New hope for rare joint disease: arthritis drug tocilizumab tested in CPPD

NCT ID NCT07254637

Not yet recruiting Disease control Sponsor: Assistance Publique - Hôpitaux de Paris Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether tocilizumab, an anti-inflammatory drug already used for rheumatoid arthritis, can reduce joint pain and improve quality of life in people with chronic inflammatory calcium pyrophosphate deposition disease (CPPD) that hasn't improved with standard treatments. Eighty adults will receive monthly infusions of tocilizumab or a placebo for three months. The main goal is to see if pain decreases after treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: tocilizumab (a drug that blocks inflammation, given as an IV infusion)
What this could lead to: If it works, this could offer a new treatment option for people with chronic inflammatory CPPD who have not responded to standard therapies.
What could go wrong: This is a small, early-phase trial (Phase 2) with only 80 participants. The drug may not prove effective, and side effects from tocilizumab (such as infections) are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

chondrocalcinosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CALCIUM PYROPHOSPHATE DEPOSITION DISEASE

Contacts and locations

Locations

CHU de Dijon

Dijon, 21000, France
CHU de Nantes

Nantes, 44000, France
CHU de Rennes

Rennes, 35200, France
CHU de Saint-Étienne

Saint-Etienne, 42100, France
Centre Hospitalier Sud-Francilien

Corbeil-Essonnes, Paris, 91100, France
Groupe Hospitalier Intercommunal Le Raincy-Montfermeil

Paris, 93370, France
Groupe Hospitalier de l'Institut Catholique de Lille

Lomme, Lille, 59462, France
Hôpital Bichat Claude-Bernard

Paris, 75018, France
Hôpital Le Kremlin Bicêtre

Paris, 94270, France
Hôpital Tenon

Paris, 75020, France
Hôpital de la Croix Saint-Simon

Paris, 75020, France
Lariboisière hospital

Paris, Paris Paris, 75010, France