Weekly shot may halt arthritis progression in kids

NCT ID NCT03841357

Completed Disease control Sponsor: Duke University Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether a weekly injection of abatacept (Orencia) plus usual care could prevent juvenile idiopathic arthritis (JIA) from spreading to more joints or causing eye inflammation. 121 children with recent-onset JIA affecting 4 or fewer joints took part. The goal was to see if 24 weeks of treatment could keep the disease from becoming more severe over 18 months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Abatacept (Orencia) injection
What this could lead to: If successful, this could offer a way to stop early-stage juvenile arthritis from becoming more severe, reducing the need for stronger medications.
What could go wrong: This is a completed Phase 3 trial, but results may not apply to all children. Abatacept can increase infection risk and other side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

arthritic joint disease juvenile idiopathic arthritis oligoarticular juvenile idiopathic arthritis polyarticular juvenile idiopathic arthritis prevention target uveitis prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

JUVENILE IDIOPATHIC ARTHRITIS

Contacts and locations

Locations

Boston Children's Hospital

Boston, Massachusetts, 02115, United States
Children's Hospital at Montefiore/ Albert Einstein University Hospital

The Bronx, New York, 10461, United States
Children's Hospital of Philadelphia

Philadelphia, Pennsylvania, 19104, United States
Cincinnati Children's Hospital Medical Center

Cincinnati, Ohio, 45229, United States
Hackensack University Medical Center

Hackensack, New Jersey, 07601, United States
Mayo Clinic

Rochester, Minnesota, 55905, United States
MetroHealth System

Cleveland, Ohio, 44109, United States
Monroe Carell Jr Children's Hospital at Vanderbilt

Nashville, Tennessee, 37232, United States
Nationwide Children's Hospital

Columbus, Ohio, 43205, United States
Riley Hospital for Children at Indiana University Health

Indianapolis, Indiana, 46202, United States
Seattle Children's Hospital

Seattle, Washington, 98105, United States
Shands at the University of Florida

Gainesville, Florida, 32610, United States
The Children's Hospital Colorado

Aurora, Colorado, 80045, United States
University of California at San Francisco Medical Center

San Francisco, California, 94143, United States
University of Iowa Hospitals of Clinics

Iowa City, Iowa, 52242, United States
University of Louisville School of Medicine/ Norton Charities Pediatric Clinical Research Unit

Louisville, Kentucky, 40202, United States
University of Minnesota; Children's Hospital and Clinics of Minnesota

Minneapolis, Minnesota, 55454, United States
University of North Carolina

Chapel Hill, North Carolina, 27514, United States
University of Utah

Salt Lake City, Utah, 84158, United States

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