Arthritic joint disease

This study tests whether wearing a knee sleeve daily for five years can slow the progression of knee arthritis and reduce pain in adults aged 50 to 64 who have had knee pain for at least three months. Participants are randomly assigned to either wear a knee sleeve every day or no…

This trial investigates whether adding hip strengthening exercises to a standard quadriceps program better preserves knee cartilage thickness and improves symptoms in people with knee osteoarthritis. Fifty-six adults with mild-to-moderate knee OA will be randomly assigned to one …

This study tests two procedures done before ACL surgery: draining excess knee joint fluid (arthrocentesis) or injecting platelet-rich plasma (PRP) from the patient's own blood. The goal is to see if either reduces inflammatory chemicals linked to cartilage damage. About 99 adults…

This first-in-human study tests the safety of a new drug called HBM7020. It will first be given to healthy volunteers at low doses, then to people with moderate to severe autoimmune diseases like lupus, rheumatoid arthritis, scleroderma, and Sjögren's disease. The goal is to see …

This study tests whether freeze-dried fecal bacteria, given as oral capsules, can improve symptoms in 40 adults with active rheumatoid arthritis that hasn't responded to standard drugs. Participants will receive either the fecal transplant or a placebo for 24 weeks. The main goal…

This 52-week study will compare three drugs—tocilizumab, telitacicept, and methotrexate—in 204 people with rheumatoid arthritis who also have interstitial lung disease. The main goal is to see which drug best improves lung function. Participants will continue their usual arthriti…

This study tests whether a supervised resistance exercise program, done for 2 weeks before and 12 weeks after total hip replacement, improves muscle mass and strength in adults aged 60 and older with severe hip osteoarthritis. Participants are randomly assigned to either the exer…

This early-phase trial is testing whether stem cells from donated bone marrow (CG-BM1) are safe for people with ankylosing spondylitis, a chronic inflammatory arthritis. Forty adults aged 18 to 40 will receive either the stem cells or a placebo by IV once a week for four weeks. T…

This study will compare two drugs, tofacitinib and upadacitinib, added to standard methotrexate treatment for rheumatoid arthritis. One hundred adults in Pakistan will take one of the two drugs daily for six months. Researchers will measure disease activity and side effects to se…

This study tests two experimental drugs, goflikicept and olokizumab, in 52 adults with Still's disease, a rare inflammatory condition. The goal is to see if these drugs can quickly bring the disease under control and keep it from flaring up. Participants will receive either the s…

This study tests whether adding a Chinese herbal formula (Si Miao Xiao Bi Tang) to standard rheumatoid arthritis medication can improve symptoms. About 132 adults with active RA will receive either the herbal medicine or a placebo for 12 weeks. The main goal is to see if more peo…

This study will test a new cementless hip stem (Mfinity collared stem) in 95 adults needing total hip replacement due to osteoarthritis. The main goal is to see how many implants survive without needing revision after one year, with a follow-up at two years. Researchers will trac…

This trial compares two ways of aligning the knee during a bone-cutting surgery (high tibial osteotomy) for people with knee arthritis and bow legs. One method aims for natural knee motion (kinematic), the other for straight leg alignment (mechanical). The study will track 100 ad…

This study tests an experimental injection called TG-C for people with early hip osteoarthritis. The injection contains cells that release a growth factor to help repair damaged cartilage. 255 adults will receive either TG-C or a placebo, and researchers will track pain and hip f…

This study tests a new way to treat infected knee replacements. About 100 adults having surgery for an infected knee will be randomly assigned to receive either standard care or standard care plus an extra treatment. The extra treatment involves injecting antibiotics along with s…

This early study tests a new drug called MTM-H-001 in 75 adults with B-cell-related autoimmune diseases, including lupus, multiple sclerosis, and rheumatoid arthritis. The main goal is to check safety and find the right dose. Participants receive the drug by injection, and resear…

This study compares two ways of giving the drug tocilizumab to people with rheumatoid arthritis that is under control. One method uses a fixed dose for everyone, while the other adjusts the dose based on weight. The goal is to see if the simpler fixed-dose method works just as we…

This study is for adults aged 40 and older who have two or more chronic conditions like high blood pressure, diabetes, or depression. Researchers are testing a program that includes a digital decision-support system for doctors, telemedicine for specialist advice, and a mobile ap…

This early-stage trial tests a new drug called KT502 in 27 adults with moderate to severe rheumatoid arthritis. The drug is designed to deplete certain immune cells (B cells) that contribute to joint inflammation. The main goal is to check safety and find the right dose, not yet …

This phase 2 trial tests whether disulfiram, a drug already approved for alcohol use disorder, can safely reduce joint inflammation in people with rheumatoid arthritis who are overweight. Twenty adults with active arthritis despite standard treatment will take either disulfiram o…

This early-stage study tests whether a single infusion of a patient's own modified immune cells (CAR-T cells) is safe for people with severe autoimmune diseases like lupus, rheumatoid arthritis, or scleroderma that haven't improved with standard treatments. Only 6 adults aged 18-…

This study is testing a new shoulder implant that doesn't use a stem, designed for people with arthritis or shoulder damage. About 136 adults will receive the implant and be followed for 2 years to see if it improves shoulder function and pain. The goal is to confirm the implant …

This early-phase trial tests a new stem cell treatment (HS_SW01) for people with ankylosing spondylitis, a type of arthritis that causes spine pain and stiffness. The study will include 18 adults aged 18 to 65. Researchers aim to check if the treatment is safe and if it helps red…

This early-phase study tests a new treatment called BEN301, which uses specially engineered immune cells (CAR-Tregs) to calm overactive immune responses in people with autoimmune diseases like scleroderma, rheumatoid arthritis, lupus, and inflammatory muscle disease. The trial wi…

This study tests a stem cell product called XytriX, made from donated umbilical cord cells, for treating knee osteoarthritis. About 75 adults with mild to severe knee arthritis will receive an injection into the knee joint. The goal is to see if it safely reduces pain and improve…

This study tests whether adding deucravacitinib to standard therapy helps adults with psoriatic arthritis that is not well controlled. About 128 participants will receive the combination and be monitored for 48 weeks. The goal is to reduce skin and joint symptoms and improve qual…

This study tests whether a treatment using special viruses (called phages) can safely and effectively treat infections in hip or knee replacements caused by Staphylococcus aureus bacteria. About 100 adults will receive either the phage therapy or a placebo during a standard surge…

This study tests whether methotrexate, a drug used for other types of arthritis, can slow joint damage in people with painful hand osteoarthritis that hasn't gotten better with standard treatments. About 170 adults with erosive hand osteoarthritis will receive either methotrexate…

This early-phase study tests a single injection of ICM-203, a gene therapy that delivers a gene to promote cartilage growth and reduce inflammation in the knee. About 18 adults with mild to moderate knee osteoarthritis will receive escalating doses to check safety and whether it …

This study tests whether adding venlafaxine, a common antidepressant, to standard rheumatoid arthritis (RA) treatment can better control disease activity. About 70 adults with moderate to severe RA who are already on stable medication will receive either venlafaxine or a placebo …

This study follows 150 adults with moderate-to-severe rheumatoid arthritis who have received the SetPoint System, an implanted device that uses nerve stimulation to control inflammation. Researchers will monitor device safety, ease of use, and how well it controls disease activit…

This early study tests a new treatment called CD19/BCMA CAR-T for people with severe autoimmune diseases like lupus and Sjögren's syndrome that haven't improved with standard care. The treatment involves taking a patient's own immune cells, modifying them to target specific immun…

This study will follow 100 adults who receive the 5C® MEDic Knee System during knee replacement surgery. Researchers want to see how long the implant lasts without needing another operation and track any complications over 5 years. Participants will also fill out health questionn…

This study tests whether antibiotic-coated braided sutures work as well as standard monofilament sutures in patients with infected hip or knee replacements. Surgeons currently use weaker monofilament sutures in infected cases to reduce bacterial growth. If the coated braided sutu…

This study tests whether specially designed viruses (bacteriophages) can eliminate a persistent bacterial infection in a hip replacement joint. One adult who has failed all standard surgeries and antibiotics will receive the viruses directly into the joint and through an IV for t…

This early-phase trial tests whether a single injection of Mytocel MSK (made from a patient's own ear cartilage) can improve knee osteoarthritis better than standard PRP injections. Thirty adults with mild-to-moderate knee arthritis will receive either the new cell therapy or PRP…

This Phase 4 trial tests ivarmacitinib, a once-daily pill, in 100 adults with moderate-to-severe rheumatoid arthritis who did not improve on standard drugs. The study will measure joint symptom improvement after 12 weeks and monitor safety. Ivarmacitinib works by blocking inflamm…

This study tests whether a piece of human umbilical cord membrane can be used as a cushion in the thumb joint to treat arthritis. About 22 people with thumb arthritis who haven't improved with standard care will receive the implant during surgery. Researchers will track pain, thu…

This study tests whether adding a steroid (prednisone) to standard antibiotics can improve joint function in adults with septic arthritis, a serious joint infection. Two hundred participants will receive either prednisone or a placebo for 7 days. The main goal is to see if steroi…

This early-stage study tests a new drug, BMS-986528, in 84 adults with rheumatoid arthritis that hasn't responded well to other treatments. The main goal is to check safety and how the body processes the drug. Researchers will also look for signs that it might help control the di…

This study tests a new drug called TQH3906 for people with active psoriatic arthritis, a condition causing joint pain and skin patches. About 156 adults will receive either TQH3906, a placebo, or an existing drug (tofacitinib) for 12 weeks. The main goal is to see if TQH3906 impr…

This study compares two treatment combinations for adults with psoriatic arthritis who did not get enough relief from methotrexate alone. One group will receive apremilast plus methotrexate, the other adalimumab plus methotrexate. Researchers will measure joint and skin disease a…

This study tests a community-based exercise program for people aged 50 and older who have at least two chronic conditions, such as heart disease, diabetes, arthritis, or obesity. The program is designed to improve muscle strength, heart and lung fitness, and overall well-being. R…

This study tests whether the drug upadacitinib can reduce how often people with axial spondyloarthritis (a type of arthritis affecting the spine) get sudden eye inflammation (acute anterior uveitis). About 200 adults who have had at least one eye flare in the past year will take …

This study tests whether taking oral tranexamic acid for three days after hip replacement surgery can reduce pain, swelling, and help patients walk sooner. About 101 adults with end-stage osteoarthritis will receive the drug or placebo. The goal is to see if this simple pill impr…

This study tests an experimental drug called QLS12010 in 180 adults with moderate-to-severe rheumatoid arthritis. Participants are randomly assigned to receive different doses of the drug or a placebo for 12 weeks. The main goal is to see if the drug reduces joint swelling and te…

This study looks at whether two common diabetes drugs, GLP-1 analogs and SGLT2 inhibitors, can reduce osteoarthritis symptoms like joint pain and stiffness in people with type 2 diabetes. Researchers will follow 390 adults over 50 who have been on one of these drugs for at least …

This study looks at whether baricitinib, a drug for rheumatoid arthritis, can improve blood clotting and cholesterol levels compared to standard treatments. About 100 adults with active RA will take baricitinib for 3 months. Researchers will measure changes in clotting markers an…

This study tests whether tocilizumab, an anti-inflammatory drug already used for rheumatoid arthritis, can reduce joint pain and improve quality of life in people with chronic inflammatory calcium pyrophosphate deposition disease (CPPD) that hasn't improved with standard treatmen…

This study compares a new scaffold implant (MaioRegen Prime) to standard surgical cleaning (debridement) for treating deep cartilage lesions in the knee. About 400 patients aged 18-60 with knee lesions will be randomly assigned to one of the two procedures. The main goal is to se…

This study looks at the long-term results of a surgery that replaces the missing growth plate at the top of the thigh bone in children who lost it due to a severe hip infection. Researchers will check how well the bone heals and how well the hip works at least five years after th…

This study tests a program that uses artificial intelligence to guide exercise and continuous glucose monitors to help people with both knee osteoarthritis and obesity. The goal is to see if it can improve blood sugar control, reduce knee pain, and lower the need for knee replace…

This early-stage study tests a single infusion of stem cells from donated umbilical cords in 16 adults with moderate to severe rheumatoid arthritis that hasn't improved with standard treatments. The main goal is to check safety and side effects over 52 weeks, while also looking f…

This trial tests a new surgical system for knee osteoarthritis that uses 3D planning, custom guides, and augmented reality to improve alignment and reduce pain. About 150 people aged 40-70 with mild-to-moderate knee arthritis will be assigned to either the new system or tradition…

This Phase 2 trial tests whether adding a lab-made antibody called natrunix to standard methotrexate treatment helps people with moderate to severe rheumatoid arthritis who haven't improved enough on methotrexate alone. About 108 participants will receive weekly shots of either n…

This study tests whether semaglutide (Ozempic), a drug used for diabetes and weight loss, can slow the buildup of plaque in arteries of people with psoriatic arthritis who do not have diabetes. Forty participants will receive either semaglutide or no additional treatment for 24 w…

This study tests whether adding a very low dose of the steroid prednisolone (4 mg daily for 4 weeks, then tapering off) to standard treatment helps control symptoms in people newly diagnosed with active rheumatoid arthritis. About 112 adults will be randomly assigned to receive e…

This study will test the drug tofacitinib in 58 children with juvenile idiopathic arthritis (JIA) to see if it improves disease control after 12 months. Researchers will use real-world medical records to measure changes in arthritis activity. The goal is to find out if tofacitini…

This study compares two strategies for slowly reducing prednisolone (a steroid) in people with stable rheumatoid arthritis. One method splits a 5 mg tablet into halves, the other reduces by 1 mg at a time. Over six months, 206 participants will be followed to see which approach k…

This study compares two surgical techniques to realign the knee in people with early arthritis and bowleg deformity. Twenty-eight adults will be randomly assigned to receive either a plate and screws or an external fixator to stabilize the bone after it is cut and repositioned. R…

This study compares robotic-assisted knee replacement to the traditional manual method in 170 adults aged 50-80 with end-stage knee arthritis. Participants are randomly assigned to one of the two surgeries and followed for 2 years to measure knee function, recovery speed, and cos…

This study is testing the LEGION Medial Stabilized knee implant in 144 people who need total knee replacement due to arthritis or joint damage. The goal is to see how well the implant holds up over 10 years without needing revision surgery. Participants will receive one of three …

This study tests whether a Mediterranean diet can lower disease activity and improve quality of life in 110 people with axial spondyloarthritis (a type of arthritis affecting the spine) who are already on biologic therapy. Participants will either follow a structured Mediterranea…

This Phase 3 trial tests whether a single injection of MAG200 stem cells can improve pain and daily function in adults with knee osteoarthritis. About 573 participants will receive either a low dose, a high dose, or a placebo injection. The study aims to confirm if this approach …

This study tests a new treatment using CD19 CAR T-cells for people with severe autoimmune diseases that haven't improved with standard therapies. About 30 participants will receive a single dose of these engineered immune cells after chemotherapy. The goal is to see if it's safe …

This early-phase trial tests whether the weight-loss drug semaglutide can improve outcomes for obese patients waiting for total knee replacement. 54 participants will receive the drug for 48 weeks before and after surgery. The goal is to see if weight loss reduces pain and compli…

This study tests a comprehensive management service package for older adults (65+) who have two or more chronic conditions like high blood pressure, diabetes, or arthritis. The package includes digital tools, personalized lifestyle advice, and long-term support. Researchers will …

Rheumatoid arthritis and gout can look alike, making them hard to tell apart early. This study will use ultrasound to see if it can reliably distinguish between the two conditions. Researchers will examine 100 adults with suspected or confirmed arthritis, scoring joint inflammati…

This study tests a special imaging agent (99mTc-NTP 15-5) to see if it can spot arthritis-damaged joints in the hands and tell the difference between osteoarthritis and rheumatoid arthritis. About 80 adults with one of these conditions will get a scan. The goal is to improve diag…

This study tests a new CT scan technique to see if it can accurately detect loose hip implants before revision surgery. 600 patients scheduled for hip replacement revision will get the special CT scan, and the results will be compared to what the surgeon finds during the actual o…

This study looks at two substances in the blood, IL-18 and IL-18BP, to see if they can help doctors tell apart different causes of fever in children. Researchers will measure these levels in 9 children with conditions like juvenile arthritis, autoinflammatory diseases, or serious…

This study will test whether adding a T2 mapping sequence to a standard MRI can improve detection of early knee osteoarthritis. Researchers will compare MRI scans from 28 healthy volunteers and 28 patients with early OA. The goal is to see if this extra scan can measure cartilage…

This study compares two ways to diagnose bleeding problems during surgery: a quick bedside test (viscoelastic test) and standard lab tests. The goal is to see which method gives faster results, helping doctors treat bleeding sooner. About 210 adults having high-risk surgeries (li…

This study looks at whether a physiotherapist can accurately diagnose subacute knee injuries (lasting 1 week to 3 months) using a video consultation instead of an in-person exam. Researchers will compare three types of assessments: video-based, in-person without special knee test…

This study will test a special ultrasound technique called shear-wave elastography to see if it can better detect tendon inflammation (enthesitis) in people with psoriatic arthritis. Researchers will compare this method with standard ultrasound and also look at how it relates to …

This study will test whether artificial intelligence can accurately tell the difference between inflammatory arthritis (like rheumatoid arthritis) and degenerative arthritis (like osteoarthritis) in people aged 60 and older. Researchers will compare the AI's analysis of X-rays, M…

This study tests whether a new medicine called Fexuprazan (Fexuclue) can prevent stomach ulcers caused by NSAID painkillers like ibuprofen. About 360 adults with joint or muscle pain who need daily NSAIDs will take either Fexuprazan or an older drug (Lansoprazole) for 24 weeks. T…

This study looks at a personalized plan to help older adults prevent falls. It includes 50 people aged 65 or older who have sarcopenia (muscle loss) and knee or hip arthritis. Researchers will test balance, strength, and range of motion to create a tailored fall prevention strate…

This study tests whether adding an oral supplement (PEA) to a series of knee injections (adelmidrol and hyaluronic acid) can better reduce pain and improve function in people with knee arthritis. The injections aim to protect the joint from damage, while the supplement may help c…

This study tests whether adding a simple numbing injection (SSSI) to standard pain blocks can better control pain after knee replacement surgery. About 90 adults aged 45-90 will be randomly assigned to receive either the extra injection or a sham (fake) one. The main goal is to s…

This trial compares three ways to manage pain after total knee replacement. All patients receive standard nerve blocks, but some also get an anti-inflammatory drug (dexamethasone) or a combination of dexamethasone and a sedative (dexmedetomidine). The goal is to see which approac…

This study investigates whether adding High-Intensity Laser Therapy (HILT) to standard physiotherapy helps people with mild-to-moderate knee osteoarthritis. Seventy-two participants will receive either real or sham laser sessions alongside exercise-based physiotherapy. Researcher…

This pilot study compares two standard-of-care radiofrequency ablation (RFA) techniques for chronic knee pain caused by osteoarthritis. Adults already scheduled for knee RFA are randomly assigned to receive either a standard 3-target or a novel 6-target nerve ablation protocol. T…

This study looks at ways to reduce pain during knee steroid injections for osteoarthritis. Researchers will test if using a thinner needle or a numbing spray (ethyl chloride) makes the injection hurt less. 88 adults with knee osteoarthritis will rate their pain right after the sh…

This study tests whether adding shock wave therapy to a knee strengthening exercise program reduces pain and improves function more than exercise alone in people with knee osteoarthritis. Forty patients with moderate knee pain will be randomly assigned to either exercise only or …

This study tests whether an 8-week program of yoga and meditation delivered through a mobile app can reduce anxiety in adults with stable rheumatoid arthritis. About 100 participants will either use the app daily or continue with standard care. Researchers will measure changes in…

This study will compare two treatments—low-level laser therapy and iontophoresis (a method that uses a mild electric current to deliver medication through the skin)—for knee osteoarthritis. Sixty-six adults aged 45 to 65 with mild to moderate knee arthritis will be randomly assig…

This study will compare two probiotic drinks—Bacillus clausii and a mix of four bacterial strains—in 138 children aged 1 to 5 with acute watery diarrhea. All children will also receive standard care like rehydration and zinc. The goal is to see which probiotic reduces diarrhea du…

This study will test whether an 8-week yoga program done live over Zoom can improve balance, endurance, and well-being in 32 children aged 8-12 with juvenile idiopathic arthritis (JIA). The yoga sessions are led by certified physiotherapists and include breathing, poses, and medi…

This study will follow 300 adults aged 50 and older with knee osteoarthritis who are scheduled for a 3-week thermal spa treatment. Researchers will use wearable sensors to measure knee movement fluidity before and after the spa program, and at 3 and 12 months later. They will als…

This study compares two ways to manage knee osteoarthritis: doing your own exercise at a local fitness center versus supervised sessions with a physiotherapist. Researchers want to see if the cheaper, more flexible gym option is just as good at reducing pain and improving quality…

This study tests whether combining the medication duloxetine with a structured walking program can improve physical function, reduce pain, and ease depressive symptoms in veterans with knee osteoarthritis. Participants will be assigned to either the drug-plus-exercise group or a …

This study tests whether walking backwards on a treadmill (called retro walking) can help reduce pain and improve how people with knee osteoarthritis walk. Participants will do retro walking sessions, starting with 10 minutes and gradually increasing up to 30 minutes if pain stay…

This pilot study tests whether a topical CBD oil can reduce pain in people with knee osteoarthritis. Thirty participants will apply either CBD in castor oil or plain castor oil to their knees twice daily for 30 days, then switch treatments. Researchers will track pain scores and …

This study will follow 80 people with chronic pain (like back, hip, or nerve pain) who are getting a procedure called cryoneurolysis, which uses cold to temporarily block pain signals. Researchers want to see if it leads to meaningful pain relief and better daily function over 12…

This study compares two ways to align the knee during total knee replacement in 80 obese adults (BMI 35+). One method uses robotic or computer assistance, the other uses traditional manual tools. The goal is to see which leads to better knee motion and recovery after surgery.

This study tests a physical therapy program designed for older adults with knee osteoarthritis. The program focuses on mobility, balance, and fall prevention, and also considers each person's mental abilities. Forty participants aged 60 and older will take part in 16 sessions ove…

This study will test whether Egoscue postural exercises, alone or combined with a hands-on technique called Mobilization with Movement (MWM), can reduce pain, improve balance, and boost quality of life in people with knee osteoarthritis. Researchers plan to enroll 56 adults aged …

This study tests whether a gel called Conjuran can reduce pain in people with knee osteoarthritis better than the current standard treatment, Hyruan. About 180 adults with mild to moderate knee arthritis will receive two cycles of injections, each cycle consisting of five weekly …

This study tests whether a special exercise method called Sahrmann's approach can reduce pain and improve knee function better than standard physical therapy in people with knee osteoarthritis. Forty adults aged 40 to 60 with moderate knee arthritis will be assigned to one of two…

This Phase 2 trial tests an experimental oral drug, LY4065967, for knee pain caused by osteoarthritis. About 150 adults with chronic knee pain and confirmed osteoarthritis will receive either the drug or a placebo. The main goal is to see if the drug safely reduces pain intensity…

This study will test Mobithron Xtra, an oral supplement containing hyaluronic acid, collagen, and Boswellia extract, in 100 adults with knee osteoarthritis. Participants will take it once daily for 3 months while researchers track changes in pain, stiffness, and daily function us…

This study compares two pain relief methods after total knee replacement: a long-acting pain shot (Zynrelef) given directly into the knee during surgery versus a standard nerve block. The goal is to see which method better reduces the need for opioid painkillers in the first 72 h…

This study tests whether a single injection of concentrated bone marrow cells can reduce pain and improve function in people with hip osteoarthritis better than a standard steroid injection. One hundred adults with moderate to severe hip arthritis will be randomly assigned to rec…

This study tests whether TECAR therapy—a device that delivers gentle heat deep into the knee—can reduce pain, improve balance, and boost quality of life in elderly men with knee osteoarthritis. Eighty men will receive either real TECAR plus standard physiotherapy or a sham versio…

This study compares two ways to perform total hip replacement: the standard direct lateral approach and a newer, less invasive method called SuperPATH. Researchers want to see if SuperPATH reduces pain, blood loss, and recovery time while improving joint stability. 100 adults nee…

This study will test whether taking prednisone for 5 days after knee or hip replacement surgery helps reduce pain, swelling, and the need for opioids compared to the standard steroid given only during surgery. About 104 adults will participate, and their blood sugar will be track…

This study compares two spinal anesthetics, ropivacaine and bupivacaine, in 176 people having hip replacement surgery. The goal is to see which one allows faster return of feeling and movement while still controlling pain well enough for same-day discharge.

This study tests whether a short, digitally guided exercise program before total knee replacement is practical and helpful. Sixty adults with knee osteoarthritis will either do the 10-14 day program or receive usual care. The main goal is to see if people stick with it and find i…

This study tests whether an AI-powered app can guide people with knee osteoarthritis through exercises at home, reducing pain and improving function as well as in-person physiotherapy. About 176 adults aged 50 and older with knee pain will be split into two groups: one receiving …

This study tests whether adding suzetrigine (Journavx) to standard pain management can lower pain and reduce the need for opioid painkillers after total knee replacement. About 75 adults with knee arthritis will take the drug as part of their post-surgery care. The goal is to imp…

This study looks at two different methods to control pain after total knee replacement. One method combines two nerve blocks given by an anesthesiologist, while the other uses a nerve block plus a local painkiller injection by the surgeon. Researchers will review the medical reco…

This early study tests the safety of a single injection of a new polymer called ABR1 for knee osteoarthritis. About 25 adults with moderate to severe knee pain will receive the injection and be followed for 12 weeks. The main goal is to see if the treatment causes any side effect…

This study looks at whether using a gentle pulling force (mechanical traction) on the knee before or after exercise works better for easing pain and improving movement in people with knee osteoarthritis. Researchers will compare three groups: traction before exercise, traction af…

This study tests whether colchicine, a drug used for gout, can lower inflammation and pain in people with CPPD disease. About 150 adults will take either colchicine or a placebo daily for 6 months. Researchers will measure blood markers and joint symptoms to see if the drug helps…

This study tests whether a special knee and heel brace, combined with strength exercises done while sitting or lying down, can reduce pain and improve walking in people with knee osteoarthritis. Twenty participants will be randomly assigned to get either this new brace or a stand…

This study looks at whether adding kinesiotaping (a special elastic tape) to standard physical therapy can improve pain, movement, and fear of activity in people with knee osteoarthritis. Sixty adults aged 40-65 with mild knee arthritis will be randomly assigned to receive either…

This study tests whether a special light treatment, called photobiomodulation, can reduce pain and swelling in people with long-term knee osteoarthritis. Researchers will measure pain levels before and after treatment in 30 adults aged 50 and older. The goal is to find a drug-fre…

This study tests whether combining blood-flow-restricted exercise (light exercise with a cuff on the leg) and pain education can reduce pain and improve movement in people with knee osteoarthritis. About 90 adults aged 40 and older with knee osteoarthritis will take part. The goa…

This study compares two common shoulder replacement surgeries—anatomic and reverse—for people with shoulder arthritis and an intact rotator cuff. Researchers want to see which surgery leads to better pain relief and function one year after the procedure. About 108 participants wi…

This study tests whether adding high-intensity pulsed electromagnetic field (HI-PEMF) therapy to standard exercise can reduce pain and improve daily function in people who have had a total hip replacement. Forty adults who had hip replacement due to osteoarthritis will receive ei…

This study tests whether the drug vilamakitug can reduce symptoms of axial spondyloarthritis, a type of arthritis that causes back pain and stiffness. About 150 adults with active disease will receive either the drug or a placebo. The main goal is to see if more people get at lea…

This study will test whether high-intensity laser therapy, added to standard physiotherapy, can increase knee cartilage thickness and reduce pain in people with knee osteoarthritis. About 58 adults aged 40-60 with moderate knee OA will receive either laser plus physiotherapy or p…

This trial tests whether a genicular nerve block given before knee replacement surgery can reduce pain and the need for opioids. About 70 adults with knee osteoarthritis will receive either the nerve block or a placebo injection. Researchers will track pain levels, opioid use, an…

This study looks at three different ways to manage pain during and after hip replacement surgery in people aged 60 and older. All participants will get spinal anesthesia, but some will also get a nerve block around the hip joint, with or without an extra anti-inflammatory drug. T…

This study looks at whether a drug called acemetacin can reduce pain and control disease activity in adults with active axial spondyloarthritis, a type of inflammatory arthritis that mainly affects the spine. About 150 people aged 18 to 65 will take a daily pill for 4 weeks. Rese…

This study compares two methods of pain control after total knee replacement: a single injection of numbing medicine versus a continuous drip through a small tube for 48 hours. About 78 adults aged 40-80 will be randomly assigned to one of the two groups. The goal is to see which…

This study tests two ways to numb the knee after total knee replacement. One method uses a low-dose anesthetic on three main nerves, while the other uses a higher dose on two smaller nerves. The goal is to see which provides better pain relief with less muscle weakness, so patien…

This study tests whether applying bee venom gel to the knee during ultrasound therapy can reduce pain and improve movement in people with knee osteoarthritis. Thirty adults aged 40-75 will either get the bee venom treatment or a placebo gel. Researchers will measure pain, walking…

This study tests whether a substance made from stem cells (called secretome) can reduce pain and improve knee function in people with moderate knee osteoarthritis. Fifty adults aged 40-70 will receive either the secretome or a standard treatment (sodium hyaluronate) via injection…

This study looks at whether a well-formulated ketogenic diet can reduce pain and improve thinking in adults with osteoarthritis and mild cognitive impairment. Ten participants will follow a supervised low-carb, high-fat diet for a period, with before-and-after tests for pain, phy…

This study compares two types of total knee replacement surgery for people with knee osteoarthritis: one done manually and one assisted by a robotic device (VELYS). About 346 participants will be randomly assigned to one of the two surgeries and followed for a year to see which l…

This study looks at whether a program called PREP helps veterans who need total knee replacement for osteoarthritis. The program includes exercises before surgery and a week of intense rehab after. Researchers will check pain, function, and mental health for up to a year after su…

This study tests a pain-relief method called cryoneurolysis, which uses cold to temporarily freeze nerves, for people waiting months for hip or knee replacement surgery. The goal is to reduce pain and the need for opioid painkillers, which can be risky if used long-term. Research…

This study tests whether adding high-intensity laser therapy to standard physical therapy helps reduce pain and improve movement after knee replacement surgery. About 46 adults aged 50 to 80 will be randomly assigned to receive either real laser therapy or a sham treatment alongs…

This study tests whether adding a new nerve block to standard pain treatment can reduce pain and improve recovery after total knee replacement. About 132 adults having knee surgery will be randomly assigned to receive either the standard block alone or the standard block plus the…

This study compares two types of physical therapy for knee osteoarthritis: one done in a pool and one on land. Sixty-six adults aged 40-65 with knee osteoarthritis will receive either aquatic or land-based mobilization therapy for four weeks. Researchers will measure pain, stiffn…

This study compares a new treatment—focused shockwave therapy—to standard physical rehabilitation for people with mild to moderate knee osteoarthritis. About 60 participants will be randomly assigned to one of the two groups. The goal is to see if shockwave therapy can reduce kne…

This study looks at whether adding trunk (core) stabilization exercises to standard physical therapy can reduce knee pain and improve daily function in people with knee osteoarthritis who also have back pain (knee-spine syndrome). About 70 adults aged 40-60 with moderate knee art…

This study tests a 2-hour online class called Empowered Relief for 100 adults with advanced knee or hip osteoarthritis who cannot have joint replacement surgery. The class teaches simple pain management skills based on cognitive behavioral therapy and mindfulness. Researchers wil…

This study looks at whether a special two-bar knee brace, combined with strength exercises that don't put weight on the knee, can help people with knee osteoarthritis feel less pain and stiffness. 18 adults aged 45-60 with moderate knee arthritis will be split into two groups: on…

This study compares two surgical treatments for thumb arthritis: a prosthetic joint replacement (arthroplasty) versus removal of a small bone at the thumb base (trapeziectomy). Researchers will enroll 64 adults aged 18-69 with thumb arthritis that hasn't improved with non-surgica…

This study will look back at medical records of 133 adults aged 40-70 with painful knee osteoarthritis who received a single injection of hyaluronic acid. The goal is to see if one shot can reduce pain, stiffness, and improve function, potentially offering a simpler alternative t…

This study looks at whether drinking a daily whole food plant-based smoothie for two weeks before revision knee replacement surgery can lower inflammation and pain afterward. Twenty-four adults scheduled for surgery will either add the smoothie to their diet or make no changes. R…

This study tests whether gently rocking in a chair three times a day for 30 minutes helps people aged 65 and older recover after hip replacement surgery. Sixty participants will be randomly assigned to either rock or sit still in a chair. Researchers will measure how many people …

This study tests a new drug called AD-211 to find the best dose for easing knee pain from osteoarthritis. About 200 people with knee osteoarthritis will take part in this double-blind, placebo-controlled trial. The main goal is to measure pain reduction during activity over 24 ho…

This study looks at whether adding a nerve block to the back of the hip to two standard front-hip blocks can improve pain relief after hip surgery. About 50 adults having hip surgery will be split into two groups to compare pain scores and the need for extra pain medicine in the …

This study tests whether a 3-week strength training program, done with or without a special knee brace, can improve muscle function and symptoms in people with moderate knee osteoarthritis. 120 participants aged 55-75 will be randomly assigned to different training and brace grou…

This study tests a robot-aided elliptical trainer designed to improve knee control in directions other than just bending and straightening. The goal is to reduce knee pain and improve function in 36 adults aged 45-85 with knee osteoarthritis. Participants will use the device to r…

This study looks at whether walking to music or a metronome can help reduce pain and change how muscles work in people with chronic knee osteoarthritis. Twenty adults with knee pain will walk under different conditions—with music, with a metronome, or without either—while researc…

This study looks at whether using AI-made videos to show patients what happens during knee replacement surgery can lower their anxiety and fear of moving after the operation. About 150 adults aged 55 and older who are scheduled for knee replacement will take part. Half will get s…

This study compares two minimally invasive procedures to relieve long-term knee pain from osteoarthritis. One uses radiofrequency (heat) to block pain nerves, the other uses a small amount of alcohol. About 50 adults aged 45-85 with moderate to severe knee pain will be randomly a…

This study looks at whether a smartphone app that teaches cognitive behavioral therapy can help young adults (ages 15-39) with hip pain feel less depressed, anxious, and stressed. Researchers will also measure pain, physical function, and opioid use. Half of the 150 participants …

This pilot study will test whether a nurse-led telehealth self-monitoring program is acceptable and practical for people with rheumatoid arthritis. 104 adults who recently had a flare or medication change will use a web platform to report symptoms monthly. A rheumatology nurse wi…

This study compares two robot-assisted knee replacement methods for people with severe knee arthritis. One method uses a CT scan to plan the surgery (image-based), while the other uses a simpler approach without a scan (imageless). The goal is to see if the imageless method works…

This study tests a new injection called NANOVAE for people with knee osteoarthritis. The treatment is made from human amniotic fluid and is given directly into the knee joint. The goal is to see if it is safe and can help reduce pain and improve function. The study will include 2…

This study tests whether a single injection of platelet-rich plasma (PRP) can reduce pain and improve hand function in adults with thumb base osteoarthritis. 88 participants will receive either PRP or a placebo (saline) injection and be followed for one year. The goal is to see i…

This phase 2 trial tests a wearable device that delivers continuous ultrasound to the knee for 1-4 hours daily, with or without a diclofenac pain patch, compared to a standard steroid injection. 240 adults aged 65-85 with mild to moderate knee osteoarthritis will use the device a…

This study tests whether a structured progressive resistance training program can improve muscle strength in adults with rheumatoid arthritis (RA). About 118 participants will either do supervised exercises 3 times a week for 6 weeks or continue their usual care. Researchers will…

This study tests if a surgeon can numb the knee during replacement surgery as effectively as an anesthesiologist using ultrasound. 48 adults having both knees replaced will get one method on each knee. The goal is to see if the surgeon's technique provides equal pain relief and r…

This study will test whether a 6-week aerobic exercise program can improve quality of life, mood, and fatigue in women with rheumatoid arthritis. Sixty-four participants with low disease activity will either continue standard care or add five weekly exercise sessions. Researchers…

This trial tests whether using ultrasound to guide a nerve-freezing procedure (radiofrequency ablation) is better than the standard X-ray-guided method for people with chronic knee osteoarthritis. Fifty-two adults over 50 with severe knee pain will be randomly assigned to one of …

This study tests whether taking tranexamic acid pills for a week after knee replacement surgery helps people recover better. 350 adults having their first knee replacement will receive either the drug or a placebo. Researchers will track pain, stiffness, and function for up to 2 …

This study looks at whether injecting platelet-rich plasma (PRP) into the sacroiliac joint after hip replacement surgery can help people recover faster and have less pain. About 60 adults with hip arthritis who are scheduled for a hip replacement will take part. Half will get the…

This study explores whether exercising just one leg can improve strength, balance, and pain in both legs for older adults with knee osteoarthritis. Forty-five participants aged 60-80 will be assigned to different unilateral training programs for 8 weeks. Researchers will measure …

This study tests whether low-dose radiation can safely ease arthritis pain and swelling that some cancer patients get from immunotherapy. About 20 adults with cancer who developed joint inflammation from their treatment will receive six small radiation doses over 2-3 weeks. The m…

This study tests a pre-surgery support program for people waiting for hip or knee replacement. The program includes education, medical navigation, and exercise to improve risk factors like blood sugar and fitness. Researchers want to see if the program is feasible and helps patie…

This study will compare the effects of a single injection of platelet-rich plasma (PRP) versus conditioned serum (CS) in 60 people with knee osteoarthritis. Participants must have had knee pain for at least 6 months and meet specific criteria. The goal is to see which treatment b…

This early-stage study tests a new anti-CD14 injection for knee osteoarthritis in 30 Veterans. The goal is to see if the shot is safe and feasible, and if it can reduce pain and improve function. Participants will receive either a low dose, high dose, or placebo injection and be …

This study compares two pain relief methods for people undergoing total knee replacement: injecting numbing medicine into the knee area versus blocking several nerves around the knee. The goal is to see which method reduces the need for strong painkillers like opioids in the firs…

This study compares two ways to restrict blood flow during exercise—using a special floss band or a traditional cuff—to see which better reduces pain and improves movement in people with knee osteoarthritis. 46 adults aged 40-60 with mild to moderate knee OA will do leg exercises…

This study tests whether a 5-minute guided breathing technique called box breathing can help older adults (65+) manage stress and recover better after total knee replacement. Thirty-two participants will be randomly assigned to either the breathing exercise or a control activity.…

This study tests whether adding lavender aromatherapy massage to standard care can reduce pain and improve wrist movement in people with rheumatoid arthritis. About 100 adults with stable medication will be randomly assigned to get the massage or not. Researchers will measure pai…

This study tests whether tecar therapy, a type of targeted radiofrequency treatment, can reduce pain and improve physical function in people with chronic knee osteoarthritis. About 60 adults aged 40 to 75 with moderate knee arthritis will receive the therapy or a sham treatment. …

This pilot study tests whether pulsed electromagnetic field (PEMF) therapy can reduce pain and improve function in people with inflammatory knee osteoarthritis. Fifty participants will receive either active PEMF or a sham treatment twice a week for 8 weeks. The study measures pai…

This study tests whether a long-acting painkiller (bupivacaine-meloxicam) can reduce pain and the need for opioid medications after robot-assisted knee replacement. 150 adults with knee osteoarthritis will receive either the new painkiller or a standard injection. Researchers wil…

This study tests a special brace designed to gently distract (separate) the knee joint, aiming to reduce pain and improve function in people with medial knee osteoarthritis. Researchers will enroll 150 adults aged 30-70 with a BMI under 35. Participants will wear the brace and be…

This early-phase trial will test four orthobiologic treatments—PRP, bone marrow concentrate, hyaluronic acid, and nanofat—in 300 adults with various muscle, joint, tendon, or bone conditions. The goal is to see if these natural substances can reduce pain and improve joint functio…

This early study tests a device that uses gentle sound waves to treat chronic pain in the knee, nerves, or joints. Five adults with moderate-to-severe pain will receive a single 15-minute session. The goal is to see if the treatment safely reduces pain by at least half and improv…

This study tests two types of leg exercises—closed chain (like mini-squats) and open chain (like leg lifts)—both done with a blood flow restriction cuff on the thigh, in people with mild knee osteoarthritis. Forty participants aged 45-75 will do these exercises plus standard phys…

This study tests whether taking the drug tranexamic acid for up to 7 days after total knee replacement can improve pain, function, and knee movement. About 351 adults having knee surgery will be randomly assigned to take the drug for 3 days, 7 days, or a placebo. Researchers will…

This study tests whether a structured educational program can help adults with hemophilia who have chronic joint pain. The program teaches about pain, emotions, and coping strategies. 70 participants will be randomly assigned to either the education program or usual care, and the…

This study tests whether doing balance exercises with your eyes closed soon after knee replacement surgery improves recovery. About 66 people aged 60-85 who had a knee replaced due to arthritis will be split into two groups: one does standard rehab, the other adds special balance…

This study tests whether adding dual-task exercises—combining physical movements with mental tasks—improves pain, balance, and function after total knee replacement better than standard home exercises alone. Forty adults aged 50-65 who had a knee replacement will be split into tw…

This study looks at whether cooling the knee after total knee replacement surgery can help reduce pain and improve early recovery. About 99 adults having knee replacement will be randomly assigned to receive cooling with a special bandage, an ice pack, or standard care without co…

This study tests whether using a heart rate sensor to personalize home exercise can reduce pain and improve daily function better than a standard exercise program. About 240 adults aged 45+ with mild-to-moderate knee osteoarthritis will follow a 12-week program, with follow-up at…

This study compares adding electrical dry needling to standard physical therapy versus physical therapy alone for knee osteoarthritis. Forty-four adults aged 40-60 with moderate to severe knee pain will receive treatment for 6 weeks. Researchers will measure changes in pain, knee…

This study tests whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can reduce chronic pain in people with psoriatic arthritis. Researchers will give 40 adults with low disease activity but ongoing pain either real rTMS o…

This study tests whether auriculotherapy (ear acupuncture) can reduce pain after outpatient surgery for thumb arthritis. Sixty adults undergoing endoscopic thumb surgery will receive either real or sham ear acupuncture. Pain levels will be measured from day 1 to day 3 after surge…

This pilot study tests whether getting extra sleep (sleep banking) before knee or hip replacement surgery can help reduce chronic pain and the need for painkillers after the operation. Researchers will enroll 22 adults aged 18-74 scheduled for joint replacement at a Navy medical …

This study tests whether a program that strengthens the quadriceps and calf muscles can improve walking, reduce pain, and enhance sleep in people with knee osteoarthritis. About 52 adults aged 40-60 with moderate knee arthritis will be randomly assigned to either the exercise pro…

This study tests whether a powder made from Rosa roxburghii (a type of rose fruit) can help people recover after total knee replacement surgery for osteoarthritis. 184 participants will take either the supplement or a placebo daily for 30 days after surgery. Researchers will meas…

This study tests whether applying metformin gel through the skin with a mild electric current (iontophoresis) plus physical therapy can reduce pain and improve function in postmenopausal women with knee osteoarthritis. Sixty-eight women aged 50-70 will receive either the active g…

This study compares two add-on treatments for knee osteoarthritis in overweight women: walking on an anti-gravity treadmill that unloads the joints, or taking alpha-lipoic acid and omega-3 supplements. Both aim to reduce pain and improve function better than standard physical the…

This study looks at whether using a device called the Alexis wound retractor during hip replacement surgery helps wounds heal faster and reduces infections. About 202 adults with hip arthritis having a first-time hip replacement will take part. Researchers will compare healing, s…

This study tests whether adding a procedure called fenestration (making small holes in the cyst wall) to standard aspiration and steroid injection can improve outcomes for people with painful Baker's cysts behind the knee. Forty-four adults with knee osteoarthritis and a Baker's …

This study tests whether a mild electrical stimulation (called subthreshold stimulation) can reduce fatigue and improve leg muscle function in people with rheumatoid arthritis. Researchers will also measure inflammation and daily function. The study will include 84 adults aged 30…

This study tests whether using ultrasound therapy before a steroid injection into the joint can improve pain and swelling for people with arthritis. About 100 adults with arthritis in their arms or legs will receive the combined treatment. The goal is to see if the ultrasound hel…

This study tests whether a 12-week program of high-intensity interval training and strength training can improve heart and metabolic health in people with psoriatic arthritis. Researchers will also measure changes in fitness, pain, fatigue, and quality of life. The trial plans to…

This study tests whether hypnotherapy can reduce pain and anxiety in children aged 6 to 18 during needle procedures like injections or blood draws. About 70 kids with conditions like juvenile arthritis or lupus will be randomly assigned to receive either hypnotherapy or standard …

This study looks at whether a mobile app can help people with common pains (neck, shoulder, back, or knee) do their prescribed home exercises more regularly. About 30 adults will be split into two groups: one using the app and one doing traditional exercises. The goal is to see i…

This pilot study tests whether a home-based brain stimulation device (tDCS) can help people recover better after total knee replacement. About 70 adults scheduled for knee surgery will use the device before and after their operation. The main goal is to see if the study is feasib…

This study looks at whether leaving out bicarbonate from the numbing medicine (lidocaine with adrenaline) affects how well people recover the day after hand or foot surgery. About 150 adults having common procedures like carpal tunnel release or bunion surgery will be randomly as…

This study looks at whether healthy lifestyle education and personalized physical activity advice can reduce pain and improve daily function in people with knee osteoarthritis. About 26 adults aged 40 and older with knee osteoarthritis will be placed into one of three groups: sup…

This study compares general anesthesia (being fully asleep) with spinal anesthesia (numbing the lower body) in 600 adults having knee or hip replacement as outpatient surgery. The goal is to see which method leads to successful same-day discharge without readmission. Researchers …

This study tests a nursing program based on the ABC-X model for 117 adults aged 30-65 getting their first total knee replacement. The program helps patients and families handle stress, find support, and think more positively. Researchers will measure mental strength, self-care, e…

This study tests whether adding a specific nerve-stretching exercise (femoral nerve mobilization) to standard physical therapy can reduce pain and improve function in people with knee osteoarthritis. Fifty patients aged 50 or older with mild to moderate knee arthritis will be ran…

This early-phase trial tests whether giving a drug called palmitoylethanolamide before total knee replacement surgery can lower pain afterward. One adult aged 40–80 will receive either the drug or a placebo pill. Pain will be measured using a standard scale at 6, 12, and 24 hours…

This study will compare two different nerve block combinations used alongside standard anesthesia for total knee replacement surgery. One group gets an adductor canal block plus an iPACK block, while the other gets an adductor canal block plus a genicular nerve block. The goal is…

This study will enroll 68 adults aged 45-70 with grade III knee osteoarthritis to compare two physical therapy techniques: Mulligan mobilization with eccentric exercises versus Kaltenborn sustained mobilization with eccentric exercises. Participants will attend 3 sessions per wee…

This early-stage study tests a drug called CX-011 for moderate to severe knee osteoarthritis pain. About 72 adults aged 18-75 with knee osteoarthritis will receive the drug via injection into the knee joint. The main goals are to check safety and tolerability, and to see if it re…

This study tests whether a gel containing etodolac, applied to the skin over the knee, can improve pain and function when added to standard physiotherapy. Thirty people with mild to moderate knee osteoarthritis will receive either physiotherapy alone or physiotherapy plus the gel…

This study compares two physical therapy approaches for people with knee osteoarthritis: a gentle 'positional release' technique targeting tight leg muscles, versus balance and coordination exercises. Researchers will measure changes in pain, stiffness, and daily function in 60 p…

This study compares two surgical techniques for total knee replacement: mechanical alignment (the traditional method) and kinematic alignment (a newer approach). Researchers want to see which method leads to less pain and better knee function after surgery. About 96 adults with k…

This study will test two non-drug approaches—pain neuroscience education and vagus nerve stimulation—against traditional exercise in 36 people with rheumatoid arthritis. The goal is to see which method best reduces pain, improves quality of life, and lowers inflammation over 8 we…

This study compares two types of knee replacement surgery for people with arthritis on the inner side of the knee. About 100 adults will be randomly assigned to get either a partial or total knee replacement. Researchers will track pain, function, and quality of life for up to tw…

This study looks at whether combining resistance exercises with an anti-inflammatory diet can reduce pain, improve daily function, and boost quality of life in people with rheumatoid arthritis. About 100 adults with low to moderate disease activity will follow a structured progra…

This study will compare sensory-motor training (exercises that improve how your brain senses joint position) with resistance training (strengthening exercises) in 52 adults aged 40-60 with early-stage knee osteoarthritis (Grade 1 or 2). The goal is to see which approach better re…

This study tests whether an artificial intelligence system can create personalized exercise plans for people with rheumatoid arthritis. 147 patients with mild-to-moderate disease will be split into three groups: one using the AI system via a smartphone app, one using paper exerci…

This study tests a gel called Sensovisc, injected into the knee joint to reduce pain and improve movement in people with knee osteoarthritis. About 75 adults with moderate knee arthritis will receive the gel and be followed for 6 months. The goal is to see if the gel safely eases…

This study will compare three common injection treatments for knee osteoarthritis: steroids, dextrose prolotherapy, and platelet-rich plasma (PRP). Seventy-two adults aged 40 to 80 with moderate to severe knee arthritis will receive one of the three injections. Researchers will m…

This study looks at whether a common procedure for varicose veins—called endovenous ablation—can also reduce knee pain in people aged 80 and older. The researchers will follow 50 participants for one year after treatment, measuring pain and knee function. The goal is to see if im…

This study tests a gel called Sensovisc, made of sodium hyaluronate, injected into the hip joint to relieve pain from osteoarthritis. The gel aims to restore the joint's natural fluid, reducing pain and improving movement. Researchers will track 25 adults with moderate hip arthri…

This study tests a program called BOOST-OA designed to help veterans with knee osteoarthritis stick to their home exercise routines. The program includes goal-setting tools during physical therapy and follow-up health coaching calls for 9 months after therapy ends. Researchers wi…

This study tests whether a new tablet called Laybon is as good as an existing drug (Layla) at reducing knee pain from osteoarthritis. About 172 adults aged 40-80 with knee osteoarthritis will take either Laybon or Layla twice daily for 8 weeks. The main goal is to see if knee pai…

This study tests whether injecting tiny gold particles into the knee can reduce pain and the need for additional treatments in people with knee osteoarthritis. About 240 adults with long-term knee pain will receive either gold microparticles or a placebo. The goal is to see if th…

This study tests whether inulin, a prebiotic fiber from chicory root, can reduce inflammation and knee pain in older adults with osteoarthritis. Over 8 weeks, 84 participants will take either inulin or a placebo daily. Researchers will measure changes in blood markers of inflamma…

This study tests whether wrapping an elastic band around the knee (tissue flossing) combined with simple exercises can reduce pain and improve movement in people with knee osteoarthritis. Fifty-eight adults aged 40-70 with mild to moderate knee OA will be split into two groups: o…

This study tests whether virtual lifestyle-focused pain care works as well as in-person care for adults with chronic back, knee, or hip pain living in rural areas. Participants will receive up to 10 sessions over six months, either in-person with a physiotherapist or virtually wi…

This study tests a therapeutic education program designed to improve self-image and self-esteem in adults with chronic inflammatory rheumatic diseases like rheumatoid arthritis and spondyloarthritis. Sixty participants will complete questionnaires and interviews before and after …

This early-phase trial tests whether injecting a fluid made from stem cells (called secretome) mixed with growth factors from the patient's own blood can safely reduce knee pain and improve function in people with mild knee osteoarthritis. The study will enroll 25 adults aged 30-…

This study tests whether adding a steroid to the standard pain injection during total knee replacement improves pain control and reduces the need for opioid painkillers. 240 adults undergoing knee replacement will be randomly assigned to receive either the standard injection, one…

This observational study will follow 150 people with thoracolumbar spine fractures to see how the injury and its treatment (surgery or non-surgical care) affect joint and disc degeneration over time. Researchers will compare CT scans and pain scores between treated patients and a…

This study checks how consistently six doctors can grade degeneration of the small joints in the spine (facet joints) using CT scans. It includes 12 patients and uses the Pathria scale. The goal is to see if the grading method is reliable, not to test a treatment.

This study tests whether two different capsule forms of the experimental drug SKI-O-703 are absorbed similarly in the body. About 48 healthy adults (Korean and Caucasian) will take a single dose of each form on separate days, with blood samples taken to compare drug levels. The r…

This study will test whether common orthopedic materials, like titanium alloy and polylactic acid (PLA), are safe for use in knee surgery. Researchers will expose human tissue samples from 50 knee replacement patients to these materials in the lab. They will check for cell damage…

This study looks at whether a routine blood test can predict which patients with knee osteoarthritis will get good pain relief from platelet-rich plasma (PRP) injections. Researchers will enroll 120 people aged 40-60 with moderate knee arthritis. Each person will receive three PR…

This study will test whether a short health aid—a tool that corrects common misunderstandings about knee osteoarthritis—can help patients feel less worried and make clearer treatment choices. About 159 adults with knee osteoarthritis will be randomly assigned to review the health…

This study looks at how two thumb muscles work in people with and without thumb base osteoarthritis while they do six daily tasks like turning a key or writing. Researchers will use sticky sensors to record muscle activity. The goal is to find differences that could lead to bette…

This study uses brain MRI to compare brain activity in women over 40 with knee osteoarthritis who have two different types of pain: joint-related pain and nerve-related pain. Researchers will look at a brain region called the anterior insula to see if activity differs between the…

This study will measure how much of the drug TREMFYA (guselkumab) passes into breast milk of 10 nursing women who are already taking it for conditions like psoriasis, psoriatic arthritis, ulcerative colitis, or Crohn's disease. Researchers will collect milk samples to estimate th…

This study will follow about 950 people who receive hip or knee replacements using Stryker implants, some with the Mako robotic-arm system and some without. Researchers will track how long the implants last and how well patients feel and function over five years. The goal is to g…

This study investigates whether alexithymia—a condition where people struggle to identify and describe their emotions—affects how well patients with knee osteoarthritis respond to physical therapy. Sixty participants aged 40 to 75 with moderate knee osteoarthritis will receive a …

This study will measure a protein called IL-41 in the blood of 90 people with ankylosing spondylitis or psoriatic arthritis, plus healthy volunteers. Researchers want to see if higher levels of this protein are linked to more active disease. The goal is to find a simple blood tes…

This study looks at 80 people having hip or knee replacement surgery to compare two ways of giving a drug called tranexamic acid, which helps reduce bleeding. Half will get the drug through a standard IV, and the other half will get it injected into the bone. Researchers will mea…

This study will check 45 adults with ankylosing spondylitis for peripheral neuropathy (nerve damage in the arms and legs) using nerve conduction tests. Researchers want to see if nerve problems are linked to higher disease activity, increased pain sensitivity, and worse quality o…

This study will compare two FDA-approved machines that make platelet-rich plasma (PRP) for people with knee osteoarthritis. PRP is made from a person's own blood and is injected into the knee to help with pain and stiffness. The researchers will check if the two machines produce …

This study looks at how often muscle weakness and loss (sarcopenia) happens in people aged 15 to 40 with juvenile idiopathic arthritis. Researchers will measure grip strength, do body scans, and use questionnaires to check muscle health. The goal is to find out how common this pr…

This study aims to translate and adapt a widely used questionnaire for musculoskeletal problems into Urdu. Researchers will enroll 110 Urdu-speaking adults, including patients with muscle or joint issues and healthy volunteers. The goal is to create a validated tool to measure sy…

This study checks whether two short questionnaires can accurately measure physical fitness in children aged 10–18 with juvenile idiopathic arthritis or familial Mediterranean fever. Researchers will compare the questionnaire results with standard fitness tests. If the questionnai…

This study looks at how thumb arthritis changes joint pressure and how two types of surgery (with or without a metal implant) affect that pressure. Researchers will use CT scans and computer models to simulate loads in the thumb joint. 40 adults aged 50 to 88 with moderate to sev…

This study follows 150 people aged 18-60 who had big toe fusion surgery for hallux rigidus or hallux valgus. Researchers want to see how well patients return to physical activities, especially cross-country skiing, by comparing current sports function to before surgery. Participa…

This study will follow 500 people with knee injuries or knee osteoarthritis who receive standard care at a hospital in China. Researchers will collect medical history, imaging, and function tests at the start and then again at 6, 12, and 24 months. The goal is to better understan…

This study tests whether smartphone data and optional smartwatches can detect early signs of psoriatic arthritis in people with psoriasis. About 3,458 adults with psoriasis but no arthritis will use an app that passively collects phone data. The goal is to develop algorithms that…

This study looks at how patients feel when reading their own medical notes. Some will read the original doctor's note, others will read a simpler version written by artificial intelligence. Researchers want to see if the AI summary changes how much patients trust their doctor or …

This study will test a new care pathway for rehabilitation after total knee replacement. The pathway includes a patient education booklet and optimized scheduling of physical therapy. Researchers want to see if this approach improves recovery and reduces differences based on race…

This study will test a new positioning aid called Tru-Vu that helps radiographers take clearer wrist x-rays. About 1,800 adults with wrist injuries or arthritis will be included across three different healthcare centers in Newfoundland and Labrador. Researchers want to see if the…

This study will follow 100 people getting a total knee replacement to see if those with chronic venous insufficiency (poor blood flow in leg veins) have more wound healing problems. Participants will have an ultrasound before surgery to check their veins and then be monitored for…

This observational study follows 400 adults with psoriatic arthritis who are starting a new biologic or targeted synthetic drug as part of their routine care. Researchers want to see if treatment response differs based on how many prior advanced therapies a person has tried, and …

This study will track sleep patterns in 20 people before and after reverse shoulder replacement surgery. Participants will wear a MotionWatch 8 sleep tracker for a week before surgery and again 6 months after. The goal is to see if better sleep is linked to better recovery and sh…

This observational study in Mexico will follow 30 adults already taking tirzepatide for conditions like diabetes or obesity. Researchers will use MRI scans of the knees, CT scans of the heart, and body composition tests to see how the drug affects cartilage, heart fat, and overal…

This study will compare women with knee osteoarthritis who also have lipedema (a fat tissue disorder) to those without lipedema. Researchers will use ultrasound to measure knee cartilage thickness and questionnaires to assess pain and daily function. The goal is to understand if …

This study looks at two different ways to perform reverse total shoulder replacement in 130 people aged 60-85 with severe shoulder arthritis and torn rotator cuffs. The goal is to see which technique leads to better muscle activity and arm movement. Participants will have their s…

This study follows 60 adults getting hip or knee replacement to track their sleep before and up to 6 months after surgery. Participants use a special device and app to measure sleep quality, pain, and recovery. The goal is to learn when sleep returns to normal so doctors can give…

This study will check how many people with knee osteoarthritis also have sarcopenia—a condition of low muscle mass and strength. Researchers in Upper Egypt will study 224 adults aged 40 and older to measure muscle health, nutrition, and quality of life. The goal is to better unde…

This study looks at whether two substances in the blood, IL-6 and MMP-7, can help doctors diagnose and predict the course of a rare lung disease in children. Researchers will measure these markers in 60 children with immune-mediated interstitial lung disease and compare them to h…

This study looks back at medical records of 3,500 adults who had a first-time knee replacement to compare different brands of knee implants. Researchers want to see which implant leads to better knee function, fewer complications, and lower costs over time. The goal is to help do…

This study will use ultrasound to check for tendon inflammation (tenosynovitis) in children with two types of juvenile idiopathic arthritis (JIA): polyarticular and oligoarticular. Researchers will examine 106 children under 16 at Assiut University Hospital, comparing physical ex…

This study will follow 200 people who have had a complex or revision hip replacement at University Hospitals Leuven. The goal is to track how many need another surgery and why, and to improve care by learning from real-world results. No new treatment is being tested—this is an ob…

This study looks at how starting a gradual running program affects knee joint health in people who are new to running, including those with knee osteoarthritis. Researchers will use MRI scans to measure changes in knee cartilage over six months. The goal is to understand whether …

This observational study will measure two substances in the blood—COMP and MMP-3—in 60 people with knee osteoarthritis and healthy controls. Researchers want to see if these markers relate to pain, function, and X-ray findings. No treatment is given; the goal is to better underst…

This study looks at whether it's possible to run a larger trial of a community-based program called Good Boost+ for adults waiting for knee replacement surgery. The program includes weekly group water exercises and land-based exercises, plus peer support. Researchers will measure…

This study aims to learn which FDA-approved rheumatoid arthritis (RA) medication works best for each individual patient. Researchers will enroll 18 adults with newly diagnosed, moderately to severely active RA. Participants will try up to four different RA drugs in a random order…

This study follows 60 adults with hand or upper limb injuries to see if improvements in the first weeks of rehab can predict function months later. A digital tool created by a therapist tracks progress and patient feedback. The goal is to help clinicians make better, data-driven …

This study will follow 100 adults with knee arthritis who are scheduled for knee replacement surgery. Researchers will measure how changes in the shape of the knee bones after surgery affect how well the knee bends and how much pain patients feel. The goal is to find the best ali…

This study will look at the health records of 350 people with psoriasis in Costa Rica to find out how many also have conditions like obesity, diabetes, high blood pressure, heart disease, or psoriatic arthritis. Researchers want to understand how these problems relate to psoriasi…

This observational study will look at 138 adults with hemophilia and joint damage to understand how central pain mechanisms and psychological factors like anxiety affect pain interference in daily activities. Researchers will measure pain intensity, sleep quality, and pain self-e…

This observational study will follow 50 patients with primary spondylodiscitis, a serious spinal infection, for one year. Researchers will track cure rates, pain levels, and daily function using standard treatments like antibiotics and braces. The goal is to understand how well c…

This study will measure the activity of a gene called TNFAIP3 in 110 people with ankylosing spondylitis or psoriatic arthritis. The goal is to see if the gene's expression is linked to how active the disease is. Researchers will use a blood test to check gene levels and compare t…

This study looks at whether using a tourniquet during total knee replacement is necessary. A tourniquet is a tight band that stops blood flow to reduce bleeding during surgery. Researchers want to see if doing the surgery without a tourniquet works just as well. Thirty adults wit…

This study looks at whether analyzing synovial tissue can help doctors better manage pigmented villonodular synovitis (PVNS), a rare joint disease that causes pain and joint damage. Researchers will collect tissue samples from 30 patients through biopsy or surgery to assess quali…

This study will use special PET/MRI scans to look at changes in knee metabolism after a procedure called genicular artery embolization (GAE) for knee osteoarthritis. The goal is to understand why some people get good pain relief and others do not. About 25 adults with moderate to…

This study tracks surgeon stress during partial knee replacements. Using a wearable vest, researchers measure heart rate, breathing, and energy burned while surgeons operate with either a manual or computer-assisted technique. The goal is to see if computer guidance makes the sur…

This study compares two different X-ray views—full-leg standing and Rosenberg—to measure a specific knee angle (MPTA) in 49 patients scheduled for high tibial osteotomy. The goal is to see if one view gives more consistent or accurate measurements, which could help surgeons bette…

This study will use advanced CT and MRI scans to see how knee realignment treatments (surgery or braces) affect bone structure and cartilage in 30 people with early knee osteoarthritis. Researchers want to understand why some treatments fail, so they can improve care for younger …

This study looks at how your sense of joint position, fear of moving, balance, and sensory processing affect recovery after knee osteoarthritis surgery. Researchers will measure these factors in 75 people aged 50-75 who had a total knee replacement 4-6 weeks ago. The goal is to b…

This study tests whether a smartphone app can help people with rheumatoid arthritis, spondyloarthritis, or psoriatic arthritis learn how to use their anti-rheumatic drugs more safely. About 144 adults will either use the app or receive standard care with a website. The goal is to…

This observational registry will follow 50 patients with psoriasis or psoriatic arthritis who are receiving IL-23 inhibitors (guselkumab or risankizumab) as part of their routine care in Costa Rica. Researchers will track how well the drugs improve skin and joint symptoms and qua…

This study looks at thumb osteoarthritis, a common cause of pain and weakness at the base of the thumb. Researchers will assess 93 people using a broad approach that includes physical, psychological, and social factors. They will also test whether artificial intelligence can pred…

This study investigates the connection between temporomandibular joint (TMJ) disorders and tinnitus (ringing in the ears). Researchers will use 3D jaw imaging and hearing tests in 50 adults to see if jaw bone shape and arthritis are linked to tinnitus. The goal is to better under…

This pilot study will test whether a smartwatch can measure pain levels in 15 people with knee osteoarthritis. Participants will wear an Embrace Plus smartwatch that tracks electrodermal activity (skin signals) while reporting their pain during standard physical tests. The goal i…

This study looks at how fear of movement (kinesiophobia) affects daily function in people with rheumatoid arthritis. Researchers will compare 200 RA patients with 200 healthy volunteers to understand links between fear, pain, fatigue, mood, and muscle loss. The goal is to find no…

This study will use DEXA bone scans to see how the CoreHip hip replacement stem affects bone density around the implant over two years. Forty adults with hip arthritis or other hip conditions will be enrolled. The goal is to understand if the implant's design helps maintain healt…

This study looks at whether children with juvenile idiopathic arthritis (JIA) have scoliosis (a curved spine) and how it affects their daily life, posture, and arthritis activity. Researchers will check 200 children aged 8-18 using X-rays and health surveys. The goal is to unders…

This study looks at how the antibiotic delafloxacin spreads through the body in 20 adults with serious skin, soft tissue, bone, or joint infections. Researchers will measure drug levels in blood and in tissues collected during surgery. The goal is to understand if the drug reache…

This study at Montpellier University Hospital will look at whether low muscle mass and strength before hip replacement surgery affects how well people aged 75 and older regain their independence. About 20 volunteers will have blood tests, scans, and a tiny muscle sample taken dur…

This study looks at how two thumb muscles work during different exercises in people with and without thumb base osteoarthritis. Researchers will measure muscle activity using sensors while participants perform everyday tasks like turning a key or picking up a coin. The goal is to…

This study will interview 63 people, including patients with prosthetic joint infections, their family members, and healthcare professionals, to understand their experiences. The goal is to use this information to create a therapeutic education program that helps patients manage …

This observational study will measure levels of certain immune proteins (IL-17, IL-38, IL-41) and the HLA-B27 gene in 84 people with ankylosing spondylitis and a healthy control group. The goal is to see if these markers are linked to disease activity and severity. No treatment i…

This study aims to see if certain markers in the blood (CCR6 and CCL20) are linked to rheumatoid arthritis. Researchers will compare 60 adults with RA to healthy people. The goal is to learn more about the disease, not to test a new treatment.

This study tests a new digital health tool designed to help adults aged 40 and older who have two or more long-term health conditions, like high blood pressure, diabetes, or depression. The tool includes an electronic system to guide doctors, telemedicine for specialist visits, a…

This study looks at a blood protein called FAP, which is linked to tissue scarring and inflammation. Researchers will measure FAP levels in people with rheumatoid arthritis and systemic sclerosis, as well as healthy volunteers, and compare them with standard tests and lung functi…

This study aims to see if a submaximal bike test, called the Ekblom-Bak test, gives consistent results when repeated in people with hip or knee osteoarthritis. Forty patients will take the test twice, one to two weeks apart. The goal is to determine if this test can be reliably u…

This study will check if a protein called Tim-3 on certain white blood cells (neutrophils) is linked to disease activity in people with ankylosing spondylitis. Researchers will measure Tim-3 levels and compare them with inflammation markers and MRI scans of the hip and sacroiliac…

This study will collect blood samples from 30,000 adults in the UK with various health conditions, including blood clots, infections, heart disease, diabetes, and more. The samples will be used to develop and fine-tune new diagnostic tests for the cobas® lumira device, which allo…

This study looks at a protein called isthmin-1 in the blood of people with rheumatoid arthritis (RA) compared to healthy volunteers. Researchers want to see if higher levels of this protein match up with more active disease, as seen on ultrasound scans. The goal is to find a simp…

This study will check if certain blood markers (like NLR and PLR) can predict how well people recover after surgery for a joint infection. Researchers will follow 200 adults who need a two-stage joint replacement revision. The goal is to find cheap, easy tests that help doctors p…

This study aims to find out how common Borrelia arthritis is in Denmark and how it affects patients. Researchers will test blood and joint fluid from 350 adults with joint swelling to look for Borrelia bacteria. Participants will also answer questions about symptoms and tick expo…

This study examines how much the tensor fascia latae muscle is damaged during hip replacement surgery through the front approach. Researchers will compare the amount of muscle damage to how well patients recover at 6 weeks and 6 months. The goal is to understand if less muscle da…

This study will look at tissue and bacteria samples from 20 people having surgery for severe temporomandibular joint (TMJ) problems like ankylosis or osteoarthritis. Researchers want to find out what causes these severe conditions and whether bacteria in the joint affect recovery…

This study will use a smart knee implant (Persona IQ®) to continuously track movement after total knee replacement surgery. Researchers want to compare two surgical approaches (medial parapatellar vs. subvastus) to see which leads to better early recovery. About 110 adults gettin…

This study tests a decision support system called SmaRTWork to help people on sick leave due to muscle or back pain return to work. About 298 adults in Norway will either use the system or receive usual care. The main goal is to see if the tool helps them return to work sustainab…

This study will test if a digital education app helps patients prepare for hip or knee replacement surgery. About 160 adults scheduled for a first-time joint replacement will either use the app or receive standard preparation. The goal is to see if the app improves knowledge, con…

This study looks at how two different exercise programs—high-intensity intervals and moderate continuous activity—affect a blood marker called irisin, as well as disease activity, physical function, and quality of life in people with axial spondyloarthritis. About 75 adults with …

This study will measure harmful molecules called AGEs in 300 people with various rheumatic diseases (like rheumatoid arthritis and ankylosing spondylitis) and compare them to healthy volunteers. AGEs build up over time and can cause inflammation. Researchers will use a non-invasi…

This study will compare blood test results and ultrasound images of joints in 72 people with rheumatoid arthritis. Half are taking JAK inhibitors, and half are on traditional treatments. The goal is to see if certain blood markers can reliably show how active the disease is, whic…

This study will compare MRI scans with standard X-rays to see which method better detects knee joint damage in adults with hemophilia who have had repeated bleeding in the knee. Researchers will use special scoring systems to measure early and advanced joint changes. The goal is …

This study looks at whether regular video calls with a lung specialist can help people in rural areas who have a rare lung disease linked to autoimmune conditions like rheumatoid arthritis. Ten adults will get care through a team that includes local doctors and a specialist at Ma…

This study follows 150 people at different risk levels for rheumatoid arthritis (RA) to see what factors might lead to the disease. Participants provide blood, urine, stool, and saliva samples, and answer questions about their lifestyle. The goal is to identify triggers like smok…

This study follows 100 children aged 6 to 17 with juvenile psoriatic or enthesitis-related arthritis who are taking secukinumab. Researchers will observe how doctors adjust treatment after the disease becomes inactive, and whether patients experience flares. The goal is to learn …

This study will use a special blood test called mass spectrometry to look at immune cells in 500 people with various autoimmune diseases and healthy volunteers. The goal is to find patterns that could help doctors diagnose these conditions sooner. No treatments are being tested; …

This study looks at whether the bacteria in your gut (the gut microbiome) is different in people whose knee replacements fail versus those whose knees work well. Researchers will compare gut bacteria in 30 patients needing repeat knee surgery to those with successful implants. Th…

This study looks at how two types of rheumatoid arthritis (RA) drugs—anti-TNF-α and non-TNF-α—affect patients' aerobic capacity, muscle strength, fatigue, and heart disease risk factors. Researchers will measure oxygen use during exercise, muscle strength, and disease activity in…

This study looks at whether two substances in the blood, called MMP7 and MMP9, can help identify lung disease in people with rheumatoid arthritis. Researchers will compare 81 participants: those with rheumatoid arthritis and lung disease, those with rheumatoid arthritis alone, an…

This study looks at how having a structured, values-based conversation affects people's decisions about diagnostic imaging tests for common musculoskeletal conditions like arthritis, carpal tunnel syndrome, and tendon problems. About 220 adults from a specialty clinic will read a…

This study will follow 50 adults with varicose veins and chronic knee pain who are scheduled for standard vein treatment (laser or radiofrequency ablation). Researchers will measure changes in knee pain, stiffness, and function before and after the procedure. The goal is to see i…

This study will collect health information, samples, and data from 100 people in Luxembourg (800 total across Europe) who have rheumatoid diseases and are starting or changing treatment. Researchers hope to find patterns that can predict which treatments work best for each person…

This study uses computer simulations to better understand how a subcutaneous (under-the-skin) form of the drug infliximab works in people with inflammatory bowel disease (IBD) and rheumatoid arthritis. Researchers will analyze data from previous trials to create a model that pred…