New drug shows promise for debilitating spinal arthritis

NCT ID NCT06378697

Completed Disease control Sponsor: Akeso Source: ClinicalTrials.gov ↗

Summary

This study tested whether an investigational drug called AK111 could reduce symptoms and improve quality of life for people with active ankylosing spondylitis, a painful inflammatory arthritis of the spine. Over 500 participants were randomly assigned to receive either AK111 or a placebo (inactive substance) for 16 weeks, followed by a longer treatment period. The main goal was to see if AK111 was more effective than the placebo at reducing pain and stiffness and if it was safe to use.

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Contacts and locations

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Locations

1001-Peking University Third Hospital

Beijing, Beijing Municipality, China
1002-Xuanwu Hospital Capital Medical University

Beijing, Beijing Municipality, China
1004-Zhongda Hospital Southeast University

Nanjing, Jiangsu, China
1005-Nanfang Hospital

Guangzhou, Guangdong, China
1006-The First Affiliated Hospital of Bengbu Medical University

Bengbu, Anhui, China
1007-Nanjing Drum Tower Hospital

Nanjing, Jiangsu, China
1008-The Seventh Affiliated Hospital, Sun Yat-sen University

Shenzhen, Guangdong, China
1009-Second Hospital of Shanxi Medical University

Taiyuan, Shanxi, China
1010-West China Hospital,Sichuan University

Chengdu, Sichuan, China
1011-Zhuzhou Central Hospital

Zhuzhou, Hunan, China
1012-Hebei Petro China Central Hospital

Langfang, Hebei, China
1013-Xuzhou Central Hospital

Xuzhou, Jiangsu, China
1014-Affiliated Hospital of Jiangsu University

Zhenjiang, Jiangsu, China
1015-Taizhou Hospital of Zhejiang Province

Taizhou, Zhejiang, China
1016-Zaozhuang Municipal Hospital

Zaozhuang, Shandong, China
1017-Changzhou NO.2 People's Hospital

Changzhou, Jiangsu, China
1018-Affiliated Hospital of Nantong University

Nantong, Jiangsu, China
1019-Linyi City People Hospital

Linyi, Shandong, China
1020-The Second Affiliated Hospital of Nanchang University

Nanchang, Jiangxi, China
1021-The People's Hospital of Guangxi Zhuang Autonomous Region

Nanning, Guangxi, China
1022-The First Affiliated Hospital of Hainan Medical University

Haikou, Hainan, China
1023-The People's Hospital of Xinjiang Uyghur Autonomous Region

Ürümqi, Xinjiang, China
1024-Liuzhou People's Hospital

Liuchow, Guangxi, China
1025-Guangzhou First People's Hospital

Guangzhou, Guangdong, China
1026-Shenzhen People's Hospital

Shenzhen, Guangdong, China
1027-Lanzhou University Second Hospital

Lanzhou, Gansu, China
1028- Jining First People's Hospital

Jining, Shandong, China
1029-Hebei General Hospital

Shijiazhuang, Hebei, China
1030-Jieyang People's Hospital

Jieyang, Guangdong, China
1031-The First Affiliated Hospital of University of South China

Hengyang, Hunan, China
1032-Yueyang Central Hospital

Yueyang, Hunan, China
1033-The First Hospital of Qiqihar

Qiqihar, Heilongjiang, China
1034-Affiliated Hospital of Hebei University

Baoding, Hebei, China
1035-Wuxi People's Hospital

Wuxi, Jiangsu, China
1036-Jiangsu Province Hospital

Nanjing, Jiangsu, China
1037-The Second People's Hospital of Lianyungang

Lianyungang, Jiangsu, China
1038-Anhui Provincial Hospital

Hefei, Anhui, China
1039-The First Affiliated Hospital of Nanchang University

Nanchang, Jiangxi, China
1040- Huzhou Third People's Hospital

Huzhou, Zhejiang, China
1041-Affiliated Hospital of North Sichuan Medical College

Nanchong, Sichuan, China
1042-Peking University Shougang Hospital

Beijing, Beijing Municipality, China
1043-Yuncheng Central Hospital

Yuncheng, Shanxi, China
1044-Jilin Provincial People's Hospital

Changchun, Jilin, China
1045-The First Affiliated Hospital of Henan University of Science and Technology

Luoyang, Henan, China
1046-Pingxiang People's Hospital

Pingxiang, Jiangxi, China
1047-The First Affiliated Hospital of Gannan Medical College

Ganzhou, Jiangxi, China
1048-Mianyang Central Hospital

Mianyang, Sichuan, China
1049-The First Affiliated Hospital of Xiamen University

Xiamen, Fujian, China
1050-The First Affiliated Hospital of Wenzhou Medical University

Wenzhou, Zhejiang, China
1051-Shiyan People's Hospital

Shiyan, Hubei, China
1053-Nanyang Central Hospital

Nanyang, Henan, China
1054-Linfen Central Hospital

Linfen, Shanxi, China
1055-Weifang People's Hospital

Weifang, Shandong, China
1056-Zhongshan Traditional Chinese Medicine Hospital

Zhongshan, Guangdong, China

Conditions

Explore the condition pages connected to this study.

ANKYLOSING SPONDYLITIS