New combo therapy shows promise for kids with stubborn arthritis
NCT ID NCT07428551
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether adding leflunomide to standard methotrexate treatment helps children with polyarticular juvenile idiopathic arthritis (JIA) that did not improve with methotrexate alone. Fifty children were randomly assigned to receive either the combination or methotrexate alone for 24 weeks. Researchers measured disease activity using the JADAS-27 score and functional impairment using a questionnaire.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- leflunomide plus methotrexate
- What this could lead to
- If it works, this combination could offer better disease control for children with JIA who do not respond to methotrexate alone.
- What could go wrong
- This is a small, single-center trial with only 50 participants. Results may not apply to all patients, and side effects from adding leflunomide are possible.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Bangladesh Medical University
Dhaka, Bangladesh
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