement, pain,…

This study tested whether adding dexamethasone or dexmedetomidine to a standard nerve block (erector spinae plane block) improves pain control after total knee replacement. 90 adults undergoing knee surgery received one of the two drugs or a placebo alongside the nerve block. Res…

This study looked at 130 people having knee replacement surgery for osteoarthritis. It compared two ways to manage pain: one using a nerve block near the knee, and the other adding extra numbing medicine around the joint. The goal was to see which method helped patients recover f…

This study tested an experimental drug called DFV890 in 115 adults aged 50-80 with painful knee osteoarthritis. Participants received either the drug or a placebo to see if it reduced pain and inflammation. The goal was to find a new way to ease symptoms and improve daily functio…

This study tested two treatments—shock wave therapy and pulsed electromagnetic field therapy—in 60 people with mild to moderate knee osteoarthritis. The goal was to see which one better reduces pain, improves daily function, and increases knee movement. Participants were aged 40 …

This study tested whether a health coaching program (called CAPPA) combined with a Fitbit could help employees with chronic knee pain become more physically active. Thirty-nine participants were split into two groups: one received physical activity coaching, the other received ge…

This study tested two different exercise programs in 28 children and teens with rheumatic diseases like juvenile arthritis and familial Mediterranean fever. One program used external focus (thinking about the movement's effect), the other used internal focus (thinking about the b…

This study tested whether an injection of etanercept, a targeted anti-inflammatory drug, works better than a standard steroid injection for sudden joint swelling in people with rheumatoid arthritis. 34 adults with active arthritis in a knee, wrist, ankle, or elbow took part. The …

This study compared a single injection of sterile amniotic fluid to the standard steroid shot for knee osteoarthritis. 60 adults with moderate knee arthritis who had not gotten relief from other treatments took part. The main goal was to see if the amniotic fluid could reduce the…

This pilot study looked at whether passive static stretching can increase hip flexibility in three groups: people who had hip replacement, those with long-term hip pain, and healthy volunteers. Twelve participants followed a 4-week stretching program three times a week under supe…

This study tested whether a clinical Pilates program can reduce symptoms of hip osteoarthritis. Fifty-two adults with hip OA were assigned to either clinical Pilates or standard therapeutic exercises twice a week for 12 weeks. Researchers measured pain, movement, balance, and qua…

This study tested a physical therapy technique that uses a cuff to slightly restrict blood flow during exercise. The goal was to see if it could safely improve muscle strength and reduce pain in people with hemophilia who have ankle joint damage. 31 adults with hemophilia A or B …

This study tested whether using a stationary bike with real-time feedback on pedaling force could improve deep sensation (like joint position and vibration sense) in 40 elderly patients with knee osteoarthritis. Participants also received standard treatments like TENS and ultraso…

This study tested a pre-surgery exercise program using blood-flow restriction training in 16 older adults waiting for total knee replacement. The goal was to see if it is safe, well-tolerated, and improves muscle strength and function before surgery. Results will help design larg…

This study tested whether a connected knee brace with a phone app could improve muscle strengthening rehab for people with knee osteoarthritis. 65 adults aged 50-80 used either standard rehab or the smart brace with remote physiotherapist supervision for 8 weeks. The goal was to …

This study tested two physical therapy methods for people with moderate knee osteoarthritis (grade II). One group received hands-on manual therapy (joint mobilization, massage), while the other got standard exercises and electrotherapy. Over 6-8 weeks, researchers measured pain, …

This study tested whether eccentric muscle training (lengthening exercises) improves walking performance in people with knee osteoarthritis compared to standard concentric training (shortening exercises). Forty adults aged 40-85 with knee osteoarthritis participated in 6 weeks of…

This study tested whether adding a genicular nerve block to a standard femoral nerve block improves pain control after total knee replacement. Eighty adults having knee surgery were split into two groups: one got the standard block, the other got both blocks. Researchers measured…

This study tested whether a special ultrasonic handpiece that sprays hydroxyapatite (a natural enamel mineral) can reduce tooth sensitivity during dental cleanings for people with gum disease. Forty adults with moderate to severe periodontitis had half their mouth cleaned with th…

This study tested a hand exercise program called SARAH in 6 women with rheumatoid arthritis. The program includes strengthening, stretching, and home exercises along with education. The goal was to see if it improves hand function and reduces pain.

This study tested whether adding a specific massage technique (myofascial release) to standard physical therapy could improve quality of life for people with chronic knee pain. 45 adults with knee pain participated. The approach focused on a small muscle behind the knee called th…

This early-stage study tested whether an experimental pill called PIPE-791 is safe and can lower pain in adults with long-term osteoarthritis knee pain or chronic low back pain. 43 participants stopped their usual pain meds, then took either the study drug or a placebo daily for …

This study tested two treatments for jaw joint arthritis (TMJ osteoarthritis): platelet-rich plasma (PRP) and autologous conditioned serum (ACS), both made from the patient's own blood. 75 adults who had not improved with standard care received one of these injections after a joi…

This study tested whether injecting a mix of painkillers (bupivacaine, ketorolac, and epinephrine) around the knee during total knee replacement surgery could reduce pain and improve function better than standard pain medicines alone. Eighty adults with end-stage knee arthritis t…

This Phase 3 trial tested an experimental drug called RTX-GRT7039, given as an injection into the knee joint, to see if it reduces pain from osteoarthritis. 469 adults with knee osteoarthritis who did not get enough relief from standard treatments took part. The study compared th…

This study involved 324 adults with conditions like Crohn's disease, arthritis, or psoriasis who switched from a standard to a higher-concentration form of adalimumab (AVT-02). Researchers measured injection site pain and how well patients stuck with their treatment over 180 days…

This Phase 3 trial tested whether a single injection of RTX-GRT7039 into the knee can reduce pain in adults with knee osteoarthritis who haven't gotten enough relief from standard treatments. 466 participants received either the drug or a placebo injection. The study measured pai…

This study looked at how much numbing medicine (ropivacaine) and whether adding dexamethasone affects pain control after hip replacement. 120 adults were split into four groups, each getting a different combination. The goal was to see which approach delays the need for strong pa…

This study tested whether a gel containing piroxicam plus warming and cooling ingredients (methyl salicylate, menthol, eugenol) works as well as standard piroxicam-only or diclofenac gels for muscle and joint pain. 180 adults with conditions like ankle sprain, back pain, or knee …

This study looked at whether a special numbing injection (IPACK block) combined with a steroid shot can reduce pain in people with advanced knee osteoarthritis. 98 adults over age 40 with severe knee pain despite other treatments received the combination. Researchers measured pai…

This phase 3 trial tested the safety of an experimental drug called RTX-GRT7039, given as a knee injection to 714 adults with moderate to severe osteoarthritis pain that wasn't helped by standard treatments. The study focused on side effects and did not measure how well the drug …

This study tested two types of leg exercises in 24 women with knee osteoarthritis to see which better improves muscle strength, knee movement, and daily function. Participants did either eccentric (lengthening) or concentric (shortening) quadriceps exercises three times a week fo…

This study tested whether a smartphone app with mapping technology helps people start rehabilitation sooner after hip replacement surgery. 142 adults who had a hip replacement used either the app or standard care (calling their family doctor). The app shows nearby rehab centers, …

This study tested a WeChat mini-program that provides personalized rehab plans, progress tracking, and emotional support for people recovering from hip or knee replacement surgery. 140 adults aged 18-80 used the app alongside standard care, or standard care alone. The goal was to…

This pilot study tested whether adding a fibrin sealant (VeraSeal) to the standard medication tranexamic acid (TXA) during total knee replacement improves early recovery. 78 patients with end-stage knee osteoarthritis were randomly assigned to receive either TXA alone or TXA plus…

This study tested a phone-based version of the Walk With Ease program for 267 adults with arthritis, gout, fibromyalgia, rheumatoid arthritis, osteoarthritis, or lupus. Participants followed a 6-week walking program delivered by phone, and researchers measured changes in pain, ph…

This study tested whether changing the angle of a leg exercise machine (N-K Table) from 0° to 50° helps people with knee osteoarthritis activate their thigh muscles more. Forty-three women aged 50-65 with knee osteoarthritis did isotonic knee extensions at both angles. Muscle act…

This early-phase trial tested a single injection of SYN321, a drug that breaks down into pain-relieving substances, in 35 people with painful knee osteoarthritis. The main goal was to check safety and tolerability at three different doses compared to a placebo injection. Research…

This study tested a special insole that measures foot pressure to help people walk better after hip replacement surgery. 200 adults were split into four groups: some used the smart insole with real-time feedback, some without feedback, some used a different device, and some had s…

This study tested whether resveratrol, a natural substance found in grapes and red wine, can reduce pain in people with knee osteoarthritis. 142 adults with painful knee arthritis took either resveratrol or a placebo pill daily for three months. The main goal was to measure chang…

This study tested a personalized program of exercise and manual therapy (like stretching and massage) in 10 adults with severe hemophilia who had multiple damaged joints. The goal was to see if it could reduce pain, improve joint movement and strength, boost heart-lung fitness, a…

This study looked at 90 adults having knee replacement surgery to see which nerve block technique works better for pain control and getting patients moving sooner. One group got a fascia iliaca plane block, the other got a combination of adductor canal and IPACK blocks. Researche…

This study looked at whether adding platelet-rich plasma (PRP) injections to a supervised exercise program helps people with knee osteoarthritis more than exercise alone. 84 adults aged 40-70 with moderate knee arthritis took part. Researchers measured pain, function, and movemen…

This study tested whether a simple home-based thigh exercise can reduce knee pain in older adults with osteoarthritis. Fifty people aged 60 to 85 did daily 10-second thigh squeezes for 28 days, and some also used topical gels like CBD or arnica. The goal was to see if this low-co…

This study tested two simple home treatments for early-stage knee osteoarthritis: a structured exercise program versus a topical pain-relief gel (diclofenac). 83 adults aged 40-70 participated. The goal was to see which approach better reduces pain and improves daily function, he…

This study tested two types of hyaluronic acid injections for knee osteoarthritis in 88 recreational athletes aged 50-70. One group received a single dose of cross-linked hyaluronic acid, while the other got two doses of straight-bonded hyaluronic acid. Researchers measured pain,…

This study tested a new injectable lubricant called CCoat for people with mild to moderate knee osteoarthritis. 125 participants received either a single injection of CCoat or a placebo and were followed for six months. The goal was to see if CCoat safely reduces pain and improve…

This study tested whether using a cold and compression brace for six weeks after knee replacement surgery helps reduce pain and the need for painkillers. 208 patients who had a total or partial knee replacement were asked to use the brace five times a day for up to 20 minutes. Re…

This study tested two types of radiofrequency ablation—a procedure that uses heat to calm pain-signaling nerves—in 26 people with advanced knee osteoarthritis whose pain didn't improve with standard treatments. The goal was to see which method, conventional or cooled, better redu…

This study tested a 12-week exercise program designed for people with both congestive heart failure and knee osteoarthritis. 94 adults took part, with half doing low-impact aerobic and strength exercises and the other half receiving standard care. The goal was to see if the tailo…

This study looked at whether adding Tai Chi exercises to standard physical therapy helps older adults (ages 60-80) with knee osteoarthritis. 96 participants were split into three groups: standard therapy alone, therapy with virtual reality training, or therapy with Tai Chi. The g…

This study looked at whether adding a nerve block (PENG block) to a standard steroid injection into the hip joint can better relieve pain from hip osteoarthritis. Researchers followed 50 patients whose pain persisted despite other treatments. The goal was to see if the combinatio…

This study tested whether a self-administered oxytocin nasal spray could reduce pain and improve function in older adults with knee osteoarthritis. Over 4 weeks, 83 participants used either the spray or a placebo. The goal was to see if oxytocin, a natural pain-relieving hormone,…

This study tested whether a custom knee brace connected to a mobile app and motion sensors can improve symptoms and daily function for people with knee osteoarthritis. 36 adults aged 45-75 with mild to moderate knee OA wore their assigned brace for 6 months and completed surveys …

This early-stage study tested a new drug called APPA-1 in 40 healthy volunteers and people with osteoarthritis. The main goal was to see if the drug is safe and how the body processes it. Researchers also looked at how food and gender affect the drug. This is a first step to see …

This study tested a new treatment for knee osteoarthritis using stem cells from umbilical cord tissue. 31 people aged 55-70 with moderate knee arthritis received the stem cells either with or without a minor knee surgery (arthroscopy). The goal was to see if the treatment could r…

This study compared two hands-on therapies—Strain Counter Strain and Myofascial Release—for people with knee osteoarthritis. 44 adults aged 40 to 65 with grade 2 knee osteoarthritis took part. The goal was to see which technique better reduces pain and improves daily function and…

This study tested whether wet cupping therapy, an ancient practice where small cuts are made on the skin and cups are used to draw out a small amount of blood, can help people with ankylosing spondylitis, a type of arthritis that mainly affects the spine. Half of the 100 particip…

This study looked at whether adding craniosacral therapy (a gentle, hands-on technique) to a home exercise program could reduce pain and improve function in people with knee osteoarthritis. Twenty-one adults participated, with one group receiving the therapy weekly for six weeks …

This study looked at 123 people who had knee replacement surgery using the MAKO robot. Researchers tracked their pain, steps, and motion with a Fitbit and knee brace to see if robotic help leads to faster recovery compared to traditional surgery. The goal is to find out if the ro…

This study tested whether two structured telemedicine visits, added between regular doctor appointments, could help people with psoriatic arthritis improve their quality of life and reduce disease impact. 101 adults with active symptoms took part. The visits focused on lifestyle …

This study tested whether a single injection of platelet-rich plasma (PRP) from the ACP Max™ system can help people with knee osteoarthritis. Forty-five adults with knee pain and X-ray evidence of arthritis received either the PRP injection or a standard steroid injection. The ma…

This pilot study tested whether an injection made from a patient's own blood, called A2MRP, is safe and can help with moderate knee osteoarthritis. Twenty adults with painful knee OA received a single ultrasound-guided injection. Researchers tracked side effects and measured pain…

This study compared two physical therapy techniques—Mulligan's Pain Release Phenomenon and Kaltenborn Mobilization—for knee osteoarthritis. 44 adults aged 40-65 with early knee osteoarthritis received either technique plus conventional exercises for 6 weeks. Researchers measured …

This study tested a single injection of lorecivivint into the knee joint of 501 people with moderate-to-severe knee osteoarthritis. The goal was to see if it reduces pain and improves function over 56 weeks compared to a placebo. Participants reported their pain levels weekly, an…

This study tested two different therapy methods to help people with knee osteoarthritis feel less pain and move better. 44 adults aged 40 to 60 with moderate knee arthritis took part. One group received a special hands-on therapy called the Fascial Distortion Model, while the oth…

This study tested whether adding a nerve-freezing procedure (genicular nerve radiofrequency ablation) to standard knee replacement surgery could reduce pain and improve knee function afterward. Seventy adults with advanced knee osteoarthritis took part. The goal was to see if the…

This study tested a program called OPERAS that includes a web app for tracking symptoms and a physiotherapist who gives activity advice using a Fitbit. The goal was to see if it helps people with rheumatoid arthritis feel more confident managing their disease. 132 adults with rhe…

This study looked at whether the drug Acthar can reduce inflammation and improve symptoms during a rheumatoid arthritis (RA) flare. Forty adults with RA who were having a flare took part. Researchers used ultrasound and disease activity scores to measure changes after treatment.

This study tested whether L-carnitine, a natural supplement, can reduce pain, stiffness, and improve physical function in people with mild to moderate knee osteoarthritis. 66 participants took either L-carnitine or a placebo three times daily for 8 weeks. The goal was to see if L…

This study looked at whether telehealth follow-up (phone or video calls) after total knee replacement helps patients regain function, take care of themselves, and do daily activities better than standard discharge instructions. About 60 adults who had knee replacement surgery wer…

This study tested a single injection of a drug called lorecivivint in the knee joint of 496 people with moderate to severe knee osteoarthritis. The goal was to see if it reduces pain and improves function compared to a placebo (fake injection) over 28 weeks. Participants reported…

This study tested whether injecting a patient's own processed fat tissue into the arthritic hip joint could safely reduce pain and improve movement. Thirty adults with mild to moderate hip osteoarthritis received one ultrasound-guided injection. Researchers measured changes in pa…

This study looked at 60 adults who had knee replacement surgery to see which of two nerve block combinations worked better for pain. One group got a biceps femoris short head block plus an adductor canal block, and the other got an IPACK block plus an adductor canal block. Resear…

This study looked at 45 people with knee osteoarthritis to see which combination of exercises works best for reducing pain and improving movement. Participants were split into three groups, each doing different mixes of strengthening, stretching, and biking exercises. The goal wa…

This pilot study tested whether listening to a 12-minute guided mindfulness meditation before total knee replacement surgery could improve patients' mental well-being and physical recovery. Thirty adults scheduled for knee replacement were randomly assigned to receive the meditat…

This study tested three simple distraction methods—virtual reality headset, a squishy squeeze toy, and poetry reading—to see if they could help control pain after total knee replacement surgery. 140 adults were split into four groups, with three trying one of the distractions and…

This early study tested whether injecting a special mixture of cells from a person's own belly fat into their arthritic knee is safe and doable. Nine adults with knee osteoarthritis received the injection. The main goal was to check for side effects, not to measure pain relief, s…

This study looked at whether five simple physiotherapy exercises could help improve balance and reaction speed in older adults (ages 65-95) with arthritis of the spine. Sixty participants were split into two groups: one did a three-week exercise program, the other did not. The re…

This study tested whether injecting a person's own processed fat (MFAT) into the knee works better than a standard steroid shot for osteoarthritis pain. Forty adults with moderate knee arthritis received either MFAT or a steroid injection. Researchers tracked pain and symptom cha…

This study looked at whether showing patients pictures of their damaged cartilage and new knee joint after surgery helps them feel better and move better early on. About 80 adults with severe knee arthritis who had a knee replacement took part. The goal was to see if seeing the p…

This study looked at two different massage methods—instrument-assisted soft tissue mobilization and cross fiber massage—to see which works better for pain and movement after total knee replacement. 50 adults aged 40-60 who had knee replacement surgery took part. The goal was to f…

This study looked at how common muscle and posture problems are in physiotherapy students and whether a special physiotherapy program could help. 44 students with back pain and muscle tightness received treatments like trigger point release, stretching, and joint mobilization. Th…

This phase 3 study tested a weekly injection called retatrutide in 445 people who are overweight or have obesity and also have knee osteoarthritis. The goal was to see if it reduces knee pain and helps with weight loss. Participants received either the drug or a placebo for about…

This study tested whether injecting a sugar-water solution (prolotherapy) into the knee, combined with a personalized exercise program, could reduce pain and improve function in people with knee osteoarthritis. 74 adults with grade 2 knee OA took part. Researchers measured pain, …

This study looked at 80 people who had knee replacement surgery for arthritis. It compared two methods of closing the skin: a special skin adhesive alone versus the same adhesive with a polyester mesh. The goal was to see which method gave better scar healing and made patients ha…

This study looked at two ways to manage pain after knee replacement surgery: a shot around the knee joint and a nerve block in the thigh. The goal was to see which method helps patients recover better and feel less pain. Sixty adults who had knee replacement took part, and their …

This study tested whether a special thermo-active knee sleeve (Reparel™) plus a standard corticosteroid injection works better than a plain compression sleeve plus the same injection for knee osteoarthritis. Forty adults with knee OA who chose non-surgical treatment were followed…

This completed study tested whether combining underwater ultrasound therapy with custom-made foot orthotics can help people with rheumatoid arthritis who have foot pain. Fifty-five participants received the treatments, and researchers measured pain, balance, and quality of life. …

This completed study looked at how Voltaren Gel (a topical pain reliever) affects mobility and quality of life in 196 adults with knee osteoarthritis pain. Participants used the gel as directed for up to 3 weeks while wearing an activity tracker. The goal was to see if the gel he…

This study tested whether using 10 mL or 20 mL of numbing medicine around the knee after replacement surgery could reduce the need for strong painkillers. 120 adults having knee replacement took part. The goal was to see if the smaller dose works just as well, with less medicatio…

This study tested a movement therapy called Mulligan mobilization in 36 people with knee osteoarthritis. The goal was to see if it could reduce pain and improve how muscles work. Participants were aged 50 to 70 with moderate knee pain. The therapy involves gentle, repeated moveme…

This study tested whether kinesiology tape, applied to the back and shoulders, can reduce pain and improve posture, balance, and breathing in people with ankylosing spondylitis. 63 adults with the condition took part. The tape was compared with routine home exercises to see if it…

This study tested if using heat to destroy a nerve in the kneecap (patellar denervation) during total knee replacement surgery reduces pain and improves knee function afterward. 64 adults with knee osteoarthritis took part. The goal was to see if this extra step helps people reco…

This study tested a dietary supplement containing Boswellia serrata, curcumin, and MSM in 100 adults with joint pain or stiffness. Participants took either the supplement or a placebo for a period, and researchers measured inflammation markers and arthritis symptoms using a stand…

This study looks at families where one sibling has a rheumatic disease (like rheumatoid arthritis or lupus) and the other does not. Researchers compare their blood, genes, and environmental exposures to find clues about why one got sick. Over 1,000 participants are involved, incl…

This completed study looked at how the social networks of caregivers affect their stress and health when caring for someone with an inherited disease. Researchers surveyed over 680 participants, including family members and formal caregivers, to understand caregiving burden and s…

This study is looking at how nutrition affects disease activity in people with rheumatic diseases like rheumatoid arthritis, lupus, and psoriatic arthritis. Researchers will measure the nutritional status of 460 participants using several different tools and compare it to how act…

This study translated the Generic Functional Index, a questionnaire that measures how well people can do daily activities, into Turkish. Researchers tested it with 200 adults who have muscle or joint problems to see if it is accurate and reliable. The goal is to give Turkish-spea…

This study examined 750 emergency patients with joint pain to find out which germs cause septic arthritis. Researchers compared standard lab cultures with a new PCR test to see which works better. The goal is to help doctors diagnose joint infections more quickly and accurately.

This study follows people newly diagnosed with psoriatic arthritis (PsA) to see how a 'treat to target' approach works in everyday clinics. Participants receive standard care, often starting with methotrexate, and their disease activity is tracked over time. The goal is to unders…

This completed study reviewed data from 31 patients who had knee replacement revision surgery due to aseptic loosening (the implant coming loose without infection). Researchers used a regional registry and X-ray analysis to understand the causes and economic impact. The goal was …

This completed study from France examined joint fluid from 20 people with arthritis to see if acid-sensing ion channels (ASICs) play a role in pain. Researchers wanted to find natural compounds that activate these channels during inflammation. The goal is to validate ASICs as tar…

This study looked at a type of immune cell called B regulatory cells in 100 people—some healthy and some with rheumatoid arthritis (RA). The goal was to understand how these cells differ between the two groups and how they might help control the disease. By identifying unique fea…

This study followed 813 people with early rheumatoid arthritis in France to see how often and why doctors prescribe TNF blockers. Researchers tracked symptoms, joint damage, and treatment success over 5 years. The goal was to learn which patients benefit most and how well doctors…

This study followed 813 people with early rheumatoid arthritis in France to see how often doctors prescribe TNF blockers alone (without other arthritis drugs) and how well they work. Researchers tracked symptoms, joint damage, and how long patients stayed on treatment over 5 year…

This study looked at whether French doctors follow EULAR recommendations to check heart disease risk every year in patients with rheumatoid arthritis. Over 7000 patients were included. The goal was to see how often tests like blood sugar, cholesterol, and heart scans were prescri…

This study looked at three ways to help people with rheumatoid arthritis take their methotrexate medication as prescribed: usual doctor visits, text message reminders, or a chat with a pharmacist. The goal was to see which method works best to improve adherence. The study include…

This study compared muscle oxygen levels in the thigh muscle of 34 people with and without knee osteoarthritis. Participants did a simple squat exercise while a device measured oxygen in the muscle. The goal was to understand how knee OA affects muscle function and recovery, whic…

This completed study looked at 340 people to understand how certain proteins in the lungs, called autoantibodies, might be linked to the start of rheumatoid arthritis (RA). Researchers collected sputum (mucus from the lungs) from people at risk for RA, those already diagnosed, an…

This study tested whether a new version of the arthritis drug abatacept (called KSHB002) works similarly to the approved drug Orencia. Three hundred healthy adults received a single injection of either the new drug or Orencia. Researchers measured drug levels in the blood, checke…

This study tested whether wearable motion sensors can accurately measure spinal movement in people with ankylosing spondylitis (AS), a condition that causes back pain and stiffness. Forty participants (20 with AS and 20 healthy volunteers) wore sensors while performing everyday m…

This study followed 163 people with chronic inflammatory rheumatism (like rheumatoid arthritis) who had a recent COVID-19 infection. Researchers measured their antibody levels over two years to see how immunosuppressive drugs affect antibody persistence. The goal was to better un…

This study looked at whether healthcare professionals in Saudi Arabia are aware of and follow safety measures for the drug leflunomide, used for rheumatoid and psoriatic arthritis. Researchers surveyed 302 doctors and pharmacists to see if they received and read safety materials,…

This study involved 20 adults over age 50 to measure how soft tissues (skin, fat, muscle) around the knee react when pressed by a brace. Researchers used an ultrasound probe to push on the leg and record force and displacement. The goal is to gather data that could lead to more c…

This completed study looked at how the COVID-19 pandemic and social distancing impacted the mental health of 259 adults with chronic inflammatory rheumatism (like rheumatoid arthritis or ankylosing spondylitis). Researchers used questionnaires to measure stress, depression, anxie…

This study examined whether women with autoimmune diseases or inflammatory rheumatism receive proper gynecological follow-up, including cervical cancer screening and contraception advice. Researchers surveyed 318 women with conditions like lupus, rheumatoid arthritis, and Sjögren…

This study looked at the safety of the drug RINVOQ in over 4,200 Japanese adults with rheumatoid arthritis, a condition causing joint pain and swelling. Researchers reviewed medical records for three years to count serious infections and other side effects that happened during no…

This study compared two types of surgical retractors used during hip replacement surgery to see if one caused fewer infections. 144 patients were randomly assigned to receive either a Charnley retractor or an Alexis O-Ring retractor. The researchers took tissue samples during sur…

This study aimed to find blood markers that can predict whether the drug adalimumab will successfully treat ankylosing spondylitis after 6 months. Researchers analyzed blood samples from 50 adults starting adalimumab for the first time. The goal was to create an algorithm to help…

This completed study tested a smart wearable device called gaitQ that monitors and cues walking in people with long-term movement conditions like Parkinson's, stroke, multiple sclerosis, and arthritis. Researchers collected movement data from 98 participants in a lab to see if th…

This completed study investigated whether air pollution affects flare-ups in people with rheumatoid arthritis, ankylosing spondylitis, or psoriatic arthritis. Researchers followed 86 patients for 6 months, asking them to complete weekly questionnaires about their symptoms. They a…

This study looked at 235 people to understand how certain immune cells, called innate T cells, might be involved in systemic sclerosis (a rare disease that causes hardening of the skin and organs). Researchers compared patients with systemic sclerosis to those with other autoimmu…

This study looked at 343 adults with infections in their artificial hip or knee joints. It compared two common surgeries: one-stage (removing and replacing the joint in one operation) and two-stage (removing the joint, treating the infection, then replacing it later). The main go…

This study looked at 40 people who had knee replacement surgery to see if the type of implant affects recovery. One group got a cruciate-retaining implant, the other a posterior-stabilized implant. Researchers measured pain, function, fear of movement, quality of life, and how mu…

This study tested a device called NaviFast 6D, a miniature measuring arm used during hip replacement surgery to help surgeons check leg length and hip offset. Researchers compared measurements from the device to standard X-ray measurements in 84 adults undergoing hip replacement.…

This pilot study looked at factors that predict pain and function after total knee replacement. Researchers tested a brief mindfulness-based cognitive behavioral therapy in a small group of patients and compared them to those receiving usual care. The goal was to see if this appr…

This pilot study looked at how weight loss affects bone density in overweight or obese men. 44 men either followed a reduced-calorie diet to lose weight or maintained their weight for 6 months. Researchers measured changes in bone density and quality to see if weight loss has any…

This study looked at different questionnaires that patients fill out after hip or knee surgery to see how well they measure recovery. Researchers wanted to find better ways to compare results across studies and understand what counts as a meaningful improvement for French patient…

This study looked at whether a team-based health assessment before knee or hip replacement surgery improves quality of life and reduces healthcare costs for patients aged 65 and older with multiple chronic conditions. 157 patients were randomly assigned to receive either usual ca…

This completed study from Turkey looked at how well rheumatoid arthritis patients can use their arms and hands. Researchers tested 26 patients using a pegboard and ring test for arm exercise, a hand dynamometer for grip strength, and a daily living test. The goal was to better un…

This study looked at 50 adults having knee replacement surgery to see if a computer-guided tool (imageless navigation) can measure key knee angles as accurately as a CT scan. The tool creates a digital model of the knee during surgery, which could avoid the need for a preoperativ…

This study measured phytoestrogens (plant-based compounds) in the blood and urine of 63 premenopausal women with active lupus, other autoimmune diseases, or no disease. Researchers also asked about diet and measured estradiol levels. The goal was to see if these dietary compounds…

This study looked at whether measuring drug levels and anti-drug antibodies in the blood of rheumatoid arthritis patients can help doctors make better treatment decisions. 52 patients starting adalimumab or certolizumab were randomly assigned to have their test results shared wit…

This completed study looked at nearly 7,000 adults with inflammatory joint diseases like rheumatoid arthritis and psoriatic arthritis. Researchers compared two versions of a standard health survey (EQ-5D-3L and EQ-5D-5L) to see which one better measures health and quality of life…

This study looked at how a mix of step-aerobic and resistance training affects the knee joint in postmenopausal women with mild knee osteoarthritis. 103 women were split into two groups: one did the special exercise program, and the other followed standard home exercises. Researc…

This study looked at how different positions affect joint space measurements in people with knee osteoarthritis. 21 patients had MRI scans while standing and lying down, with their knees bent and straight. The goal was to understand how these positions change the distance between…

This study looked at DNA methylation patterns in stored samples from 90 patients with rare skeletal disorders, sarcomas, or inflammatory arthritis. The goal was to better understand these patterns and explore their potential for diagnosis and treatment. The research aimed to impr…

This study looked at blood samples from 24 people with axial spondyloarthritis (a type of inflammatory arthritis) and 12 healthy volunteers to understand how a receptor called KIR3DL2 contributes to inflammation. Researchers also tested whether a drug called IPH4102 could reduce …

This study looked at knee tissue that was removed during total knee replacement surgery in 29 patients. The goal was to learn more about how knee diseases and injuries affect bone and tissue structure, and to test new ideas for future treatments like custom implants or 3D-printed…

This study looked at how different types of shoe insoles affect knee movement and quality of life in people with knee osteoarthritis. Thirty participants were tested to see if insoles change how the knee works during walking and if any benefits are linked to these mechanical chan…

This study looked at 618 people aged 18 to 70 who had hip replacement surgery to see if they developed new low back pain afterward. Researchers tracked how many patients experienced their first episode of low back pain after the procedure. The goal was simply to observe and measu…

This completed study followed 73 adults with bone or joint infections who needed antibiotics for at least 6 weeks. Researchers tracked how often side effects occurred, how severe they were, and whether they affected quality of life. The goal was to understand why some patients st…

This study looked at whether drinking whey protein and doing simple home exercises for two weeks before hip replacement surgery helps people recover faster. Researchers measured blood markers, how soon patients could walk, and how long they stayed in the hospital. The goal is to …

This study looked at how being tired affects the chance of tripping and falling in adults aged 55-70 with and without knee osteoarthritis. 24 participants wore activity monitors, walked on a treadmill for 30 minutes, and did strength and balance tests before and after. Researcher…

This study looked at 40 people with knee osteoarthritis who received injections of platelet-rich plasma (PRP) made from their own blood. Researchers measured pain, function, and inflammation markers to see how PRP might help. The goal was to better understand the treatment's effe…

This study looked at 64 people with knee osteoarthritis to see how balance and leg muscle strength relate to their ability to do everyday tasks like walking, standing up from a chair, and climbing stairs. Researchers used tests like the 6-minute walk and a balance platform to mea…

This study tested a program where doctors refer inactive people with chronic diseases (like diabetes, heart disease, or obesity) to an exercise professional for personalized counseling. The goal was to see if this referral scheme helps people become more active compared to just g…

This study tested whether changes in pupil size can reliably measure pain. Twenty adults with hip or knee arthritis received brief heat pulses while researchers recorded their pupil responses and pain ratings. The goal was to see if pupil diameter could serve as an objective pain…

This study tested whether a low-dose standing CT scanner can detect early signs of arthritis in people who had an ankle fracture. Researchers followed 97 adults for up to 5 years, measuring joint space changes and pain. The goal was to see if this imaging method could predict ost…

This study tested a new way to measure heart fitness (VO2 max) in 30 people before and after hip replacement surgery. Participants wore a small chest sensor to estimate VO2 max without exercise. The goal was to see if this method can track natural recovery over 12 weeks. It is a …

This completed study looked at how tofacitinib, a rheumatoid arthritis drug, changes body fat, muscle, and bone density in 10 patients. Researchers measured visceral fat, lean mass, and bone marrow fat before and after treatment. The goal was to gather early data, not to prove th…

This study tested a new lightweight device called PYTHEAS ODYSSEE that helps surgeons place screws in the spine more accurately. Fourteen adults having spine surgery used the device to guide screw placement. The goal was to see if the device reduces screw misplacement and is safe…

This study tested whether a smartphone app and a wearable activity tracker are practical and acceptable for people with inflammatory rheumatic diseases like rheumatoid arthritis and spondyloarthritis. Over 14 days, 50 participants answered short surveys on their phone and wore a …

This study looked at bone tissue from 34 men who had hip replacement surgery due to femoral head necrosis (bone death in the hip joint). Researchers used advanced imaging and spectroscopy to identify changes in bone structure and composition. The goal was to better understand wha…

This completed study followed 360 adults and children with chronic respiratory and other medical conditions to see how their immune systems responded to COVID-19 vaccines over 18 months. Researchers measured antibody, T cell, and B cell levels before vaccination and every 3 month…

This study looked at 62 people with knee osteoarthritis to see which factors predict a good response to radial pressure wave therapy. Researchers analyzed data from a previous trial to find links between patient traits like age, weight, and pain levels and their improvement after…

This study looked at whether regular nurse check-ins could spot the return of rheumatoid arthritis symptoms sooner than standard doctor visits. 51 adults with controlled arthritis on rituximab took part. The goal was to see if nurses could detect early signs of a flare, potential…

This study looks at whether CT scans are better than regular X-rays for measuring how the spine stiffens and fuses in people with ankylosing spondylitis. Researchers will follow 63 adults over 4 years, using scans, blood tests, and flexibility measurements. The goal is to find a …

This completed study looked at whether adding an integrated care model—including traditional Chinese medicine—to standard treatment could lower inflammation and depressive symptoms in people with rheumatoid arthritis. Researchers measured blood markers of inflammation and used a …

This study looked at 65 adults with ankylosing spondylitis, a type of arthritis that affects the spine. Researchers wanted to see if a blood test called the CALLY index could measure inflammation better than patient-reported symptoms. They reviewed medical records and compared th…

This study looked at 20 people with severe knee arthritis who needed a knee replacement. They were randomly given one of two types of implants: a rotating platform or a fixed one. Researchers used 3D walking analysis before and after surgery to see which implant led to better wal…

This study looked at chest expansion, lung function, and a new measure of breathing muscle strength called the S-index in 52 people with radiographic axial spondyloarthritis and healthy controls. The goal was to see if these measures differ between the two groups and if the S-ind…

This study examined whether arthritis in the hands is linked to more severe arthritis in the knees and hips. Researchers used hand X-rays to assess joint damage in 479 adults aged 40 to 75 with confirmed knee or hip arthritis. The goal was to better understand how arthritis progr…

This study looked at whether placing a drain after knee replacement surgery affects how much hemoglobin drops and whether patients need a blood transfusion. 102 patients were randomly assigned to get a drain or not. The goal is to see if drains help or hurt in terms of blood loss…

This study followed 293 people with autoimmune diseases and healthy volunteers to see how COVID-19 infection or vaccination affects their immune system, inflammation, and blood vessels. Participants were grouped based on their COVID-19 history and had up to 5 visits over 12-18 mo…

This pilot study tested whether wearable sensors (Syde devices) can reliably track knee osteoarthritis symptoms at home over two months. 43 participants wore the sensors on their ankles and wrists to record movement data, which was compared with standard clinic tests. The goal wa…

This study tested whether a mobile app (mymobility) paired with an Apple Watch can help people recover after hip or knee replacement surgery, possibly replacing standard physical therapy. Over 6,500 adults who were scheduled for joint replacement used the app for guided exercises…

This study looked at 72 people with hip osteoarthritis to see if X-ray findings match how they feel day-to-day. Researchers measured pain, stiffness, physical function, and balance, then compared those to X-ray severity scores. The goal was to better understand the connection bet…

This pilot study tested whether a transition coach can help 16-17 year olds with Juvenile Idiopathic Arthritis or Inflammatory Bowel Disease move from pediatric to adult care. The coach met with each teen for 8 one-hour sessions covering self-advocacy, medication management, and …

This study looked at why the quadriceps (thigh) muscle sometimes stops working properly after total knee replacement surgery. Researchers measured muscle inhibition in 20 patients during their hospital stay and tracked their recovery for 6 weeks. The goal was to understand how th…

This study tested whether specially trained physiotherapists can safely diagnose and treat non-urgent muscle and joint pain in the emergency room, compared to standard care from doctors. 102 patients with back, neck, or shoulder pain were randomly assigned to either a physiothera…

This completed study examined the link between erectile dysfunction, nerve pain, disease activity, and daily function in 90 men with axial spondyloarthritis (a type of arthritis affecting the spine). Participants were either on anti-TNF drugs, NSAIDs, or were healthy volunteers. …

This completed study tested whether training rheumatology clinicians in shared decision making helps veterans with rheumatoid arthritis. About 900 patients from VA clinics took part. The training taught doctors to acknowledge treatment options and involve patients in choices. Res…

This study tested a surgical navigation system called NextAR TKA that helps surgeons balance soft tissues during knee replacement. Forty adults scheduled for knee replacement with a specific implant were enrolled. The goal was to see if the system improves patient-reported outcom…

This completed study looked at how psychological resilience and body image relate to pain in people with rheumatoid arthritis or fibromyalgia, compared to healthy volunteers. Researchers measured these factors using questionnaires in 124 adults. The goal was to better understand …

This study explored the connection between knee pain and the ability to sense the position of the lower back in 56 adults with knee osteoarthritis. Participants had their knee pain measured and performed a test to see how accurately they could feel their back's position. The goal…

This study examined nearly 100,000 people who had knee replacement for arthritis to see if those who previously had weight-loss surgery faced different risks of complications or needing another surgery. Researchers focused on how body weight at the time of knee replacement and th…

This study followed 18 adults with active ankylosing spondylitis who were starting anti-TNF therapy for the first time. Researchers measured their sleep quality using overnight sleep tests and a questionnaire, and tracked their daily step counts with a wearable device. The goal w…

This study tested updated features of the ROSA Knee System, a robot used during knee replacement surgery. Forty adults having knee replacement took part. The goal was to check if the new features were safe and easy for surgeons to use, not to cure or treat the disease.

This study looked at why people with hemophilia and damaged knee or ankle joints feel ongoing pain. Researchers measured pain sensitivity, fear of movement, and anxiety in 146 adults. The goal was to better understand central sensitization—a condition where the nervous system sta…

This study used MRI to examine neck muscles in 158 people with ankylosing spondylitis (AS), a type of arthritis that affects the spine. Researchers measured muscle size, fat buildup, and spine alignment, comparing them to healthy controls. The goal was to better understand how AS…

This study followed 285 adults who had knee replacement surgery for osteoarthritis. Researchers wanted to see how knee pain and the way people perceive their knee (like feeling it's less familiar or harder to control) are linked over time. Participants filled out questionnaires b…

This study aimed to create and test a decision aid for people with psoriasis or psoriatic arthritis who are starting or switching treatments. Researchers worked with 37 patients and their doctors to design a tool that supports shared decision-making. The goal was to help patients…

This study looked at whether specially engineered versions of a natural immune protein (IL-2) can selectively boost regulatory T cells, which help calm the immune system. Researchers took blood samples from 67 people with various autoimmune or inflammatory conditions and tested t…

This study tested whether coaching sessions are practical for young people with rheumatic diseases moving from pediatric to adult care. 26 participants received up to 8 coaching sessions covering self-advocacy, medication management, and future planning. The main goal was to see …

This study looked at whether taking acetaminophen (like Tylenol) can reduce aspirin's ability to prevent heart attacks. Researchers gave 55 healthy adults and smokers both drugs in different orders to see if timing matters. The goal was to understand if acetaminophen interferes w…

This completed study used Danish national health records to compare infection rates after total knee replacement in obese (BMI ≥30) versus non-obese patients. Researchers analyzed data from over 100,000 adults who had knee replacement for osteoarthritis between 2011 and 2021. The…

This study looked at two ways of doing a knee realignment surgery (open wedge high tibial osteotomy) to see which one keeps the important blood vessels behind the knee safer. 40 people with knee arthritis took part. Researchers used CT scans to measure the distance between the su…

This study looked at a protein called MMP-9, which is involved in breaking down joint tissue in rheumatoid arthritis. Researchers measured genetic variations of MMP-9 in 60 people with active rheumatoid arthritis and compared them to healthy volunteers. The goal was to better und…

This study looked at 44 adults with osteoarthritis who took mineral baths (balneotherapy) for three weeks. Researchers used heart ultrasound before and after to see if the baths changed heart function. The goal was to better understand how balneotherapy affects the heart, especia…

This study tested a personalized web-based care plan for over 5,700 adults with knee or hip osteoarthritis. The goal was to help patients and their doctors make more informed decisions about treatments, including whether to have joint replacement surgery. The study measured how w…

This completed study looked at 84 adults with knee osteoarthritis to see how common fear of movement (kinesiophobia) is and how it relates to pain and daily function. Researchers measured fear, pain, and physical ability using standard questionnaires. The goal was to understand i…

This study looked at how small molecules called microRNAs change during pregnancy in women with rheumatoid arthritis or lupus. Researchers collected blood and urine samples before and after pregnancy from 50 women to see if these changes relate to disease activity. The goal is to…

This study tested whether custom carbon fiber braces can reduce harmful forces on the ankle joint after a fracture, which may lower the risk of developing arthritis. Twenty-two adults with healed ankle fractures walked with and without different brace designs while researchers me…

This study followed 225 people who had ACL reconstruction surgery to see how their knees were doing 10 years later. Researchers looked at X-rays and pain scores to find out which factors increase the risk of developing osteoarthritis. The goal is to better understand long-term ou…

This study followed 432 people who had ACL reconstruction surgery to see who develops osteoarthritis years later. Researchers measured knee joint space on x-rays and looked at injury details, surgical factors, and patient traits. The goal is to identify risk factors that could he…

This early-stage trial tested the safety and tolerability of an experimental drug called AZD1163 in 108 healthy volunteers. Participants received either the drug or a placebo by IV or injection, and researchers monitored side effects and how the drug moved through the body. Since…

This study looked at 368 patients with severe ankle arthritis who chose surgery. Researchers used surveys, step counts, and motion-capture walking tests to compare how well different surgical procedures improved function and quality of life. The goal was to find out which surgery…

This study followed 472 adults aged 18-75 who received a specific type of hip replacement to see how long the implants lasted. Researchers used patient surveys and survival curves to measure device performance. The goal was to gather long-term data, not to test a new treatment.

This study looked at how the drug methotrexate and its main byproduct leave the body in people with rheumatoid arthritis. Researchers measured levels in urine to create a reference range. This could help doctors identify patients who are not taking their medication as prescribed.

This study looked at how core endurance, finger grip strength, and fatigue relate to hand function in people with rheumatoid arthritis. Researchers measured these factors in 113 participants. The goal was to better understand these connections, which could help guide future treat…

This study looked at 50 Egyptian patients with rheumatoid arthritis to see if methotrexate affects lung health. Half were taking methotrexate, and half were on other treatments. Researchers used lung function tests and CT scans to check for lung disease. They found no difference …

This study looked at how reducing inflammation might lower heart disease risk in people with rheumatoid arthritis. Researchers measured heart blood flow in 74 patients before and after treatment with certolizumab, a drug that fights inflammation. The goal was to see if better con…

This study measured two newer blood markers (calprotectin and serum amyloid protein) alongside standard tests in 20 children with juvenile arthritis and related conditions. The goal was to see if these markers could better track disease flare-ups in everyday clinic visits. The st…

This study tested whether a wearable sensor can detect changes in knee joint loading after a small amount of fluid is injected into the knee (simulating injury). Fourteen healthy adults aged 18-35 participated. Researchers measured walking patterns, muscle activity, and balance b…

This study looked back at 54 people who had a hip replacement with a specific part called the CL TRAUMA cemented stem. The goal was to see if the part was safe and worked well. Researchers measured how well patients could move and if they had pain using a standard hip score.

This study looked at 207 people who had knee replacement surgery to see if removing the surgical drain before or after the first physical therapy session makes a difference. The goal was to compare bleeding, complications, hospital stay, and pain. The results could help doctors d…

This study tested four different cuff designs for carbon fiber ankle-foot orthoses (braces) in 35 healthy adults and people with ankle arthritis or injury. Researchers measured comfort, pain, foot pressure, and walking mechanics to see which cuff design people liked best. The goa…