New combo therapy shows promise for kids with stubborn arthritis
NCT ID NCT07428551
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether adding leflunomide to standard methotrexate treatment helps children with polyarticular juvenile idiopathic arthritis (JIA) that did not improve with methotrexate alone. Fifty children were randomly assigned to receive either the combination or methotrexate alone for 24 weeks. Researchers measured disease activity using the JADAS-27 score and functional impairment using a questionnaire.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
leflunomide plus methotrexate
What this could lead to
If it works, this combination could offer better disease control for children with JIA who do not respond to methotrexate alone.
What could go wrong
This is a small, single-center trial with only 50 participants. Results may not apply to all patients, and side effects from adding leflunomide are possible.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Bangladesh Medical University
Dhaka, Bangladesh