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Could a common diabetes pill boost arthritis remission?

NCT ID NCT04196868

Completed Disease control Sponsor: University Hospital, Bordeaux Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 09, 2026 · Updated 2 times

Summary

This study tests whether adding metformin, a diabetes drug, to standard methotrexate therapy helps more people with rheumatoid arthritis achieve disease control. About 128 adults with active RA who have not recently taken methotrexate will receive either methotrexate plus metformin or methotrexate plus a placebo. The goal is to see if the combination reduces joint inflammation and disease activity better than methotrexate alone.

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Conditions

The condition(s) this trial relates to.

rheumatoid arthritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ARTHRITIS, RHEUMATOID

Contacts and locations

Locations

  • CH de Cahors - service de rhumatologie

    Cahors, France

  • CH de Libourne - service de rhumatologie

    Libourne, France

  • CH de Pau - service de rhumatologie

    Pau, France

  • CH de la Côte Basque - service de rhumatologie

    Bayonne, France

  • CH du Mans - service de rhumatologie

    Le Mans, France

  • CHD de Vendée - service de rhumatologie

    La Roche-sur-Yon, France

  • CHR Orléans la Source - service de rhumatologie

    Orléans, France

  • CHU de Bordeaux - service de rhumatologie

    Bordeaux, France

  • CHU de Brest - service de rhumatologie

    Brest, France

  • CHU de Montpellier - service de rhumatologie

    Montpellier, France

  • CHU de Toulouse - service de rhumatolgie

    Toulouse, France

  • Clinique de l'Infirmerie protestante de Lyon - service de rhumatologie

    Caluire-et-Cuire, France

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